Tubular complexes as a source for islet neogenesis in the pancreas of diabetes-prone BB rats

Laboratory Investigation

Volumn 85, Issue 5, 2005, Pages 675-688

  Wang, Gen Sheng ^a   Rosenberg, Lawrence ^b   Scott, Fraser W ^a  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Islet neoformation; Stem cell; Transdifferentiation; Tubular complex; Type I diabetes

Indexed keywords

AMYLASE; CHROMOGRANIN; GENE PRODUCT; GLUCAGON; INSULIN; KERATIN; NESTIN; PANCREAS POLYPEPTIDE; SCATTER FACTOR RECEPTOR; SOMATOSTATIN; TRANSCRIPTION FACTOR PDX 1; VIMENTIN;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; CELL DEATH; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; INSULIN DEPENDENT DIABETES MELLITUS; MORPHOMETRICS; NONHUMAN; PANCREAS DUCT; PANCREAS INJURY; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PANCREAS ISLET DISEASE; PRIORITY JOURNAL; RAT; RAT STRAIN; STEM CELL; T LYMPHOCYTE; TUBULAR COMPLEX;

AMYLASES; ANIMALS; APOPTOSIS; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; CELL PROLIFERATION; DIABETES MELLITUS, TYPE 1; DISEASE MODELS, ANIMAL; IN SITU NICK-END LABELING; ISLETS OF LANGERHANS; KERATINS; PANCREAS, EXOCRINE; RATS; RATS, INBRED BB; RATS, INBRED WF; REGENERATION; STEM CELLS; VIMENTIN;

EID: 18744394636     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: 10.1038/labinvest.3700259     Document Type: Article

References (49)

1. Steele C, Hagopian WA, Gitelman S, et al. Insulin secretion in type I diabetes. Diabetes 2004;53:426-433.
2. Bonner-Weir S. Perspective: postnatal pancreatic beta cell growth. Endocrinology 2000;141:1926-1929.
3. Sharma A, Zangen DH, Reitz P, et al. The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration. Diabetes 1999;48:507-513.
4. Bouwens L. Transdifferentiation versus stem cell hypothesis for the regeneration of islet beta-cells in the pancreas. Microsc Res Tech 1998;43:332-336.
5. Tokoro T, Tezel E, Nagasaka T, et al. Differentiation of acinar cells into acinoductular cells in regenerating rat pancreas. Pancreatology 2003;3:487-496.
6. Bockman DE. Toward understanding pancreatic disease: from architecture to cell signaling. Pancreas 1995;11:324-329.
7. Bockman DE. Cells of origin of pancreatic cancer: experimental animal tumors related to human pancreas. Cancer 1981;47:1528-1534.
8. Bookman DE, Boydston WR, Anderson MC. Origin of tubular complexes in human chronic pancreatitis. Am J Surg 1982;144:243-249.
9. Pound AW, Walker NI. Involution of the pancreas after ligation of the pancreatic ducts. I: a histological study. Br J Exp Pathol 1981;62:547-558.
10. Rosenberg L, Brown RA, Duguid WP. A new approach to the induction of duct epithelial hyperplasia and nesidioblastosis by cellophane wrapping of the hamster pancreas. J Surg Res 1983;35:63-72.
11. Bockman DE, Guo J, Buchler P, et al. Origin and development of the precursor lesions in experimental pancreatic cancer in rats. Lab Invest 2003;83:853-859.
12. Jimenez RE, Z'Graggen K, Hartwig W, et al. Immunohistochemical characterization of pancreatic tumors induced by dimethylbenzanthracene in rats. Am J Pathol 1999;154:1223-1229.
13. Rosenberg L, Duguid WP, Brown RA. Development of experimental cancer in the head of the pancreas by surgical induction of tissue injury. Am J Surg 1984; 147:146-151.
14. Bonner-Weir S, Baxter LA, Schuppin GT, et al. A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development. Diabetes 1993;42:1715-1720.
15. Lipsett M, Finegood DT. beta-cell neogenesis during prolonged hyperglycemia in rats. Diabetes 2002;51: 1834-1841.
16. Iovanna JL. Redifferentiation and apoptosis of pancreatic cells during acute pancreatitis. Int J Pancreatol 1996;20:77-84.
17. Wagner M, Luhrs H, Kloppel G, et al. Malignant transformation of duct-like cells originating from acini in transforming growth factor transgenic mice. Gastroenterology 1998;115:1254-1262.
18. Lardon J, Huyens N, Rooman I, et al. Exocrine cell transdifferentiation in dexamethasone-treated rat pancreas. Virchows Arch 2004;444:61-65.
19. Arias AE, Bendayan M. Differentiation of pancreatic acinar cells into duct-like cells in vitro. Lab Invest 1993;69:518-530.
20. De Lisle RC, Logsdon CD. Pancreatic acinar cells in culture: expression of acinar and ductal antigens in a growth-related manner. Eur J Cell Biol 1990;51: 64-75.
21. Hall PA, Lemoine NR. Rapid acinar to ductal transdifferentiation in cultured human exocrine pancreas. J Pathol 1992;166:97-103.
22. Rooman I, Heremans Y, Heimberg H, et al. Modulation of rat pancreatic acinoductal transdifferentiation and expression of PDX-1 in vitro. Diabetologia 2000;43: 907-914.
23. Bockman DE. Morphology of the exocrine pancreas related to pancreatitis. Microsc Res Tech 1997;37: 509-519.
24. Jia D, Otsuki M. Bezafibrate, a peroxisome proliferator-activated receptor (PPAR)-alpha activator, prevents pancreatic degeneration in obese and diabetic rats. Pancreas 2003;26:286-291.
25. Scott FW, Cloutier HE, Kleemann R, et al. Potential mechanisms by which certain foods promote or inhibit the development of spontaneous diabetes in BB rats: dose, timing, early effect on islet area, and switch in infiltrate from Th1 to Th2 cells. Diabetes 1997;46: 589-598.
26. Wang GS, Gruber H, Smyth P, et al. Hydrolysed casein diet protects BB rats from developing diabetes by promoting islet neogenesis. J Autoimmun 2000;15: 407-416.
27. Rao PS, Mangipudy RS, Mehendale HM. Tissue injury and repair as parallel and opposing responses to CCl4 hepatotoxicity: a novel dose-response. Toxicology 1997;118:181-193.
28. Bouwens L. Islet morphogenesis and stem cell markers. Cell Biochem Biophys 2004;40:81-88.
29. Bulotta A, Di Cesare E, Ponte E, et al. Increased c-met expression during ductal beta cell neogenesis in experimental autoimmune diabetes. Growth Factors 2001;19:259-267.
30. Gu G, Brown JR, Melton DA. Direct lineage tracing reveals the ontogeny of pancreatic cell fates during mouse embryogenesis. Mech Dev 2003;120: 35-43.
31. Suzuki A, Nakauchi H, Taniguchi H. Prospective isolation of multipotent pancreatic progenitors using flow-cytometric cell sorting. Diabetes 2004;53: 2143-2152.
32. Calvo EL, Boucher C, Pelletier G, et al. Ontogeny of hepatocyte growth factor and c-met/hgf receptor in rat pancreas. Biochem Biophys Res Commun 1996;229: 257-263.
33. Jensen J, Heller RS, Funder-Nielsen T, et al. independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the Notch pathway in repression of premature differentiation. Diabetes 2000;49:163-176.
34. Grapin-Botton A, Majithia AR, Melton DA. Key events of pancreas formation are triggered in gut endoderm by ectopic expression of pancreatic regulatory genes. Genes Dev 2001;15:444-454.
35. Schwitzgebel VM, Scheel DW, Conners JR, et al. Expression of neurogenin3 reveals an islet cell precursor population in the pancreas. Development 2000;127:3533-3542.
36. Zulewski H, Abraham EJ, Gerlach MJ, et al. Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes. Diabetes 2001;50:521-533.
37. Hunziker E, Stein M. Nestin-expressing cells in the pancreatic islets of Langerhans. Biochem Biophys Res Commun 2000;271:116-119.
38. Yokoyama-Hayashi K, Takahashi T, Kakita A, et al. Expression of PGP9.5 in ductal cells of the rat pancreas during development and regeneration: can it be a marker for pancreatic progenitor cells? Endocr J 2002;49:61-74.
39. Rooman I, Lardon J, Bouwens L. Gastrin stimulates beta-cell neogenesis and increases islet mass from transdifferentiated but not from normal exocrine pancreas tissue. Diabetes 2002;51:686-690.
40. Wilson ME, Scheel D, German MS. Gene expression cascades in pancreatic development. Mech Dev 2003; 120:65-80.
41. Kojima H, Fujimiya M, Matsumura K, et al. NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice. Nat Med 2003;9:596-603.
42. Gu G, Dubauskaite J, Melton DA. Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development 2002;129:2447-2457.
43. Reid LE, Walker NI. Acinar cell apoptosis and the origin of tubular complexes in caerulein-induced pancreatitis. Int J Exp Pathol 1999;80:205-215.
44. Kim SY, Lee SH, Kim BM, et al. Activation of nestin-positive duct stem (NPDS) cells in pancreas upon neogenic motivation and possible cytodifferentiation into insulin-secreting cells from NPDS cells. Dev Dyn 2004;230:1-11.
45. Heremans Y, Van De Casteele M, in't Veld P, et al. Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3. J Cell Biol 2002;159: 303-312.
46. Lardon J, Rooman I, Bouwens L. Nestin expression in pancreatic stellate cells and angiogenic endothelial cells. Histochem Cell Biol 2002;117:535-540.
47. Humphrey RK, Bucay N, Beattie GM, et al. Characterization and isolation of promoter-defined nestin-positive cells from the human fetal pancreas. Diabetes 2003;52:2519-2525.
48. Treutelaar MK, Skidmore JM, Dias-Leme CL, et al. Nestin-lineage cells contribute to the microvasculature but not endocrine cells of the islet. Diabetes 2003;52:2503-2512.
49. Li M, Miyagawa J, Moriwaki M, et al. Analysis of expression profiles of islet-associated transcription and growth factors during beta-cell neogenesis from duct cells in partially duct-ligated mice. Pancreas 2003;27:345-355.