Intestinal responses to xenobiotics

Toxicology in Vitro

Volumn 15, Issue 4-5, 2001, Pages 373-378

  Carriere V ^a   Chambaz, J ^a   Rousset, M ^a  

^a SORBONNE UNIVERSITÉ   (France)

Author keywords

Caco 2 TC7 clone; CYP1A1; CYP3A4; Enterocytes; Glucose metabolism

Indexed keywords

CYTOCHROME P450 1A1; CYTOCHROME P450 3A4; DRUG METABOLIZING ENZYME; LIVER ENZYME; XENOBIOTIC AGENT;

BIOTRANSFORMATION; CELL CLONE; CELL FUNCTION; CELL ISOLATION; CELL STRAIN CACO 2; CONFERENCE PAPER; CONTROLLED STUDY; DETOXIFICATION; ELECTRIC POTENTIAL; ENZYME INDUCTION; ENZYME METABOLISM; GASTROINTESTINAL TRACT; GLUCOSE METABOLISM; HUMAN; HUMAN CELL; IN VITRO STUDY; INTESTINE CELL; INTESTINE EPITHELIUM; INTESTINE FUNCTION; LIVER CELL;

ANIMALS; BETA-NAPHTHOFLAVONE; CACO-2 CELLS; COBALT; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 ENZYME SYSTEM; ENTEROCYTES; ENZYME INDUCTION; ENZYME INHIBITORS; HUMANS; INTESTINAL MUCOSA; METABOLIC DETOXICATION, DRUG; MIXED FUNCTION OXYGENASES; MODELS, BIOLOGICAL; RNA, MESSENGER; XENOBIOTICS;

EID: 0034832993     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0887-2333(01)00039-X     Document Type: Article

References (38)

1. Drug absorption studies of prodrug esters using the Caco-2 model: Evaluation of ester hydrolysis and transepithelial transport
2. Primary porcine enterocyte and hepatocyte cultures to study drug oxidation reactions
3. Substrate specificity and some properties of phenol sulfotranferase from human intestinal Caco-2 cells
4. Evidence for glucuronide conjugation of p-nitrophenol in the Caco-2 cell model
5. Regulation of cytochrome P4501A1 gene expression in a human intestinal cell line, Caco-2
6. Characterisation of a newly isolated Caco-2 clone (TC-7), as a model of transport processes and biotransformation of drugs
7. Expression of cytochrome P-450 3A in HT29-MTX cells and Caco-2 clone TC7
8. Regulation of sucrase-isomaltase and hexose transporters in Caco-2 cells: A role for cytochrome P-4501A1?
9. Hypoxia and CYP1A1 induction-dependent regulation of proteins involved in glucose utilization in Caco-2 cells
10. Differential expression of sucrase-isomaltase in clones isolated from early and late passages of the cell line Caco-2: Evidence for a glucose-dependent negative regulation
11. Function and regulation of the multidrug resistance gene
12. Characterization of furazolidone apical-related effects to human polarized intestinal cells
13. A human colonic cell line sharing similarities with enterocytes as a model to examine oral absorption; advantages and limitations of the Caco-2 model
14. Absence of Hela cell contamination in 169 cell lines derived from human tumors
15. Cytochrome P450 enzyme activity and protein expression in primary porcine enterocyte and hepatocyte cultures
16. Age-dependent expression of P-glycoprotein gp170 in Caco-2 cell monolayers
17. Catalytic activities, protein and mRNA-expression of cytochrome P450 Isoenzymes in intestinal cell lines
18. Illegitimate expression of apolipoprotein A-II in Caco-2 cells is due to chromatin organization
19. The detoxification enzyme systems
20. Presence and differential expression of SGLT1, GLUT1, GLUT2, GLUT3 and GLUT5 hexose-transporter mRNAs in Caco-2 cell clones in relation to cell growth and glucose consumption
21. Characterization of CYP3A gene subfamily expression in human gastrointestinal tissues
22. Localization of cytochromes P450 in human tissues: Implications for chemical toxicity
23. Repression of gene expression by oxidative stress
24. Development of intestinal transport function in mammals
25. Use of the dissociating enzyme Thermolysin to generate viable human normal intestinal epithelial cell cultures
26. Primary cultures of fully differentiated and pure human intestinal epithelial cells
27. Biochemical characterisation of resistance to mitoxantrone and adriamycin in Caco-2 human colon carcinoma cells: A possible role of glutathione-S-transferase
28. Enterocyte-like differentiation and polarization of the human colon carcinoma cell line Caco-2 in culture
29. Comparative studies of drug-metabolising enzymes in dog, monkey and human small intestines and in Caco-2 cells
30. Regulation of cytochrome P450 in cultured human colonic cells
31. The human colon carcinoma cell line HT-29 and Caco-2: Two in vitro models for the study of intestinal differentiation
32. Expression of enzymatically active CYP3A4 by Caco-2 cells grown on extracellular matrix-coated permeable supports in the presence of 1α,25-dihydroxyvitamin D3
33. AH receptor signaling pathways
34. A conditionally immortalized epithelial cell line for studies of intestinal drug transport
35. Glucose regulation of gene transcription
36. Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: Implications for drug delivery and activity in cancer chemotherapy
37. Hypoxia-inducible factor 1 is a basic-helix-loop-PAS heterodimer regulated by cellular O2 tension
38. Use of cultured cell lines in studies of intestinal cell differentiation and function