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0001379523
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99
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35848970437
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Surprisingly, the use of the more reactive 4-iodotoluene as a coupling agent did not produce the desired product in a better yield. Only 45% was obtained to produce 1 using CuCl and the Heck reaction conditions described in Table 1, entry 4.
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Surprisingly, the use of the more reactive 4-iodotoluene as a coupling agent did not produce the desired product in a better yield. Only 45% was obtained to produce 1 using CuCl and the Heck reaction conditions described in Table 1, entry 4.
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100
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35848963496
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The 1,1-disubstituted alkene was also isolated 5-10, in some cases and accounted for some of the lower yields
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The 1,1-disubstituted alkene was also isolated (5-10%) in some cases and accounted for some of the lower yields.
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103
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35848964159
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Aldehyde 11 is readily available in five steps from commercially available 3,4-dimethoxybenzaldehyde. See the Supporting Information for details.
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Aldehyde 11 is readily available in five steps from commercially available 3,4-dimethoxybenzaldehyde. See the Supporting Information for details.
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104
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35848947836
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Ketone 13 is readily available in four steps from known 4-(hydroxymethyl)-2-methoxyphenyl acetate. See the Supporting Information for details.
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Ketone 13 is readily available in four steps from known 4-(hydroxymethyl)-2-methoxyphenyl acetate. See the Supporting Information for details.
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105
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0242712444
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IMesCuCl: Chemical Equation Presented
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IMesCuCl: (Chemical Equation Presented)
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