Exploring the active site of human factor Xa protein by NMR screening of small molecule probes

Organic and Biomolecular Chemistry

Volumn 1, Issue 23, 2003, Pages 4235-4241

  Fielding, Lee ^a   Fletcher, Dan ^a   Rutherford, Samantha ^a   Kaur, Jasmit ^a,b   Mestres, Jordi ^a,c  

^a MERCK RESEARCH LABORATORIES   (United States)

^b OSI Pharmaceuticals   (United Kingdom)

^c UNIVERSITAT POMPEU FABRA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; COMPOSITION EFFECTS; MOLECULAR WEIGHT; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SATURATION (MATERIALS COMPOSITION);

BINDING ISOTHERMS; LIGANDS;

PROTEINS;

BLOOD CLOTTING FACTOR 10A; ENZYME INHIBITOR; LIGAND;

ARTICLE; BINDING COMPETITION; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; DRUG SCREENING; HUMAN; METABOLISM; MOLECULAR PROBE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

BINDING SITES; BINDING, COMPETITIVE; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; FACTOR XA; HUMANS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR PROBES; MOLECULAR STRUCTURE;

EID: 0348041598     PISSN: 14770520     EISSN: None     Source Type: Journal    
DOI: 10.1039/b310265c     Document Type: Article

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