Osmoregulation of Bile Formation

Methods in Enzymology

Volumn 428, Issue , 2007, Pages 313-324

  Kubitz, Ralf ^a   Häussinger, Dieter ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID; BILE ACID CONJUGATE; CARRIER PROTEIN; GLUCURONIDE; GLUTATHIONE; INTEGRIN;

BILE FLOW; BILE SECRETION; BILIARY EXCRETION; HUMAN; INTRAHEPATIC BILE DUCT; MOLECULAR DYNAMICS; NONHUMAN; OSMOREGULATION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; PROTEIN PROCESSING; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TRANSLATION REGULATION; TRANSPORT KINETICS; ANIMAL; BILE; ELECTROLYTE BALANCE; LIVER; METABOLISM; OSMOSIS; PHYSIOLOGY; SECRETION;

ANIMALS; BILE; BILE ACIDS AND SALTS; BILE CANALICULI; HUMANS; INTEGRINS; LIVER; OSMOSIS; SIGNAL TRANSDUCTION; WATER-ELECTROLYTE BALANCE;

EID: 35748953443     PISSN: 00766879     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0076-6879(07)28018-8     Document Type: Chapter

References (45)

1. Aplin A.E., Howe A., Alahari S.K., and Juliano R.L. Signal transduction and signal modulation by cell adhesion receptors: The role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins. Pharmacol. Rev. 50 (1998) 197-263
2. Becker S., Reinehr R., Graf D., vom Dahl S., and Häussinger D. Hydrophobic bile salts induce hepatocyte shrinkage via NADPH oxidase activation. Cell. Physiol. Biochem. 19 (2007) 89-98
3. Beuers U., Bilzer M., Chittattu A., Kullak-Ublick G.A., Keppler D., Paumgartner G., and Dombrowski F. Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liver. Hepatology 33 (2001) 1206-1216
4. Carloni V., Mazzocca A., Pantaleo P., Cordella C., Laffi G., and Gentilini P. The integrin, alpha6beta1, is necessary for the matrix-dependent activation of FAK and MAP kinase and the migration of human hepatocarcinoma cells. Hepatology 34 (2001) 42-49
5. Dombrowski F., Kubitz R., Chittattu A., Wettstein M., Saha N., and Häussinger D. Electron-microscopic demonstration of multidrug resistance protein 2 (Mrp2) retrieval from the canalicular membrane in response to hyperosmolarity and lipopolysaccharide. Biochem. J. 348 Pt. 1 (2000) 183-188
6. Green R.M., Beier D., and Gollan J.L. Regulation of hepatocyte bile salt transporters by endotoxin and inflammatory cytokines in rodents. Gastroenterology 111 (1996) 193-198
7. Groen A.K., van der Meer R., and Westerhoff H.V. In: Sies H. (Ed). "Control of Metabolic Fluxes" (1982), Academic Press, London
8. Hagenbuch B., and Meier P.J. Molecular cloning, chromosomal localization, and functional characterization of a human liver Na+/bile acid cotransporter. J. Clin. Invest. 93 (1994) 1326-1331
9. Hagenbuch B., and Meier P.J. The superfamily of organic anion transporting polypeptides. Biochim. Biophys. Acta 1609 (2003) 1-18
10. Hallbrucker C., Lang F., Gerok W., and Häussinger D. Cell swelling increases bile flow and taurocholate excretion into bile in isolated perfused rat liver. Biochem. J. 281 Pt. 3 (1992) 593-595
11. Häussinger D. The role of cellular hydration in the regulation of cell function. Biochem. J. 313 Pt. 3 (1996) 697-710
12. Häussinger D., Hallbrucker C., Saha N., Lang F., and Gerok W. Cell volume and bile acid excretion. Biochem. J. 288 Pt. 2 (1992) 681-689
13. Häussinger D., Kurz A.K., Wettstein M., Graf D., vom D.S., and Schliess F. Involvement of integrins and Src in tauroursodeoxycholate-induced and swelling-induced choleresis. Gastroenterology 124 (2003) 1476-1487
14. Häussinger D., Saha N., Hallbrucker C., Lang F., and Gerok W. Involvement of microtubules in the swelling-induced stimulation of transcellular taurocholate transport in perfused rat liver. Biochem. J. 291 Pt. 2 (1993) 355-360
15. Häussinger D., Schmitt M., Weiergräber O., and Kubitz R. Short-term regulation of canalicular transport. Semin. Liver Dis. 20 (2000) 307-321
16. Hsu S.L., Cheng C.C., Shi Y.R., and Chiang C.W. Proteolysis of integrin alpha5 and beta1 subunits involved in retinoic acid-induced apoptosis in human hepatoma Hep3B cells. Cancer Lett. 167 (2001) 193-204
17. Hynes R.O. Integrins: Bidirectional, allosteric signaling machines. Cell 110 (2002) 673-687
18. Ingber D.E. Integrins, tensegrity, and mechanotransduction. Gravit. Space Biol. Bull. 10 (1997) 49-55
19. Kipp H., and Arias I.M. Newly synthesized canalicular ABC transporters are directly targeted from the Golgi to the hepatocyte apical domain in rat liver. J. Biol. Chem. 275 (2000) 15917-15925
20. Kubitz R., D' Urso D., Keppler D., and Häussinger D. Osmodependent dynamic localization of the multidrug resistance protein 2 in the rat hepatocyte canalicular membrane. Gastroenterology 113 (1997) 1438-1442
21. Kubitz R., Helmer A., and Häussinger D. Biliary transport systems: Short-term regulation. Methods Enzymol. 400 (2005) 542-557
22. 2+-dependent protein kinase C isoforms induce cholestasis in rat liver. J. Biol. Chem. 279 (2004) 10323-10330
23. Kubitz R., Warskulat U., Schmitt M., and Häussinger D. Dexamethasone- and osmolarity-dependent expression of the multidrug-resistance protein 2 in cultured rat hepatocytes. Biochem. J. 340 Pt. 3 (1999) 585-591
24. Kubitz R., Wettstein M., Warskulat U., and Häussinger D. Regulation of the multidrug resistance protein 2 in the rat liver by lipopolysaccharide and dexamethasone. Gastroenterology 116 (1999) 401-410
25. Kurz A.K., Graf D., Schmitt M., vom Dahl S., and Häussinger D. Tauroursodesoxycholate-induced choleresis involves p38(MAPK) activation and translocation of the bile salt export pump in rats. Gastroenterology 121 (2001) 407-419
26. Lang F., Busch G.L., Ritter M., Volkl H., Waldegger S., Gulbins E., and Häussinger D. Functional significance of cell volume regulatory mechanisms. Physiol. Rev. 78 (1998) 247-306
27. Miranti C.K., and Brugge J.S. Sensing the environment: A historical perspective on integrin signal transduction. Nat. Cell Biol. 4 (2002) E83-E90
28. Mühlfeld A., Kubitz R., Dransfeld O., Häussinger D., and Wettstein M. Taurine supplementation induces Mrp2 and Bsep expression in rats and prevents endotoxin-induced cholestasis. Arch. Biochem. Biophys. 413 (2003) 32-40
29. Mukhopadhyay S., Ananthanarayanan M., Stieger B., Meier P.J., Suchy F.J., and Anwer M.S. Sodium taurocholate cotransporting polypeptide is a serine, threonine phosphoprotein and is dephosphorylated by cyclic adenosine monophosphate. Hepatology 28 (1998) 1629-1636
30. Noe B., Schliess F., Wettstein M., Heinrich S., and Häussinger D. Regulation of taurocholate excretion by a hypo-osmolarity-activated signal transduction pathway in rat liver. Gastroenterology 110 (1996) 858-865
31. Reinehr R., Becker S., Braun J., Eberle A., Grether-Beck S., and Häussinger D. Endosomal acidification and activation of NADPH oxidase isoforms are upstream events in hyperosmolarity-induced hepatocyte apoptosis. J. Biol. Chem. 281 (2006) 23150-23166
32. Reinehr R., Becker S., Keitel V., Eberle A., Grether-Beck S., and Häussinger D. Bile salt-induced apoptosis involves NADPH oxidase isoform activation. Gastroenterology 129 (2005) 2009-2031
33. Rius M., Hummel-Eisenbeiss J., Hofmann A.F., and Keppler D. Substrate specificity of human ABCC4 (MRP4)-mediated cotransport of bile acids and reduced glutathione. Am. J. Physiol. Gastrointest. Liver Physiol. 290 (2006) G640-G649
34. Rius M., Nies A.T., Hummel-Eisenbeiss J., Jedlitschky G., and Keppler D. Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane. Hepatology 38 (2003) 374-384
35. Ruoslahti E. RGD and other recognition sequences for integrins. Annu. Rev. Cell Dev. Biol. 12 (1996) 697-715
36. Schliess F., Reissmann R., Reinehr R., vom Dahl S., and Häussinger D. Involvement of integrins and Src in insulin signaling toward autophagic proteolysis in rat liver. J. Biol. Chem. 279 (2004) 21294-21301
37. Schmitt M., Kubitz R., Lizun S., Wettstein M., and Häussinger D. Regulation of the dynamic localization of the rat Bsep gene-encoded bile salt export pump by anisoosmolarity. Hepatology 33 (2001) 509-518
38. Schmitt M., Kubitz R., Wettstein M., vom Dahl S., and Häussinger D. Retrieval of the mrp2 gene encoded conjugate export pump from the canalicular membrane contributes to cholestasis induced by tert-butyl hydroperoxide and chloro-dinitrobenzene. Biol. Chem. 381 (2000) 487-495
39. Simon F.R., Fortune J., Iwahashi M., Gartung C., Wolkoff A., and Sutherland E. Ethinyl estradiol cholestasis involves alterations in expression of liver sinusoidal transporters. Am. J. Physiol. 271 (1996) G1043-G1052
40. +/taurocholate cotransporting polypeptide in rat liver. Gastroenterology 107 (1994) 1781-1787
41. Torimura T., Ueno T., Kin M., Harad R., Nakamura T., Sakamoto M., Kumashiro R., Yano H., Kojiro M., and Sata M. Laminin deposition to type IV collagen enhances haptotaxis, chemokinesis, and adhesion of hepatoma cells through beta1-integrins. J. Hepatol. 35 (2001) 245-253
42. vom Dahl S., Schliess F., Reissmann R., Gorg B., Weiergraber O., Kocalkova M., Dombrowski F., and Häussinger D. Involvement of integrins in osmosensing and signaling toward autophagic proteolysis in rat liver. J. Biol. Chem. 278 (2003) 27088-27095
43. Warskulat U., Kubitz R., Wettstein M., Stieger B., Meier P.J., and Häussinger D. Regulation of bile salt export pump mRNA levels by dexamethasone and osmolarity in cultured rat hepatocytes. Biol. Chem. 380 (1999) 1273-1279
44. Webster C.R., Blanch C.J., Phillips J., and Anwer M.S. Cell swelling-induced translocation of rat liver Na(+)/taurocholate cotransport polypeptide is mediated via the phosphoinositide 3-kinase signaling pathway. J. Biol. Chem. 275 (2000) 29754-29760
45. Wettstein M., Noe B., and Häussinger D. Metabolism of cysteinyl leukotrienes in the perfused rat liver: The influence of endotoxin pretreatment and the cellular hydration state. Hepatology 22 (1995) 235-240