Decreased levels of hypoxic cells in gefitinib treated ER+ HER-2 overexpressing MCF-7 breast cancer tumors are associated with hyperactivation of the mTOR pathway: Therapeutic implications for combination therapy with rapamycin

Breast Cancer Research and Treatment

Volumn 106, Issue 3, 2007, Pages 319-331

  Dragowska, Wieslawa H ^a   Verreault, Maïté ^a   Yapp, Donald T T ^a,c   Warburton, Corinna ^a   Edwards, Lincoln ^a   Ramsay, Euan C ^a   Huxham, Lynsey A ^b   Minchinton, Andrew I ^b,c   Gelmon, Karen ^a   Bally, Marcel B ^a,c  

^a BRITISH COLUMBIA CANCER AGENCY   (Canada)

^b BRITISH COLUMBIA CANCER RESEARCH CENTRE   (Canada)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Breast cancer; Gefitinib; HER 2; MTOR; Tumor microenvironment

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; GEFITINIB; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; RAPAMYCIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; CELL STRAIN MCF 7; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG EFFICACY; DRUG POTENTIATION; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HYPOXIC CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; MICROENVIRONMENT; MOLECULAR THERAPY; MOUSE; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STATISTICAL SIGNIFICANCE;

ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BREAST NEOPLASMS; CELL HYPOXIA; CELL LINE, TUMOR; FEMALE; HUMANS; MICE; PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-AKT; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; RECEPTORS, ESTROGEN; SIROLIMUS;

EID: 35648976029     PISSN: 01676806     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10549-007-9502-2     Document Type: Article

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