Obesity and the metabolic syndrome in Mediterranean countries: A hypothesis related to olive oil

Molecular Nutrition and Food Research

Volumn 51, Issue 10, 2007, Pages 1260-1267

  Soriguer, Federico ^a   Rojo Martínez, Gemma ^a   De Fonseca, Fernando Rodriguez ^b   García Escobar, Eva ^a   Fuentes, Eduardo García ^a   Olveira, Gabriel ^a  

^a HOSPITAL REGIONAL UNIVERSITARIO DE MÁLAGA   (Spain)

^b Hospital University Carlos Haya de Málaga   (Spain)

Author keywords

Adipose tissue; Mediterranean diet; Metabolic syndrome; Obesity; Olive oil

Indexed keywords

ACYL COENZYME A DESATURASE; LIPID; OLIVE OIL; OMEGA 6 FATTY ACID; SCD1 PROTEIN, HUMAN; UNCLASSIFIED DRUG; VEGETABLE OIL;

ADIPOSE TISSUE; BLOOD; CHEMISTRY; ENVIRONMENT; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; MEDITERRANEAN DIET; METABOLIC SYNDROME X; OBESITY; PHYSIOLOGY; REVIEW; SOUTHERN EUROPE;

ADIPOSE TISSUE; DIET, MEDITERRANEAN; ENVIRONMENT; FATTY ACIDS, OMEGA-6; HUMANS; LIPIDS; MEDITERRANEAN REGION; METABOLIC SYNDROME X; OBESITY; PLANT OILS; STEAROYL-COA DESATURASE;

EID: 35548985332     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.200700021     Document Type: Review

References (73)

1. Kopelman, P. G., Obesity as a medical problem. Nature 2000, 404, 635-643.
2. Friedman, J. M., Modem science versus the stigma of obesity. Nat. Med. 2004, 10, 563-569.
3. Unger, R. H., Lipotoxic diseases. Annu. Rev. Med. 2002, 53, 319-336.
4. Neel, J. V., The "thrifty genotype" in 1998. Nutr. Rev. 1999, 57, S2-S9.
5. Bray, G. A., Popkin, B. M., Dietary fat intake does affect obesity. Am. J. Clin. Nutr. 1998, 68, 1157-1173.
6. Willet, W., Is dietary fat a mayor determinant of body fat? Am. J. Clin. Nutr. 1998, 67, 556S-562S.
7. Lissner, L., Keitmann, B. L., Dietary fat and obesity: evidence for epidemiology. Eur. J. Clin. Nutr. 1995, 49, 79-90.
8. Colditz, G. A., Willett, W. C., Stampfer, M. J., London, S. J. et al., Patterns of weight change and their relation to diet in a cohort of healthy women. Am. J. Clin. Nutr. 1990, 51, 1100-1105.
9. Fu, J., Gaetani, F. J., Oveisi, F., Lo Verme, J. et al., Oleyletanolamide regulates feeding and body weight througth activation of the nuclear receptor PPAR-alpha. Nature 2003, 425, 90-93.
10. Ailhaud, G., Guesnet, P., Fatty acid composition of fats is an early determinant of childhood obesity: a short review and an opinion. Obes. Rev. 2004, 5, 21-26.
11. Yam, D., Eliraz, A., Berry, E. M., Diet and disease - the Israeli paradox: possible dangers of a high omega-6 polyunsaturated fatty acid diet. Isr. J. Med. Sci. 1996, 32, 1134-1143.
12. Serra-Majem, L., Ngo de la Cruz, J., Ribas, L., Tur, J. A., Olive oil and the Mediterranean diet: beyond the rhetoric. Eur. J. Clin. Nutr. 2003, 57, S2-S7.
13. Fernandez de la Puebla, R. A., Fuentes, F., Perez-Martinez, P., Sanchez, E. et al., A reduction in dietary saturated fat decreases body fat content in overweight, hypercholesterolemic males. Nutr. Metab. Cardiovasc. Dis. 2003, 13, 273-277.
14. Soriguer, F., Moreno, F., Rojo-Martinez, G., Garcia-Fuentes, E. et al., Monounsaturated n-9 fatty acids and adipocyte lipolysis in rats. Br. J. Nutr. 2003, 90, 1015-1022.
15. Soriguer, F., Esteva, I., Rojo-Martínez, G., Ruiz de Adana, M. S. et al., Monounsaturated fatty acids from cooking oils are associated with lower insulin resistance in the general population (Pizarra study). Eur. J Endocrinol 2004, 150, 33-39.
16. Soriguer, F., Moreno, F., Rojo-Martinez, G., Cardona, F. et al., Redistribution of abdominal fat after a period of food restriction in rats is related to the type of dietary fat. Br. J. Nutr. 2003, 89, 115-122.
17. Poissonnet, C. M., Burdi, A. R., Bookstein, F. L., Growth and development of human adipose tissue during early gestation. Early Hum. Dev. 1983, 8, 1-11.
18. Soriguer Escofet, F., Esteva de Antonio, I., Tinahones, F. J., Pareja, A., Adipose tissue fatty acids and size and number of fat cells from birth to 9 years of AgemA cross-sectional study in 96 boys. Metabolism 1996, 45, 1395-1401.
19. Hager, A., Sjöström, L., Arvidsson, B., Björntorp, P., Smith, U., Body fat and adipose tissue cellularity in infants: a longitudinal study. Metabolism 1977, 26, 607-614.
20. Boulton, T. J. C., Dunlop, M., Court, J. M., The growth and development of fat cells in infancy. Pediatr. Res. 1978, 12, 908-911.
21. Hauner, H., Wabitsch, M., Pfeiffer, E. E., Proliferation and differentiation of adipose tissue derived stromal-vascular cells from children at different ages, in: Björntorp, P., Rössner, S. (Eds), Obesity in Europe 88: Proceedings of the First European Congress on Obesity. Libbey, London 1989, pp. 195-200.
22. Hirsch, J., Knittle, J. L., Celularity of obese and nonobese human adipose tissue. Fed. Proc. 1970, 29, 1516-1521.
23. Djian, O., Roncari, D. A. K., Hollenberg, C. H., Influence of anatomic site and age on the replication and differentiation in rat adipocyte precursors in culture. J. Clin. Invest. 1983, 72, 1200-1208.
24. Kirkland, J. L., Hollenberg, C. H., Gillon, W. S., Age, anatomic site, and the replication and differentiation of adipocyte precursors. Am. J. Physiol. 1990, 255, C206-C210.
25. Amri, E., Ailhaud, G., Grimaldi, P. A., Fatty acids as signal transducing molecules: involvement in the differentiation of preadipose to adipose cells. J. Lipid Res. 1994, 35, 930-937.
26. Garland, M., Sacks, F. M., Colditz, G. A., Rimm, E. B. et al., The relation between dietary intake and adipose tissue composition of selected fatty acids in US women. Am. J. Clin. Nutr. 1998, 67, 25-30.
27. McClearn, G. E., Nature and nurture: interaction and coaction. Am. J. Med. Genet. B. Neuropsychiatr. Genet. 2004, 124, 124-130.
28. Carmelli, D., Swan, G. E., Robinette, D., Fabsitz, R., Genetic influence on smoking. Study of male twins. N. Engl. J. Med. 1992, 327, 829-833.
29. Singer, P., Una izquierda darviniana. Politica, evolución, cooperación, Critica, Barcelona 2000.
30. Neel, J. V., Diabetes mellitus: A thrifty genotype redered detrimental by progress. Am. J. Hum. Gene. 1962, 14, 353-362.
31. Tabarin, A., Diz-Chaves, Y., Carmona, M. C., Catargi, B. et al., Resistance to diet-induced obesity in mu-opioid receptordeficient mice: evidence for a "thrifty gene". Diabetes 2005, 54, 3510-3516.
32. Stunkard, A. J., Current views on obesity. Am. J. Med. 1996, 100, 230-236.
33. Seidell, J. C., Obesity in Europe: scaling and epidemic. Int. J. Obes. Relat. Metab. Disord. 1995, 19, S1-S4.
34. Quiles, J., Vioque, J., Prevalencia de obesidad en la Comunidad Valenciana. Med. Clin. (Barc.) 1996, 106, 529-533.
35. Soriguer, F., Rojo-Martinez, G., Esteva de Antonio, I., Ruiz de Adana, M. S. et al., Prevalence of obesity in south-east Spain and its relation with social and health factors. Eur. J. Epidemiol. 2004, 19, 33-40.
36. Keys, A. B., Seven countries: a multivariate analysis of death and coronary heart disease. Mass Harvard University Press, Cambridge 1980.
37. Martinez-Gonzalez, M. A., Varo, J. J., Santos, J. L., de Irala, J. et al., Prevalence of physical activity during leisure time in the European Union. Med. Sci. Sports Exerc. 2001, 33, 1142-1146.
38. Moreno, L. A., Sarri, A., Popkin, B. M., The nutrition transition in Spain: a European Mediterranean country. Eur. J. Clin. Nutr. 2002, 56, 992-1003.
39. Serra-Majen, L., Ribas, L., Loveras, G., Salleras, L., Changing patterns of fat comsumption in Spain. Eur. J. Clin. Nutr. 1993, 47, S13-S20.
40. Trichopoulou, A., Costacou, T., Bamia, C., Trichopoulos, D., Adherence to a Mediterranean diet and survival in a Greek population. N Engl. J. Med. 2003, 348, 2599-2608.
41. de Lorgeril, M., Renaud, S., Mamelle, N., Salen, P. et al., Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease. Lancet 1994, 343, 1454-1459.
42. Singh, R. B., Dubnov, G., Niaz, M. A., Ghosh, S. et al. Effect of an Indo-Mediterranean diet on progression of coronary artery disease in high risk patients (Indo-Mediterranean Diet Heart Study): a randomised single-blind trial. Lancet 2002, 360, 1455-1461.
43. Perez-Jimenez, F., Alvarez de Cienfuegos, G., Badimon, L., Barja, G. et al., International conference on the healthy effect of virgin olive oil. Eur. J. Clin. Invest. 2005, 35, 421-424.
44. Willett, W. C., Sacks, F., Trichopoulou, A., Drescher, G. et al., Mediterranean diet pyramid: a cultural model for healthy eating. Am. J. Clin. Nutr. 1995, 61, S1402-S1406.
45. Soriguer, F., Moreno, F., Rojo-Martinez, G., Garcia-Fuentes, E. et al., Monounsaturated n-9 fatty acids and adipocyte lipolysis in rats. Br. J. Nutr. 2003, 90, 1015-1022.
46. Soriguer, F., Rojo-Martinez, G., Dobarganes, M. C., Garcia Almeida, J. M. et al., Hypertension is related to the degradation of dietary frying oils. Am. J. Clin. Nutr. 2003, 78, 1092-1097.
47. Miyazaki, M., Kim, H. J., Man, W. C. Ntambi, J. M., Oleoyl-CoA is the major de novo product of stearoyl-CoA desaturase 1 gene isoform and substrate for the biosynthesis of the Harderian gland 1-alkyl-2,3- diacylglycerol. J. Biol. Chem. 2001, 276, 39455-39461.
48. Ntambi, J. M., The regulation of stearoyl-CoA desaturase (SCD). Prog. Lipid. Res. 1995, 34, 139-150.
49. Dobrzyn, A., Ntambi J. M., Stearoyl-CoA desaturase as a new drug target for obesity treatment. Obes. Rev. 2005, 6, 169-174.
50. Soriguer, F., Tinahones, F., Monzón, A., Pareja, A. et al., Varying incorporation of fatty acids in muscle, adipose, pancreatic exocrine tissue and thymocites in adult rats fed with diet rich in differents fatty acids. Eur. J. Epidemiol. 2000, 16, 585-594.
51. Roche, E., Buteau, J., Aniento, I., Reig, J. A. et al., Palmitate and oleate induce the immediate-early response genes c-fos and nur-77 in the pancreatic beta-cell line INS-1. Diabetes 1999, 48, 2007-2014.
52. Cohen, P., Miyazaki, M., Socci, N. D., Hagge-Greenberg, A. et al., Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss. Science 2002, 297, 240-243.
53. [53 Ntambi, J. M., Miyazaki, M., Stoehr, J. P., Lan, H. et al., Loss of stearoyl-CoA desaturase-1 function protects mice against adipos-ity. Proc. Natl. Acad. Sci. USA 2002, 99, 11482-11486.
54. Dobrzyn, P., Dobrzyn, A., Miyazaki, M., Cohen, P. et al., Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver. Proc. Natl. Acad. Sci. USA 2004, 101, 6409-6414.
55. Lee, S. H., Dobrzyn, A., Dobrzyn, P., Rahman, S. M. et al., Lack of stearoyl-CoA desaturase 1 upregulates basal thermogenesis, but causes hypothermia in cold environment. J Lipid. Res. 2004, 45, 1674-1682.
56. Araya, J., Rodrigo, R., Videla, L. A., Thielemann, L. et al., Increase in long-chain polyunsaturated nuclear receptor peroxisome proliferator-activated receptor alpha fatty acid n-6/n-3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease. Clin. Sci. (Lond). 2004, 106, 635-643.
57. Hulver, M. W., Berggren, J. R., Carper, M. J., Miyazaki, M. et al., Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans. Cell Metab. 2005, 2, 251-261.
58. Miyazaki, M., Kim, Y. C., Gray-Keller, M. P., Attie, A. D., Ntambi, J. M., The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1. J. Biol Chem. 2000, 275, 30132-30138.
59. Miyazaki, M., Kim, Y. C., Ntambi, J. M., A lipogenic diet in mice with a disruption of the stearoyl-CoA desaturase 1 gene reveals a stringent requirement of endogenous monounsaturated fatty acids for triglyceride synthesis. J. Lipid Res. 2001, 42, 1018-1024.
60. Miyazaki, M., Dobrzyn, A., Sampath, H., Lee, S. H. et al., Reduced adiposity and liver steatosis by stearoyl-CoA desaturase deficiency are independent of peroxisome proliferator-activated peceptor-alpha. J. Biol. Chem. 2004, 279, 35017-35024.
61. Serrano, A., Pavón, F. J., Del Arco, I., Rojo, G. et al., Oleylethanolamide changes in both fatty acid composition and desaturase mRNA expression in a new model of liver steatosis. Obes. Metab. 2006, 2, 155-164.
62. Attie, A. D., Krauss, R. M., Gray-Keller, M. P., Brownlie, A. et al., Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia. J. Lipid Res. 2002, 43, 1899-1907.
63. Rahman, S. M., Dobrzyn, A., Dobrzyn, P., Lee, S. H. et al., Stearoyl-CoA desaturase 1 deficiency elevates insulin-signaling components and down-regulates protein-tyrosine phosphatase IB in muscle. Proc. Natl. Acad. Sci. USA 2003, 100, 11110-11115.
64. Unger, R. H., Lipid overload and overflow: metabolic trauma and the metabolic syndrome. Trends Endocrinol. Metab. 2003, 14, 398-403.
65. Dobrzyn, A., Dobrzyn, P., Lee, S. H., Miyazaki, M. et al., Stearoyl-CoA desaturase-1 deficiency reduces ceramide synthesis by downregulating serine palmitoyltransferase and increasing ß-oxidation in skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 2005, 288, E599-E607.
66. Ntambi, J. M., Miyazaki, M., Dobrzyn, A., Regulation of stearoyl-CoA desaturase expression. Lipids 2004, 39, 1061-1065.
67. Miyazaki, M., Dobrzyn, A., Man, W. C. et al., Stearoyl-CoA desaturase 1 gene expression is necessary for fructose-mediated induction of lipogenic gene expression by sterol regulatory element-binding protein-1c-dependent and independent mechanisms. J. Biol. Chem. 2004, 279, 25164-25171.
68. Ntambi, J. M., The regulation of saturase (SCD). Prog. Lipid Res. 1995, 34, 139-150.
69. Zohary, D., Spiegel-Roy, P., Beginnings of fruit growing in the world. Science 1975, 187, 319-327.
70. Keys, A., Taylor, H. L., Blackburn, H., Brozek, J. et al., Coronary heart disease among Minnesota business and professional men followed 15 years. Circulation 1963, 28, 381-395.
71. Burr, G. O., Burr, M. M., On the nature and role of the fatty acids essential in nutrition. J.Biol. Chem. 1930, 86, 587.
72. Cunnane, S. C., Problems with essential fatty acids: time for a new paradigm? Prog. Lipid Res. 2003, 42, 544-568.
73. Spector, A. A., Hoak, J. C., Fry, G. L., Stoll, L. L. et al., Essential fatty acid availability and prostacyclin production by cultured human endothelial cells. Prog. Lipid Res. 1981, 20, 471-477.