Increased islet neogenesis without increased islet mass precedes autoimmune attack in diabetes-prone rats

Laboratory Investigation

Volumn 87, Issue 12, 2007, Pages 1240-1251

  Kauri, Lisa M ^a   Wang, Gen Sheng ^a   Patrick, Christopher ^a,b   Bareggi, Mirella ^a,b   Hill, David J ^c   Scott, Fraser W ^a,b  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

^c LAWSON HEALTH RESEARCH INSTITUTE   (Canada)

Author keywords

cell; Apoptosis; BioBreeding rat; Cell cycle; Diabetes; Islet neogenesis

Indexed keywords

BIOLOGICAL MARKER; CYCLIN D2; CYCLIN DEPENDENT KINASE INHIBITOR 1A; INSULIN; MESSENGER RNA; NEUROGENIN 3; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; BIOBREEDING RAT; CELL COUNT; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL PROLIFERATION; CONTROLLED STUDY; DIABETES MELLITUS; ENDOCRINE CELL; HYPOTHESIS; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INNATE IMMUNITY; LASER CAPTURE MICRODISSECTION; MORPHOMETRICS; NERVE CELL DIFFERENTIATION; NONHUMAN; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEM CELL; WEANING;

ANIMALS; APOPTOSIS; AUTOIMMUNITY; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL CYCLE; CELL PROLIFERATION; CELL SIZE; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DIABETES MELLITUS, TYPE 1; HOMEODOMAIN PROTEINS; INSULIN; ISLETS OF LANGERHANS; NERVE TISSUE PROTEINS; RATS; TRANS-ACTIVATORS;

EID: 36248969612     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.3700687     Document Type: Article

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