Characterization of nociceptive responses and spinal releases of nitric oxide metabolites and glutamate evoked by different concentrations of formalin in rats

Pain

Volumn 92, Issue 1-2, 2001, Pages 107-115

  Okuda, Kazuhiro ^a   Sakurada, Chikai ^b   Takahashi, Mitsuo ^a   Yamada, Tatsuo ^a   Sakurada, Tsukasa ^b  

^a FUKUOKA UNIVERSITY   (Japan)

^b DAIICHI UNIVERSITY OF PHARMACY   (Japan)

Author keywords

Flinching; Formalin test; Glutamate; Intrathecal microdialysis; Licking biting; Nitric oxide; Spinal cord

Indexed keywords

FORMALDEHYDE; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID; NITRATE; NITRIC OXIDE; NITRITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; BITE; CONTROLLED STUDY; DOSE RESPONSE; INJECTION SITE; LICKING; MALE; METABOLITE; NEUROTRANSMITTER RELEASE; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD; SUBARACHNOID SPACE;

ANIMALS; BEHAVIOR, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FORMALDEHYDE; GLUTAMIC ACID; HINDLIMB; MALE; MICRODIALYSIS; NITRATES; NITRIC OXIDE; NITRITES; NOCICEPTORS; PAIN MEASUREMENT; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD;

EID: 0035063934     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3959(00)00476-0     Document Type: Article

References (44)

1. Nociceptive action of excitatory amino acids in the mouse: Effects of spinally administered opioids, phencyclidine and sigma agonists
2. The formalin test: Scoring properties of the first and second phases of the pain response in rats
3. Subcutaneous formalin induces a segmental release of Met-enkephalin-like material from the rat spinal cord
4. Nitric oxide, a novel neuronal messenger
5. The behavioural effects of an N-methylaspartate receptor antagonist following application to the lumbar spinal cord of conscious rats
6. Met-enkephalin levels and opioid receptors in the spinal cord of chronic suffering rats
7. The formalin test: A validation of the weighted-scores method of behavioural pain rating
8. Subcutaneous formalin-induced activity of dorsal horn neurones in the rat: Different responses to an intrathecal opiate administered pre- or post-formalin
9. Peripheral origins and central modulation of subcutaneous formalin-induced activity of rat dorsal horn neurones
10. The formalin test: A quantitative study of the analgesic effects of morphine, meperidine and brain stem stimulation in rats and cat
11. Nitric oxide synthase immunoreactivity in rat spinal cord
12. Electrophysiological evidence for a role of nitric oxide in prolonged chemical nociception in the rat
13. Sensitization of spinal neurons by non-noxious stimuli in the awake but not anesthetized state
14. Prodynorphin gene expression is enhanced in the spinal cord of chronic arthritic rats
15. The formalin test in mice: Dissociation between inflammatory and non-inflammatory pain
16. Electroencephalographic responses to the formalin test in rats
17. The effect of morphine, methadone and meperidine on some reflex responses of spinal animals to nociceptive stimulation
18. Involvement of nitric oxide in spinally mediated hyperalgesia in the mouse
19. Induction of spinal cord neuronal nitric oxide synthase (NOS) after formalin injection in the rat hind paw
20. Spinal nitric oxide synthesis inhibition blocks NMDA-induced thermal hyperalgesia and produces antinociception in the formalin test in rats
21. The spinal loop dialysis catheter: Characterization of use in the unanesthetized rat
22. Nitric oxide (NO) and nociceptive processing in the spinal cord
23. Production of endogenous nitric oxide and activation of soluble guanylate cyclase are required for N-methyl-D-aspartate-produced facilitation of the nociceptive tailflick reflex
24. The role of nitric oxide in the development and maintenance of the hyperalgesia produced by intraplantar injection of carrageenan in the rat
25. A model of chronic pain in the rat: Functional correlates of alterations in the activity of opioid systems
26. G-nitro arginine methyl ester exhibits antinociceptive activity in the mouse
27. L-NAME blocks responses to NMDA, substance P and noxious cutaneous stimuli in cat dorsal horn
28. Enhanced descending modulation of nociception in rats with persistent hindpaw inflammation
29. The formalin test in mice: Effect of formalin concentration
30. Spinal pain suppression mechanisms may differ for phasic and tonic pain
31. The effects of substance P analogues on the scratching, biting and licking response induced by intrathecal injection of N-methyl-D-aspartate in mice
32. Effect of spinal nitric oxide inhibition on capsaicin-induced nociceptive response
33. Involvement of nitric oxide in spinally mediated capsaicin- and glutamate-induced behavioural responses in the mouse
34. Changes in tonic descending inhibition of spinal neurons with articular input during the development of acute arthritis in the cat
35. Persistent cardiovascular and behavioral nociceptive responses to subcutaneous formalin require peripheral nerve input
36. Pituitary-adrenocortical responses to persistent noxious stimuli in the awake rat: Endogenous corticosterone does not reduce nociception in the formalin test
37. Immunohistochemistry of nitric oxide synthase demonstrates immunoreactive neurons in spinal cord and dorsal root ganglia of man and rat
38. The formalin test: An evaluation of the method
39. Nitric oxide synthase and GABA colocalize in lamina II of rat spinal cord
40. Standardization of the rat paw formalin test for the evaluation of analgesics
41. Naloxone causes apparent antinociception and pronociception simultaneously in the rat paw formalin test
42. Nitric oxide contributes to central sensitization following intradermal injection of capsaicin
43. Nitric oxide synthase inhibitor blocks spinal sensitization induced by formalin injection into the rat paw
44. Pharmacodynamics of plasma nitrate/nitrite as an indication of nitric oxide formation in conscious dogs