Chromosome kissing

Current Opinion in Genetics and Development

Volumn 17, Issue 5, 2007, Pages 443-450

  Cavalli, Giacomo ^a  

^a INSTITUTE OF HUMAN GENETICS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMATIN STRUCTURE; CHROMOSOME ANALYSIS; CHROMOSOME KISSING; CHROMOSOME REARRANGEMENT; CHROMOSOME TRANSLOCATION; CHROMOSOMES AND CHROMOSOMAL PHENOMENA; DNA DAMAGE; DNA STRAND BREAKAGE; EUKARYOTE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE EXPRESSION; GENE REARRANGEMENT; GENE SILENCING; IMMUNOHISTOCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; REVIEW;

CHROMATIN; CHROMOSOME POSITIONING; CHROMOSOMES, HUMAN; GENE SILENCING; GENOMICS; HUMANS; TRANSCRIPTION, GENETIC; TRANSLOCATION, GENETIC;

EID: 35649003087     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gde.2007.08.013     Document Type: Review

References (52)

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18. •], this study shows that the two X-chromosomes undergo transient co-localization at the onset of the X-inactivation process. They point out to a role for kissing in the processes of X-chromosome counting and in the choice of the copy to be inactivated.
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28. ••] only affected the OR genes in cis, and had no effects on distant OR genes, arising a matter of debate on this subject.
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38. •], this paper established one variation of the 3C method to catch contact partners at a large scale. This variant of the method exploits highly multiplexed PCR to detect simultaneously different possible contacts. The paper presents an application of the method to detect contacts within the β-globin genomic region.
39. •] this paper reports on the establishment of a modified 3C procedure (called 4C for 3C-on-chip) to study the interacting partners of the mouse β-globin locus. The main difference with the other papers is that the analysis is done by hybridization of the DNA with custom-made DNA microarrays, allowing a more extensive analysis to be performed. The data clearly show the cis prevalence of the kissing interactions and their plasticity in different cell types. The contacts do not only involve active genes with β-globin, but also inactive OR clusters, suggesting that the regulation of OR genes may involve clustering not only for activation but also for silencing. Concerning β-globin, the interacting partners do not overtly seem to be co-regulated, suggesting that, at least in some cases, chromosome kissing may reflect spatial proximity and random sharing of transcription factories rather than specific co-regulation.
40. ••]. Here the authors coupled open-ended 3C to cloning and sequencing to analyze the mouse HoxB1 locus.
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47. Goetze S., Mateos-Langerak J., Gierman H.J., de Leeuw W., Giromus O., Indemans M.H., Koster J., Ondrej V., Versteeg R., and van Driel R. The three-dimensional structure of human interphase chromosomes is related to the transcriptome map. Mol Cell Biol 27 (2007) 4475-4487. The authors analyze specific chromosome domains called ridges and anti-ridges that are rich or poor in transcribed genes, respectively. They find that ridges invariably localize toward the center of the nucleus, while anti-ridges tend to be closer to the periphery. When consecutive domains are painted in FISH experiments, they always separate and show little intermingling. This suggests that chromatin may have a natural tendency to fold reducing intermingling. Thus, intermingling is allowed in the nucleus but is likely to be restricted to specific loci.
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