Comparison of the pharmacological properties of GK11 and MK801, two NMDA receptor antagonists: Towards an explanation for the lack of intrinsic neurotoxicity of GK11

Journal of Neurochemistry

Volumn 103, Issue 4, 2007, Pages 1682-1696

  Vandame, D ^a   Desmadryl, G ^a   Becerril Ortega, J ^b   Teigell, M ^c   Crouzin, N ^d   Buisson, A ^c   Privat, A ^a   Hirbec, H ^a,e  

^a INSERM   (France)

^b GIP CYCERON   (France)

^c NEUREVA   (France)

^d CNRS   (France)

^e HÔPITAL SAINT ELOI   (France)

Author keywords

Excitotoxicity; Gacyclidine (GK11); NMDA antagonist; Recombinant NMDA receptor; Whole cell recording

Indexed keywords

CALCIUM; DIZOCILPINE; GACYCLIDINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; EMBRYO; HIPPOCAMPUS; IC 50; IMAGING; NERVE CELL; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; SYNAPSE; WHOLE CELL;

ANIMALS; CELLS, CULTURED; CYCLOHEXENES; DIZOCILPINE MALEATE; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID ANTAGONISTS; HIPPOCAMPUS; MICE; NEUROPROTECTIVE AGENTS; PIPERIDINES; RATS; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 35449004380     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2007.04925.x     Document Type: Article

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