메뉴 건너뛰기




Volumn 72, Issue 23, 2007, Pages 8755-8759

Dual mechanisms of DNA damage by MoCH3(η3-allyl) (CO)2(phen) complexes

Author keywords

[No Author keywords available]

Indexed keywords

BACKBONE CLEAVAGE; BASE-LABILE RESIDUES; DEOXYRIBOSE MOIETY; DUAL MECHANISMS;

EID: 35948986266     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo0712704     Document Type: Article
Times cited : (9)

References (39)
  • 1
  • 6
    • 33646930348 scopus 로고    scopus 로고
    • For examples of chemical approaches to ameliorating cisplatin resistance: Natile, G; Marzilli, L. G. Coord. Chem. Rev. 2006, 250, 1315-1331
    • For examples of chemical approaches to ameliorating cisplatin resistance: Natile, G; Marzilli, L. G. Coord. Chem. Rev. 2006, 250, 1315-1331.
  • 9
    • 0029833916 scopus 로고    scopus 로고
    • Other agents have shown both backbone modification and base oxidation, although not simultaneously with a single activation method. For examples, see
    • Other agents have shown both backbone modification and base oxidation, although not simultaneously with a single activation method. For examples, see: Hall D. B.; Barton, J. K. Nature 1996, 382, 731-735.
    • (1996) Nature , vol.382 , pp. 731-735
    • Hall, D.B.1    Barton, J.K.2
  • 15
    • 35949003651 scopus 로고    scopus 로고
    • The number of single- and double-strand cleavage events was determined via the statistical test of Povirk et al, which assumes a Poisson distribution of strand cuts; see ref 7
    • The number of single- and double-strand cleavage events was determined via the statistical test of Povirk et al., which assumes a Poisson distribution of strand cuts; see ref 7.
  • 16
    • 35948990124 scopus 로고    scopus 로고
    • h + 1)/4L: Freifelder, D.; Trumbo, B. Biopolymers 1969, 7, 681], in which h is the maximum separation in base pairs between cuts on opposite strand that produces linear DNA (h = 16) and L is the number of phosphodiester bonds per strand of DNA (4361 for pBR322).
    • h + 1)/4L: Freifelder, D.; Trumbo, B. Biopolymers 1969, 7, 681], in which h is the maximum separation in base pairs between cuts on opposite strand that produces linear DNA (h = 16) and L is the number of phosphodiester bonds per strand of DNA (4361 for pBR322).
  • 17
    • 35948976629 scopus 로고    scopus 로고
    • Densitometry was accomplished with the NIH ImageJ software program. The amount of supercoiled DNA was multiplied by a factor of 1.22 to account for reduced ethidium bromide intercalation into the form I plasmid DNA.
    • Densitometry was accomplished with the NIH ImageJ software program. The amount of supercoiled DNA was multiplied by a factor of 1.22 to account for reduced ethidium bromide intercalation into the form I plasmid DNA.
  • 37
    • 35948981879 scopus 로고    scopus 로고
    • It has been asserted that methylperoxyl radical is a poor hydrogen atom abstractor, because of the slowness of this reaction. For a detailed discussion of the rates of the processes in Scheme 3, see ref 6
    • It has been asserted that methylperoxyl radical is a poor hydrogen atom abstractor, because of the slowness of this reaction. For a detailed discussion of the rates of the processes in Scheme 3, see ref 6.
  • 38
    • 3042777743 scopus 로고    scopus 로고
    • Interestingly, complexes 1 and 2 are some of the very few Mo complexes that have been found to cause DNA cleavage: Peng, J.; Li, W.; Zhao, X.; Han, Z.; Huang, B. Chem. Res. Chin. Univ. 2004, 20, 6-9.
    • Interestingly, complexes 1 and 2 are some of the very few Mo complexes that have been found to cause DNA cleavage: Peng, J.; Li, W.; Zhao, X.; Han, Z.; Huang, B. Chem. Res. Chin. Univ. 2004, 20, 6-9.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.