Cysteine cathepsins are not involved in Fas/CD95 signalling in primary skin fibroblasts

FEBS Letters

Volumn 581, Issue 27, 2007, Pages 5185-5190

  Bojič, Lea ^a   Petelin, Ana ^a   Stoka, Veronika ^a   Reinheckel, Thomas ^b   Peters, Christoph ^b   Turk, Vito ^a   Turk, Boris ^a  

^a JO EF STEFAN INSTITUTE   (Slovenia)

^b UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Apoptosis; Caspases; Cathepsin; Cathepsin B; Cell death; Fas CD95

Indexed keywords

CASPASE 8; CATHEPSIN; CATHEPSIN B; CYCLOHEXIMIDE; CYSTEINE; FAS ANTIGEN; PROTEIN BCL 2; PROTEIN BID;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL COUNT; CONTROLLED STUDY; GENOTYPE; LYSOSOME; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SKIN FIBROBLAST;

ANIMALS; ANTIGENS, CD95; APOPTOSIS; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CATHEPSIN B; CELLS, CULTURED; CYCLOHEXIMIDE; FIBROBLASTS; LYSOSOMES; MICE; MICE, KNOCKOUT; MITOCHONDRIA; SIGNAL TRANSDUCTION; SKIN; SUBSTRATE SPECIFICITY;

EID: 35548939832     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2007.10.005     Document Type: Article

References (39)

1. Peter M.E., and Krammer P.H. The CD95(APO-1/Fas) DISC and beyond. Cell Death Differ. 10 (2003) 26-35
2. Wajant H. The Fas signaling pathway: more than a paradigm. Science 296 (2002) 1635-1636
3. Boatright K.M., and Salvesen G.S. Mechanisms of caspase activation. Curr. Opin. Cell Biol. 15 (2003) 725-731
4. Scaffidi C., Fulda A., Scinivasan A., Friesen C., Li F., Tomaselli K.J., Debatin K.M., Krammer P.H., and Peter M.E. Two CD95 (Apo-1/Fas) signalling pathways. EMBO J. 17 (1998) 1675-1687
5. Debatin K., and Krammer P.H. Death receptors in chemotherapy and cancer. Oncogene 23 (2004) 2950-2966
6. Li H., Zhu H., Xu C.J., and Yuan J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94 (1998) 491-501
7. Turk V., Turk B., and Turk D. Lysosomal cysteine proteases: facts and opportunities. EMBO J. 20 (2001) 4629-4633
8. Leist M., and Jaattela M. Four deaths and a funeral: from caspases to alternative mechanisms. Nat. Rev. Mol. Cell Biol. 2 (2001) 589-598
9. Turk B., Stoka V., Rozman-Pungenčar J., Cirman T., Droga-Mazovec G., Orešić K., and Turk V. Apoptotic pathways: involvement of lysosomal proteases. Biol. Chem. 383 (2002) 1035-1044
10. Stoka V., Turk V., and Turk B. Lysosomal cysteine cathepsins: signaling pathways in apoptosis. Biol. Chem. 388 (2007) 555-560
11. Brunk U.T., Dalen H., Roberg K., and Hellquist H.B. Photo-oxidative disruption of lysosomal membranes causes apoptosis of cultured human fibroblasts. Free Rad. Biol. Med. 23 (1997) 616-626
12. Ollinger K., and Brunk U. Cellular injury induced by oxidative stress is mediated through lysosomal damage. Free Rad. Biol. Med. 19 (1995) 565-574
13. Green D.R., and Kroemer G. Pharmacological manipulation of cell death: clinical applications in sight?. J. Clin. Invest. 115 (2005) 2610-2617
14. Guicciardi M.E., Leist M., and Gores G.J. Lysosomes in cell death. Oncogene 23 (2004) 2881-2890
15. Werneburg N.W., Guicciardi M.E., Bronk S.F., and Gores G.J. Tumor necrosis factor-α-associated lysosomal permebilization is cathepsin B-dependent. Am. J. Physil. Gastrointest. Liver Physiol. 283 (2002) G947-G956
16. Nagaraj N.S., Vigneswaran N., and Zacharias W. Cathepsin B mediates TRAIL-induced apoptosis in oral cancer cells. J. Cancer Res. Clin. Oncol. 132 (2006) 171-183
17. Werneburg N.W., Guicciardi M.E., Bronk S.F., Kaufmann S.H., and Gores G.J. TRAIL activates a lysosomal pathway of apoptosis that is regulated by Bcl-2 proteins. J. Biol. Chem. 282 (2007) 28960-28970
18. Guicciardi M.E., Deussing J., Miyoshi H., Bronk S.F., Svingen P.A., Peters C., Kaufmann S.H., and Gores G.J. Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c. J. Clin. Invest. 106 (2000) 1127-1137
19. Brunk U.T., and Svensson I. Oxidative stress, growth factor starvation and Fas activation may all cause apoptosis through lysosomal leak. Redox Rep. 4 (1999) 1-11
20. Brunk U.T., Neuzil J., and Eaton J.W. Lysosomal involvement in apoptosis. Redox Rep. 6 (2001) 91-97
21. Tardy C., Autefage H., Garcia V., Levade T., and Andrieu-Labadie N. Mannose 6-phosphorylated proteins are required for tumor necrosis factor-α-induced apoptosis. J. Biol. Chem. 279 (2004) 52914-52923
22. Halangk W., Lerch M.M., Brandt-Nedelev B., Roth W., Ruthenbuerger M., Reinheckel T., Domschke W., Lippert H., Peters C., and Deussing J. Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis. J. Clin. Invest. 106 (2000) 773-781
23. Lohmüller T., Wenzler D., Hagemann S., Kiess W., Peters C., Dandekar T., and Reinheckel T. Toward computer-based cleavage site prediction of cysteine endopeptidases. Biol. Chem. 384 (2003) 899-909
24. Cirman T., Orešić K., Mazovec G.D., Turk V., Reed J.C., Myers R.M., Salvesen G.S., and Turk B. Selective disruption of lysosomes in HeLa cells triggers apoptosis mediated by cleavage of Bid by multiple papain-like lysosomal cathepsins. J. Biol. Chem. 279 (2004) 3578-3587
25. Zhao M., Eaton J.W., and Brunk U.T. Protection against oxidant-mediated lysosomal rupture: a new anti-apoptotic activity of Bcl-2?. FEBS Lett. 485 (2000) 104-108
26. Santiago B., Galindo M., Palao G., and Pablos J.L. Intracellular regulation of Fas-induced apoptosis in human fibroblasts by extracellular factors and cycloheximide. J. Immunol. (2004) 560-566
27. Rozman-Pungerčar J., Kopitar Jerala N., Bogyo M., Turk D., Vasiljeva O., Štefe I., Vandenabeele P., Brömme D., Puizdar V., Fonovič M., Trstenjak-Prebanda M., Dolenc I., Turk V., and Turk B. Inhibition of papain-like cysteine proteases and legumain by "caspase-specific" inhibitors: when reaction mechanism is more important than specificity. Cell Death Diff. 10 (2003) 881-888
28. Stoka V., Turk B., Schendel S.L., Kim T.H., Cirman T., Snipas S.J., Ellerby L.M., Bredesen D., Freeze H., Abrahamson M., Bromme D., Krajewski S., Reed J.C., Yin X.M., Turk V., and Salvesen G.S. Lysosomal protease pathways to apoptosis. Cleavage of Bid, not pro-caspases, is the most likely route. J. Biol. Chem. 276 (2001) 3149-3157
29. Turk B., and Stoka V. Protease signalling in cell death: caspases versus cysteine cathepsins. FEBS Lett. 581 (2007) 2761-2767
30. Ogasawara J., Watanabe-Fukunaga R., Adachi M., Matsuzawa A., Kasugai T., Kitamura Y., Itoh N., Suda T., and Nagata S. Lethal effect of the anti-Fas antibody in mice. Nature 364 (1993) 806-809
31. Janin A., Deschaumes C., Daneshpouy M., Estaquier J., Micic-Polianski J., Rajagopalan-Levasseur P., Akrid K., Mounier N., Gluckman E., Socie G., and Ameisen J.C. D95 engagement induces disseminated endothelial cell apoptosis in vivo: immunopathologic implications. Blood 99 (2002) 2940-2947
32. Gonzalez-Cuadrado S., Lorz C., Garcia del Moral R., O'Valle F., Alonso C., Ramiro F., Ortiz-Gonzalez A., Egido J., and Oritz A. Agonistic anti-Fas antibodies induce glomerular cell apoptosis in mice in vivo. Kidney Int. 51 (1997) 1739-1746
33. Saile B., Knittel T., Matthes N., Schott P., and Ramadori G. CD95/CD95L-mediated apoptosis of the hepatic stellate cell: a mechanism terminating uncontrolled hepatic stellate cell proliferation during hepatic tissue repair. Am. J. Pathol. 151 (1997) 1265-1272
34. Okamoto K., Asahara H., Kobayashi T., Matsuno H., Hasunuma T., Kobata T., Sumida T., and Nishioka K. Induction of apoptosis in rheumatoid synovium by Fas ligand gene transfer. Gene Ther. 5 (1998) 331-338
35. Jaattela M. Multiple cell death pathways as regulators of tumour initiation and progression. Oncogene 23 (2004) 2746-2756
36. Stoka V., Turk B., and Turk V. Lysosomal cysteine proteases: structural features and their role in apoptosis. IUBMB Life 57 (2005) 347-353
37. Bivik C.A., Larsson P.K., Kågedal K.M., Rosdahl I.K., and Ollinger K.M. UVA/B-induced apoptosis in human melanocytes involves translocation of cathepsins and Bcl-2 family members. J. Invest. Dermatol. 126 (2006) 1119-1127
38. Kagedal K., Zhao M., Svensson I., and Brunk U.T. Sphingosine-induced apoptosis is dependent on lysosomal proteases. Biochem. J. 359 (2001) 335-343
39. Wattiaux R., Wattiau-De Coninck S., Thirion J., Gasingirwa M., and Jadot M. Lysosomes and Fas-mediated liver cell death. Biochem. J. 403 (2007) 89-95