메뉴 건너뛰기




Volumn 88, Issue 3, 2008, Pages 230-237

Long-term cognitive deficits induced by a single, extremely low dose of tetrahydrocannabinol (THC): Behavioral, pharmacological and biochemical studies in mice

Author keywords

9 tetrahydrocannabinol (THC); Cannabinoid; CB1 receptor; Cognitive deficits; Extracellular signal regulated kinase (ERK); SR141716A; Water T maze

Indexed keywords

CANNABINOID 1 RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; RIMONABANT; TETRAHYDROCANNABINOL;

EID: 36148983440     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2007.08.005     Document Type: Article
Times cited : (26)

References (61)
  • 1
    • 0029830331 scopus 로고    scopus 로고
    • Cannabis: pharmacology and toxicology in animals and humans
    • Adams I.B., and Martin B.R. Cannabis: pharmacology and toxicology in animals and humans. Addiction 91 (1996) 1585-1614
    • (1996) Addiction , vol.91 , pp. 1585-1614
    • Adams, I.B.1    Martin, B.R.2
  • 2
    • 0036000275 scopus 로고    scopus 로고
    • Modulation of the Ras/Raf/MEK/ERK pathway by Ca(2+), and calmodulin
    • Agell N., Bachs O., Rocamora N., and Villalonga P. Modulation of the Ras/Raf/MEK/ERK pathway by Ca(2+), and calmodulin. Cell Signal 14 (2002) 649-654
    • (2002) Cell Signal , vol.14 , pp. 649-654
    • Agell, N.1    Bachs, O.2    Rocamora, N.3    Villalonga, P.4
  • 3
    • 0022921460 scopus 로고
    • Pharmacokinetics and metabolism of delta 1-tetrahydrocannabinol and other cannabinoids with emphasis on man
    • Agurell S., Halldin M., Lindgren J.E., Ohlsson A., Widman M., Gillespie H., et al. Pharmacokinetics and metabolism of delta 1-tetrahydrocannabinol and other cannabinoids with emphasis on man. Pharmacol Rev 38 (1986) 21-43
    • (1986) Pharmacol Rev , vol.38 , pp. 21-43
    • Agurell, S.1    Halldin, M.2    Lindgren, J.E.3    Ohlsson, A.4    Widman, M.5    Gillespie, H.6
  • 5
    • 0030023599 scopus 로고    scopus 로고
    • Does heavy marijuana use impair human cognition and brain function?
    • Block R.I. Does heavy marijuana use impair human cognition and brain function?. Jama 275 (1996) 560-561
    • (1996) Jama , vol.275 , pp. 560-561
    • Block, R.I.1
  • 6
    • 0029586743 scopus 로고
    • Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1
    • Bouaboula M., Poinot-Chazel C., Bourrie B., Canat X., Calandra B., Rinaldi-Carmona M., et al. Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1. Biochem J 312 Pt 2 (1995) 637-641
    • (1995) Biochem J , vol.312 , Issue.PART 2 , pp. 637-641
    • Bouaboula, M.1    Poinot-Chazel, C.2    Bourrie, B.3    Canat, X.4    Calandra, B.5    Rinaldi-Carmona, M.6
  • 7
    • 0037444557 scopus 로고    scopus 로고
    • Regulation of extracellular signal-regulated kinase by cannabinoids in hippocampus
    • Derkinderen P., Valjent E., Toutant M., Corvol J.C., Enslen H., Ledent C., et al. Regulation of extracellular signal-regulated kinase by cannabinoids in hippocampus. J Neurosci 23 (2003) 2371-2382
    • (2003) J Neurosci , vol.23 , pp. 2371-2382
    • Derkinderen, P.1    Valjent, E.2    Toutant, M.3    Corvol, J.C.4    Enslen, H.5    Ledent, C.6
  • 8
    • 4544275181 scopus 로고    scopus 로고
    • The endocannabinoid system and its therapeutic exploitation
    • Di Marzo V., Bifulco M., and De Petrocellis L. The endocannabinoid system and its therapeutic exploitation. Nat Rev. Drug Discov 3 (2004) 771-784
    • (2004) Nat Rev. Drug Discov , vol.3 , pp. 771-784
    • Di Marzo, V.1    Bifulco, M.2    De Petrocellis, L.3
  • 10
    • 33749259104 scopus 로고    scopus 로고
    • NMDA receptor activity in learning spatial procedural strategies II. The influence of cerebellar lesions
    • Federico F., Leggio M.G., Neri P., Mandolesi L., and Petrosini L. NMDA receptor activity in learning spatial procedural strategies II. The influence of cerebellar lesions. Brain Res Bull 70 (2006) 356-367
    • (2006) Brain Res Bull , vol.70 , pp. 356-367
    • Federico, F.1    Leggio, M.G.2    Neri, P.3    Mandolesi, L.4    Petrosini, L.5
  • 11
    • 0017198043 scopus 로고
    • Residual learning deficit after heavy exposure to cannabis or alcohol in rats
    • Fehr K.A., Kalant H., and LeBlanc A.E. Residual learning deficit after heavy exposure to cannabis or alcohol in rats. Science 192 (1976) 1249-1251
    • (1976) Science , vol.192 , pp. 1249-1251
    • Fehr, K.A.1    Kalant, H.2    LeBlanc, A.E.3
  • 12
    • 14044260113 scopus 로고    scopus 로고
    • Neurocognitive consequences of marihuana-a comparison with pre-drug performance
    • Fried P.A., Watkinson B., and Gray R. Neurocognitive consequences of marihuana-a comparison with pre-drug performance. Neurotoxicol Teratol 27 (2005) 231-239
    • (2005) Neurotoxicol Teratol , vol.27 , pp. 231-239
    • Fried, P.A.1    Watkinson, B.2    Gray, R.3
  • 13
    • 0036893729 scopus 로고    scopus 로고
    • Mechanism of extracellular signal-regulated kinase activation by the CB(1) cannabinoid receptor
    • Galve-Roperh I., Rueda D., Gomez del Pulgar T., Velasco G., and Guzman M. Mechanism of extracellular signal-regulated kinase activation by the CB(1) cannabinoid receptor. Mol Pharmacol 62 (2002) 1385-1392
    • (2002) Mol Pharmacol , vol.62 , pp. 1385-1392
    • Galve-Roperh, I.1    Rueda, D.2    Gomez del Pulgar, T.3    Velasco, G.4    Guzman, M.5
  • 14
    • 0038382242 scopus 로고    scopus 로고
    • Non-acute (residual) neurocognitive effects of cannabis use: a meta-analytic study
    • Grant I., Gonzalez R., Carey C.L., Natarajan L., and Wolfson T. Non-acute (residual) neurocognitive effects of cannabis use: a meta-analytic study. J Int Neuropsychol Soc 9 (2003) 679-689
    • (2003) J Int Neuropsychol Soc , vol.9 , pp. 679-689
    • Grant, I.1    Gonzalez, R.2    Carey, C.L.3    Natarajan, L.4    Wolfson, T.5
  • 15
    • 0015605703 scopus 로고
    • A neuropsychological assessment of the effects of moderate marihuana use
    • Grant I., Rochford J., Fleming T., and Stunkard A. A neuropsychological assessment of the effects of moderate marihuana use. J of Nerv Ment Dis 156 (1973) 278-280
    • (1973) J of Nerv Ment Dis , vol.156 , pp. 278-280
    • Grant, I.1    Rochford, J.2    Fleming, T.3    Stunkard, A.4
  • 17
    • 0034467577 scopus 로고    scopus 로고
    • Control of the cell survival/death decision by cannabinoids
    • Guzman M., Sanchez C., and Galve-Roperh I. Control of the cell survival/death decision by cannabinoids. J Mol Med 78 (2001) 613-625
    • (2001) J Mol Med , vol.78 , pp. 613-625
    • Guzman, M.1    Sanchez, C.2    Galve-Roperh, I.3
  • 18
    • 0032493197 scopus 로고    scopus 로고
    • Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants
    • Hampson A.J., Grimaldi M., Axelrod J., and Wink D. Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants. Proc Natl Acad Sci U S A 95 (1998) 8268-8273
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 8268-8273
    • Hampson, A.J.1    Grimaldi, M.2    Axelrod, J.3    Wink, D.4
  • 20
    • 33645106228 scopus 로고    scopus 로고
    • Long-term effects of frequent cannabis use on working memory and attention: an fMRI study
    • Jager G., Kahn R.S., Van Den Brink W., Van Ree J.M., and Ramsey N.F. Long-term effects of frequent cannabis use on working memory and attention: an fMRI study. Psychopharmacology 185 (2006) 358-368
    • (2006) Psychopharmacology , vol.185 , pp. 358-368
    • Jager, G.1    Kahn, R.S.2    Van Den Brink, W.3    Van Ree, J.M.4    Ramsey, N.F.5
  • 21
    • 10944265031 scopus 로고    scopus 로고
    • Spatial working memory in heavy cannabis users: a functional magnetic resonance imaging study
    • Kanayama G., Rogowska J., Pope H.G., Gruber S.A., and Yurgelun-Todd D.A. Spatial working memory in heavy cannabis users: a functional magnetic resonance imaging study. Psychopharmacology 176 (2004) 239-247
    • (2004) Psychopharmacology , vol.176 , pp. 239-247
    • Kanayama, G.1    Rogowska, J.2    Pope, H.G.3    Gruber, S.A.4    Yurgelun-Todd, D.A.5
  • 22
    • 0023833764 scopus 로고
    • Quantitative changes in hippocampal structure following long-term exposure to delta 9-tetrahydrocannabinol: possible mediation by glucocorticoid systems
    • Landfield P.W., Cadwallader L.B., and Vinsant S. Quantitative changes in hippocampal structure following long-term exposure to delta 9-tetrahydrocannabinol: possible mediation by glucocorticoid systems. Brain Res 443 (1988) 47-62
    • (1988) Brain Res , vol.443 , pp. 47-62
    • Landfield, P.W.1    Cadwallader, L.B.2    Vinsant, S.3
  • 23
    • 0034703446 scopus 로고    scopus 로고
    • Changes in hippocampal morphology following chronic treatment with the synthetic cannabinoid WIN 55,212-2
    • Lawston J., Borella A., Robinson J.K., and Whitaker-Azmitia P.M. Changes in hippocampal morphology following chronic treatment with the synthetic cannabinoid WIN 55,212-2. Brain Res 877 (2000) 407-410
    • (2000) Brain Res , vol.877 , pp. 407-410
    • Lawston, J.1    Borella, A.2    Robinson, J.K.3    Whitaker-Azmitia, P.M.4
  • 24
    • 0037307212 scopus 로고    scopus 로고
    • To die or not to die for neurons in ischemia, traumatic brain injury and epilepsy: a review on the stress-activated signaling pathways and apoptotic pathways
    • Liou A.K., Clark R.S., Henshall D.C., Yin X.M., and Chen J. To die or not to die for neurons in ischemia, traumatic brain injury and epilepsy: a review on the stress-activated signaling pathways and apoptotic pathways. Prog Neurobiol 69 (2003) 103-142
    • (2003) Prog Neurobiol , vol.69 , pp. 103-142
    • Liou, A.K.1    Clark, R.S.2    Henshall, D.C.3    Yin, X.M.4    Chen, J.5
  • 25
    • 0033135122 scopus 로고    scopus 로고
    • Cannabis use and cognitive decline in persons under 65 years of age
    • Lyketsos C.G., Garrett E., Liang K.Y., and Anthony J.C. Cannabis use and cognitive decline in persons under 65 years of age. Am J Epidemiol 149 (1999) 794-800
    • (1999) Am J Epidemiol , vol.149 , pp. 794-800
    • Lyketsos, C.G.1    Garrett, E.2    Liang, K.Y.3    Anthony, J.C.4
  • 26
  • 27
    • 0036488182 scopus 로고    scopus 로고
    • Neuroprotective properties of cannabinoids against oxidative stress: role of the cannabinoid receptor CB1
    • Marsicano G., Moosmann B., Hermann H., Lutz B., and Behl C. Neuroprotective properties of cannabinoids against oxidative stress: role of the cannabinoid receptor CB1. J Neurochem 80 (2002) 448-456
    • (2002) J Neurochem , vol.80 , pp. 448-456
    • Marsicano, G.1    Moosmann, B.2    Hermann, H.3    Lutz, B.4    Behl, C.5
  • 28
    • 0142038950 scopus 로고    scopus 로고
    • Neuroprotective and brain edema-reducing efficacy of the novel cannabinoid receptor agonist BAY 38-7271
    • Mauler F., Hinz V., Augstein K.H., Fassbender M., and Horvath E. Neuroprotective and brain edema-reducing efficacy of the novel cannabinoid receptor agonist BAY 38-7271. Brain Res 989 (2003) 99-111
    • (2003) Brain Res , vol.989 , pp. 99-111
    • Mauler, F.1    Hinz, V.2    Augstein, K.H.3    Fassbender, M.4    Horvath, E.5
  • 29
    • 0036156353 scopus 로고    scopus 로고
    • Cannabinoids and brain injury: therapeutic implications
    • Mechoulam R., Panikashvili D., and Shohami E. Cannabinoids and brain injury: therapeutic implications. Trends Mol Med 8 (2002) 58-61
    • (2002) Trends Mol Med , vol.8 , pp. 58-61
    • Mechoulam, R.1    Panikashvili, D.2    Shohami, E.3
  • 30
    • 0037161476 scopus 로고    scopus 로고
    • Endocannabinoids and neuroprotection
    • RE5
    • Mechoulam R., Spatz M., and Shohami E. Endocannabinoids and neuroprotection. Sci STKE 2002 (2002) RE5
    • (2002) Sci STKE , vol.2002
    • Mechoulam, R.1    Spatz, M.2    Shohami, E.3
  • 31
    • 0345352739 scopus 로고    scopus 로고
    • Prenatal exposure to a cannabinoid agonist produces memory deficits linked to dysfunction in hippocampal long-term potentiation and glutamate release
    • Mereu G., Fa M., Ferraro L., Cagiano R., Antonelli T., Tattoli M., et al. Prenatal exposure to a cannabinoid agonist produces memory deficits linked to dysfunction in hippocampal long-term potentiation and glutamate release. Proc Natl Acad Sci U S A 100 (2003) 4915-4920
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 4915-4920
    • Mereu, G.1    Fa, M.2    Ferraro, L.3    Cagiano, R.4    Antonelli, T.5    Tattoli, M.6
  • 32
    • 0019957779 scopus 로고
    • Place navigation impaired in rats with hippocampal lesions
    • Morris R.G., Garrud P., Rawlins J.N., and O'Keefe J. Place navigation impaired in rats with hippocampal lesions. Nature 297 (1982) 681-683
    • (1982) Nature , vol.297 , pp. 681-683
    • Morris, R.G.1    Garrud, P.2    Rawlins, J.N.3    O'Keefe, J.4
  • 33
    • 0032578510 scopus 로고    scopus 로고
    • Inhibition of the p44/42 MAP kinase pathway protects hippocampal neurons in a cell-culture model of seizure activity
    • Murray B., Alessandrini A., Cole A.J., Yee A.G., and Furshpan E.J. Inhibition of the p44/42 MAP kinase pathway protects hippocampal neurons in a cell-culture model of seizure activity. Proc Natl Acad Sci U S A 95 (1998) 11975-11980
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 11975-11980
    • Murray, B.1    Alessandrini, A.2    Cole, A.J.3    Yee, A.G.4    Furshpan, E.J.5
  • 34
    • 0033561159 scopus 로고    scopus 로고
    • Cannabinoids and neuroprotection in global and focal cerebral ischemia and in neuronal cultures
    • Nagayama T., Sinor A.D., Simon R.P., Chen J., Graham S.H., Jin K., et al. Cannabinoids and neuroprotection in global and focal cerebral ischemia and in neuronal cultures. J Neurosci 19 (1999) 2987-2995
    • (1999) J Neurosci , vol.19 , pp. 2987-2995
    • Nagayama, T.1    Sinor, A.D.2    Simon, R.P.3    Chen, J.4    Graham, S.H.5    Jin, K.6
  • 35
    • 33748206802 scopus 로고    scopus 로고
    • Repeated cannabinoid exposure during perinatal, adolescent or early adult ages produces similar longlasting deficits in object recognition and reduced social interaction in rats
    • O'Shea M., McGregor I.S., and Mallet P.E. Repeated cannabinoid exposure during perinatal, adolescent or early adult ages produces similar longlasting deficits in object recognition and reduced social interaction in rats. J Psychopharmacol 20 (2006) 611-621
    • (2006) J Psychopharmacol , vol.20 , pp. 611-621
    • O'Shea, M.1    McGregor, I.S.2    Mallet, P.E.3
  • 36
    • 33749544716 scopus 로고    scopus 로고
    • Discovery of the presence and functional expression of cannabinoid CB2 receptors in brain
    • Onaivi E.S., Ishiguro H., Gong J.P., Patel S., Perchuk A., Meozzi P.A., et al. Discovery of the presence and functional expression of cannabinoid CB2 receptors in brain. Ann N Y Acad Sci 1074 (2006) 514-536
    • (2006) Ann N Y Acad Sci , vol.1074 , pp. 514-536
    • Onaivi, E.S.1    Ishiguro, H.2    Gong, J.P.3    Patel, S.4    Perchuk, A.5    Meozzi, P.A.6
  • 38
    • 0025355316 scopus 로고
    • The role of the amygdala and the hippocampus in working memory for spatial and non-spatial information
    • Peinado-Manzano M.A. The role of the amygdala and the hippocampus in working memory for spatial and non-spatial information. Behav Brain Res 38 (1990) 117-134
    • (1990) Behav Brain Res , vol.38 , pp. 117-134
    • Peinado-Manzano, M.A.1
  • 39
    • 0029762298 scopus 로고    scopus 로고
    • Cerebellar contribution to spatial event processing: Morris water maze and T-maze
    • Petrosini L., Molinari M., and Dell'Anna M.E. Cerebellar contribution to spatial event processing: Morris water maze and T-maze. Eur J Neurosci 8 (1996) 1882-1896
    • (1996) Eur J Neurosci , vol.8 , pp. 1882-1896
    • Petrosini, L.1    Molinari, M.2    Dell'Anna, M.E.3
  • 40
    • 0030070793 scopus 로고    scopus 로고
    • The residual cognitive effects of heavy marijuana use in college students
    • Pope Jr. H.G., and Yurgelun-Todd D. The residual cognitive effects of heavy marijuana use in college students. Jama 275 (1996) 521-527
    • (1996) Jama , vol.275 , pp. 521-527
    • Pope Jr., H.G.1    Yurgelun-Todd, D.2
  • 41
    • 1642315483 scopus 로고    scopus 로고
    • Modulation of extracellular signal-regulated kinases cascade by chronic delta 9-tetrahydrocannabinol treatment
    • Rubino T., Forlani G., Vigano D., Zippel R., and Parolaro D. Modulation of extracellular signal-regulated kinases cascade by chronic delta 9-tetrahydrocannabinol treatment. Mol Cell Neurosci 25 (2004) 355-362
    • (2004) Mol Cell Neurosci , vol.25 , pp. 355-362
    • Rubino, T.1    Forlani, G.2    Vigano, D.3    Zippel, R.4    Parolaro, D.5
  • 42
    • 0037198522 scopus 로고    scopus 로고
    • The cannabinoid agonist DALN positively modulates L-type voltage-dependent calcium-channels in N18TG2 neuroblastoma cells
    • Rubovitch V., Gafni M., and Sarne Y. The cannabinoid agonist DALN positively modulates L-type voltage-dependent calcium-channels in N18TG2 neuroblastoma cells. Brain Res Mol Brain Res 101 (2002) 93-102
    • (2002) Brain Res Mol Brain Res , vol.101 , pp. 93-102
    • Rubovitch, V.1    Gafni, M.2    Sarne, Y.3
  • 43
    • 1642450673 scopus 로고    scopus 로고
    • The involvement of VEGF receptors and MAPK in the cannabinoid potentiation of Ca2+ flux into N18TG2 neuroblastoma cells
    • Rubovitch V., Gafni M., and Sarne Y. The involvement of VEGF receptors and MAPK in the cannabinoid potentiation of Ca2+ flux into N18TG2 neuroblastoma cells. Brain Res. Mol Brain Res 120 (2004) 138-144
    • (2004) Brain Res. Mol Brain Res , vol.120 , pp. 138-144
    • Rubovitch, V.1    Gafni, M.2    Sarne, Y.3
  • 44
    • 0032530577 scopus 로고    scopus 로고
    • Regional selective neuronal degeneration after protein phosphatase inhibition in hippocampal slice cultures: evidence for a MAP kinase-dependent mechanism
    • Runden E., Seglen P.O., Haug F.M., Ottersen O.P., Wieloch T., Shamloo M., et al. Regional selective neuronal degeneration after protein phosphatase inhibition in hippocampal slice cultures: evidence for a MAP kinase-dependent mechanism. J Neurosci 18 (1998) 7296-7305
    • (1998) J Neurosci , vol.18 , pp. 7296-7305
    • Runden, E.1    Seglen, P.O.2    Haug, F.M.3    Ottersen, O.P.4    Wieloch, T.5    Shamloo, M.6
  • 45
    • 0031724645 scopus 로고    scopus 로고
    • Involvement of sphingomyelin hydrolysis and the mitogen-activated protein kinase cascade in the Delta9-tetrahydrocannabinol-induced stimulation of glucose metabolism in primary astrocytes
    • Sanchez C., Galve-Roperh I., Rueda D., and Guzman M. Involvement of sphingomyelin hydrolysis and the mitogen-activated protein kinase cascade in the Delta9-tetrahydrocannabinol-induced stimulation of glucose metabolism in primary astrocytes. Mol Pharmacol 54 (1998) 834-843
    • (1998) Mol Pharmacol , vol.54 , pp. 834-843
    • Sanchez, C.1    Galve-Roperh, I.2    Rueda, D.3    Guzman, M.4
  • 46
    • 3242786506 scopus 로고    scopus 로고
    • Are cannabinoid drugs neurotoxic or neuroprotective?
    • Sarne Y., and Keren O. Are cannabinoid drugs neurotoxic or neuroprotective?. Med Hypotheses 63 (2004) 187-192
    • (2004) Med Hypotheses , vol.63 , pp. 187-192
    • Sarne, Y.1    Keren, O.2
  • 47
    • 28944437048 scopus 로고    scopus 로고
    • Cannabinoids: between neuroprotection and neurotoxicity
    • Sarne Y., and Mechoulam R. Cannabinoids: between neuroprotection and neurotoxicity. Curr Drug Targets-Cns Neurol Disord 4 (2005) 677-684
    • (2005) Curr Drug Targets-Cns Neurol Disord , vol.4 , pp. 677-684
    • Sarne, Y.1    Mechoulam, R.2
  • 48
    • 0025720576 scopus 로고
    • Neurotoxicology of cannabis and THC: a review of chronic exposure studies in animals
    • Scallet A.C. Neurotoxicology of cannabis and THC: a review of chronic exposure studies in animals. Pharmacol Biochem Behav 40 (1991) 671-676
    • (1991) Pharmacol Biochem Behav , vol.40 , pp. 671-676
    • Scallet, A.C.1
  • 49
    • 0023619607 scopus 로고
    • Morphometric studies of the rat hippocampus following chronic delta-9-tetrahydrocannabinol (THC)
    • Scallet A.C., Uemura E., Andrews A., Ali S.F., McMillan D.E., Paule M.G., et al. Morphometric studies of the rat hippocampus following chronic delta-9-tetrahydrocannabinol (THC). Brain Res 436 (1987) 193-198
    • (1987) Brain Res , vol.436 , pp. 193-198
    • Scallet, A.C.1    Uemura, E.2    Andrews, A.3    Ali, S.F.4    McMillan, D.E.5    Paule, M.G.6
  • 50
    • 0029870716 scopus 로고    scopus 로고
    • The ALIAmide palmitoylethanolamide and cannabinoids, but not anandamide, are protective in a delayed postglutamate paradigm of excitotoxic death in cerebellar granule neurons
    • Skaper S.D., Buriani A., Dal Toso R., Petrelli L., Romanello S., Facci L., and Leon A. The ALIAmide palmitoylethanolamide and cannabinoids, but not anandamide, are protective in a delayed postglutamate paradigm of excitotoxic death in cerebellar granule neurons. Proc Natl Acad Sci U S A 93 (1996) 3984-3989
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 3984-3989
    • Skaper, S.D.1    Buriani, A.2    Dal Toso, R.3    Petrelli, L.4    Romanello, S.5    Facci, L.6    Leon, A.7
  • 51
    • 0029015217 scopus 로고
    • Differential impairments of selective attention due to frequency and duration of cannabis use
    • Solowij N., Michie P.T., and Fox A.M. Differential impairments of selective attention due to frequency and duration of cannabis use. Biol Psychiatry 37 (1995) 731-739
    • (1995) Biol Psychiatry , vol.37 , pp. 731-739
    • Solowij, N.1    Michie, P.T.2    Fox, A.M.3
  • 52
    • 0037029103 scopus 로고    scopus 로고
    • Cognitive functioning of long-term heavy cannabis users seeking treatment
    • Solowij N., Stephens R.S., Roffman R.A., Babor T., Kadden R., Miller M., et al. Cognitive functioning of long-term heavy cannabis users seeking treatment. Jama 287 (2002) 1123-1131
    • (2002) Jama , vol.287 , pp. 1123-1131
    • Solowij, N.1    Stephens, R.S.2    Roffman, R.A.3    Babor, T.4    Kadden, R.5    Miller, M.6
  • 53
    • 0034697364 scopus 로고    scopus 로고
    • Persistent activation of ERK contributes to glutamate-induced oxidative toxicity in a neuronal cell line and primary cortical neuron cultures
    • Stanciu M., Wang Y., Kentor R., Burke N., Watkins S., Kress G., et al. Persistent activation of ERK contributes to glutamate-induced oxidative toxicity in a neuronal cell line and primary cortical neuron cultures. J Biol Chem 275 (2000) 12200-12206
    • (2000) J Biol Chem , vol.275 , pp. 12200-12206
    • Stanciu, M.1    Wang, Y.2    Kentor, R.3    Burke, N.4    Watkins, S.5    Kress, G.6
  • 54
    • 0020564101 scopus 로고
    • Behavioral effects of prolonged administration of delta 9-tetrahydrocannabinol in the rat
    • Stiglick A., and Kalant H. Behavioral effects of prolonged administration of delta 9-tetrahydrocannabinol in the rat. Psychopharmacology (Berl) 80 (1983) 325-330
    • (1983) Psychopharmacology (Berl) , vol.80 , pp. 325-330
    • Stiglick, A.1    Kalant, H.2
  • 55
    • 0020069389 scopus 로고
    • Learning impairment in the radial-arm maze following prolonged cannabis treatment in rats
    • Stiglick A., and Kalant H. Learning impairment in the radial-arm maze following prolonged cannabis treatment in rats. Psychopharmacology (Berl) 77 (1982) 117-123
    • (1982) Psychopharmacology (Berl) , vol.77 , pp. 117-123
    • Stiglick, A.1    Kalant, H.2
  • 56
    • 0020083110 scopus 로고
    • Residual effects of prolonged cannabis administration on exploration and DRL performance in rats
    • Stiglick A., and Kalant H. Residual effects of prolonged cannabis administration on exploration and DRL performance in rats. Psychopharmacology (Berl) 77 (1982) 124-128
    • (1982) Psychopharmacology (Berl) , vol.77 , pp. 124-128
    • Stiglick, A.1    Kalant, H.2
  • 57
    • 33744980677 scopus 로고    scopus 로고
    • ERK-dependent modulation of cerebellar synaptic plasticity after chronic Delta9-tetrahydrocannabinol exposure
    • Tonini R., Ciardo S., Cerovic M., Rubino T., Parolaro D., Mazzanti M., et al. ERK-dependent modulation of cerebellar synaptic plasticity after chronic Delta9-tetrahydrocannabinol exposure. J Neurosci 26 (2006) 5810-5818
    • (2006) J Neurosci , vol.26 , pp. 5810-5818
    • Tonini, R.1    Ciardo, S.2    Cerovic, M.3    Rubino, T.4    Parolaro, D.5    Mazzanti, M.6
  • 58
    • 33751399536 scopus 로고    scopus 로고
    • A single low dose of tetrahydrocannabinol induces long-term cognitive deficits
    • Tselnicker I., Keren O., Hefetz A., Pick C.G., and Sarne Y. A single low dose of tetrahydrocannabinol induces long-term cognitive deficits. Neurosci Lett 411 (2007) 108-111
    • (2007) Neurosci Lett , vol.411 , pp. 108-111
    • Tselnicker, I.1    Keren, O.2    Hefetz, A.3    Pick, C.G.4    Sarne, Y.5
  • 59
    • 0035437865 scopus 로고    scopus 로고
    • Neuroprotection by Delta9-tetrahydrocannabinol, the main active compound in marijuana, against ouabain-induced in vivo excitotoxicity
    • van der Stelt M., Veldhuis W.B., Bar P.R., Veldink G.A., Vliegenthart J.F., and Nicolay K. Neuroprotection by Delta9-tetrahydrocannabinol, the main active compound in marijuana, against ouabain-induced in vivo excitotoxicity. J Neurosci 21 (2001) 6475-6479
    • (2001) J Neurosci , vol.21 , pp. 6475-6479
    • van der Stelt, M.1    Veldhuis, W.B.2    Bar, P.R.3    Veldink, G.A.4    Vliegenthart, J.F.5    Nicolay, K.6
  • 61
    • 26844504226 scopus 로고    scopus 로고
    • Identification and functional characterization of brainstem cannabinoid CB2 receptors
    • Van Sickle M.D., Duncan M., Kingsley P.J., Mouihate A., Urbani P., Mackie K., et al. Identification and functional characterization of brainstem cannabinoid CB2 receptors. Science 310 (2005) 329-332
    • (2005) Science , vol.310 , pp. 329-332
    • Van Sickle, M.D.1    Duncan, M.2    Kingsley, P.J.3    Mouihate, A.4    Urbani, P.5    Mackie, K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.