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Volumn 2, Issue 6, 2007, Pages 587-595

Future of RNAi-based therapies for human papillomavirus-associated cervical cancer

Author keywords

Akt; Bd 2; Cervical carcinoma; Human papillomavirus E6 E7; MTor; NF B; P53; RNA interference

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CISPLATIN; COMPLEMENTARY RNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LENTIVIRUS VECTOR; LIPOSOME; MAMMALIAN TARGET OF RAPAMYCIN; NANOPARTICLE; ONCOPROTEIN; PROTEIN BCL 2; PROTEIN E6; PROTEIN E7; PROTEIN KINASE B; PROTEIN MDM2; PROTEIN P53; RIBOZYME; RNA INDUCED SILENCING COMPLEX; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR E2F; WART VIRUS VACCINE;

EID: 36348993176     PISSN: 17460794     EISSN: None     Source Type: Journal    
DOI: 10.2217/17460794.2.6.587     Document Type: Review
Times cited : (1)

References (79)
  • 1
    • 33748761925 scopus 로고    scopus 로고
    • : The burden of HPV-related cancers
    • Parkin DM, Bray F: Chapter 2: The burden of HPV-related cancers. Vaccine 24(Suppl. 3), S11-S25 (2006).
    • (2006) Vaccine , vol.24 , Issue.SUPPL. 3
    • Parkin, D.M.1    Bray, F.2
  • 2
    • 33646413672 scopus 로고    scopus 로고
    • The global health burden of infection-associated cancers in the year 2002
    • Parkin DM, The global health burden of infection-associated cancers in the year 2002. Int. J. Cancer 118, 3030-3044 (2006).
    • (2006) Int. J. Cancer , vol.118 , pp. 3030-3044
    • Parkin, D.M.1
  • 3
    • 0036559896 scopus 로고    scopus 로고
    • Papillomaviruses and cancer: From basic studies to clinical application
    • zur Hausen H: Papillomaviruses and cancer: from basic studies to clinical application. Nat. Rev. Cancer 2, 342-350 (2002).
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 342-350
    • zur Hausen, H.1
  • 4
    • 1342300675 scopus 로고    scopus 로고
    • Physical state and expression of HPV DNA in benign and dysplastic cervical tissue: Different levels of viral integration are correlated with lesion grade
    • Hudelist G, Manavi M, Pischinger KI et al: Physical state and expression of HPV DNA in benign and dysplastic cervical tissue: different levels of viral integration are correlated with lesion grade. Gynecol Oncol. 92, 873-880 (2004).
    • (2004) Gynecol Oncol , vol.92 , pp. 873-880
    • Hudelist, G.1    Manavi, M.2    Pischinger, K.I.3
  • 5
    • 0033740178 scopus 로고    scopus 로고
    • Repression of human papillomavirus oncogenes in HeLa cervical carcinoma cells causes the orderly reactivation of dormant tumor suppressor pathways
    • Goodwin EC, DiMaio D: Repression of human papillomavirus oncogenes in HeLa cervical carcinoma cells causes the orderly reactivation of dormant tumor suppressor pathways. Proc. Natl Acad. Sci. USA 97, 12513-12518 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 12513-12518
    • Goodwin, E.C.1    DiMaio, D.2
  • 6
    • 0024809865 scopus 로고
    • Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product
    • Munger K, Werness BA, Dyson N, Phelps WC, Harlow E, Howley PM: Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product. EMBO J. 8, 4099-4105 (1989).
    • (1989) EMBO J , vol.8 , pp. 4099-4105
    • Munger, K.1    Werness, B.A.2    Dyson, N.3    Phelps, W.C.4    Harlow, E.5    Howley, P.M.6
  • 7
    • 0023809597 scopus 로고
    • Correlation of modified human papilloma virus early gene expression with altered growth properties in C4-1 cervical carcinoma cells
    • von Knebel Doeberitz M, Oltersdorf T, Schwarz E, Gissmann L: Correlation of modified human papilloma virus early gene expression with altered growth properties in C4-1 cervical carcinoma cells. Cancer Res. 48, 3780-3786 (1988).
    • (1988) Cancer Res , vol.48 , pp. 3780-3786
    • von Knebel Doeberitz, M.1    Oltersdorf, T.2    Schwarz, E.3    Gissmann, L.4
  • 8
    • 34548152357 scopus 로고    scopus 로고
    • Basic mechanisms of high-risk human papillomavinis-induced carcinogenesis: Roles of E6 and E7 proteins
    • Narisawa-Saito M, Kiyono T: Basic mechanisms of high-risk human papillomavinis-induced carcinogenesis: roles of E6 and E7 proteins. Cancer Sci. 98(10), 1505-1511 (2007).
    • (2007) Cancer Sci , vol.98 , Issue.10 , pp. 1505-1511
    • Narisawa-Saito, M.1    Kiyono, T.2
  • 9
    • 0037325976 scopus 로고    scopus 로고
    • Human papillomavirus-induced carcinogenesis and the ubiquitin-proteasome system
    • Scheffner M, Whitaker NJ: Human papillomavirus-induced carcinogenesis and the ubiquitin-proteasome system. Semin. Cancer Biol. 13, 59-67 (2003).
    • (2003) Semin. Cancer Biol , vol.13 , pp. 59-67
    • Scheffner, M.1    Whitaker, N.J.2
  • 10
    • 27544455180 scopus 로고    scopus 로고
    • RNA interference against human papillomavirus oncogenes in cervical cancer cells results in increased sensitivity to cisplatin
    • Putral LN, Bywater MJ, Gu W et al.: RNA interference against human papillomavirus oncogenes in cervical cancer cells results in increased sensitivity to cisplatin. Mol Pharmacol 68, 1311-1319 (2005).
    • (2005) Mol Pharmacol , vol.68 , pp. 1311-1319
    • Putral, L.N.1    Bywater, M.J.2    Gu, W.3
  • 11
    • 33749873618 scopus 로고    scopus 로고
    • Inhibition of cervical cancer cell growth in vitro and in vivo with lentiviral-vector delivered short hairpin RNA targeting human papillomavirus E6 and E7 oncogenes
    • Gu W, Putral L, Hengst K et al.: Inhibition of cervical cancer cell growth in vitro and in vivo with lentiviral-vector delivered short hairpin RNA targeting human papillomavirus E6 and E7 oncogenes. Cancer Gene Ther. 13, 1023-1032 (2006).
    • (2006) Cancer Gene Ther , vol.13 , pp. 1023-1032
    • Gu, W.1    Putral, L.2    Hengst, K.3
  • 12
    • 33646167060 scopus 로고    scopus 로고
    • The E7 oncoprotein is translated from spliced E6·1 transcripts in high-risk human papillomavirus type 16-or type 18-positive cervical cancer cell lines via transtation reinitiation
    • Tang S, Tao M, McCoy JP Jr, Zheng ZM: The E7 oncoprotein is translated from spliced E6·1 transcripts in high-risk human papillomavirus type 16-or type 18-positive cervical cancer cell lines via transtation reinitiation. J. Virol. 80, 4249-4263 (2006)
    • (2006) J. Virol , vol.80 , pp. 4249-4263
    • Tang, S.1    Tao, M.2    McCoy Jr, J.P.3    Zheng, Z.M.4
  • 13
    • 33751404361 scopus 로고    scopus 로고
    • Adenovirus-mediated transfer of human papillomavirus 16 E6/E7 antisense RNA and induction of apoptosis in cervical cancer
    • Hamada K, Shirakawa T, Gotoh A, Roth JA, Follen M: Adenovirus-mediated transfer of human papillomavirus 16 E6/E7 antisense RNA and induction of apoptosis in cervical cancer. Gynecol. Oncol. 103, 820-830 (2006).
    • (2006) Gynecol. Oncol , vol.103 , pp. 820-830
    • Hamada, K.1    Shirakawa, T.2    Gotoh, A.3    Roth, J.A.4    Follen, M.5
  • 14
    • 0033812598 scopus 로고    scopus 로고
    • Retrovirus-mediated delivery of HPV16 E7 antisense RNA inhibited tumorigenicity of CaSki cells
    • Choo CK, Ling MT, Suen CK, Chan KW, Kwong YL: Retrovirus-mediated delivery of HPV16 E7 antisense RNA inhibited tumorigenicity of CaSki cells. Gynecol. Oncol. 78, 293-301 (2000).
    • (2000) Gynecol. Oncol , vol.78 , pp. 293-301
    • Choo, C.K.1    Ling, M.T.2    Suen, C.K.3    Chan, K.W.4    Kwong, Y.L.5
  • 15
    • 0028008734 scopus 로고
    • Cationic liposomes mediated delivery of antisense oligonucleotides targeted to HPV 16 E7 mRNA in CaSki cells
    • Lappalainen K, Urtti A, Jaaskelainen I, Syrjanen K Syrjanen S: Cationic liposomes mediated delivery of antisense oligonucleotides targeted to HPV 16 E7 mRNA in CaSki cells. Antiviral Res. 23, 119-130 (1994).
    • (1994) Antiviral Res , vol.23 , pp. 119-130
    • Lappalainen, K.1    Urtti, A.2    Jaaskelainen, I.3    Syrjanen, K.4    Syrjanen, S.5
  • 16
    • 0029969074 scopus 로고    scopus 로고
    • Effects of liposomal antisense oligonucleotides on mRNA and protein levels of the HPV 16 E7 oncogene
    • Lappalainen K, Pirila L, Jaaskelainen I, Syrjanen K, Syrjanen S: Effects of liposomal antisense oligonucleotides on mRNA and protein levels of the HPV 16 E7 oncogene. Anticancer Res. 16, 2485-2492 (1996).
    • (1996) Anticancer Res , vol.16 , pp. 2485-2492
    • Lappalainen, K.1    Pirila, L.2    Jaaskelainen, I.3    Syrjanen, K.4    Syrjanen, S.5
  • 17
    • 0042825268 scopus 로고    scopus 로고
    • Advances in the development of ribozymes and antisense oligodeoxynucleotides as antiviral agents for human papillomaviruses
    • Alvarez-Salas LM, Benitez-Hess ML, DiPaolo JA: Advances in the development of ribozymes and antisense oligodeoxynucleotides as antiviral agents for human papillomaviruses. Antivir. Ther. 8, 265-278 (2003).
    • (2003) Antivir. Ther , vol.8 , pp. 265-278
    • Alvarez-Salas, L.M.1    Benitez-Hess, M.L.2    DiPaolo, J.A.3
  • 18
    • 0029436666 scopus 로고
    • Effectiveness of three ribozymes for cleavage of an RNA transcript from human papillomavirus type 18
    • Chen Z, Kamath P Zhang S, Weil MM, Shillitoe EJ: Effectiveness of three ribozymes for cleavage of an RNA transcript from human papillomavirus type 18. Cancer Gene Ther. 2, 263-271 (1995).
    • (1995) Cancer Gene Ther , vol.2 , pp. 263-271
    • Chen, Z.1    Kamath, P.2    Zhang, S.3    Weil, M.M.4    Shillitoe, E.J.5
  • 19
    • 0029685259 scopus 로고    scopus 로고
    • Effects on tumor cells of ribozymes that cleave the RNA transripts of human papillomavirus type 18
    • Chen Z, Kamath P, Zhang S, St John L, Adler-Storthz K, Shillitoe EJ: Effects on tumor cells of ribozymes that cleave the RNA transripts of human papillomavirus type 18. Cancer Gene Ther. 3, 18-23 (1996).
    • (1996) Cancer Gene Ther , vol.3 , pp. 18-23
    • Chen, Z.1    Kamath, P.2    Zhang, S.3    St John, L.4    Adler-Storthz, K.5    Shillitoe, E.J.6
  • 21
    • 0030298504 scopus 로고    scopus 로고
    • Adenovirus-mediated transfer of HPV 16 E6/E7 antisense RNA to human cervical cancer cells
    • Hamada K Sakaue M, Alemany R et al.: Adenovirus-mediated transfer of HPV 16 E6/E7 antisense RNA to human cervical cancer cells. Gynecol. Oncol. 63, 219-227 (1996).
    • (1996) Gynecol. Oncol , vol.63 , pp. 219-227
    • Hamada, K.1    Sakaue, M.2    Alemany, R.3
  • 22
    • 13444262170 scopus 로고    scopus 로고
    • Inhibition of respiratory viruses by nasally administered siRNA
    • Bitko V, Musiyenko A, Shulyayeva O, Barik S: Inhibition of respiratory viruses by nasally administered siRNA. Nat. Med. 11(1), 50-55 (2004).
    • (2004) Nat. Med , vol.11 , Issue.1 , pp. 50-55
    • Bitko, V.1    Musiyenko, A.2    Shulyayeva, O.3    Barik, S.4
  • 23
    • 9144272819 scopus 로고    scopus 로고
    • Using RNAi to catch Drosophila genes in a web of interactions: Insights into cancer research
    • Dasgupta R, Perrimon N: Using RNAi to catch Drosophila genes in a web of interactions: insights into cancer research. Oncogene 23, 8359-8365 (2004).
    • (2004) Oncogene , vol.23 , pp. 8359-8365
    • Dasgupta, R.1    Perrimon, N.2
  • 24
    • 4644350944 scopus 로고    scopus 로고
    • Unlocking the potential of the human genome with RNA interference
    • Hannon GJ, Rossi JJ; Unlocking the potential of the human genome with RNA interference. Nature 431, 371-378 (2004).
    • (2004) Nature , vol.431 , pp. 371-378
    • Hannon, G.J.1    Rossi, J.J.2
  • 25
    • 0036839458 scopus 로고    scopus 로고
    • Inhibition of HIV-1 infection by small interfering RNA-mediated RNA interference
    • Capodici J, Kariko, F, Weissman D: Inhibition of HIV-1 infection by small interfering RNA-mediated RNA interference. J. Immunol. 169, 5196-5201 (2002).
    • (2002) J. Immunol , vol.169 , pp. 5196-5201
    • Capodici, J.1    Kariko, F.2    Weissman, D.3
  • 26
    • 0037173610 scopus 로고    scopus 로고
    • Modulation of HIV-1 replication by RNA interference
    • Jacque JM, Triques K, Stevenson M: Modulation of HIV-1 replication by RNA interference. Nature 418, 435-438 (2002).
    • (2002) Nature , vol.418 , pp. 435-438
    • Jacque, J.M.1    Triques, K.2    Stevenson, M.3
  • 28
    • 0037026601 scopus 로고    scopus 로고
    • Selective silencing of viral gene expression in HPV-positive human cervical carcinoma cells treated wil siRNA, a primer of RNA interference
    • Jiang M, Milner J: Selective silencing of viral gene expression in HPV-positive human cervical carcinoma cells treated wil siRNA, a primer of RNA interference. Oncogene 21, 6041-6048 (2002).
    • (2002) Oncogene , vol.21 , pp. 6041-6048
    • Jiang, M.1    Milner, J.2
  • 29
    • 0141730323 scopus 로고    scopus 로고
    • siRNA targeting of the viral E6 oncogene efficiently kills human papillomavirus-positive cancer cells
    • Butz K, Ristriani T, Hengstermann A, Denk C, Scheffner M, Hoppe-Seyler F: siRNA targeting of the viral E6 oncogene efficiently kills human papillomavirus-positive cancer cells. Oncogene 22, 5938-5945 (2003).
    • (2003) Oncogene , vol.22 , pp. 5938-5945
    • Butz, K.1    Ristriani, T.2    Hengstermann, A.3    Denk, C.4    Scheffner, M.5    Hoppe-Seyler, F.6
  • 30
    • 0038032792 scopus 로고    scopus 로고
    • RNA interference. of human papillomavirus type 18 E6 and E7 induces sencicence in HeLa cells
    • Hall AH, Alexander KA. RNA interference. of human papillomavirus type 18 E6 and E7 induces sencicence in HeLa cells. J. Virol 77, 6066-6069 (2003).
    • (2003) J. Virol , vol.77 , pp. 6066-6069
    • Hall, A.H.1    Alexander, K.A.2
  • 31
    • 0348133602 scopus 로고    scopus 로고
    • In vitro and in vivo growth suppression of human papillomavirus 16-positive cervical cancer cells by E6 siRNA
    • Yoshinouchi M, Yamada T, Kizaki M et al.: In vitro and in vivo growth suppression of human papillomavirus 16-positive cervical cancer cells by E6 siRNA Mol. Ther. 8, 762-768 (2003).
    • (2003) Mol. Ther , vol.8 , pp. 762-768
    • Yoshinouchi, M.1    Yamada, T.2    Kizaki, M.3
  • 32
    • 16644366010 scopus 로고    scopus 로고
    • Selective silencing of viral gene E6 and E7 expression in HPV-positive human cervical carcinoma cells using small interfering RNAs
    • Jiang M, Milner J: Selective silencing of viral gene E6 and E7 expression in HPV-positive human cervical carcinoma cells using small interfering RNAs. Methods Mol Biol. 292, 401-420 (2004).
    • (2004) Methods Mol Biol , vol.292 , pp. 401-420
    • Jiang, M.1    Milner, J.2
  • 33
    • 14544298301 scopus 로고    scopus 로고
    • Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle
    • Schiffelers RM, Ansari A, Xu J et al.: Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle. Nucleic Acids Res. 32, E149 (2004).
    • (2004) Nucleic Acids Res , vol.32
    • Schiffelers, R.M.1    Ansari, A.2    Xu, J.3
  • 34
    • 31344435146 scopus 로고    scopus 로고
    • RNA nanotechnology: Engineering, assembly and applications in detection, gene delivery and therapy
    • Guo P: RNA nanotechnology: engineering, assembly and applications in detection, gene delivery and therapy. J. Nanosci. Nanotechnol. 5, 1964-1982 (2005).
    • (2005) J. Nanosci. Nanotechnol , vol.5 , pp. 1964-1982
    • Guo, P.1
  • 36
    • 0000172793 scopus 로고    scopus 로고
    • Cationic liposomes target angiogenic endothelial cells in tumors and chronic inflammation in mice
    • Thurston G, McLean JW, Rizen M et al.: Cationic liposomes target angiogenic endothelial cells in tumors and chronic inflammation in mice. J. Clin. Invest. 101, 1401-1413 (1998).
    • (1998) J. Clin. Invest , vol.101 , pp. 1401-1413
    • Thurston, G.1    McLean, J.W.2    Rizen, M.3
  • 37
    • 20144387142 scopus 로고    scopus 로고
    • Intravesical administration of small interfering RNA targeting PLK-1 successfully prevents the growth of bladder cancer
    • Nogawa M, Yuasa T, Kimura S et al.: Intravesical administration of small interfering RNA targeting PLK-1 successfully prevents the growth of bladder cancer. J. Clin. Invest. 115, 978-985 (2005).
    • (2005) J. Clin. Invest , vol.115 , pp. 978-985
    • Nogawa, M.1    Yuasa, T.2    Kimura, S.3
  • 38
    • 14644413531 scopus 로고    scopus 로고
    • Novel cationic cardiolipin analogue-based liposome for efficient DNA and small interfering RNA delivery in vitro and in vivo
    • Chien PY, Wang J, Carbonaro D et al.: Novel cationic cardiolipin analogue-based liposome for efficient DNA and small interfering RNA delivery in vitro and in vivo. Cancer Gene Ther. 12, 321-328 (2005).
    • (2005) Cancer Gene Ther , vol.12 , pp. 321-328
    • Chien, P.Y.1    Wang, J.2    Carbonaro, D.3
  • 39
    • 33646185371 scopus 로고    scopus 로고
    • RNAi-mediated gene silencing in non-human primates
    • Zimmermann TS, Lee AC, Akinc A et al.: RNAi-mediated gene silencing in non-human primates. Nature 441, 111-114 (2006).
    • (2006) Nature , vol.441 , pp. 111-114
    • Zimmermann, T.S.1    Lee, A.C.2    Akinc, A.3
  • 40
    • 33845590980 scopus 로고    scopus 로고
    • Toxicity in mice expressing short hairpin RNAs gives new insight into RNAi
    • Snove O Jr, Rossi JJ: Toxicity in mice expressing short hairpin RNAs gives new insight into RNAi. Genome Biol. 7, 231 (2006).
    • (2006) Genome Biol , vol.7 , pp. 231
    • Snove Jr, O.1    Rossi, J.J.2
  • 41
    • 33746153768 scopus 로고    scopus 로고
    • RNAi in moderation
    • Barik S: RNAi in moderation. Nat. Biotechnol. 24, 796-797 (2006).
    • (2006) Nat. Biotechnol , vol.24 , pp. 796-797
    • Barik, S.1
  • 42
    • 1242319384 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 escapes from RNA interference-mediated inhibition
    • Das AT, Brummelkamp TR, Westerhout EM et al.: Human immunodeficiency virus type 1 escapes from RNA interference-mediated inhibition. J. Virol. 78, 2601-2605 (2004).
    • (2004) J. Virol , vol.78 , pp. 2601-2605
    • Das, A.T.1    Brummelkamp, T.R.2    Westerhout, E.M.3
  • 43
    • 33645506348 scopus 로고    scopus 로고
    • Short-term induction and long-term suppression of HPV16 oncogene silencing by RNA interference in cervical cancer cells
    • Tang S, Tao M, McCoy JP Jr, Zheng ZM: Short-term induction and long-term suppression of HPV16 oncogene silencing by RNA interference in cervical cancer cells. Oncogene 25, 2094-2104 (2006).
    • (2006) Oncogene , vol.25 , pp. 2094-2104
    • Tang, S.1    Tao, M.2    McCoy Jr, J.P.3    Zheng, Z.M.4
  • 44
    • 35948978483 scopus 로고    scopus 로고
    • Multiple signal pathways in the leukemogenesis and therapeutic implications
    • Epub ahead of print
    • Chen J, McMillan NA: Multiple signal pathways in the leukemogenesis and therapeutic implications. Leuk. Res. (2007). (Epub ahead of print).
    • (2007) Leuk. Res
    • Chen, J.1    McMillan, N.A.2
  • 45
    • 18144416611 scopus 로고    scopus 로고
    • The transcriptional targets of p53 in apoptosis control
    • Yu J, Zhang L: The transcriptional targets of p53 in apoptosis control. Biochem. Biophys. Res. Commun. 331, 851-858 (2005).
    • (2005) Biochem. Biophys. Res. Commun , vol.331 , pp. 851-858
    • Yu, J.1    Zhang, L.2
  • 46
    • 0242329884 scopus 로고    scopus 로고
    • p53 functions through stress- and promoter-specific recruitment of transcription initiation components before and after DNA damage
    • Espinosa JM, Verdun RE, Emerson BM: p53 functions through stress- and promoter-specific recruitment of transcription initiation components before and after DNA damage. Mol. Cell 12, 1015-1027 (2003).
    • (2003) Mol. Cell , vol.12 , pp. 1015-1027
    • Espinosa, J.M.1    Verdun, R.E.2    Emerson, B.M.3
  • 47
    • 2442563828 scopus 로고    scopus 로고
    • HPV18 E6 and E7 genes affect cell cycle, pRB and p53 of cervical tumor cells and represent prominent candidates for intervention by use peptide nucleic acids (PNAs)
    • Braun K, Ehemann V, Waldeck W et al.: HPV18 E6 and E7 genes affect cell cycle, pRB and p53 of cervical tumor cells and represent prominent candidates for intervention by use peptide nucleic acids (PNAs). Cancer Lett. 209, 37-49 (2004).
    • (2004) Cancer Lett , vol.209 , pp. 37-49
    • Braun, K.1    Ehemann, V.2    Waldeck, W.3
  • 48
    • 33646343474 scopus 로고    scopus 로고
    • An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors
    • Brummelkamp TR, Fabius AW, Mullenders J et al.: An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors. Nat. Chem. Biol. 2, 202-206 (2006).
    • (2006) Nat. Chem. Biol , vol.2 , pp. 202-206
    • Brummelkamp, T.R.1    Fabius, A.W.2    Mullenders, J.3
  • 49
    • 0037404804 scopus 로고    scopus 로고
    • Transduction of adenovirus-mediated wild-type p53 after radiotherapy in human cervical cancer cells
    • Huh JJ, Wolf JK, Fightmaster DL, Lotan R, Follen M: Transduction of adenovirus-mediated wild-type p53 after radiotherapy in human cervical cancer cells. Gynecol. Oncol. 89, 243-250 (2003).
    • (2003) Gynecol. Oncol , vol.89 , pp. 243-250
    • Huh, J.J.1    Wolf, J.K.2    Fightmaster, D.L.3    Lotan, R.4    Follen, M.5
  • 50
    • 34247255540 scopus 로고    scopus 로고
    • An inhibitory effect on cell proliferation by blockage of the MAPK/estrogen receptor/MDM2 signal pathway in gynecologic cancer
    • Suga S, Kato K, Ohgami T et al.: An inhibitory effect on cell proliferation by blockage of the MAPK/estrogen receptor/MDM2 signal pathway in gynecologic cancer. Gynecol. Oncol. 105, 341-350 (2007).
    • (2007) Gynecol. Oncol , vol.105 , pp. 341-350
    • Suga, S.1    Kato, K.2    Ohgami, T.3
  • 51
    • 0024535228 scopus 로고
    • The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product
    • Dyson N, Howley PM, Munger K, Harlow E: The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science 243, 934-937 (1989).
    • (1989) Science , vol.243 , pp. 934-937
    • Dyson, N.1    Howley, P.M.2    Munger, K.3    Harlow, E.4
  • 52
    • 9444280836 scopus 로고    scopus 로고
    • High level HPV-16 E7 oncoprotein expression correlates with reduced pRb-levels in cervical biopsies
    • Fiedler M, Muller-Holzner E, Viertler HP et al.: High level HPV-16 E7 oncoprotein expression correlates with reduced pRb-levels in cervical biopsies. FASEB J. 18, 1120-1122 (2004).
    • (2004) FASEB J , vol.18 , pp. 1120-1122
    • Fiedler, M.1    Muller-Holzner, E.2    Viertler, H.P.3
  • 53
    • 0037667702 scopus 로고    scopus 로고
    • Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
    • Narita M, Nunez S, Heard E et al.: Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell 113, 703-716 (2003).
    • (2003) Cell , vol.113 , pp. 703-716
    • Narita, M.1    Nunez, S.2    Heard, E.3
  • 54
    • 0026526437 scopus 로고
    • E2F: A link between the Rb tumor suppressor protein and viral oncoproteins
    • Nevins JR: E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. Science 258, 424-429 (1992).
    • (1992) Science , vol.258 , pp. 424-429
    • Nevins, J.R.1
  • 56
    • 34249337114 scopus 로고    scopus 로고
    • Transgenic E2F1 expression in the mouse brain induces a human-like bimodal pattern of tumors
    • Olson MV, Johnson DG, Jiang H et al.: Transgenic E2F1 expression in the mouse brain induces a human-like bimodal pattern of tumors. Cancer Res. 67, 4005-4009 (2007).
    • (2007) Cancer Res , vol.67 , pp. 4005-4009
    • Olson, M.V.1    Johnson, D.G.2    Jiang, H.3
  • 57
    • 33646192904 scopus 로고    scopus 로고
    • Involvement of protein kinase C and E2F-5 in euxanthone-induced neurite differentiation of neuroblastoma
    • Ha WY, Wu PK, Kok TW et al.: Involvement of protein kinase C and E2F-5 in euxanthone-induced neurite differentiation of neuroblastoma. Int. J. Biochem. Cell Biol. 38, 1393-1401 (2006).
    • (2006) Int. J. Biochem. Cell Biol , vol.38 , pp. 1393-1401
    • Ha, W.Y.1    Wu, P.K.2    Kok, T.W.3
  • 58
    • 0025905183 scopus 로고
    • The E2F transcription factor is a cellular target for the Rb protein
    • Chellappan SP, Hiebert S, Mudryj M, Horowitz JM, Nevins JR: The E2F transcription factor is a cellular target for the Rb protein. Cell 65, 1053-1061 (1991).
    • (1991) Cell , vol.65 , pp. 1053-1061
    • Chellappan, S.P.1    Hiebert, S.2    Mudryj, M.3    Horowitz, J.M.4    Nevins, J.R.5
  • 59
    • 0026778547 scopus 로고
    • Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins
    • Matsushime H, Ewen ME, Strom DK et al.: Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins. Cell 71, 323-334 (1992).
    • (1992) Cell , vol.71 , pp. 323-334
    • Matsushime, H.1    Ewen, M.E.2    Strom, D.K.3
  • 60
    • 0027229136 scopus 로고
    • Functional interactions of the retinoblastoma protein with mammalian D-type cyclins
    • Ewen ME, Sluss HK, Sherr CJ, Matsushime H, Kato J, Livingston DM: Functional interactions of the retinoblastoma protein with mammalian D-type cyclins. Cell 73, 487-497 (1993).
    • (1993) Cell , vol.73 , pp. 487-497
    • Ewen, M.E.1    Sluss, H.K.2    Sherr, C.J.3    Matsushime, H.4    Kato, J.5    Livingston, D.M.6
  • 61
    • 34548496015 scopus 로고    scopus 로고
    • Hui KM: P16(INK4A)-silencing augments DNA damage-induced apoptosis in cervical cancer cells
    • Lau WM, Ho TH, Hui KM: p16(INK4A)-silencing augments DNA damage-induced apoptosis in cervical cancer cells. Oncogene (2007).
    • (2007) Oncogene
    • Lau, W.M.1    TH, H.2
  • 62
    • 33745241083 scopus 로고    scopus 로고
    • Human papillomavirus type 16 E7 up-regulates AKT activity through the retinoblastoma protein
    • Menges CW, Baglia LA, Lapoint R, McCance DJ: Human papillomavirus type 16 E7 up-regulates AKT activity through the retinoblastoma protein. Cancer Res. 66, 5555-5559 (2006).
    • (2006) Cancer Res , vol.66 , pp. 5555-5559
    • Menges, C.W.1    Baglia, L.A.2    Lapoint, R.3    McCance, D.J.4
  • 63
    • 33846474766 scopus 로고    scopus 로고
    • Molecular profiling of cervical cancer progression
    • Hagemann T, Bozanovic T, Hooper S et al.: Molecular profiling of cervical cancer progression. Br. J. Cancer 96, 321-328 (2007).
    • (2007) Br. J. Cancer , vol.96 , pp. 321-328
    • Hagemann, T.1    Bozanovic, T.2    Hooper, S.3
  • 64
    • 34248198039 scopus 로고    scopus 로고
    • Preferential chemosensitization of PTEN-mutated prostate cells by silencing the Akt kinase
    • Priulla M, Calastretti A, Bruno P et al.: Preferential chemosensitization of PTEN-mutated prostate cells by silencing the Akt kinase. Prostate 67, 782-789 (2007).
    • (2007) Prostate , vol.67 , pp. 782-789
    • Priulla, M.1    Calastretti, A.2    Bruno, P.3
  • 65
    • 33646197484 scopus 로고    scopus 로고
    • Inhibition of the mammalian target of rapamycin (mTOR) by rapamycin increases chemosensitivity of CaSki cells to paclitaxel
    • Faried LS, Faried A, Kanuma T et al.: Inhibition of the mammalian target of rapamycin (mTOR) by rapamycin increases chemosensitivity of CaSki cells to paclitaxel. Eur. J. Cancer 42, 934-947 (2006).
    • (2006) Eur. J. Cancer , vol.42 , pp. 934-947
    • Faried, L.S.1    Faried, A.2    Kanuma, T.3
  • 66
    • 20244365941 scopus 로고    scopus 로고
    • The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation
    • Beuvink I, Boulay A, Fumagalli S et al.: The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation. Cell 120, 747-759 (2005).
    • (2005) Cell , vol.120 , pp. 747-759
    • Beuvink, I.1    Boulay, A.2    Fumagalli, S.3
  • 67
    • 33947495259 scopus 로고    scopus 로고
    • Silencing mammalian target of rapamycin signaling by small interfering RNA enhances rapamycin-induced autophagy in malignant glioma cells
    • Iwamaru A, Kondo Y, Iwado E et al.: Silencing mammalian target of rapamycin signaling by small interfering RNA enhances rapamycin-induced autophagy in malignant glioma cells. Oncogene 26, 1840-1851 (2007).
    • (2007) Oncogene , vol.26 , pp. 1840-1851
    • Iwamaru, A.1    Kondo, Y.2    Iwado, E.3
  • 68
    • 0037426670 scopus 로고    scopus 로고
    • NF-κB is constitutively activated in high-grade squamous intraepithelial lesions and squamous cell carcinomas of the human uterine cervix
    • Nair A, Venkatraman M, Maliekal TT, Nair B, Karunagaran D: NF-κB is constitutively activated in high-grade squamous intraepithelial lesions and squamous cell carcinomas of the human uterine cervix. Oncogene 22, 50-58 (2003).
    • (2003) Oncogene , vol.22 , pp. 50-58
    • Nair, A.1    Venkatraman, M.2    Maliekal, T.T.3    Nair, B.4    Karunagaran, D.5
  • 69
    • 17244367193 scopus 로고    scopus 로고
    • Constitutive activation of nuclear factor-κB: Preferntial homodimerization of p50 subunits in cervical carcinoma
    • Prusty BK, Husain SA, Das BC: Constitutive activation of nuclear factor-κB: preferntial homodimerization of p50 subunits in cervical carcinoma. Front. Biosci. 10, 1510-1519 (2005).
    • (2005) Front. Biosci , vol.10 , pp. 1510-1519
    • Prusty, B.K.1    Husain, S.A.2    Das, B.C.3
  • 70
    • 4444376712 scopus 로고    scopus 로고
    • Signaling to NF-κB
    • Hayden MS, Ghosh S: Signaling to NF-κB. Genes Dev. 18, 2195-2224 (2004).
    • (2004) Genes Dev , vol.18 , pp. 2195-2224
    • Hayden, M.S.1    Ghosh, S.2
  • 71
    • 34249819647 scopus 로고    scopus 로고
    • Targeted RNA interference of phosphatidylinositol 3-kinase p110-β induces apoptosis and proliferation arrest in endometrial carcinoma cells
    • An HJ, Cho NH, Yang HS et al.: Targeted RNA interference of phosphatidylinositol 3-kinase p110-β induces apoptosis and proliferation arrest in endometrial carcinoma cells. J. Pathol. 212, 161-169 (2007).
    • (2007) J. Pathol , vol.212 , pp. 161-169
    • An, H.J.1    Cho, N.H.2    Yang, H.S.3
  • 72
    • 0035504081 scopus 로고    scopus 로고
    • Transcriptional regulation of Bcl-2 by nuclear factor κB and its significance in prostate cancer
    • Catz SD, Johnson JL: Transcriptional regulation of Bcl-2 by nuclear factor κB and its significance in prostate cancer. Oncogene 20, 7342-7351 (2001).
    • (2001) Oncogene , vol.20 , pp. 7342-7351
    • Catz, S.D.1    Johnson, J.L.2
  • 73
    • 0038103154 scopus 로고    scopus 로고
    • NF-κB2/p100 induces Bcl-2 expression
    • Viatour P, Bentires-Alj M, Chariot A et al.: NF-κB2/p100 induces Bcl-2 expression. Leukemia 17, 1349-1356 (2003).
    • (2003) Leukemia , vol.17 , pp. 1349-1356
    • Viatour, P.1    Bentires-Alj, M.2    Chariot, A.3
  • 74
    • 0034007705 scopus 로고    scopus 로고
    • The possible role of p53 and Bcl-2 and expression in cervical carcinomas and their premalignant lesions
    • Dimitrakakis C, Kymionis G, Diakomanolis E et al.: The possible role of p53 and Bcl-2 and expression in cervical carcinomas and their premalignant lesions. Gynecol. Oncol. 77, 129-136 (2000).
    • (2000) Gynecol. Oncol , vol.77 , pp. 129-136
    • Dimitrakakis, C.1    Kymionis, G.2    Diakomanolis, E.3
  • 75
    • 33947614806 scopus 로고    scopus 로고
    • siRNA-mediated Bcl-2 and Bcl-xl gene silencing sensitizes human hepatoblastoma cells to chemotherapeutic drugs
    • Lei XY, Zhong M, Feng LF, Zhu BY, Tang SS, Liao DF: siRNA-mediated Bcl-2 and Bcl-xl gene silencing sensitizes human hepatoblastoma cells to chemotherapeutic drugs. Clin. Exp. Pharmacol. Physiol. 34, 450-456 (2007).
    • (2007) Clin. Exp. Pharmacol. Physiol , vol.34 , pp. 450-456
    • Lei, X.Y.1    Zhong, M.2    Feng, L.F.3    Zhu, B.Y.4    Tang, S.S.5    Liao, D.F.6
  • 76
    • 34250693622 scopus 로고    scopus 로고
    • Combination siRNA targeting Bcl-2 antagonizes siRNA against thymidylate synthase in human tumor cell lines
    • Pandyra A, Berg R, Vincent M, Koropatnick J: Combination siRNA targeting Bcl-2 antagonizes siRNA against thymidylate synthase in human tumor cell lines. J. Pharmacol. Exp. Ther. 322(1), 123-132 (2007).
    • (2007) J. Pharmacol. Exp. Ther , vol.322 , Issue.1 , pp. 123-132
    • Pandyra, A.1    Berg, R.2    Vincent, M.3    Koropatnick, J.4
  • 77
    • 36348959407 scopus 로고    scopus 로고
    • The effect of small interfering RNA (siRNA) against the Bcl-2 gene on apoptosis and chemosensitivity in a canine mammary gland tumor cell line
    • Epub ahead of print
    • Nagamatsu K, Tsuchiya F, Oguma K, Maruyama H, Kano R, Hasegawa A: The effect of small interfering RNA (siRNA) against the Bcl-2 gene on apoptosis and chemosensitivity in a canine mammary gland tumor cell line. Res. Vet. Sci. (2007) (Epub ahead of print).
    • (2007) Res. Vet. Sci
    • Nagamatsu, K.1    Tsuchiya, F.2    Oguma, K.3    Maruyama, H.4    Kano, R.5    Hasegawa, A.6
  • 78
    • 22144475879 scopus 로고    scopus 로고
    • Ribozyme targeting HPV16 E6/E7 transcripts in cervical cancer cells suppresses cell growth and sensitizes cells to chemotherapy and radiotherapy
    • discussion 1135-1126
    • Zheng Y, Zhang J, Rao Z: Ribozyme targeting HPV16 E6/E7 transcripts in cervical cancer cells suppresses cell growth and sensitizes cells to chemotherapy and radiotherapy. Cancer Biol. Ther. 3, 1129-1134; discussion 1135-1126 (2004).
    • (2004) Cancer Biol. Ther , vol.3 , pp. 1129-1134
    • Zheng, Y.1    Zhang, J.2    Rao, Z.3
  • 79
    • 33748792540 scopus 로고    scopus 로고
    • : HPV vaccines and screening in the prevention of cervical cancer; conclusions from a 2006 workshop of international experts
    • 24(Suppl. 3) S
    • Wright TC, Bosch FX, Franco EL et al.: Chapter 30: HPV vaccines and screening in the prevention of cervical cancer; conclusions from a 2006 workshop of international experts. Vaccine 24(Suppl. 3) S251-S261 (2006).
    • (2006) Vaccine
    • Wright, T.C.1    Bosch, F.X.2    Franco, E.L.3


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