Protective role of calreticulin in HFE hemochromatosis

Free Radical Biology and Medicine

Volumn 44, Issue 1, 2008, Pages 99-108

  Pinto, Jorge P ^a   Ramos, Pedro ^a,b   de Almeida, Sérgio F ^a,c   Oliveira, Susana ^a,c   Breda, Laura ^b   Michalak, Marek ^d   Porto, Graça ^a,c,e   Rivella, Stefano ^b   de Sousa, Maria ^a,c  

^a UNIVERSITY OF PORTO   (Portugal)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c UNIVERSITY OF PORTO   (Portugal)

^d UNIVERSITY OF ALBERTA   (Canada)

^e HOSPITAL DE SANTO ANTÓNIO   (Portugal)

Author keywords

Calreticulin; Hereditary hemochromatosis; HFE; Iron; Oxidative stress

Indexed keywords

CALRETICULIN; HEPCIDIN; HFE PROTEIN; IRON; MESSENGER RNA;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE EXPRESSION; GENE MUTATION; GENE OVEREXPRESSION; GENETIC ANALYSIS; HEMOCHROMATOSIS; HUMAN; HUMAN CELL; MALE; OXIDATIVE STRESS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ADULT; AGED; ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; CALRETICULIN; CELL LINE; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION REGULATION; HEMOCHROMATOSIS; HEPATOCYTES; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; MALE; MEMBRANE PROTEINS; MICE; MIDDLE AGED; MONOCYTES; MUTATION, MISSENSE; OXIDATIVE STRESS; RATS; RECEPTORS, TRANSFERRIN; RNA, MESSENGER; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 36249031555     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2007.09.014     Document Type: Article

References (40)

1. Beutler E. Hemochromatosis: genetics and pathophysiology. Annu. Rev. Med. 57 (2006) 331-347
2. Feder J.N., Penny D.M., Irrinki A., Lee V.K., Lebrón J.A., Watson N., Tsuchihashi Z., Sigal E., Bjorkman P.J., and Schatzman R.C. The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 1472-1477
3. Carlson H., Zhang A.-S., Fleming W.H., and Enns C.A. The hereditary hemochromatosis protein, HFE, lowers intracellular iron levels independently of transferrin receptor 1 in TRVb cells. Blood 105 (2005) 2564-2570
4. Chua A.C., Olynyk J.K., Leedman P.J., and Trinder D. Nontransferrin-bound iron uptake by hepatocytes is increased in the Hfe knockout mouse model of hereditary hemochromatosis. Blood 104 (2004) 1519-1525
5. Goswami T., and Andrews N.C. Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing. J. Biol. Chem. 281 (2006) 28494-28498
6. Fleming R.E., and Britton R.S. Iron imports. VI. HFE and regulation of intestinal iron absorption. Am. J. Physiol., Endocrinol Metabol. Gastrointest. Physiol. 290 (2006) G590-G594
7. Beutler E., Felitti V.J., Koziol J.A., Ho N.J., and Gelbart T. Penetrance of 845G → A (C282Y) HFE hereditary haemochromatosis mutation in the USA. Lancet 359 (2002) 211-218
8. Waheed A., Parkkila S., Zhou X.Y., Tomatsu S., Tsuchihashi Z., Feder J.N., Schatzman R.C., Britton R.S., Bacon B.R., and Sly W.S. Hereditary hemochromatosis: effects of C282Y and H63D mutations on association with beta2-microglobulin, intracellular processing, and cell surface expression of the HFE protein in COS-7 cells. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 12384-12389
9. Pinto J.P., Ramos P., and de Sousa M. Overexpression of HFE in HepG2 cells reveals differences in intracellular distribution and co-localization of wt- and mutated forms. Blood cells mol. diseases 39 (2007) 75-81
10. de Almeida S.F., Fleming J.V., Azevedo J.E., Carmo-Fonseca M., and de Sousa M. Stimulation of an unfolded protein response impairs MHC class I expression. J. Immunol. 178 (2007) 3612-3619
11. Xu C., Bailly-Maitre B., and Reed J.C. Endoplasmic reticulum stress: cell life and death decisions. J. Clin. Invest. 115 (2005) 2656-2664
12. Nunez M.T., Osorio A., Tapia V., Vergara A., and Mura C.V. Iron-induced oxidative stress up-regulates calreticulin levels in intestinal epithelial (Caco-2) cells. J. Cell. Biochem. 82 (2001) 660-665
13. Bedard K., MacDonald N., Collins J., and Cribb A. Cytoprotection following endoplasmic reticulum stress protein induction in continuous cell lines. Basic Clin. Pharmacol. Toxicol. 94 (2004) 124-131
14. 2+ disturbances, and cell death in renal epithelial cells. J. Biol. Chem. 272 (1997) 21751-21759
15. Yu Z., Luo H., Fu W., and Mattson M.P. The endoplasmic reticulum stress-responsive protein GRP78 protects neurons against excitotoxicity and apoptosis: suppression of oxidative stress and stabilization of calcium homeostasis. Exp. Neurol. 155 (1999) 302-314
16. Gao B., Adhikari R., Howarth M., Nakamura K., Gold M.C., Hill A.B., Knee R., Michalak M., and Elliott T. Assembly and antigen-presenting function of MHC class I molecules in cells lacking the ER chaperone calreticulin. Immunity 16 (2002) 99-109
17. Abramoff M.D., Magalhães P.J., and Ram S.J. Image processing with Image J. Biophoton. Int. 11 (2004) 36-42
18. Toyokuni S. Iron and carcinogenesis: from Fenton reaction to target genes. Redox Rep. 7 (2002) 189-197
19. Kokame K., Kato H., and Miyata T. Identification of ERSE-II, a new cis-acting element responsible for the ATF6-dependent mammalian unfolded protein response. J. Biol. Chem. 276 (2001) 9199-9205
20. Mura C., le Gac G., Jacolot S., and Ferec C. Transcriptional regulation of the human HFE gene indicates high liver expression and erythropoiesis coregulation. FASEB J. 18 (2004) 1922-1924
21. Corsi B., Levi S., Cozzi A., Corti A., Altimare D., Albertini A., and Arosio P. Overexpression of the hereditary hemochromatosis protein, HFE, in HeLa cells induces an iron-deficient phenotype. FEBS Lett. 460 (1999) 149-152
22. Lebrón J.A., Bennett M.J., Vaughn D.E., Chirino A.J., Snow P.M., Mintier G.A., Feder J.N., and Bjorkman P.J. Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor. Cell 93 (1998) 111-123
23. Gross C.N., Irrinki A., Feder J.N., and Enns C.A. Co-trafficking of HFE, a nonclassical major histocompatibility complex class I protein, with the transferrin receptor implies a role in intracellular iron regulation. J. Biol. Chem. 273 (1998) 22068-22074
24. Enns C.A. Possible roles of the hereditary hemochromatosis protein, HFE, in regulating cellular iron homeostasis. Biol. Res. 39 (2006) 105-111
25. Bridle K.R., Frazer D.M., Wilkins S.J., Dixon J.L., Purdie D.M., Crawford D.H., Subramaniam V.N., Powell L.W., Anderson G.J., and Ramm G.A. Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis. Lancet 361 (2003) 669-673
26. Gehrke S.G., Herrmann T., Kulaksiz H., Merle U., Bents K., Kaiser I., Riedel H.D., and Stremmel W. Iron stores modulate hepatic hepcidin expression by an HFE-independent pathway. Digestion 72 (2005) 25-32
27. Ahmad K.A., Ahmann J.R., Migas M.C., Waheed A., Britton R.S., and Bacon B.R. Decreased liver hepcidin expression in the Hfe knockout mouse. Blood cells mol. diseases 29 (2002) 361-366
28. Constante M., Jiang W., Wang D., Raymond V.A., Bilodeau M., and Santos M.M. Distinct requirements for Hfe in basal and induced hepcidin levels in iron overload and inflammation. Am. J. Physiol., Endocrinol Metabol. Gastrointest. Physiol. 291 (2006) G229-G237
29. Bedard K., Szabo E., Michalak M., and Opas M. Cellular functions of endoplasmic reticulum chaperones calreticulin, calnexin, and ERp57. Int. Rev. Cyt. 245 (2005) 91-121
30. Cribb A.E., Peyrou M., Muruganandan S., and Schneider L. The endoplasmic reticulum in xenobiotic toxicity. Drug Metab. Rev. 37 (2005) 405-442
31. Tardif K.D., Waris G., and Siddiqui A. Hepatitis C virus, ER stress, and oxidative stress. Trends Microbiol. 13 (2005) 159-163
32. Dalle-Donne I., Rossi R., Colombo R., Giustarini D., and Milzani A. Biomarkers of oxidative damage in human disease. Clin. Chem. 52 (2006) 601-623
33. Dhalla N.S., Temsah R.M., and Netticadan T. Role of oxidative stress in cardiovascular diseases. J. Hypertens 18 (2000) 655-673
34. Jenner P. Oxidative stress in Parkinson's disease. Ann. Neurol. 53 (2003) S26-S36
35. Sayre L.M., Smith M.A., and Perry G. Chemistry and biochemistry of oxidative stress in neurodegenerative disease. Curr. Med. Chem. 8 (2001) 721-738
36. Feder J.N., Gnirke A., Thomas W., Tsuchihashi Z., Ruddy D.A., Basava A., Dormishian F., Domingo R., Ellis M.C., Fullan A., Hinton L.M., Jones N.L., Kimmel B.E., Kronmal G.S., Lauer P., Lee V.K., Loeb D.B., Mapa F.A., McClelland E., Meyer N.C., Mintier G.A., Moeller N., Moore T., Morikang E., Prass C.E., Quintana L., Starnes S.M., Schatzman R.C., Brunke K.J., Drayna D.T., Risch N.J., Bacon B.R., and Wolff R.K. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat. Genet. 13 (1996) 399-408
37. Feder J.N., Tsuchihashi Z., Irrinki A., Lee V.K., Mapa F.A., Morikang E., Prass C.E., Starnes S.M., Wolff R.K., Parkkila S., Sly W.S., and Schatzman R.C. The hemochromatosis founder mutation in HLA-H disrupts beta2-microglobulin interaction and cell surface expression. J. Biol. Chem. 272 (1997) 14025-14028
38. Parkkila S., Waheed A., Britton R.S., Feder J.N., Tsuchihashi Z., Schatzman R.C., Bacon B.R., and Sly W.S. Immunohistochemistry of HLA-H, the protein defective in patients with hereditary hemochromatosis, reveals unique pattern of expression in gastrointestinal tract. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 2534-2539
39. Rutkowski D.T., Arnold S.M., Miller C.N., Wu J., Li J., Gunnison K.M., Mori K., Sadighi Akha A.A., Raden D., and Kaufman R.J. Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins. PLoS Biol. 4 (2006) e374
40. Parkkila S., Parkkila A.K., Waheed A., Britton R.S., Zhou X.Y., Fleming R.E., Tomatsu S., Bacon B.R., and Sly W.S. Cell surface expression of HFE protein in epithelial cells, macrophages, and monocytes. Haematologica 85 (2000) 340-345