Identification and specificity studies of small-molecule ligands for SH3 protein domains

Journal of Medicinal Chemistry

Volumn 47, Issue 22, 2004, Pages 5405-5417

  Inglis, Steven R ^a   Stojkoski, Cvetan ^a   Branson, Kim M ^a,b   Cawthray, Jacquie F ^a   Fritz, Daniel ^a   Wiadrowski, Emma ^a   Pyke, Simon M ^a   Booker, Grant W ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b CSIRO   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 6 BROMOQUINOLINE; 2 AMINO 6 CHLOROQUINOLINE; 2 AMINO 6 FLUOROQUINOLINE; 2 AMINO 6 METHOXYQUINOLINE; 2 AMINO 6 METHYLQUINOLINE; 2 AMINOQUINOLINE; 6 (1,3 DIOXAN 2 YL)QUINOLIN 2 AMINE; 6 (1,3 DIOXOLAN 2 YL)QUINOLIN 2 AMINE; AMINOQUINOLINE DERIVATIVE; BINDING PROTEIN; HETEROCYCLIC COMPOUND; LIGAND; PEPTIDE DERIVATIVE; PHOSPHOTRANSFERASE; PROLINE; PROTEIN SH3; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; DRUG POTENCY; DRUG SPECIFICITY; DRUG SYNTHESIS; LIGAND BINDING; PROTEIN PROTEIN INTERACTION; PROTON NUCLEAR MAGNETIC RESONANCE; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; SRC HOMOLOGY DOMAIN; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; AMINOQUINOLINES; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; FLUORESCENCE POLARIZATION; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROLINE; PROTEIN-TYROSINE KINASES; QUINAZOLINES; SEQUENCE ALIGNMENT; SRC HOMOLOGY DOMAINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 6044275971     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049533z     Document Type: Article

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