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Volumn 21, Issue 11, 2007, Pages 2246-2257

Identification of TSC-22 as a potential tumor suppressor that is upregulated by Flt3-D835V but not Flt3-ITD

Author keywords

[No Author keywords available]

Indexed keywords

CD135 ANTIGEN; LEUCINE ZIPPER PROTEIN; MIDOSTAURIN; PHOSPHOTRANSFERASE; PROTEIN TSC 22; SMALL INTERFERING RNA; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

EID: 35548974356     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/sj.leu.2404883     Document Type: Article
Times cited : (21)

References (51)
  • 1
    • 0025770646 scopus 로고
    • A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations
    • Matthews W, Jordan CT, Wiegand GW, Pardoll D, Lemischka IR. A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations. Cell 1991; 65: 1143-1152.
    • (1991) Cell , vol.65 , pp. 1143-1152
    • Matthews, W.1    Jordan, C.T.2    Wiegand, G.W.3    Pardoll, D.4    Lemischka, I.R.5
  • 3
    • 0027955112 scopus 로고
    • STK-1, the human homolog of Flk-2/Flt3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells
    • Small D, Levenstein M, Kim E, Carow C, Amin S, Rockwell P et al. STK-1, the human homolog of Flk-2/Flt3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells. Proc Natl Acad Sci USA 1994; 91 459-463.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 459-463
    • Small, D.1    Levenstein, M.2    Kim, E.3    Carow, C.4    Amin, S.5    Rockwell, P.6
  • 4
    • 9244260192 scopus 로고    scopus 로고
    • Human FLT3/FLK2 receptor tyrosine kinase is expressed at the surface of normal and malignant hematopoietic cells
    • Rosnet O, Buhring HJ, Marchetto S, Rappold I, Lavagna C, Sainty D et al. Human FLT3/FLK2 receptor tyrosine kinase is expressed at the surface of normal and malignant hematopoietic cells. Leukemia 1996; 10: 238-248.
    • (1996) Leukemia , vol.10 , pp. 238-248
    • Rosnet, O.1    Buhring, H.J.2    Marchetto, S.3    Rappold, I.4    Lavagna, C.5    Sainty, D.6
  • 5
    • 0029097145 scopus 로고
    • Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors
    • Mackarehtschian K, Hardin JD, Moore KA, Boast S, Goff SP, Lemischka IR. Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors. Immunity 1995; 3: 147-161.
    • (1995) Immunity , vol.3 , pp. 147-161
    • Mackarehtschian, K.1    Hardin, J.D.2    Moore, K.A.3    Boast, S.4    Goff, S.P.5    Lemischka, I.R.6
  • 6
    • 0026457216 scopus 로고
    • Expression of the FMS/KIT-like gene FLT3 in human acute leukemias of the myeloid and lymphoid lineages
    • Birg F, Courcoul M, Rosnet O, Bardin F, Pebusque MJ, Marchetto S et al. Expression of the FMS/KIT-like gene FLT3 in human acute leukemias of the myeloid and lymphoid lineages. Blood 1992; 80: 2584-2593.
    • (1992) Blood , vol.80 , pp. 2584-2593
    • Birg, F.1    Courcoul, M.2    Rosnet, O.3    Bardin, F.4    Pebusque, M.J.5    Marchetto, S.6
  • 7
    • 13344282746 scopus 로고    scopus 로고
    • Expression of the hematopoietic growth factor receptor FLT3 (STK-1/Flk2) in human leukemias
    • Carow CE, Levenstein M, Kaufmann SH, Chen J, Amin S, Rockwell P et al. Expression of the hematopoietic growth factor receptor FLT3 (STK-1/Flk2) in human leukemias. Blood 1996; 87: 1089-1096.
    • (1996) Blood , vol.87 , pp. 1089-1096
    • Carow, C.E.1    Levenstein, M.2    Kaufmann, S.H.3    Chen, J.4    Amin, S.5    Rockwell, P.6
  • 8
    • 0030451722 scopus 로고    scopus 로고
    • internal tandem duplication of the Flt3 gene found in acute myeloid leukemia
    • Nakao M, Yokota S, Iwai T, Kaneko H, Horiike S, Kashima K et al. internal tandem duplication of the Flt3 gene found in acute myeloid leukemia. Leukemia 1996; 10: 1911-1918.
    • (1996) Leukemia , vol.10 , pp. 1911-1918
    • Nakao, M.1    Yokota, S.2    Iwai, T.3    Kaneko, H.4    Horiike, S.5    Kashima, K.6
  • 9
    • 0031686409 scopus 로고    scopus 로고
    • Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product
    • Kiyoi H, Towatari M, Yokota S, Hamaguchi M, Ohno R, Saito H et al. Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product. Leukemia 1998; 12: 1333-1337.
    • (1998) Leukemia , vol.12 , pp. 1333-1337
    • Kiyoi, H.1    Towatari, M.2    Yokota, S.3    Hamaguchi, M.4    Ohno, R.5    Saito, H.6
  • 10
    • 0035168677 scopus 로고    scopus 로고
    • Prevalence and prognostic significance of Flt3 internal tandem duplication in pediatric acute myeloid leukemia
    • Meshinchi S, Woods WG, Stirewalt DL, Sweetser DA, Buckley JD, Tjoa TK et al. Prevalence and prognostic significance of Flt3 internal tandem duplication in pediatric acute myeloid leukemia. Blood 2001; 97 89-94.
    • (2001) Blood , vol.97 , pp. 89-94
    • Meshinchi, S.1    Woods, W.G.2    Stirewalt, D.L.3    Sweetser, D.A.4    Buckley, J.D.5    Tjoa, T.K.6
  • 12
    • 0036659931 scopus 로고    scopus 로고
    • Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: Correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease
    • Schnittger S, Schoch C, Dugas M, Kern W, Staib P, Wuchter C et al. Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: Correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease. Blood 2002; 100: 59-66.
    • (2002) Blood , vol.100 , pp. 59-66
    • Schnittger, S.1    Schoch, C.2    Dugas, M.3    Kern, W.4    Staib, P.5    Wuchter, C.6
  • 13
    • 0037097716 scopus 로고    scopus 로고
    • Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: Association with FAB subtypes and identification of subgroups with poor prognosis
    • Thiede C, Steudel C, Mohr B, Schaich M, Schakel U, Platzbecker U et al. Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: Association with FAB subtypes and identification of subgroups with poor prognosis. Blood 2002; 99: 4326-4335.
    • (2002) Blood , vol.99 , pp. 4326-4335
    • Thiede, C.1    Steudel, C.2    Mohr, B.3    Schaich, M.4    Schakel, U.5    Platzbecker, U.6
  • 14
    • 0035871889 scopus 로고    scopus 로고
    • Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies
    • Yamamoto Y, Kiyoi H, Nakano Y, Suzuki R, Kodera Y, Miyawaki S et al. Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. Blood 2001; 97: 2434-2439.
    • (2001) Blood , vol.97 , pp. 2434-2439
    • Yamamoto, Y.1    Kiyoi, H.2    Nakano, Y.3    Suzuki, R.4    Kodera, Y.5    Miyawaki, S.6
  • 16
    • 0035885955 scopus 로고    scopus 로고
    • The presence of a FLT3 internal tandem duplication in pa-tients with acute myeloid leukemia (AML) addsimportant prognostic information to cytogeneticrisk group and response to the first cycle of che-motherapy: Analysis of 854 patients from theUnited Kingdom Medical Research Council AML 10 and 12 trials
    • Kottaridis PD, Gale RE, Frew ME, Harrison G, Langabeer SE, Belton AA et al. The presence of a FLT3 internal tandem duplication in pa-tients with acute myeloid leukemia (AML) addsimportant prognostic information to cytogeneticrisk group and response to the first cycle of che-motherapy: Analysis of 854 patients from theUnited Kingdom Medical Research Council AML 10 and 12 trials. Blood 2001; 98: 1752-1759.
    • (2001) Blood , vol.98 , pp. 1752-1759
    • Kottaridis, P.D.1    Gale, R.E.2    Frew, M.E.3    Harrison, G.4    Langabeer, S.E.5    Belton, A.A.6
  • 17
    • 0034598830 scopus 로고    scopus 로고
    • Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines
    • Hayakawa F, Towatari M, Kiyoi H, Tanimoto M, Kitamura T, Saito H et al. Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines. Oncogene 2000; 19: 624-631.
    • (2000) Oncogene , vol.19 , pp. 624-631
    • Hayakawa, F.1    Towatari, M.2    Kiyoi, H.3    Tanimoto, M.4    Kitamura, T.5    Saito, H.6
  • 18
    • 0034554796 scopus 로고    scopus 로고
    • Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways
    • Mizuki M, Fenski R, Halfter H, Matsumura I, Schmidt R, Muller C et al. Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways. Blood 2000; 96: 3907-3914.
    • (2000) Blood , vol.96 , pp. 3907-3914
    • Mizuki, M.1    Fenski, R.2    Halfter, H.3    Matsumura, I.4    Schmidt, R.5    Muller, C.6
  • 19
    • 0000796896 scopus 로고    scopus 로고
    • Constitutive activation of FLT3 in acute myeloid leukaemia and its consequences for growth of 32D cells
    • Fenski R, Flesch K, Serve S, Mizuki M, Oelmann E, Kratz-Albers K et al. Constitutive activation of FLT3 in acute myeloid leukaemia and its consequences for growth of 32D cells. Br J Haematol 2000; 108: 322-330.
    • (2000) Br J Haematol , vol.108 , pp. 322-330
    • Fenski, R.1    Flesch, K.2    Serve, S.3    Mizuki, M.4    Oelmann, E.5    Kratz-Albers, K.6
  • 20
    • 0141465061 scopus 로고    scopus 로고
    • The role of FLT3 in haematopoietic malignancies
    • Stirewalt DL, Radich JP. The role of FLT3 in haematopoietic malignancies. Nat Rev Cancer 2003; 3: 650-665.
    • (2003) Nat Rev Cancer , vol.3 , pp. 650-665
    • Stirewalt, D.L.1    Radich, J.P.2
  • 21
    • 0036786289 scopus 로고    scopus 로고
    • internal tandem duplication of FLT3 in relapsed acute myeloid leukemia: A comparative analysis of bone marrow samples from 108 adult patients at diagnosis and relapse
    • Shih LY, Huang CF, Wu JH, Lin TL, Dunn P, Wang PN et al. internal tandem duplication of FLT3 in relapsed acute myeloid leukemia: A comparative analysis of bone marrow samples from 108 adult patients at diagnosis and relapse. Blood 2002; 100: 2387-2392.
    • (2002) Blood , vol.100 , pp. 2387-2392
    • Shih, L.Y.1    Huang, C.F.2    Wu, J.H.3    Lin, T.L.4    Dunn, P.5    Wang, P.N.6
  • 22
    • 12244282411 scopus 로고    scopus 로고
    • incidence and prognostic value of FLT3 internal tandem duplication and D835 mutations in acute myeloid leukemia
    • Moreno I, Martin G, Bolufer P, Barragan E, Rueda E, Roman J et al. incidence and prognostic value of FLT3 internal tandem duplication and D835 mutations in acute myeloid leukemia. Haematologica 2003; 88: 19-24.
    • (2003) Haematologica , vol.88 , pp. 19-24
    • Moreno, I.1    Martin, G.2    Bolufer, P.3    Barragan, E.4    Rueda, E.5    Roman, J.6
  • 23
    • 0141836914 scopus 로고    scopus 로고
    • FLT3: ITDoes matter in leukemia
    • Levis M, Small D. FLT3: ITDoes matter in leukemia. Leukemia 2003; 17: 1738-1752.
    • (2003) Leukemia , vol.17 , pp. 1738-1752
    • Levis, M.1    Small, D.2
  • 24
    • 0037838661 scopus 로고    scopus 로고
    • Overexpression and constitutive activation of FLT3 induces STAT5 activation in primary acute myeloid leukemia blast cells
    • Spiekermann K, Bagrintseva K, Schwab R, Schmieja K, Hiddemann W. Overexpression and constitutive activation of FLT3 induces STAT5 activation in primary acute myeloid leukemia blast cells. Clin Cancer Res 2003; 9: 2140-2150.
    • (2003) Clin Cancer Res , vol.9 , pp. 2140-2150
    • Spiekermann, K.1    Bagrintseva, K.2    Schwab, R.3    Schmieja, K.4    Hiddemann, W.5
  • 25
    • 22044448746 scopus 로고    scopus 로고
    • AML-associated Flt3 kinase domain mutations show signal transduction differences compared with Flt3 ITD mutations
    • Choudhary C, Schwable J, Brandts C, Tickenbrock L, Sargin B, Kindler T et al. AML-associated Flt3 kinase domain mutations show signal transduction differences compared with Flt3 ITD mutations. Blood 2005; 106: 265-273.
    • (2005) Blood , vol.106 , pp. 265-273
    • Choudhary, C.1    Schwable, J.2    Brandts, C.3    Tickenbrock, L.4    Sargin, B.5    Kindler, T.6
  • 26
    • 0026670791 scopus 로고
    • Isolation of a gene encoding a putative leucine zipper structure that is induced by transforming growth factor beta 1 and other growth factors
    • Shibanuma M, Kuroki T, Nose K. Isolation of a gene encoding a putative leucine zipper structure that is induced by transforming growth factor beta 1 and other growth factors. J Biol Chem 1992; 267: 10219-10224.
    • (1992) J Biol Chem , vol.267 , pp. 10219-10224
    • Shibanuma, M.1    Kuroki, T.2    Nose, K.3
  • 27
    • 0030424964 scopus 로고    scopus 로고
    • Molecular cloning and characterization of a transcription factor for the C-type natriuretic peptide gene promoter
    • Ohta S, Shimekake Y, Nagata K. Molecular cloning and characterization of a transcription factor for the C-type natriuretic peptide gene promoter, Eur J Biochem 1996; 242: 460-466.
    • (1996) Eur J Biochem , vol.242 , pp. 460-466
    • Ohta, S.1    Shimekake, Y.2    Nagata, K.3
  • 29
    • 0031974643 scopus 로고    scopus 로고
    • Induction of TSC-22 by treatment with a new anticancer drug, vesnarinone, in a human salivary gland cancer cell
    • Kawamata H, Nakashiro K, Uchida D, Hino S, Omotehara F, Yoshida H et al. Induction of TSC-22 by treatment with a new anticancer drug, vesnarinone, in a human salivary gland cancer cell. Br J Cancer 1998; 77: 71-78.
    • (1998) Br J Cancer , vol.77 , pp. 71-78
    • Kawamata, H.1    Nakashiro, K.2    Uchida, D.3    Hino, S.4    Omotehara, F.5    Yoshida, H.6
  • 30
    • 0028347673 scopus 로고
    • Cloning of rat Sertoli cell follicle-stimulating hormone primary response complementary deoxyribonucleic acid: Regulation of TSC-22 gene expression
    • Hamil KG, Hall SH. Cloning of rat Sertoli cell follicle-stimulating hormone primary response complementary deoxyribonucleic acid: Regulation of TSC-22 gene expression. Endocrinology 1994; 134: 1205-1212.
    • (1994) Endocrinology , vol.134 , pp. 1205-1212
    • Hamil, K.G.1    Hall, S.H.2
  • 31
    • 0032531270 scopus 로고    scopus 로고
    • Fibroblast growth factor downregulates expression of a basic helix-loop-helix-type transcription factor, scleraxis, in a chondrocyte-like cell line, TC6
    • Kawa-uchi T, Nifuji A, Mataga N, Olson EN, Bonaventure J, Shinomiya K et al. Fibroblast growth factor downregulates expression of a basic helix-loop-helix-type transcription factor, scleraxis, in a chondrocyte-like cell line, TC6. J Cell Biochem 1998; 70: 468-477.
    • (1998) J Cell Biochem , vol.70 , pp. 468-477
    • Kawa-uchi, T.1    Nifuji, A.2    Mataga, N.3    Olson, E.N.4    Bonaventure, J.5    Shinomiya, K.6
  • 32
    • 0030910244 scopus 로고    scopus 로고
    • Novel progesterone target genes identified by an improved differential display technique suggest that progestin-induced growth inhibition of breast cancer cells coincides with enhancement of differentiation
    • Kester HA, van der Leede BM, van der Saag PT, van der Burg B. Novel progesterone target genes identified by an improved differential display technique suggest that progestin-induced growth inhibition of breast cancer cells coincides with enhancement of differentiation. J Biol Chem 1997; 172: 16637-16643.
    • (1997) J Biol Chem , vol.172 , pp. 16637-16643
    • Kester, H.A.1    van der Leede, B.M.2    van der Saag, P.T.3    van der Burg, B.4
  • 34
    • 0032799389 scopus 로고    scopus 로고
    • Dynamic expression of TSC-22 at sites of epithelial-mesenchymal interactons during mouse development
    • Dohrmann CE, Belaoussoff M, Raftery LA. Dynamic expression of TSC-22 at sites of epithelial-mesenchymal interactons during mouse development. Mech Dev 1999; 84: 147-151.
    • (1999) Mech Dev , vol.84 , pp. 147-151
    • Dohrmann, C.E.1    Belaoussoff, M.2    Raftery, L.A.3
  • 36
    • 0030748433 scopus 로고    scopus 로고
    • Mechanism of apoptotic cell death of human gastric carcinoma cells mediated by transforming growth factor beta
    • Ohta S, Yanagihara K, Nagata K. Mechanism of apoptotic cell death of human gastric carcinoma cells mediated by transforming growth factor beta. Biochem J 1997; 324: 777-782.
    • (1997) Biochem J , vol.324 , pp. 777-782
    • Ohta, S.1    Yanagihara, K.2    Nagata, K.3
  • 37
    • 0032005230 scopus 로고    scopus 로고
    • Down-regulation of TSC-22 (transforming growth factor beta-stimulated clone 22) markedly enhances the growth of a human salivary gland cancer cell line in vitro and in vivo
    • Nakashiro K, Kawamata H, Hino S, Uchida D, Miwa Y, Hamano H et al. Down-regulation of TSC-22 (transforming growth factor beta-stimulated clone 22) markedly enhances the growth of a human salivary gland cancer cell line in vitro and in vivo. Cancer Res 1998; 58: 549-555.
    • (1998) Cancer Res , vol.58 , pp. 549-555
    • Nakashiro, K.1    Kawamata, H.2    Hino, S.3    Uchida, D.4    Miwa, Y.5    Hamano, H.6
  • 38
    • 0034735991 scopus 로고    scopus 로고
    • Nuclear translocation of TSC-22 (TGF-beta-stimulated clone-22) concomitant with apoptosis: TSC-22 as a putative transcriptional regulator
    • Hino S, Kawamata H, Uchida D, Omotehara F, Miwa Y, Begum NM et al. Nuclear translocation of TSC-22 (TGF-beta-stimulated clone-22) concomitant with apoptosis: TSC-22 as a putative transcriptional regulator. Biochem Biophys Res Commun 2000; 278: 659-664.
    • (2000) Biochem Biophys Res Commun , vol.278 , pp. 659-664
    • Hino, S.1    Kawamata, H.2    Uchida, D.3    Omotehara, F.4    Miwa, Y.5    Begum, N.M.6
  • 39
    • 0042357316 scopus 로고    scopus 로고
    • Murata k, Kumagai H, Kawashima T, Tamitsu K, Irie M, Nakajima H et al. Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosine kinase 3 (FLT3). J Biol Chem 2003; 278: 32892-32898.
    • Murata k, Kumagai H, Kawashima T, Tamitsu K, Irie M, Nakajima H et al. Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosine kinase 3 (FLT3). J Biol Chem 2003; 278: 32892-32898.
  • 40
    • 0142227052 scopus 로고    scopus 로고
    • Retrovirus-mediated gene transfer and expression cloning powerful tools in functional genomics
    • Kitamura T, Koshino Y, Shibata F, Oki T, Nakajima H, Nosaka T et al. Retrovirus-mediated gene transfer and expression cloning powerful tools in functional genomics. Exp Hematol 2003; 31: 1007-1014.
    • (2003) Exp Hematol , vol.31 , pp. 1007-1014
    • Kitamura, T.1    Koshino, Y.2    Shibata, F.3    Oki, T.4    Nakajima, H.5    Nosaka, T.6
  • 41
    • 29644437920 scopus 로고    scopus 로고
    • Integrin alphallbbeta3 induces the adhesion and activation of mast cells through interaction with fibrinogen
    • Oki T, Kitaura J, Eto K, Lu Y, Maeda-Yamamoto M, Inagaki N et al. Integrin alphallbbeta3 induces the adhesion and activation of mast cells through interaction with fibrinogen. J Immunol 2006; 76: 52-60.
    • (2006) J Immunol , vol.76 , pp. 52-60
    • Oki, T.1    Kitaura, J.2    Eto, K.3    Lu, Y.4    Maeda-Yamamoto, M.5    Inagaki, N.6
  • 42
    • 0036595143 scopus 로고    scopus 로고
    • Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412
    • Weisberg E, Boulton C, Kelly LM, Manley P, Fabbro D, Meyer T et al. Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412. Cancer Cell 2002; 1 433-443.
    • (2002) Cancer Cell , vol.1 , pp. 433-443
    • Weisberg, E.1    Boulton, C.2    Kelly, L.M.3    Manley, P.4    Fabbro, D.5    Meyer, T.6
  • 43
    • 15944402069 scopus 로고    scopus 로고
    • RNAi-induced down-regulation of FLT3 expression in AML cell lines increases sensitivity to MLN518
    • Walters DK, Stoffregen EP, Heinrich MC, Deininger MW, Druker BJ. RNAi-induced down-regulation of FLT3 expression in AML cell lines increases sensitivity to MLN518. Blood 2005; 105: 2952-2954.
    • (2005) Blood , vol.105 , pp. 2952-2954
    • Walters, D.K.1    Stoffregen, E.P.2    Heinrich, M.C.3    Deininger, M.W.4    Druker, B.J.5
  • 44
    • 0033600903 scopus 로고    scopus 로고
    • Transforming growth factor-beta-stimulated clone-22 is a member of a family of leucine zipper proteins that can homo- and heterodimerize and has transcriptional repressor activity
    • Kester HA, Blanchetot C, den Hertog J, van der Saag PT, van der Burg B. Transforming growth factor-beta-stimulated clone-22 is a member of a family of leucine zipper proteins that can homo- and heterodimerize and has transcriptional repressor activity. J Biol Chem 1999; 274 27439-27447.
    • (1999) J Biol Chem , vol.274 , pp. 27439-27447
    • Kester, H.A.1    Blanchetot, C.2    den Hertog, J.3    van der Saag, P.T.4    van der Burg, B.5
  • 45
    • 0036893435 scopus 로고    scopus 로고
    • Targeted inhibition of FLT3 overcomes the block to myeloid differentiation in 32Dcl3 cells caused by expression of FLT3/ITD mutations
    • Zheng R, Friedman AD, Small D. Targeted inhibition of FLT3 overcomes the block to myeloid differentiation in 32Dcl3 cells caused by expression of FLT3/ITD mutations. Blood 2002; 100: 4154-4161.
    • (2002) Blood , vol.100 , pp. 4154-4161
    • Zheng, R.1    Friedman, A.D.2    Small, D.3
  • 48
    • 0037944120 scopus 로고    scopus 로고
    • Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations
    • Mizuki M, Schwable J, Steur C, Choudhary C, Agrawal S, Sargin B et al. Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations. Blood 2003; 101: 3164-3173.
    • (2003) Blood , vol.101 , pp. 3164-3173
    • Mizuki, M.1    Schwable, J.2    Steur, C.3    Choudhary, C.4    Agrawal, S.5    Sargin, B.6
  • 49
    • 0033946261 scopus 로고    scopus 로고
    • Over-expression of TSC-22 (TGF-beta stimulated clone-22) markedly enhances 5-fluorouracil-induced apoptosis in a human salivary gland cancer cell line
    • Uchida D, Kawamata H, Omotehara F, Miwa Y, Hino S, Begum NM et al. Over-expression of TSC-22 (TGF-beta stimulated clone-22) markedly enhances 5-fluorouracil-induced apoptosis in a human salivary gland cancer cell line. Lab Invest 2000; 80: 955-963.
    • (2000) Lab Invest , vol.80 , pp. 955-963
    • Uchida, D.1    Kawamata, H.2    Omotehara, F.3    Miwa, Y.4    Hino, S.5    Begum, N.M.6
  • 50
    • 17244368330 scopus 로고    scopus 로고
    • Tsc-22 enhances TGF-beta signaling by associating with Smad4 and induces erythroid cell differentiation
    • Choi SJ, Moon JH, Ahn YW, Ahn JH, Kim DU, Han TH. Tsc-22 enhances TGF-beta signaling by associating with Smad4 and induces erythroid cell differentiation. Mol Cell Biochem 2005; 271: 23-28.
    • (2005) Mol Cell Biochem , vol.271 , pp. 23-28
    • Choi, S.J.1    Moon, J.H.2    Ahn, Y.W.3    Ahn, J.H.4    Kim, D.U.5    Han, T.H.6
  • 51
    • 11144238273 scopus 로고    scopus 로고
    • Retinoids and myelomonocytic growth factors cooperatively activate RARA and induce human myeloid leukemia cell differentiation via MAP kinase pathways
    • Glasow A, Prodromou N, Xu K, von Lindern M, Zelent A. Retinoids and myelomonocytic growth factors cooperatively activate RARA and induce human myeloid leukemia cell differentiation via MAP kinase pathways. Blood 2005; 105: 341-349.
    • (2005) Blood , vol.105 , pp. 341-349
    • Glasow, A.1    Prodromou, N.2    Xu, K.3    von Lindern, M.4    Zelent, A.5


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