Changes in hippocampal morphology following chronic treatment with the synthetic cannabinoid WIN 55,212-2

Brain Research

Volumn 877, Issue 2, 2000, Pages 407-410

  Lawston, Jodie ^a   Borella, Alice ^a   Robinson, John K ^a   Whitaker Azmitia, Patricia M ^a  

^a STONY BROOK UNIVERSITY   (United States)

Author keywords

Dendrite; Hippocampus; Ischemia; MAP 2; Marijuana; Stress; WIN 55 212 2

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; CANNABIS; DIMETHYL SULFOXIDE; MICROTUBULE ASSOCIATED PROTEIN 2; TETRAHYDROCANNABINOL;

ANIMAL TISSUE; ARTICLE; CELL COUNT; CONTROLLED STUDY; DENTATE GYRUS; GRANULE CELL; HIPPOCAMPUS; LEARNING; MALE; MEMORY; MORPHOMETRICS; NONHUMAN; PRIORITY JOURNAL; RAT; STRESS; SUBSTANCE ABUSE;

ANALGESICS; ANIMAL; CANNABINOIDS; CELL SIZE; DENDRITES; HIPPOCAMPUS; MALE; MARIJUANA ABUSE; MEMORY DISORDERS; MICROTUBULE-ASSOCIATED PROTEINS; MORPHOLINES; NAPHTHALENES; PYRAMIDAL CELLS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0034703446     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)02739-6     Document Type: Article

References (32)

1. Aigner T. Delta-9-tetrahydocannabinol impairs visual recognition memory in rhesus monkeys. Psychopharmacology. 95:1988;507-511.
2. Amen D.G., Waugh M.J. High resolution brain SPECT imaging of marijuana smokers with AD/HD. Psychoactive Drugs. 30:1998;209-214.
3. Ameri A. The effects of cannabinoids on the brain. Prog. Neurobiol. 58:1999;315-348.
4. Berrendero F., Sepe N., Ramos J.A., Di Marzo V., Fernandez-Ruiz J.J. Analysis of cannabinoid receptor binding and mRNA expression and endogenous cannabinoid content in the developing rat brain during late gestation and early postnatal period. Synapse. 33:1999;181-191.
5. Brown E.S., Rush A.J., McEwen B.S. Hippocampal remodeling and damage by corticosteroids: implications for mood disorders. Neuropsychopharmacology. 21:1999;474-484.
6. Campbell K.A., Foster T.C., Hampson R.E., Deadwyler S.A. Effects of Delta-9-tetrahydrocannabinol on sensory-evoked potentials in the granule cells in the dentate gyrus of behaving rats. J. Pharmacol. Exp. Ther. 239:1986;941-945.
7. Chan G.C., Hinds T.R., Impey S., Storm D.R. Hippocampal neurotoxicity of Delta 9-tetrahydrocannabinol. J. Neurosci. 18:1998;5322-5332.
8. Folkerts M.M., Berman R.F., Muizelaar J.P., Rafols J.A. Disruption of MAP-2 immunostaining in rat hippocampus after traumatic brain injury. J. Neurotrauma. 15:1998;349-363.
9. Galea L.A., McEwen B.S., Tanapat P., Deak T., Spencer R.L., Dhabhar F.S. Sex differences in dendritic atrophy of CA3 pyramidal neurons in response to chronic restraint stress. Neuroscience. 81:1997;689-697.
10. Gould E., McEwen B.S., Tanapat P., Galea L.A., Fuchs E. Neurogenesis in the dentate gyrus of the adult tree shrew is regulated by psychosocial stress and NMDA receptor activation. J. Neurosci. 17:1997;2492-2498.
11. Hampson R.E., Deadwyler S.A. Role of cannabinoid receptors in memory storage. Neurobiol. Dis. 5:1998;474-482.
12. Heyser C.J., E Hampson R., Deadwyler S.A. Effects of delta-9-tetrahydrocannabinol on delayed match to sample performance in rats: Alterations of short-term memory associated with changes in task specific firing of hippocampal cells. J. Pharmacol. Exp. Ther. 264:1993;294-307.
13. Koczyk D. Differential response of microtubule-associated protein 2 (MAP-2) in rat hippocampus after exposure to trimethyltin (TMT): an immunocytochemical study. Acta Neurobiol. Exp. (Warsz). 54:1994;55-58.
14. Lichtman A.H., Dimen K.R., Martin B.R. Systemic or intrahippocampal cannabinoid administration impairs spatial memory in rats. Psychopharmacology. 119:1995;282-290.
15. Lichtman A.H., Martin B.R. Delta-9-tetrahydrocannabinol impairs spatial memory through a cannabinoid receptor mechanism. Psychopharmacology. 126:1996;125-131.
16. Mailleux P., Parmentier M., Vanderhaeghen J.J. Distribution of cannabinoid receptor messenger RNA in the human brain: an in situ hybridization histochemistry with oligonucleotides. Neurosci. Lett. 143:1992;200-204.
17. Mallet P.E., Beninger R.J. The endogenous cannabinoid receptor agonist anandamide impairs memory in rats. Behav. Pharmacol. 7:1996;276-286.
18. Masur J., Martz R.M.W., Carlini E.A. Effects of acute and chronic administration of cannabis sativa and (-)delta-9-tetrahydrocannabinol on the behavior of rats in the open field arena. Psychopharmacologia. 19:1971;388-397.
19. Matesic D.F., Lin R.C. Microtubule-associated protein 2 as an early indicator of ischemia-induced neurodegeneration in the gerbil forebrain. J. Neurochem. 63:1994;1012-1020.
20. Mazer C., Muneyyirci J., Taheny K., Raio N., Borella A., Whitaker-Azmitia P.M. Serotonin depletion during synaptogenesis leads to decreased synaptic density and learning deficits in the adult rat: a possible model of neurodevelopmental disorders with cognitive deficits. Brain Res. 760:1997;68-73.
21. McEwen B.S. Stress and hippocampal plasticity. Annu. Rev. Neurosci. 22:1999;105-122.
22. Nagayama T., Sinor A.D., Simon R.P., Chen J., Graham S.H., Jin K., Greenberg D.A. Cannabinoids and neuroprotection in global and focal cerebral ischemia and in neuronal cultures. J Neurosci. 19:1999;2987-2995.
23. Nakamura E.M., da Silva E.A., Concilio G.V., Wilkinson D.A., Masur J. Reversible effects of acute and long-term administration of delta-9 tetrahydrocannabinol (THC) on memory in the rat. Drug and Alcohol Dependence. 28:1991;167-175.
24. Ong W.Y., Mackie K. A light and electron microscopic study of the CB1 cannabinoid receptor in primate brain. Neuroscience. 92:1999;1177-1191.
25. Pope Jr H.G., Yurgelun-Todd D. The residual cognitive effects of heavy marijuana use in college students. J. Am. Med. Assoc. 275:1996;521-527.
26. Presburger G., Robinson J.K. Spatial signal detection in rats is differentially disrupted by delta-9-tetrahydrocannabinol, scopolamine, and MK-801. Behav. Brain Res. 99:1999;27-34.
27. Romero J., Berrendero F., Manzanares J., Perez A., Corchero J., Fuentes J.A., J Fernandez-Ruiz J., Ramos J.A. Time-course of the cannabinoid receptor down regulation in the adult rat brain caused by repeated exposure to Delta-9-tetrahydrocannabinol. Synapse. 30:1998;298-308.
28. Sunanda, M.S. Rao, T.R. Raju, Effect of chronic restraint stress on dendritic spines of hippocampal CA3 pyramidal neurons - a quantitative study, Brain Res. 694 (1995) 312-317.
29. Terranova J.P., Michaud J.C., Le Fur G., Soubrie P. Inhibition of long-term potentiation in rat hippocampal slices by anandamide and WIN55212-2: reversal by SR141716 A, a selective antagonist of CB1 cannabinoid receptors. Naunyn-Schmiedeberg's Arch. Pharmacol. 352:1995;576-579.
30. Vaillend C., Billard J.M., Claudepierre T., Rendon A., Dutar P., Ungerer A. Spatial discrimination learning and CA1 hippocampal synaptic plasticity in mdx and mdx3cv mice lacking dystrophin gene products. Neuroscience. 86:1998;53-66.
31. Yamasaki Y., Shigeno T., Furukawa Y., Furukawa S. Reduction in brain-derived neurotrophic factor protein level in the hippocampal CA1 dendritic field precedes the delayed neuronal damage in the rat brain. J. Neurosci. Res. 53:1998;318-329.
32. Whitaker-Azmitia P.M., Borella A., Raio N. Serotonin depletion in the adult rat causes loss of the dendritic marker MAP-2. Neuropsychopharm. 12:1995;269-272.