Selective pressures for and against genetic instability in cancer: A time-dependent problem

Journal of the Royal Society Interface

Volumn 5, Issue 18, 2008, Pages 105-121

  Komarova, Natalia L ^a,b   Sadovsky, Alexander V ^b,c   Wan, Frederic Y M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c University of California Irvine   (United States)

Author keywords

Chromosomal instability; Multistage carcinogenesis; Nonlinear control; Optimization, bang bang control; Somatic evolution; Telomeres

Indexed keywords

ARTICLE; CANCER CELL; CANCER GENETICS; CARCINOGENESIS; CHROMOSOMAL INSTABILITY; GENE MUTATION; MATHEMATICAL MODEL; MOLECULAR EVOLUTION; MUTATION RATE; TELOMERE; TIME; TUMOR SUPPRESSOR GENE;

EID: 36348978647     PISSN: 17425689     EISSN: 17425662     Source Type: Journal    
DOI: 10.1098/rsif.2007.1054     Document Type: Article

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