A shuffled CYP1A library shows both structural integrity and functional diversity

Drug Metabolism and Disposition

Volumn 35, Issue 12, 2007, Pages 2177-2185

  Johnston, Wayne A ^a   Huang, Weiliang ^a   De Voss, James J ^a   Hayes, Martin A ^b   Gillam, Elizabeth M J ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

4 NITROPHENOL; 6' DEOXYLUCIFERIN; CYTOCHROME P450 1A; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; ETHOXYRESORUFIN; LUCIFERIN; LUCIFERIN 6' CHLOROETHYL ETHER; LUCIFERIN 6' METHYL ETHER; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

ARTICLE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME STRUCTURE; ENZYME SUBSTRATE; MOLECULAR CLONING; MULTIGENE FAMILY; NONHUMAN; PRIORITY JOURNAL; XENOBIOTIC METABOLISM;

CARBON MONOXIDE; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; DNA MUTATIONAL ANALYSIS; DNA RESTRICTION ENZYMES; DNA SHUFFLING; FIREFLY LUCIFERIN; GENE LIBRARY; GENOTYPE; HUMANS; LUMINESCENT AGENTS; MUTATION; NITROPHENOLS; OXAZINES; PHENOTYPE; SPECTROPHOTOMETRY; SUBSTRATE SPECIFICITY;

MAMMALIA;

EID: 36348968330     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.107.017939     Document Type: Article

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