Chapter 28 Fragment-Based Lead Discovery

Annual Reports in Medicinal Chemistry

Volumn 42, Issue , 2007, Pages 431-448

  Congreve, Miles ^a   Murray, Christopher W ^a   Carr, Robin ^a   Rees, David C ^a  

^a ASTEX PHARMACEUTICALS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 35948974370     PISSN: 00657743     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0065-7743(07)42028-0     Document Type: Review

References (57)

1. Barker J., Courtney S., Hesterkamp T., Ullmann D., and Whiattaker M. Expert Opin. Drug Discov. 1 (2006) 225
2. Carr R.A.E., Congreve M., Murray C.W., and Rees D.C. Drug Discov. Today 10 (2005) 987
3. Erlanson D.A., McDowell R.S., and O'Brien T. J. Med. Chem. 47 (2004) 3463
4. Erlanson D.A., Wells J.A., and Braisted A.C. Annu. Rev. Biophys. Biomol. Struct. 33 (2004) 199
5. Erlanson D.A. Curr. Opin. Biotechnol. 17 (2006) 643
6. Fattori D. Drug Discov. Today 9 (2004) 229
7. Hajduk P.J. Mol. Interv. 6 (2006) 266
8. Hajduk P.J., and Greer J. Nat. Rev. Drug Discov. 6 (2007) 211
9. Johnson S.L., and Pellecchia M. Curr. Top. Med. Chem. 6 (2006) 317
10. Keseru G.M., and Makara G.M. Drug Discov. Today 11 (2006) 741
11. Leach A.R., Hann M.M., Burrows J.N., and Griffen E.J. Mol. Biosyst. 2 (2006) 430
12. Moore Jr. W.R. Curr. Opin. Drug Discov. Dev. 8 (2005) 355
13. Rees D.C., Congreve M., Murray C.W., and Carr R. Nat. Rev. Drug Discov. 3 (2004) 660
14. Zartler E.R., and Shapiro M.J. Curr. Opin. Chem. Biol. 9 (2005) 366
15. Hanessian S. ChemMedChem 1 (2006) 1301
16. Hopkins A.L., Groom C.R., and Alex A. Drug Discov. Today 9 (2004) 430
17. Bosch J., Robien M.A., Mehlin C., Boni E., Riechers A., Buckner F.S., Van Voorhis W.C., Myler P.J., Worthey E.A., Detitta G., Luft J.R., Lauricella A., Gulde S., Anderson L.A., Kalyuzhniy O., Neely H.M., Ross J., Earnest T.N., Soltis M., Schoenfeld L., Zucker F., Merritt E.A., Fan E., Verlinde C.L., and Hol W.G. J. Med. Chem. 49 (2006) 5939
18. McGrath M.E., Sprengeler P.A., Hirschbein B., Somoza J.R., Lehoux I., Janc J.W., Gjerstad E., Graupe M., Estiarte A., Venkataramani C., Liu Y., Yee R., Ho J.D., Green M.J., Lee C.S., Liu L., Tai V., Spencer J., Sperandio D., and Katz B.A. Biochemistry 45 (2006) 5964
19. Hartshorn M.J., Murray C.W., Cleasby A., Frederickson M., Tickle I.J., and Jhoti H. J. Med. Chem. 48 (2005) 403
20. Filgueira de Azevedo Jr. W., Canduri F., Basso L.A., Palma M.S., and Santos D.S. Cell Biochem. Biophys. 44 (2006) 405
21. Rummey C., Nordhoff S., Thiemann M., and Metz G. Bioorg. Med. Chem. Lett. 16 (2006) 1405
22. Nordhoff S., Cerezo-Galvez S., Feurer A., Hill O., Matassa V.G., Metz G., Rummey C., Thiemann M., and Edwards P.J. Bioorg. Med. Chem. Lett. 16 (2006) 1744
23. Fielding L., Fletcher D., Rutherford S., Kaur J., and Mestres J. Org. Biomol. Chem. 1 (2003) 4235
24. Tsao D.H., Sutherland A.G., Jennings L.D., Li Y., Rush III T.S., Alvarez J.C., Ding W., Dushin E.G., Dushin R.G., Haney S.A., Kenny C.H., Malakian A.K., Nilakantan R., and Mosyak L. Bioorg. Med. Chem. 14 (2006) 7953
25. Oblak M., Grdadolnik S.G., Kotnik M., Jerala R., Filipic M., and Solmajer T. Bioorg. Med. Chem. Lett. 15 (2005) 5207
26. Inglis S.R., Stojkoski C., Branson K.M., Cawthray J.F., Fritz D., Wiadrowski E., Pyke S.M., and Booker G.W. J. Med. Chem. 47 (2004) 5405
27. Becattini B., Culmsee C., Leone M., Zhai D., Zhang X., Crowell K.J., Rega M.F., Landshamer S., Reed J.C., Plesnila N., and Pellecchia M. Proc. Natl. Acad. Sci. USA 103 (2006) 12602
28. Black E., Breed J., Breeze A.L., Embrey K., Garcia R., Gero T.W., Godfrey L., Kenny P.W., Morley A.D., Minshull C.A., Pannifer A.D., Read J., Rees A., Russell D.J., Toader D., and Tucker J. Bioorg. Med. Chem. Lett. 15 (2005) 2503
29. Pellecchia M. Chem. Biol. 12 (2005) 961
30. Raimundo B.C., Oslob J.D., Braisted A.C., Hyde J., McDowell R.S., Randal M., Waal N.D., Wilkinson J., Yu C.H., and Arkin M.R. J. Med. Chem. 47 (2004) 3111
31. Babine R.E., Rynkiewicz M.J., Lei J., and Abdel-Meguid S. Lett. Drug Des. Discov. 1 (2004) 173
32. Neumann T., Junker H.D., Keil O., Burkert K., Ottleben H., Gamer J., Sekul R., Deppe H., Feurer A., Tomandl D., and Metz G. Lett. Drug Des. Discov. 2 (2005) 590
33. Uttamchandani M., Walsh D.P., Yao S.Q., and Chang Y.T. Curr. Opin. Chem. Biol. 9 (2005) 4
34. Oltersdorf T., Elmore S.W., Shoemaker A.R., Armstrong R.C., Augeri D.J., Belli B.A., Bruncko M., Deckwerth T.L., Dinges J., Hajduk P.J., Joseph M.K., Kitada S., Korsmeyer S.J., Kunzer A.R., Letai A., Li C., Mitten M.J., Nettesheim D.G., Ng S., Nimmer P.M., O'Connor J.M., Oleksijew A., Petros A.M., Reed J.C., Shen W., Tahir S.K., Thompson C.B., Tomaselli K.J., Wang B., Wendt M.D., Zhang H., Fesik S.W., and Rosenberg S.H. Nature 435 (2005) 677
35. Wyss D.F., Arasappan A., Senior M.M., Wang Y.S., Beyer B.M., Njoroge F.G., and McCoy M.A. J. Med. Chem. 47 (2004) 2486
36. Congreve M., Aharony D., Albert J., Callaghan O., Campbell J., Carr R.A., Chessari G., Cowan S., Edwards P.D., Frederickson M., McMenamin R., Murray C.W., Patel S., and Wallis N. J. Med. Chem. 50 (2007) 1124
37. Murray C.W., Callaghan O., Chessari G., Cleasby A., Congreve M., Frederickson M., Hartshorn M.J., McMenamin R., Patel S., and Wallis N. J. Med. Chem. 50 (2007) 1116
38. Fahr B.T., O'Brien T., Pham P., Waal N.D., Baskaran S., Raimundo B.C., Lam J.W., Sopko M.M., Purkey H.E., and Romanowski M.J. Bioorg. Med. Chem. Lett. 16 (2006) 559
39. Patterson A.W., Wood W.J., Hornsby M., Lesley S., Spraggon G., and Ellman J.A. J. Med. Chem. 49 (2006) 6298
40. Wood W.J., Patterson A.W., Tsuruoka H., Jain R.K., and Ellman J.A. J. Am. Chem. Soc. 127 (2005) 15521
41. Seth P.P., Miyaji A., Jefferson E.A., Sannes-Lowery K.A., Osgood S.A., Propp S.S., Ranken R., Massire C., Sampath R., Ecker D.J., Swayze E.E., and Griffey R.H. J. Med. Chem. 48 (2005) 7099
42. Forino M., Johnson S., Wong T.Y., Rozanov D.V., Savinov A.Y., Li W., Fattorusso R., Becattini B., Orry A.J., Jung D., Abagyan R.A., Smith J.W., Alibek K., Liddington R.C., Strongin A.Y., and Pellecchia M. Proc. Natl. Acad. Sci. USA 102 (2005) 9499
43. Sanders W.J., Nienaber V.L., Lerner C.G., McCall J.O., Merrick S.M., Swanson S.J., Harlan J.E., Stoll V.S., Stamper G.F., Betz S.F., Condroski K.R., Meadows R.P., Severin J.M., Walter K.A., Magdalinos P., Jakob C.G., Wagner R., and Beutel B.A. J. Med. Chem. 47 (2004) 1709
44. Howard N., Abell C., Blakemore W., Chessari G., Congreve M., Howard S., Jhoti H., Murray C.W., Seavers L.C., and van Montfort R.L. J. Med. Chem. 49 (2006) 1346
45. Card G.L., Blasdel L., England B.P., Zhang C., Suzuki Y., Gillette S., Fong D., Ibrahim P.N., Artis D.R., Bollag G., Milburn M.V., Kim S.H., Schlessinger J., and Zhang K.Y. Nat. Biotechnol. 23 (2005) 201
46. Blaney J.M., Nienaber V., and Burley S.K. Fragment-based lead discovery and optimization using X-ray crystallography, computational chemistry, and high throughput organic synthesis. In: Jahnke W., and Erlanson D.A. (Eds). Fragment-Based Approaches in Drug Discovery (2006), Wiley-VCH, Weinham 215-248
47. Abad-Zapatero C., and Metz J.T. Drug Discov. Today 10 (2005) 464
48. Kuntz I.D., Chen K., Sharp K.A., and Kollman P.A. Proc. Natl. Acad. Sci. USA 96 (1999) 9997
49. Hajduk P.J. J. Med. Chem 49 (2006) 6972
50. Murray C.W., and Verdonk M.L. Entropic consequences of linking ligands. In: Jahnke W., and Erlanson D.A. (Eds). Fragment-Based Approaches in Drug Discovery (2005), Wiley-VCH, Weinham 55-66
51. Ciulli A., Williams G., Smith A.G., Blundell T.L., and Abell C. J. Med. Chem. 49 (2006) 4992
52. Dill K.A. J. Biol. Chem. 272 (1997) 701
53. Hann M.M., and Oprea T.I. Curr. Opin. Chem. Biol. 8 (2004) 255
54. T. Fink and J. L. Reymond, J. Chem. Inf. Model. 2007.
55. Babaoglu K., and Shoichet B.K. Nat. Chem. Biol. 2 (2006) 720
56. Velentza A.V., Wainwright M.S., Zasadzki M., Mirzoeva S., Schumacher A.M., Haiech J., Focia P.J., Egli M., and Watterson D.M. Bioorg. Med. Chem. Lett. 13 (2003) 3465
57. Hajduk P.J. Nat. Chem. Biol. 2 (2006) 658