Molecular mechanism of inositol hexaphosphate-mediated apoptosis in human malignant glioblastoma T98G cells

Neurochemical Research

Volumn 32, Issue 12, 2007, Pages 2094-2102

  Karmakar, Surajit ^a   Banik, Naren L ^a   Ray, Swapan K ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Apoptosis; Calpain; Caspase; Glioblastoma; Inositol hexaphosphate

Indexed keywords

CALPAIN; CASPASE; CASPASE 3; CASPASE 9; CYTOCHROME C; DEOXYRIBONUCLEASE; FODRIN; INHIBITOR OF APOPTOSIS PROTEIN 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHYTIC ACID; PLANT MEDICINAL PRODUCT; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BIRC 2; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; TELOMERASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BINDING SITE; CELL STRUCTURE; CELL SURVIVAL; CELL VIABILITY; CEREAL; CONTROLLED STUDY; CORN; CYTOSOL; DIETARY FIBER; DRUG MECHANISM; ENZYME ACTIVITY; GLIOBLASTOMA; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MITOCHONDRION; NUT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; UPREGULATION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BRAIN NEOPLASMS; CALPAIN; CASPASES; CELL LINE, TUMOR; CYTOCHROMES C; CYTOSOL; DNA FRAGMENTATION; ENZYME INDUCTION; GLIOBLASTOMA; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; NERVE TISSUE PROTEINS; PHYTIC ACID; PROTO-ONCOGENE PROTEINS C-BCL-2; TRYPAN BLUE;

EID: 35848947240     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11064-007-9369-y     Document Type: Article

References (52)

1. Kelloff GJ, Crowell JA, Steele VE et al (2000) Progress in cancer chemoprevention: development of diet-derived chemopreventive agents. J Nutr 130:467S-471S
2. Fimognari C, Nusse M, Berti F et al (2004) Isothiocyanates as novel cytotoxic and cytostatic agents: molecular pathway on human transformed and non-transformed cells. Biochem Pharmacol 68:1133-1138
3. Shamsuddin AM, Vucenik I, Cole KE (1997) IP6: a novel anti-cancer agent. Life Sci 61:343-354
4. Shamsuddin AM (1999) Metabolism and cellular functions of IP6: a review. Anticancer Res 19:3733-3736
5. Ferry S, Matsuda M, Yoshida H et al (2002) Inositol hexakisphosphate blocks tumor cell growth by activating apoptotic machinery as well as by inhibiting the Akt/NFκB-mediated cell survival pathway. Carcinogenesis 23:2031-2041
6. Shamsuddin AM, Baten A, Lalwani ND (1992) Effects of inositol hexaphosphate on growth and differentiation in K562 erythroleukemia cell line. Cancer Lett 64:195-202
7. Sakamoto K, Venkatraman G, Shamsuddin AM (1993) Growth inhibition and differentiation of HT-29 cells in vitro by inositol hexaphosphate (phytic acid). Carcinogenesis 14:1815-1819
8. Shamsuddin AM, Yang GY, Vucenik I (1996) Novel anti-cancer functions of IP6: growth inhibition and differentiation of human mammary cancer cell lines in vitro. Anticancer Res 16:3287-3292
9. Zi X, Singh RP, Agarwal R (2000) Impairment of erbB1 receptor and fluid-phase endocytosis and associated mitogenic signaling by inositol hexaphosphate in human prostate carcinoma DU145 cells. Carcinogenesis 21:2225-2235
10. Shamsuddin AM, Yang GY (1995) Inositol hexaphosphate inhibits growth and inducesdifferentiation of PC-3 human prostate cancer cells. Carcinogenesis 16:1975-1979
11. Singh RP, Agarwal C, Agarwal R (2003) Inositol hexaphosphate inhibits growth, and induces G1 arrest and apoptotic death of prostate carcinoma DU145 cells: modulation of CDKI-CDK-cyclin and pRb-related protein-E2F complexes. Carcinogenesis 24:555-563
12. Vucenik I, Tantivejkul K, Zhang ZS et al (1998) IP6 in treatment of liver cancer. I. IP6 inhibits growth and reverses transformed phenotype in HepG2 human liver cancer cell line. Anticancer Res 18:4083-4090
13. Shamsuddin AM, Vucenik I (1999) Mammary tumor inhibition by IP6: a review. Anticancer Res 19:3671-3674
14. Ullah A, Shamsuddin AM (1990) Dose-dependent inhibition of large intestinal cancer by inositol hexaphosphate in F344 rats. Carcinogenesis 11:2219-2222
15. Vucenik I, Tomazic VJ, Fabian D et al (1992) Antitumor activity of phytic acid (inositol hexaphosphate) in murine transplanted and metastatic fibrosarcoma, a pilot study. Cancer Lett 65:9-13
16. Vucenik I, Kalebic T, Tantivejkul K et al (1998) Novel anticancer function of inositol hexaphosphate: inhibition of human rhabdomyosarcoma in vitro and in vivo. Anticancer Res 18:1377-1384
17. Vucenik I, Zhang ZS, Shamsuddin AM (1998) IP6 in treatment of liver cancer. II. Intra-tumoral injection of IP6 regresses pre-existing human liver cancer xenotransplanted in nude mice. Anticancer Res 18:4091-4096
18. Vucenik I, Passaniti A, Vitolo MI et al (2004) Anti-angiogenic activity of inositol hexaphosphate (IP6). Carcinogenesis 25:2115-2123
19. Jenab M, Thompson LU (2000) Phytic acid in wheat bran affects colon morphology, cell differentiation and apoptosis. Carcinogenesis 21:1547-1552
20. Agarwal C, Dhanalakshmi S, Singh RP et al (2004) Inositol hexaphosphate inhibits growth and induces G1 arrest and apoptotic death of androgen-dependent human prostate carcinoma LNCaP cells. Neoplasia 6:646-659
21. Chakrabarti AK, Yoshida Y, Powers JM et al (1988) Calcium-activated neutral proteinase in rat brain myelin and subcellular fractions. J Neurosci Res 20:351-358
22. Karmakar S, Weinberg MS, Banik NL et al (2006) Activation of multiple molecular mechanisms for apoptosis in human malignant glioblastoma T98G and U87MG cells treated with sulforaphane. Neuroscience 141:1265-1280
23. Karmakar S, Banik NL, Patel SJ et al (2006) Curcumin activated both receptor-mediated and mitochondria-mediated proteolytic pathways for apoptosis in human glioblastoma T98G cells. Neurosci Lett 407:53-58
24. Karmakar S, Banik NL, Patel SJ et al (2007) Garlic compounds induced calpain and intrinsic caspase cascade for apoptosis in human malignant neuroblastoma SH-SY5Y cells. Apoptosis 12:671-684
25. Ray SK, Karmakar S, Nowak MW et al (2006) Inhibition of calpain and caspase-3 prevented apoptosis and preserved electrophysiological properties of voltage-gated and ligand-gated ion channels in rat primary cortical neurons exposed to glutamate. Neuroscience 139:577-595
26. Karmakar S, Banik NL, Patel SJ et al (2007) 5-Aminolevulinic acid-based photodynamic therapy suppressed survival factors and activated proteases for apoptosis in human glioblastoma U87MG cells. Neurosci Lett 415:242-247
27. Kim NW, Piatyszek MA, Prowse KR et al (1994) Specific association of human telomerase activity with immortal cells and cancer. Science 266:2011-2015
28. Somasundar P, Riggs DR, Jackson BJ et al (2005) Inositol hexaphosphate (IP6): a novel treatment for pancreatic cancer. J Surg Res 126:199-203
29. Rizvi I, Riggs DR, Jackson BJ et al (2006) Inositol hexaphosphate (IP6) inhibits cellular proliferation in melanoma. J Surg Res 133:3-6
30. Farid P, Gomb SZ, Peter I et al (2001) bcl-2, p53 and bax in thyroid tumors and their relation to apoptosis. Neoplasma 48:299-301
31. Jayanthi S, Deng X, Bordelon M et al (2001) Methamphetamine causes differential regulation of pro-death and anti-death Bcl-2 genes in the mouse neocortex. FASEB J 15:1745-1752
32. Narita M, Shimizu S, Ito T et al (1998) Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria. Proc Natl Acad Sci USA 95:14681-14686
33. 2+ stores. J Biol Chem 277:9219-9225
34. Li P, Nijhawan D, Budihardjo I et al (1997) Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91:479-489
35. Kim R, Emi M, Tanabe K (2005) Caspase-dependent and -independent cell death pathways after DNA damage. Oncol Rep 14:595-599
36. Imoto I, Yang ZQ, Pimkhaokham A et al (2001) Identification of cIAP1 as a candidate target gene within an amplicon at 11q22 in esophageal squamous cell carcinomas. Cancer Res 61:6629-6634
37. Dai Z, Zhu WG, Morrison CD et al (2003) A comprehensive search for DNA amplification in lung cancer identifies inhibitors of apoptosis cIAP1 and cIAP2 as candidate oncogenes. Hum Mol Genet 12:791-801
38. Du C, Fang M, Li Y et al (2000) Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell 102:33-42
39. Verhagen AM, Ekert PG, Pakusch M et al (2000) Identification of Diablo, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell 102:43-53
40. Wilkinson JC, Wilkinson AS, Scott FL et al (2004) Neutralization of Smac/Diablo by inhibitors of apoptosis (IAPs). A caspase-independent mechanism for apoptotic inhibition. J Biol Chem 279:51082-51090
41. Adrain C, Creagh EM, Martin SJ (2001) Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2. EMBO J 20:6627-6636
42. Hasenjager A, Gillissen B, Muller A et al (2004) Smac induces cytochrome c release and apoptosis independently from Bax/Bcl-xL in a strictly caspase-3-dependent manner in human carcinoma cells. Oncogene 23:4523-4535
43. DePinho RA (2000) The age of cancer. Nature 408:248-254
44. Massard C, Zermati Y, Pauleau AL et al (2006) hTERT: a novel endogenous inhibitor of the mitochondrial cell death pathway. Oncogene 25:4505-4514
45. Jagadeesh S, Banerjee PP (2006) Inositol hexaphosphate represses telomerase activity and translocates TERT from the nucleus in mouse and human prostate cancer cells via the deactivation of Akt and PKCα. Biochem Biophys Res Commun 349:1361-1367
46. 3H] aspartate release in cultured cerebellar neurons. J Neurochem 53:1026-1030
47. 2+ influx in purified mitochondria from rat liver. Ital J Biochem 40:289-294
48. Kuida K, Zheng TS, Na S et al (1996) Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature 384:368-372
49. Yakovlev AG, Ota K, Wang G et al (2001) Differential expression of apoptotic protease-activating factor-1 and caspase-3 genes and susceptibility to apoptosis during brain development and after traumatic brain injury. J Neurosci 21:7439-7446
50. Nath R, Raser KJ, Stafford D et al (1996) Non-erythroid α-spectrin breakdown by calpain and interleukin 1β-converting-enzyme-like protease(s) in apoptotic cells: contributory roles of both protease families in neuronal apoptosis. Biochem J 319:683-690
51. Wang KK, Posmantur R, Nath R et al (1998) Simultaneous degradation of αII- and βII-spectrin by caspase 3 (CPP32) in apoptotic cells. J Biol Chem 273:22490-22497
52. Neumar RW, Xu YA, Gada H et al (2003) Cross-talk between calpain and caspase proteolytic systems during neuronal apoptosis. J Biol Chem 278:14162-14167