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Volumn 47, Issue 1, 2008, Pages 64-70

FLT3 mutations in a 10 year consecutive series of 177 childhood acute leukemias and their impact on global gene expression patterns

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN TYROSINE KINASE;

EID: 36549062926     PISSN: 10452257     EISSN: 10982264     Source Type: Journal    
DOI: 10.1002/gcc.20508     Document Type: Article
Times cited : (24)

References (50)
  • 2
    • 1942468804 scopus 로고    scopus 로고
    • Clinical impact of internal tandem duplications and activating point mutations in FLT3 in acute myeloid leukemia in elderly patients
    • Andersson A, Johansson B, Lassen C, Mitelman F, Billström R, Fioretos T. 2004. Clinical impact of internal tandem duplications and activating point mutations in FLT3 in acute myeloid leukemia in elderly patients. Eur J Haematol 72:307-313.
    • (2004) Eur J Haematol , vol.72 , pp. 307-313
    • Andersson, A.1    Johansson, B.2    Lassen, C.3    Mitelman, F.4    Billström, R.5    Fioretos, T.6
  • 8
    • 11244300074 scopus 로고    scopus 로고
    • FLT3 inhibition selectively kills childhood acute lymphoblastic leukemia cells with high levels of FLT3 expression
    • Brown P, Levis M, Shurtleff S, Campana D, Downing J, Small D. 2005. FLT3 inhibition selectively kills childhood acute lymphoblastic leukemia cells with high levels of FLT3 expression. Blood 105:812-820.
    • (2005) Blood , vol.105 , pp. 812-820
    • Brown, P.1    Levis, M.2    Shurtleff, S.3    Campana, D.4    Downing, J.5    Small, D.6
  • 9
    • 27244453278 scopus 로고    scopus 로고
    • Acute myeloid leukaemia with FLT3 gene mutations of both internal tandem duplication and point mutation type
    • Chen W, Jones D, Medeiros LJ, Luthra R, Lin P. 2005. Acute myeloid leukaemia with FLT3 gene mutations of both internal tandem duplication and point mutation type. Br J Haematol 130:726-728.
    • (2005) Br J Haematol , vol.130 , pp. 726-728
    • Chen, W.1    Jones, D.2    Medeiros, L.J.3    Luthra, R.4    Lin, P.5
  • 10
    • 0037114829 scopus 로고    scopus 로고
    • Fröhling S, Schlenk RF, Breitruck J, Benner A, Kreitmeier S, Tobis K, Döhner H, Döhner K. 2002. Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: A study of the AML Study Group Ulm. Blood 100:4372-4380.
    • Fröhling S, Schlenk RF, Breitruck J, Benner A, Kreitmeier S, Tobis K, Döhner H, Döhner K. 2002. Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: A study of the AML Study Group Ulm. Blood 100:4372-4380.
  • 11
    • 0034598830 scopus 로고    scopus 로고
    • Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines
    • Hayakawa F, Towatari M, Kiyoi H, Tanimoto M, Kitamura T, Saito H, Naoe T. 2000. Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines. Oncogene 19:624-631.
    • (2000) Oncogene , vol.19 , pp. 624-631
    • Hayakawa, F.1    Towatari, M.2    Kiyoi, H.3    Tanimoto, M.4    Kitamura, T.5    Saito, H.6    Naoe, T.7
  • 13
    • 33750483896 scopus 로고    scopus 로고
    • The antitumor effects of sunitinib (formerly SU11248) against a variety of human hematologic malignancies: Enhancement of growth inhibition via inhibition of mammalian target of rapamycin signaling
    • Ikezoe T, Nishioka C, Tasaka T, Yang Y, Komatsu N, Togitani K, Koeffler HP, Taguchi H. 2006. The antitumor effects of sunitinib (formerly SU11248) against a variety of human hematologic malignancies: Enhancement of growth inhibition via inhibition of mammalian target of rapamycin signaling. Mol Cancer Ther 5:2522-2530.
    • (2006) Mol Cancer Ther , vol.5 , pp. 2522-2530
    • Ikezoe, T.1    Nishioka, C.2    Tasaka, T.3    Yang, Y.4    Komatsu, N.5    Togitani, K.6    Koeffler, H.P.7    Taguchi, H.8
  • 16
    • 33746974277 scopus 로고    scopus 로고
    • Improving missing value imputation of microarray data by using spot quality weights
    • Johansson P, Hakkinen J. 2006. Improving missing value imputation of microarray data by using spot quality weights. BMC Bioinformatics 7:306.
    • (2006) BMC Bioinformatics , vol.7 , pp. 306
    • Johansson, P.1    Hakkinen, J.2
  • 17
    • 18044394180 scopus 로고    scopus 로고
    • Prognostic significance of FLT3 mutations in pediatric non-promyelocytic acute myeloid leukemia
    • Kang HJ, Hong SH, Kim IH, Park BK, Han KS, Cho HI, Shin HY, Ahn HS. 2005. Prognostic significance of FLT3 mutations in pediatric non-promyelocytic acute myeloid leukemia. Leuk Res 29:617-623.
    • (2005) Leuk Res , vol.29 , pp. 617-623
    • Kang, H.J.1    Hong, S.H.2    Kim, I.H.3    Park, B.K.4    Han, K.S.5    Cho, H.I.6    Shin, H.Y.7    Ahn, H.S.8
  • 18
    • 0031686409 scopus 로고    scopus 로고
    • Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product
    • Kiyoi H, Towatari M, Yokota S, Hamaguchi M, Ohno R, Saito H, Naoe T. 1998. Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product. Leukemia 12:1333-1337.
    • (1998) Leukemia , vol.12 , pp. 1333-1337
    • Kiyoi, H.1    Towatari, M.2    Yokota, S.3    Hamaguchi, M.4    Ohno, R.5    Saito, H.6    Naoe, T.7
  • 19
    • 0037061747 scopus 로고    scopus 로고
    • Mechanism of constitutive activation of FLT3 with internal tandem duplication in the juxtamembrane domain
    • Kiyoi H, Ohno R, Ueda R, Saito H, Naoe T. 2002. Mechanism of constitutive activation of FLT3 with internal tandem duplication in the juxtamembrane domain. Oncogene 21:2555-2563.
    • (2002) Oncogene , vol.21 , pp. 2555-2563
    • Kiyoi, H.1    Ohno, R.2    Ueda, R.3    Saito, H.4    Naoe, T.5
  • 20
    • 33751173636 scopus 로고    scopus 로고
    • A phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy
    • Knapper S, Burnett AK, Littlewood T, Kell WJ, Agrawal S, Chopra R, Clark R, Levis MJ, Small D. 2006. A phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy. Blood 108:3262-3270.
    • (2006) Blood , vol.108 , pp. 3262-3270
    • Knapper, S.1    Burnett, A.K.2    Littlewood, T.3    Kell, W.J.4    Agrawal, S.5    Chopra, R.6    Clark, R.7    Levis, M.J.8    Small, D.9
  • 21
    • 0035885955 scopus 로고    scopus 로고
    • The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: Analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials
    • Kottaridis PD, Gale RE, Frew ME, Harrison G, Langabeer SE, Belton AA, Walker H, Wheatley K, Bowen DT, Burnett AK, Goldstone AH, Linch DC. 2001. The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: Analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials. Blood 98:1752-1759.
    • (2001) Blood , vol.98 , pp. 1752-1759
    • Kottaridis, P.D.1    Gale, R.E.2    Frew, M.E.3    Harrison, G.4    Langabeer, S.E.5    Belton, A.A.6    Walker, H.7    Wheatley, K.8    Bowen, D.T.9    Burnett, A.K.10    Goldstone, A.H.11    Linch, D.C.12
  • 23
    • 0037096857 scopus 로고    scopus 로고
    • Clinical relevance of internal tandem duplication of the FLT3 gene in childhood acute myeloid leukemia
    • Liang DC, Shih LY, Hung IJ, Yang CP, Chen SH, Jaing TH, Liu HC, Chang WH. 2002. Clinical relevance of internal tandem duplication of the FLT3 gene in childhood acute myeloid leukemia. Cancer 94:3292-3298.
    • (2002) Cancer , vol.94 , pp. 3292-3298
    • Liang, D.C.1    Shih, L.Y.2    Hung, I.J.3    Yang, C.P.4    Chen, S.H.5    Jaing, T.H.6    Liu, H.C.7    Chang, W.H.8
  • 29
    • 0034009375 scopus 로고    scopus 로고
    • Tandem duplication of the FLT3 gene in acute lymphoblastic leukemia: A marker for the monitoring of minimal residual disease
    • Nakao M, Janssen JW, Erz D, Seriu T, Bartram CR. 2000. Tandem duplication of the FLT3 gene in acute lymphoblastic leukemia: A marker for the monitoring of minimal residual disease. Leukemia 14:522-524.
    • (2000) Leukemia , vol.14 , pp. 522-524
    • Nakao, M.1    Janssen, J.W.2    Erz, D.3    Seriu, T.4    Bartram, C.R.5
  • 36
    • 0037311919 scopus 로고    scopus 로고
    • Saeed AI, Sharov V, White J, Li J, Liang W, Bhagabati N, Braisted J, Klapa M, Currier T, Thiagarajan M, Sturn A, Snuffin M, Rezantsev A, Popov D, Ryltsov A, Kostukovich E, Borisovsky 1, Liu Z, Vinsavich A, Trush V, Quackenbush J. 2003. TM4: A free, open-source system for microarray data management and analysis. Biotechniques 34:374-378.
    • Saeed AI, Sharov V, White J, Li J, Liang W, Bhagabati N, Braisted J, Klapa M, Currier T, Thiagarajan M, Sturn A, Snuffin M, Rezantsev A, Popov D, Ryltsov A, Kostukovich E, Borisovsky 1, Liu Z, Vinsavich A, Trush V, Quackenbush J. 2003. TM4: A free, open-source system for microarray data management and analysis. Biotechniques 34:374-378.
  • 37
    • 0036659931 scopus 로고    scopus 로고
    • Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: Correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease
    • Schnittger S, Schoch C, Dugas M, Kern W, Staib P, Wuchter C, Löffler H, Sauerland CM, Serve H, Büchner F, Haferlach T, Hiddemann W. 2002. Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: Correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease. Blood 100:59-66.
    • (2002) Blood , vol.100 , pp. 59-66
    • Schnittger, S.1    Schoch, C.2    Dugas, M.3    Kern, W.4    Staib, P.5    Wuchter, C.6    Löffler, H.7    Sauerland, C.M.8    Serve, H.9    Büchner, F.10    Haferlach, T.11    Hiddemann, W.12
  • 39
    • 27144499798 scopus 로고    scopus 로고
    • Stam RW, den Boer ML, Schneider P, Nollau P, Horstmann M, Beverloo HB, van der Voort E, Valsecchi MG, de Lorenzo P, Sallan SE, Armstrong SA, Pieters R. 2005. Targeting FLT3 in primary MLL-gene-rearranged infant acute lymphoblastic leukemia. Blood 106:2484-2490.
    • Stam RW, den Boer ML, Schneider P, Nollau P, Horstmann M, Beverloo HB, van der Voort E, Valsecchi MG, de Lorenzo P, Sallan SE, Armstrong SA, Pieters R. 2005. Targeting FLT3 in primary MLL-gene-rearranged infant acute lymphoblastic leukemia. Blood 106:2484-2490.
  • 40
    • 0141465061 scopus 로고    scopus 로고
    • The role of FLT3 in haematopoietic malignancies
    • Stirewalt DL, Radich JP. 2003. The role of FLT3 in haematopoietic malignancies. Nat Rev Cancer 3:650-665.
    • (2003) Nat Rev Cancer , vol.3 , pp. 650-665
    • Stirewalt, D.L.1    Radich, J.P.2
  • 41
    • 9144244169 scopus 로고    scopus 로고
    • FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy
    • Taketani T, Taki T, Sugita K, Furuichi Y, Ishii E, Hanada R, Tsuchida M, Ida K, Hayashi Y. 2004. FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy. Blood 103:1085-1088.
    • (2004) Blood , vol.103 , pp. 1085-1088
    • Taketani, T.1    Taki, T.2    Sugita, K.3    Furuichi, Y.4    Ishii, E.5    Hanada, R.6    Tsuchida, M.7    Ida, K.8    Hayashi, Y.9
  • 43
    • 0033820091 scopus 로고    scopus 로고
    • Constitutive activation of FLT3 stimulates multiple intracellular signal transducers and results in transformation
    • Tse KF, Mukherjee G, Small D. 2000. Constitutive activation of FLT3 stimulates multiple intracellular signal transducers and results in transformation. Leukemia 14:1766-1776.
    • (2000) Leukemia , vol.14 , pp. 1766-1776
    • Tse, K.F.1    Mukherjee, G.2    Small, D.3
  • 44
    • 11144358111 scopus 로고    scopus 로고
    • Valk PJ, Verhaak RG, Beijen MA, Erpelinck CA, Barjesteh van Waalwijk van Doorn-Khosrovani S, Boer JM, Beverloo HB, Moorhouse MJ, van der Spek PJ, Löwenberg B, Delwel R. 2004. Prognostically useful gene-expression profiles in acute myeloid leukemia. N Engl J Med 350:1617-1628.
    • Valk PJ, Verhaak RG, Beijen MA, Erpelinck CA, Barjesteh van Waalwijk van Doorn-Khosrovani S, Boer JM, Beverloo HB, Moorhouse MJ, van der Spek PJ, Löwenberg B, Delwel R. 2004. Prognostically useful gene-expression profiles in acute myeloid leukemia. N Engl J Med 350:1617-1628.
  • 46
    • 0001097136 scopus 로고    scopus 로고
    • Tandem duplication of the FLT3 gene is found in acute lymphoblastic leukaemia as well as acute myeloid leukaemia but not in myelodysplastic syndrome or juvenile chronic myelogenous leukaemia in children
    • Xu F, Taki T, Yang HW, Hanada R, Hongo T, Ohnishi H, Kobayashi M, Bessho F, Yanagisawa M, Hayashi Y. 1999. Tandem duplication of the FLT3 gene is found in acute lymphoblastic leukaemia as well as acute myeloid leukaemia but not in myelodysplastic syndrome or juvenile chronic myelogenous leukaemia in children. Br J Haematol 105:155-162.
    • (1999) Br J Haematol , vol.105 , pp. 155-162
    • Xu, F.1    Taki, T.2    Yang, H.W.3    Hanada, R.4    Hongo, T.5    Ohnishi, H.6    Kobayashi, M.7    Bessho, F.8    Yanagisawa, M.9    Hayashi, Y.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.