-
1
-
-
0037420518
-
Psoriasis
-
Lebwohl M. Psoriasis. Lancet 361, 1197–1204 (2003).
-
(2003)
Lancet
, vol.361
, pp. 1197-1204
-
-
Lebwohl, M.1
-
3
-
-
3042845754
-
Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunities
-
Nickoloff BJ, Nestle FO. Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunities. J. Clin. Invest. 113, 1664–1675 (2004).
-
(2004)
J. Clin. Invest.
, vol.113
, pp. 1664-1675
-
-
Nickoloff, B.J.1
Nestle, F.O.2
-
4
-
-
25444435193
-
Getting under the skin: the immunogenetics of psoriasis
-
Bowcock AM, Krueger JG. Getting under the skin: the immunogenetics of psoriasis. Nat. Rev. Immunol. 5, 699–711 (2005).
-
(2005)
Nat. Rev. Immunol.
, vol.5
, pp. 699-711
-
-
Bowcock, A.M.1
Krueger, J.G.2
-
5
-
-
14244258610
-
Psoriasis pathophysiology: current concepts of pathogenesis
-
Krueger JG, Bowcock A. Psoriasis pathophysiology: current concepts of pathogenesis. Ann. Rheum. Dis. 64 (Suppl. 2), ii30 –ii36 (2005).
-
(2005)
Ann. Rheum. Dis.
, vol.64
, pp. ii30-ii36
-
-
Krueger, J.G.1
Bowcock, A.2
-
6
-
-
0037434789
-
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
-
Cua DJ, Sherlock J, Chen Y et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 421, 744–748 (2003).
-
(2003)
Nature
, vol.421
, pp. 744-748
-
-
Cua, D.J.1
Sherlock, J.2
Chen, Y.3
-
7
-
-
13244283212
-
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
-
Langrish CL, Chen Y, Blumenschein WM et al. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med. 201, 233–240 (2005).
-
(2005)
J. Exp. Med.
, vol.201
, pp. 233-240
-
-
Langrish, C.L.1
Chen, Y.2
Blumenschein, W.M.3
-
8
-
-
0346962972
-
Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation
-
Murphy CA, Langrish CL, Chen Y et al. Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J. Exp. Med. 198, 1951–1957 (2003).
-
(2003)
J. Exp. Med.
, vol.198
, pp. 1951-1957
-
-
Murphy, C.A.1
Langrish, C.L.2
Chen, Y.3
-
9
-
-
10344243973
-
Clinical improvement in chronic plaque-type psoriasis lesions after narrow-band UVB therapy is accompanied by a decrease in the expression of IFN-γ inducers – IL-12, IL-18 and IL-23
-
Piskin G, Tursen U, Sylva-Steenland RM, Bos JD, Teunissen MB. Clinical improvement in chronic plaque-type psoriasis lesions after narrow-band UVB therapy is accompanied by a decrease in the expression of IFN-γ inducers – IL-12, IL-18 and IL-23. Exp. Dermatol. 13, 764–772 (2004).
-
(2004)
Exp. Dermatol.
, vol.13
, pp. 764-772
-
-
Piskin, G.1
Tursen, U.2
Sylva-Steenland, R.M.3
Bos, J.D.4
Teunissen, M.B.5
-
10
-
-
31144441631
-
In vitro and in situ expression of IL-23 by keratinocytes in healthy skin and psoriasis lesions: enhanced expression in psoriatic skin
-
Piskin G, Sylva-Steenland RM, Bos JD, Teunissen MB. In vitro and in situ expression of IL-23 by keratinocytes in healthy skin and psoriasis lesions: enhanced expression in psoriatic skin. J. Immunol. 176, 1908–1915 (2006).
-
(2006)
J. Immunol.
, vol.176
, pp. 1908-1915
-
-
Piskin, G.1
Sylva-Steenland, R.M.2
Bos, J.D.3
Teunissen, M.B.4
-
11
-
-
23444432216
-
TNF inhibition rapidly down-regulates multiple proinflammatory pathways in psoriasis plaques
-
Gottlieb AB, Chamian F, Masud S et al. TNF inhibition rapidly down-regulates multiple proinflammatory pathways in psoriasis plaques. J. Immunol. 175, 2721–2729 (2005).
-
(2005)
J. Immunol.
, vol.175
, pp. 2721-2729
-
-
Gottlieb, A.B.1
Chamian, F.2
Masud, S.3
-
12
-
-
0347285359
-
Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris
-
Lee E, Trepicchio WL, Oestreicher JL et al. Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris. J. Exp. Med. 199, 125–130 (2004).
-
(2004)
J. Exp. Med.
, vol.199
, pp. 125-130
-
-
Lee, E.1
Trepicchio, W.L.2
Oestreicher, J.L.3
-
13
-
-
13844316466
-
Alefacept reduces infiltrating T cells, activated dendritic cells, and inflammatory genes in psoriasis vulgaris
-
Chamian F, Lowes MA, Lin SL et al. Alefacept reduces infiltrating T cells, activated dendritic cells, and inflammatory genes in psoriasis vulgaris. Proc. Natl Acad. Sci. USA 102, 2075–2080 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 2075-2080
-
-
Chamian, F.1
Lowes, M.A.2
Lin, S.L.3
-
14
-
-
30044435436
-
Increase in TNF-α and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a)
-
Lowes MA, Chamian F, Abello MV et al. Increase in TNF-α and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a). Proc. Natl Acad. Sci. USA 102, 19057–19062 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 19057-19062
-
-
Lowes, M.A.1
Chamian, F.2
Abello, M.V.3
-
15
-
-
33751546237
-
IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis
-
Chan JR, Blumenschein W, Murphy E et al. IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis. J. Exp. Med. 203 (12), 2577–2587 (2006).
-
(2006)
J. Exp. Med.
, vol.203
, Issue.12
, pp. 2577-2587
-
-
Chan, J.R.1
Blumenschein, W.2
Murphy, E.3
-
16
-
-
33749151636
-
An anti-IL-12p40 antibody down-regulates type 1 cytokines, chemokines, and IL-12/IL-23 in psoriasis
-
Toichi E, Torres G, McCormick TS et al. An anti-IL-12p40 antibody down-regulates type 1 cytokines, chemokines, and IL-12/IL-23 in psoriasis. J. Immunol. 177, 4917–4926 (2006).
-
(2006)
J. Immunol.
, vol.177
, pp. 4917-4926
-
-
Toichi, E.1
Torres, G.2
McCormick, T.S.3
-
17
-
-
33646577466
-
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
-
Bettelli E, Carrier Y, Gao W et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441, 235–238 (2006).
-
(2006)
Nature
, vol.441
, pp. 235-238
-
-
Bettelli, E.1
Carrier, Y.2
Gao, W.3
-
18
-
-
33646560950
-
Transforming growth factor-β induces development of the T(H)17 lineage
-
Mangan PR, Harrington LE, O’Quinn DB et al. Transforming growth factor-β induces development of the T(H)17 lineage. Nature 441, 231–234 (2006).
-
(2006)
Nature
, vol.441
, pp. 231-234
-
-
Mangan, P.R.1
Harrington, L.E.2
O’Quinn, D.B.3
-
19
-
-
32244442562
-
TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
-
Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B. TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24, 179–189 (2006).
-
(2006)
Immunity
, vol.24
, pp. 179-189
-
-
Veldhoen, M.1
Hocking, R.J.2
Atkins, C.J.3
Locksley, R.M.4
Stockinger, B.5
-
20
-
-
0033638507
-
Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
-
Oppmann B, Lesley R, Blom B et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13, 715–725 (2000).
-
(2000)
Immunity
, vol.13
, pp. 715-725
-
-
Oppmann, B.1
Lesley, R.2
Blom, B.3
-
21
-
-
0037111202
-
Regulation of virus-induced IL-12 and IL-23 expression in human macrophages
-
Pirhonen J, Matikainen S, Julkunen I. Regulation of virus-induced IL-12 and IL-23 expression in human macrophages. J. Immunol. 169, 5673–5678 (2002).
-
(2002)
J. Immunol.
, vol.169
, pp. 5673-5678
-
-
Pirhonen, J.1
Matikainen, S.2
Julkunen, I.3
-
22
-
-
0035813157
-
Toll-like receptor 2 (TLR2) and TLR4 differentially activate human dendritic cells
-
Re F, Strominger JL. Toll-like receptor 2 (TLR2) and TLR4 differentially activate human dendritic cells. J. Biol. Chem. 276, 37692–37699 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 37692-37699
-
-
Re, F.1
Strominger, J.L.2
-
24
-
-
13244290058
-
IL-12- and IL-23-induced T helper cell subsets: birds of the same feather flock together
-
Bettelli E, Kuchroo VK. IL-12- and IL-23-induced T helper cell subsets: birds of the same feather flock together. J. Exp. Med. 201, 169–171 (2005).
-
(2005)
J. Exp. Med.
, vol.201
, pp. 169-171
-
-
Bettelli, E.1
Kuchroo, V.K.2
-
25
-
-
21844444831
-
New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions
-
Hunter CA. New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions. Nat. Rev. Immunol. 5, 521–531 (2005).
-
(2005)
Nat. Rev. Immunol.
, vol.5
, pp. 521-531
-
-
Hunter, C.A.1
-
26
-
-
9644291539
-
IL-12 and IL-23: master regulators of innate and adaptive immunity
-
Langrish CL, McKenzie BS, Wilson NJ, de Waal Malefyt R, Kastelein RA, Cua DJ. IL-12 and IL-23: master regulators of innate and adaptive immunity. Immunol. Rev. 202, 96–105 (2004).
-
(2004)
Immunol. Rev.
, vol.202
, pp. 96-105
-
-
Langrish, C.L.1
McKenzie, B.S.2
Wilson, N.J.3
de Waal Malefyt, R.4
Kastelein, R.A.5
Cua, D.J.6
-
27
-
-
0037449737
-
Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17
-
Aggarwal S, Ghilardi N, Xie MH, de Sauvage FJ, Gurney AL. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J. Biol. Chem. 278, 1910–1914 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 1910-1914
-
-
Aggarwal, S.1
Ghilardi, N.2
Xie, M.H.3
de Sauvage, F.J.4
Gurney, A.L.5
-
28
-
-
33749318470
-
Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides
-
Liang SC, Tan XY, Luxenberg DP et al. Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J. Exp. Med. 203, 2271–2279 (2006).
-
(2006)
J. Exp. Med.
, vol.203
, pp. 2271-2279
-
-
Liang, S.C.1
Tan, X.Y.2
Luxenberg, D.P.3
-
29
-
-
0036604062
-
IL-23 and IL-12 have overlapping, but distinct, effects on murine dendritic cells
-
Belladonna ML, Renauld JC, Bianchi R et al. IL-23 and IL-12 have overlapping, but distinct, effects on murine dendritic cells. J. Immunol. 168, 5448–5454 (2002).
-
(2002)
J. Immunol.
, vol.168
, pp. 5448-5454
-
-
Belladonna, M.L.1
Renauld, J.C.2
Bianchi, R.3
-
30
-
-
0037114150
-
IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination
-
Gran B, Zhang GX, Yu S et al. IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination. J. Immunol. 169, 7104–7110 (2002).
-
(2002)
J. Immunol.
, vol.169
, pp. 7104-7110
-
-
Gran, B.1
Zhang, G.X.2
Yu, S.3
-
31
-
-
0036677420
-
Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12
-
Becher B, Durell BG, Noelle RJ. Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12. J. Clin. Invest. 110, 493–497 (2002).
-
(2002)
J. Clin. Invest.
, vol.110
, pp. 493-497
-
-
Becher, B.1
Durell, B.G.2
Noelle, R.J.3
-
32
-
-
10744230574
-
Role of IL-12 receptor β 1 in regulation of T cell response by APC in experimental autoimmune encephalomyelitis
-
Zhang GX, Yu S, Gran B et al. Role of IL-12 receptor β 1 in regulation of T cell response by APC in experimental autoimmune encephalomyelitis. J. Immunol. 171, 4485–4492 (2003).
-
(2003)
J. Immunol.
, vol.171
, pp. 4485-4492
-
-
Zhang, G.X.1
Yu, S.2
Gran, B.3
-
33
-
-
33646433989
-
Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis
-
Chen Y, Langrish CL, McKenzie B et al. Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis. J. Clin. Invest. 116, 1317–1326 (2006).
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 1317-1326
-
-
Chen, Y.1
Langrish, C.L.2
McKenzie, B.3
-
34
-
-
0035877257
-
Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death
-
Wiekowski MT, Leach MW, Evans EW et al. Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death. J. Immunol. 166, 7563–7570 (2001).
-
(2001)
J. Immunol.
, vol.166
, pp. 7563-7570
-
-
Wiekowski, M.T.1
Leach, M.W.2
Evans, E.W.3
-
35
-
-
0038189842
-
IL-23 production by cosecretion of endogenous p19 and transgenic p40 in keratin 14/p40 transgenic mice: evidence for enhanced cutaneous immunity
-
Kopp T, Lenz P, Bello-Fernandez C, Kastelein RA, Kupper TS, Stingl G. IL-23 production by cosecretion of endogenous p19 and transgenic p40 in keratin 14/p40 transgenic mice: evidence for enhanced cutaneous immunity. J. Immunol. 170, 5438–5444 (2003).
-
(2003)
J. Immunol.
, vol.170
, pp. 5438-5444
-
-
Kopp, T.1
Lenz, P.2
Bello-Fernandez, C.3
Kastelein, R.A.4
Kupper, T.S.5
Stingl, G.6
-
36
-
-
29744450121
-
Both IL-12p70 and IL-23 are synthesized during active Crohn’s disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody
-
Fuss IJ, Becker C, Yang Z et al. Both IL-12p70 and IL-23 are synthesized during active Crohn’s disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody. Inflamm. Bowel Dis. 12, 9–15 (2006).
-
(2006)
Inflamm. Bowel Dis.
, vol.12
, pp. 9-15
-
-
Fuss, I.J.1
Becker, C.2
Yang, Z.3
-
37
-
-
13944281011
-
Expression of interleukin-12-related cytokine transcripts in inflammatory bowel disease: elevated interleukin-23p19 and interleukin-27p28 in Crohn’s disease but not in ulcerative colitis
-
Schmidt C, Giese T, Ludwig B et al. Expression of interleukin-12-related cytokine transcripts in inflammatory bowel disease: elevated interleukin-23p19 and interleukin-27p28 in Crohn’s disease but not in ulcerative colitis. Inflamm. Bowel Dis. 11, 16–23 (2005).
-
(2005)
Inflamm. Bowel Dis.
, vol.11
, pp. 16-23
-
-
Schmidt, C.1
Giese, T.2
Ludwig, B.3
-
38
-
-
3042721899
-
Cytokine/chemokine transcript profiles reflect mucosal inflammation in Crohn’s disease
-
Stallmach A, Giese T, Schmidt C, Ludwig B, Mueller-Molaian I, Meuer SC. Cytokine/chemokine transcript profiles reflect mucosal inflammation in Crohn’s disease. Int. J. Colorectal Dis. 19, 308–315 (2004).
-
(2004)
Int. J. Colorectal Dis.
, vol.19
, pp. 308-315
-
-
Stallmach, A.1
Giese, T.2
Schmidt, C.3
Ludwig, B.4
Mueller-Molaian, I.5
Meuer, S.C.6
-
39
-
-
0141835046
-
Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells
-
Becker C, Wirtz S, Blessing M et al. Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells. J. Clin. Invest. 112, 693–706 (2003).
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 693-706
-
-
Becker, C.1
Wirtz, S.2
Blessing, M.3
-
40
-
-
33744936550
-
IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production
-
Vaknin-Dembinsky A, Balashov K, Weiner HL. IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production. J. Immunol. 176, 7768–7774 (2006).
-
(2006)
J. Immunol.
, vol.176
, pp. 7768-7774
-
-
Vaknin-Dembinsky, A.1
Balashov, K.2
Weiner, H.L.3
-
41
-
-
0036754255
-
Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses
-
Nakae S, Komiyama Y, Nambu A et al. Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses. Immunity 17, 375–387 (2002).
-
(2002)
Immunity
, vol.17
, pp. 375-387
-
-
Nakae, S.1
Komiyama, Y.2
Nambu, A.3
-
42
-
-
1342324752
-
Compromised humoral and delayed-type hypersensitivity responses in IL-23-deficient mice
-
Ghilardi N, Kljavin N, Chen Q, Lucas S, Gurney AL, De Sauvage FJ. Compromised humoral and delayed-type hypersensitivity responses in IL-23-deficient mice. J. Immunol. 172, 2827–2833 (2004).
-
(2004)
J. Immunol.
, vol.172
, pp. 2827-2833
-
-
Ghilardi, N.1
Kljavin, N.2
Chen, Q.3
Lucas, S.4
Gurney, A.L.5
De Sauvage, F.J.6
-
43
-
-
0031691282
-
Interleukin-17 and interferon-γ synergize in the enhancement of proinflammatory cytokine production by human keratinocytes
-
Teunissen MB, Koomen CW, de Waal Malefyt R, Wierenga EA, Bos JD. Interleukin-17 and interferon-γ synergize in the enhancement of proinflammatory cytokine production by human keratinocytes. J. Invest. Dermatol. 111, 645–649 (1998).
-
(1998)
J. Invest. Dermatol.
, vol.111
, pp. 645-649
-
-
Teunissen, M.B.1
Koomen, C.W.2
de Waal Malefyt, R.3
Wierenga, E.A.4
Bos, J.D.5
-
44
-
-
0032939560
-
IL-17 is produced by nickel-specific T lymphocytes and regulates ICAM-1 expression and chemokine production in human keratinocytes: synergistic or antagonist effects with IFN-γ and TNF-α
-
Albanesi C, Cavani A, Girolomoni G. IL-17 is produced by nickel-specific T lymphocytes and regulates ICAM-1 expression and chemokine production in human keratinocytes: synergistic or antagonist effects with IFN-γ and TNF-α. J. Immunol. 162, 494–502 (1999).
-
(1999)
J. Immunol.
, vol.162
, pp. 494-502
-
-
Albanesi, C.1
Cavani, A.2
Girolomoni, G.3
-
45
-
-
0033911218
-
Interleukin-17 is produced by both Th1 and Th2 lymphocytes, and modulates interferon-γ- and interleukin-4-induced activation of human keratinocytes
-
Albanesi C, Scarponi C, Cavani A, Federici M, Nasorri F, Girolomoni G. Interleukin-17 is produced by both Th1 and Th2 lymphocytes, and modulates interferon-γ- and interleukin-4-induced activation of human keratinocytes. J. Invest. Dermatol. 115, 81–87 (2000).
-
(2000)
J. Invest. Dermatol.
, vol.115
, pp. 81-87
-
-
Albanesi, C.1
Scarponi, C.2
Cavani, A.3
Federici, M.4
Nasorri, F.5
Girolomoni, G.6
-
46
-
-
0035113406
-
Response of psoriasis to interleukin-10 is associated with suppression of cutaneous type 1 inflammation, downregulation of the epidermal interleukin-8/CXCR2 pathway and normalization of keratinocyte maturation
-
Reich K, Garbe C, Blaschke V et al. Response of psoriasis to interleukin-10 is associated with suppression of cutaneous type 1 inflammation, downregulation of the epidermal interleukin-8/CXCR2 pathway and normalization of keratinocyte maturation. J. Invest. Dermatol. 116, 319–329 (2001).
-
(2001)
J. Invest. Dermatol.
, vol.116
, pp. 319-329
-
-
Reich, K.1
Garbe, C.2
Blaschke, V.3
-
47
-
-
0034660183
-
Up-regulation of macrophage inflammatory protein-3 α/CCL20 and CC chemokine receptor 6 in psoriasis
-
Homey B, Dieu-Nosjean MC, Wiesenborn A et al. Up-regulation of macrophage inflammatory protein-3 α/CCL20 and CC chemokine receptor 6 in psoriasis. J. Immunol. 164, 6621–6632 (2000).
-
(2000)
J. Immunol.
, vol.164
, pp. 6621-6632
-
-
Homey, B.1
Dieu-Nosjean, M.C.2
Wiesenborn, A.3
-
48
-
-
0037443531
-
Differential regulation of CXCR2 trafficking by Rab GTPases
-
Fan GH, Lapierre LA, Goldenring JR, Richmond A. Differential regulation of CXCR2 trafficking by Rab GTPases. Blood 101, 2115–2124 (2003).
-
(2003)
Blood
, vol.101
, pp. 2115-2124
-
-
Fan, G.H.1
Lapierre, L.A.2
Goldenring, J.R.3
Richmond, A.4
-
49
-
-
4344609710
-
Induction of granulocyte-macrophage colony-stimulating factor by a new cytokine, ML-1 (IL-17F), via Raf I-MEK-ERK pathway
-
Kawaguchi M, Kokubu F, Odaka M et al. Induction of granulocyte-macrophage colony-stimulating factor by a new cytokine, ML-1 (IL-17F), via Raf I-MEK-ERK pathway. J. Allergy Clin. Immunol. 114, 444–450 (2004).
-
(2004)
J. Allergy Clin. Immunol.
, vol.114
, pp. 444-450
-
-
Kawaguchi, M.1
Kokubu, F.2
Odaka, M.3
-
50
-
-
0036144194
-
IL-17: prototype member of an emerging cytokine family
-
Aggarwal S, Gurney AL. IL-17: prototype member of an emerging cytokine family. J. Leukoc. Biol. 71, 1–8 (2002).
-
(2002)
J. Leukoc. Biol.
, vol.71
, pp. 1-8
-
-
Aggarwal, S.1
Gurney, A.L.2
-
51
-
-
0033557728
-
Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways
-
Laan M, Cui ZH, Hoshino H et al. Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways. J. Immunol. 162, 2347–2352 (1999).
-
(1999)
J. Immunol.
, vol.162
, pp. 2347-2352
-
-
Laan, M.1
Cui, Z.H.2
Hoshino, H.3
-
52
-
-
4344688669
-
IL-17 markedly up-regulates β-defensin-2 expression in human airway epithelium via JAK and NF-κB signaling pathways
-
Kao CY, Chen Y, Thai P et al. IL-17 markedly up-regulates β-defensin-2 expression in human airway epithelium via JAK and NF-κB signaling pathways. J. Immunol. 173, 3482–3491 (2004).
-
(2004)
J. Immunol.
, vol.173
, pp. 3482-3491
-
-
Kao, C.Y.1
Chen, Y.2
Thai, P.3
-
53
-
-
0346364791
-
Epidermal overexpression of interleukin-19 and -20 mRNA in psoriatic skin disappears after short-term treatment with cyclosporine a or calcipotriol
-
Romer J, Hasselager E, Norby PL, Steiniche T, Thorn Clausen J, Kragballe K. Epidermal overexpression of interleukin-19 and -20 mRNA in psoriatic skin disappears after short-term treatment with cyclosporine a or calcipotriol. J. Invest. Dermatol. 121, 1306–1311 (2003).
-
(2003)
J. Invest. Dermatol.
, vol.121
, pp. 1306-1311
-
-
Romer, J.1
Hasselager, E.2
Norby, P.L.3
Steiniche, T.4
Thorn Clausen, J.5
Kragballe, K.6
-
54
-
-
4143095716
-
IL-22 increases the innate immunity of tissues
-
Wolk K, Kunz S, Witte E, Friedrich M, Asadullah K, Sabat R. IL-22 increases the innate immunity of tissues. Immunity 21, 241–254 (2004).
-
(2004)
Immunity
, vol.21
, pp. 241-254
-
-
Wolk, K.1
Kunz, S.2
Witte, E.3
Friedrich, M.4
Asadullah, K.5
Sabat, R.6
-
55
-
-
14844342604
-
IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes
-
Boniface K, Bernard FX, Garcia M, Gurney AL, Lecron JC, Morel F. IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes. J. Immunol. 174, 3695–3702 (2005).
-
(2005)
J. Immunol.
, vol.174
, pp. 3695-3702
-
-
Boniface, K.1
Bernard, F.X.2
Garcia, M.3
Gurney, A.L.4
Lecron, J.C.5
Morel, F.6
-
56
-
-
33646552450
-
IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis
-
Wolk K, Witte E, Wallace E et al. IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis. Eur. J. Immunol. 36, 1309–1323 (2006).
-
(2006)
Eur. J. Immunol.
, vol.36
, pp. 1309-1323
-
-
Wolk, K.1
Witte, E.2
Wallace, E.3
-
57
-
-
0030069195
-
Granulocyte-macrophage colony-stimulating factor antagonizes the transforming growth factor-β-induced expression of Fc γ RIII (CD16) on human monocytes
-
Kruger M, Coorevits L, De Wit TP, Casteels-Van Daele M, Van De Winkel JG, Ceuppens JL. Granulocyte-macrophage colony-stimulating factor antagonizes the transforming growth factor-β-induced expression of Fc γ RIII (CD16) on human monocytes. Immunology 87, 162–167 (1996).
-
(1996)
Immunology
, vol.87
, pp. 162-167
-
-
Kruger, M.1
Coorevits, L.2
De Wit, T.P.3
Casteels-Van Daele, M.4
Van De Winkel, J.G.5
Ceuppens, J.L.6
-
58
-
-
0037135659
-
+) subset of human monocytes preferentially becomes migratory dendritic cells in a model tissue setting
-
+ (FcγRIII +) subset of human monocytes preferentially becomes migratory dendritic cells in a model tissue setting. J. Exp. Med. 196, 517–527 (2002).
-
(2002)
J. Exp. Med.
, vol.196
, pp. 517-527
-
-
Randolph, G.J.1
Sanchez-Schmitz, G.2
Liebman, R.M.3
Schakel, K.4
-
59
-
-
0025873571
-
Transforming growth factor-β induces human T lymphocyte migration in vitro
-
Adams DH, Hathaway M, Shaw J, Burnett D, Elias E, Strain AJ. Transforming growth factor-β induces human T lymphocyte migration in vitro. J. Immunol. 147, 609–612 (1991).
-
(1991)
J. Immunol.
, vol.147
, pp. 609-612
-
-
Adams, D.H.1
Hathaway, M.2
Shaw, J.3
Burnett, D.4
Elias, E.5
Strain, A.J.6
-
60
-
-
2342496439
-
Transforming growth factor type β induces monocyte chemotaxis and growth factor production
-
Wahl SM, Hunt DA, Wakefield LM et al. Transforming growth factor type β induces monocyte chemotaxis and growth factor production. Proc. Natl Acad. Sci. USA 84, 5788–5792 (1987).
-
(1987)
Proc. Natl Acad. Sci. USA
, vol.84
, pp. 5788-5792
-
-
Wahl, S.M.1
Hunt, D.A.2
Wakefield, L.M.3
-
61
-
-
0026532252
-
Transforming growth factor-β 1 bifunctionally regulates murine macrophage proliferation
-
Fan K, Ruan Q, Sensenbrenner L, Chen B. Transforming growth factor-β 1 bifunctionally regulates murine macrophage proliferation. Blood 79, 1679–1685 (1992).
-
(1992)
Blood
, vol.79
, pp. 1679-1685
-
-
Fan, K.1
Ruan, Q.2
Sensenbrenner, L.3
Chen, B.4
-
62
-
-
2442548490
-
Latent TGFβ1 overexpression in keratinocytes results in a severe psoriasis-like skin disorder
-
Li AG, Wang D, Feng XH, Wang XJ. Latent TGFβ1 overexpression in keratinocytes results in a severe psoriasis-like skin disorder. EMBO J. 23, 1770–1781 (2004).
-
(2004)
EMBO J.
, vol.23
, pp. 1770-1781
-
-
Li, A.G.1
Wang, D.2
Feng, X.H.3
Wang, X.J.4
-
63
-
-
0028295190
-
Perturbation of epidermal barrier function correlates with initiation of cytokine cascade in human skin
-
Nickoloff BJ, Naidu Y. Perturbation of epidermal barrier function correlates with initiation of cytokine cascade in human skin. J. Am. Acad. Dermatol. 30, 535–546 (1994).
-
(1994)
J. Am. Acad. Dermatol.
, vol.30
, pp. 535-546
-
-
Nickoloff, B.J.1
Naidu, Y.2
-
64
-
-
0036403015
-
Association between psoriasis severity and transforming growth factor β(1) and β (2) in plasma and scales from psoriatic lesions
-
Flisiak I, Chodynicka B, Porebski P, Flisiak R. Association between psoriasis severity and transforming growth factor β(1) and β (2) in plasma and scales from psoriatic lesions. Cytokine 19, 121–125 (2002).
-
(2002)
Cytokine
, vol.19
, pp. 121-125
-
-
Flisiak, I.1
Chodynicka, B.2
Porebski, P.3
Flisiak, R.4
-
65
-
-
0025328916
-
Transforming growth factor-β 1 localization in normal and psoriatic epidermal keratinocytes in situ
-
Kane CJ, Knapp AM, Mansbridge JN, Hanawalt PC. Transforming growth factor-β 1 localization in normal and psoriatic epidermal keratinocytes in situ. J. Cell Physiol. 144, 144–150 (1990).
-
(1990)
J. Cell Physiol.
, vol.144
, pp. 144-150
-
-
Kane, C.J.1
Knapp, A.M.2
Mansbridge, J.N.3
Hanawalt, P.C.4
-
66
-
-
0034605067
-
Macrophage inflammatory protein 3α is expressed at inflamed epithelial surfaces and is the most potent chemokine known in attracting Langerhans cell precursors
-
Dieu-Nosjean MC, Massacrier C, Homey B et al. Macrophage inflammatory protein 3α is expressed at inflamed epithelial surfaces and is the most potent chemokine known in attracting Langerhans cell precursors. J. Exp. Med. 192, 705–718 (2000).
-
(2000)
J. Exp. Med.
, vol.192
, pp. 705-718
-
-
Dieu-Nosjean, M.C.1
Massacrier, C.2
Homey, B.3
-
68
-
-
0030456368
-
A role for endogenous transforming growth factor β 1 in Langerhans cell biology: the skin of transforming growth factor β 1 null mice is devoid of epidermal Langerhans cells
-
Borkowski TA, Letterio JJ, Farr AG, Udey MC. A role for endogenous transforming growth factor β 1 in Langerhans cell biology: the skin of transforming growth factor β 1 null mice is devoid of epidermal Langerhans cells. J. Exp. Med. 184, 2417–2422 (1996).
-
(1996)
J. Exp. Med.
, vol.184
, pp. 2417-2422
-
-
Borkowski, T.A.1
Letterio, J.J.2
Farr, A.G.3
Udey, M.C.4
-
69
-
-
0038644624
-
Transgenic delivery of VEGF to mouse skin leads to an inflammatory condition resembling human psoriasis
-
Xia YP, Li B, Hylton D, Detmar M, Yancopoulos GD, Rudge JS. Transgenic delivery of VEGF to mouse skin leads to an inflammatory condition resembling human psoriasis. Blood 102, 161–168 (2003).
-
(2003)
Blood
, vol.102
, pp. 161-168
-
-
Xia, Y.P.1
Li, B.2
Hylton, D.3
Detmar, M.4
Yancopoulos, G.D.5
Rudge, J.S.6
-
70
-
-
3042845742
-
Suprabasal expression of human amphiregulin in the epidermis of transgenic mice induces a severe, early-onset, psoriasis-like skin pathology: expression of amphiregulin in the basal epidermis is also associated with synovitis
-
Cook PW, Brown JR, Cornell KA, Pittelkow MR. Suprabasal expression of human amphiregulin in the epidermis of transgenic mice induces a severe, early-onset, psoriasis-like skin pathology: expression of amphiregulin in the basal epidermis is also associated with synovitis. Exp. Dermatol. 13, 347–356 (2004).
-
(2004)
Exp. Dermatol.
, vol.13
, pp. 347-356
-
-
Cook, P.W.1
Brown, J.R.2
Cornell, K.A.3
Pittelkow, M.R.4
-
71
-
-
13444269249
-
Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model
-
Sano S, Chan KS, Carbajal S et al. Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model. Nat. Med. 11, 43–49 (2005).
-
(2005)
Nat. Med.
, vol.11
, pp. 43-49
-
-
Sano, S.1
Chan, K.S.2
Carbajal, S.3
-
72
-
-
25144497098
-
Psoriasis-like skin disease and arthritis caused by inducible epidermal deletion of Jun proteins
-
Zenz R, Eferl R, Kenner L et al. Psoriasis-like skin disease and arthritis caused by inducible epidermal deletion of Jun proteins. Nature 437, 369–375 (2005).
-
(2005)
Nature
, vol.437
, pp. 369-375
-
-
Zenz, R.1
Eferl, R.2
Kenner, L.3
-
73
-
-
1542313881
-
Spontaneous development of psoriasis in a new animal model shows an essential role for resident T cells and tumor necrosis factor-α
-
Boyman O, Hefti HP, Conrad C, Nickoloff BJ, Suter M, Nestle FO. Spontaneous development of psoriasis in a new animal model shows an essential role for resident T cells and tumor necrosis factor-α. J. Exp. Med. 199, 731–736 (2004).
-
(2004)
J. Exp. Med.
, vol.199
, pp. 731-736
-
-
Boyman, O.1
Hefti, H.P.2
Conrad, C.3
Nickoloff, B.J.4
Suter, M.5
Nestle, F.O.6
-
74
-
-
22344438901
-
Plasmacytoid predendritic cells initiate psoriasis through interferon-α production
-
Nestle FO, Conrad C, Tun-Kyi A et al. Plasmacytoid predendritic cells initiate psoriasis through interferon-α production. J. Exp. Med. 202, 135–143 (2005).
-
(2005)
J. Exp. Med.
, vol.202
, pp. 135-143
-
-
Nestle, F.O.1
Conrad, C.2
Tun-Kyi, A.3
-
75
-
-
8344284998
-
Anti-interleukin-12 antibody for active Crohn’s disease
-
Mannon PJ, Fuss IJ, Mayer L et al. Anti-interleukin-12 antibody for active Crohn’s disease. N. Engl J. Med. 351, 2069–2079 (2004).
-
(2004)
N. Engl J. Med.
, vol.351
, pp. 2069-2079
-
-
Mannon, P.J.1
Fuss, I.J.2
Mayer, L.3
-
76
-
-
9744265704
-
A Phase I study evaluating the safety, pharmacokinetics, and clinical response of a human IL-12 p40 antibody in subjects with plaque psoriasis
-
Kauffman CL, Aria N, Toichi E et al. A Phase I study evaluating the safety, pharmacokinetics, and clinical response of a human IL-12 p40 antibody in subjects with plaque psoriasis. J. Invest. Dermatol. 123, 1037–1044 (2004).
-
(2004)
J. Invest. Dermatol.
, vol.123
, pp. 1037-1044
-
-
Kauffman, C.L.1
Aria, N.2
Toichi, E.3
-
77
-
-
85018932869
-
Results of a Phase II study of a human anti-interleukin (IL)-12/IL-23 monoclonal antibody in the treatment of psoriasis
-
(Abstract).
-
Langley R, Lebwohl M, Leonardi C et al. Results of a Phase II study of a human anti-interleukin (IL)-12/IL-23 monoclonal antibody in the treatment of psoriasis. J. Invest. Dermatol. (2005) (Abstract).
-
(2005)
J. Invest. Dermatol.
-
-
Langley, R.1
Lebwohl, M.2
Leonardi, C.3
-
78
-
-
33646695671
-
Rationale and safety of anti-interleukin-23 and anti-interleukin-17A therapy
-
Bowman EP, Chackerian AA, Cua DJ. Rationale and safety of anti-interleukin-23 and anti-interleukin-17A therapy. Curr. Opin. Infect. Dis. 19, 245–252 (2006).
-
(2006)
Curr. Opin. Infect. Dis.
, vol.19
, pp. 245-252
-
-
Bowman, E.P.1
Chackerian, A.A.2
Cua, D.J.3
-
79
-
-
0344585384
-
Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice
-
Nakae S, Nambu A, Sudo K, Iwakura Y. Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice. J. Immunol. 171, 6173–6177 (2003).
-
(2003)
J. Immunol.
, vol.171
, pp. 6173-6177
-
-
Nakae, S.1
Nambu, A.2
Sudo, K.3
Iwakura, Y.4
-
80
-
-
33745321276
-
IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis
-
Komiyama Y, Nakae S, Matsuki T et al. IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis. J. Immunol. 177, 566–573 (2006).
-
(2006)
J. Immunol.
, vol.177
, pp. 566-573
-
-
Komiyama, Y.1
Nakae, S.2
Matsuki, T.3
|