Convergence of multiple signaling pathways is required to coordinately up-regulate mtDNA and mitochondrial biogenesis during T cell activation

Mitochondrion

Volumn 7, Issue 6, 2007, Pages 374-385

  D'Souza, Anthony D ^a   Parikh, Neal ^a   Kaech, Susan M ^a   Shadel, Gerald S ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

AMP activated protein kinase; Biogenesis; Calcium; Cytokine; Ionomycin; Membrane potential; Mitochondria; mtDNA; mTOR; Oxidative phosphorylation; Protein kinase C; Rapamycin; Signaling; T cell; T cell receptor

Indexed keywords

CALCIUM; CYTOKINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; IONOMYCIN; MAMMALIAN TARGET OF RAPAMYCIN; MITOCHONDRIAL DNA; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; BIOGENESIS; CALCIUM SIGNALING; CELL COMPOSITION; CELL FUNCTION; CELL GROWTH; CELL ORGANELLE; CELL PROLIFERATION; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVATION; ENZYME INHIBITION; GENE AMPLIFICATION; GENOME SIZE; MEMBRANE POTENTIAL; METABOLIC REGULATION; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

ANIMALS; CALCIUM; CELL PROLIFERATION; DNA, MITOCHONDRIAL; IONOMYCIN; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MITOCHONDRIA; MULTIENZYME COMPLEXES; PROTEIN KINASE C; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TETRADECANOYLPHORBOL ACETATE; UP-REGULATION;

MAMMALIA; MURINAE;

EID: 36049013077     PISSN: 15677249     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mito.2007.08.001     Document Type: Article

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