Neuroprotective effects of gacyclidine after experimental photochemical spinal cord lesion in adult rats: Dose-window and time-window effects

Journal of Neurotrauma

Volumn 17, Issue 1, 2000, Pages 19-30

  Gaviria, Manuel ^a,b,c,d,e   Privat, Alain ^a,b,c,d,e   D'Arbigny, Pierre ^a,b,c,d,e   Kamenka, Jean Marc ^a,b,c,d,e   Haton, Henri ^a,b,c,d,e   Ohanna, Freddy ^a,b,c,d,e  

^a Centre Propara   (France)

^b UNIVERSIDAD DEL ROSARIO   (Colombia)

^c INSERM   (France)

^d IPSEN   (France)

^e Centre National de la Recherche Scientifique   (France)

Author keywords

Dose window; Gacyclidine; N methyl D aspartate; Photochemical lesion; Secondary injury; Spinal cord injury; Time window

Indexed keywords

GACYCLIDINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; EVOKED SOMATOSENSORY RESPONSE; LOCOMOTION; MALE; MOTOR PERFORMANCE; NEUROPROTECTION; NONHUMAN; RAT; SPINAL CORD INJURY; SPINAL CORD LESION;

EID: 0033973993     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/neu.2000.17.19     Document Type: Article

References (53)

1. BENVENISTE, H., DREGER, J., SCHOUSBOE, A. et al. (1984). Elevation of the extracellular concentration of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J. Neurochem. 43, 1369-1374.
2. CAMERON, T., PRADO, R., WATSON, B.D., et al. (1990). Photochemically induced cystic lesion in the rat spinal cord. I. Behavioral and morphological analysis. Exp. Neurol. 109, 214-223.
3. 3H](thiényl-2)-1 cyclohexylpipéridine (TCP) dans le système nerveux central de rat. Eur. J. Med. Chem. 22, 359-362.
4. CHOI, D.W. (1987). Ionic dependence of glutamate neurotoxicity. J. Neurosci. 7, 369-379.
5. CHOI, D.W. (1989). Calcium-mediated neurotoxicity: relationship to specific channel types and its role in ischemic damage. Trends Neurosci. 11, 21-26.
6. COLLINGRIDGE, G.L., and SINGER, W. (1990). Excitatory amino acid receptors and synaptic plasticity. Trends Pharmacol. Sci. 11, 290-296.
7. DOHRMANN, G.J., WAGNER, F.C., JR., and BUCY, P.C. (1971). The microvasculature in transitory traumatic paraplegia. An electron microscopic study in the monkey. J. Neurosurg. 35, 263-271.
8. DRIAN, M.J., KAMENKA, J.M., PIRAT, J.L., and PRIVAT, A. (1991). Non-competitive antagonists of N-methyl-D-aspartate prevent spontaneous neuronal death in primary cultures of embryonic rat cortex. J. Neurosci. Res. 29, 133-138.
9. DRIAN, M.J., KAMENKA, J.M., and PRIVAT, A. (1999). In vitro neuroprotection against glutamate toxicity provided by novel noncompetitive N-methyl-D-aspartate antagonists. J. Neurosci. Res. 57, 927-934.
10. FADEN, A.I., DEMEDIUK, P., PANTER, S.S., and VINK, R. (1989). The role of excitatory amino acids and NMDA receptors in traumatic brain injury. Science 244, 798-800.
11. FADEN, A.I., and SIMON, R.P. (1988). A potential role for excitotoxins in the pathophysiology of spinal cord injury. Ann. Neurol. 23, 623-626.
12. FADEN, A.I., LEMKE, M., SIMON, R.P., et al. (1988). N-methyl-D-aspartate antagonist MK801 improves outcome following traumatic spinal cord injury in rats: behavioral, anatomic, and neurochemical studies. J. Neurotrauma 5, 33-45.
13. FAROOQUE, M., HILLERED, L., HOLTZ, A., and OLSSON, Y. (1996). Changes of extracellular levels of amino acids after graded compression trauma to the spinal cord: an experimental study in the rat using microdialysis. J. Neurotrauma 13, 537-548.
14. GALE, K., KERASIDIS, H., and WRATHALL, J.R. (1985). Spinal cord contusion in the rat: behavioral analysis of functional neurologic impairment. Exp. Neurol. 88, 123-134.
15. GIMENEZ, Y., RIBOTTA, M., and PRIVAT, A. (1998). Biological interventions for spinal cord injury. Curr. Opin. Neurol. 11, 647-654.
16. HEBEL, R., and STROMBERG, M.W. (1986). Anatomy and Embryology of the Laboratory Rat. BioMed Verlag: Wörthsee.
17. HIRBEC, H., GAVIRIA, M., and VIGNON, J. (2000). Gacyclidine, a new neuroprotective drug. CNS Drugs (in press).
18. KAMENKA, J.M., CHICHE, B., GOUDAL, R., ET AL. (1982). Chemical synthesis and molecular pharmacology of hydroxylated 1-(1-phenylcyclohexyl)piperidine derivatives. J. Med. Chem. 25, 431-435.
19. KATAYAMA, Y., BECKER, D.P., TAMURA, T., and HOVDA, D.A. (1990). Massive increases in extracellular potassium and the indiscriminate release of glutamate following concussive brain injury. J. Neurosurg. 73, 889-900.
20. KUHN, P.L., and WRATHALL, J.R. (1998). A mouse model of graded contusive spinal cord injury. J. Neurotrauma 15, 125-140.
21. LALLEMENT, G., MESTRIES, J.C., PRIVAT, A., et al. (1997). GK11: promising additional neuroprotective therapy for organophosphate poisoning. Neurotoxicology 18, 851-856.
22. LALLEMENT, G., CLARENÇON, D., GALONNIER, M., BAUBICHON, D., BURCKHART, M.F., and PEOC'H, M. (1999). Acute soman poisoning in primates neither pretreated nor receiving immediate therapy: value of gacyclidine (GK-11) in delayed medical support. Arch. Toxicol. 73, 115-122.
23. LEVALLOIS, C., CALVET, M.C., KAMENKA, J.M., PETITE, D., and PRIVAT, A. (1992). TCP enhances the survival of human foetal spinal cord cells in culture. Brain Res. 573, 327-330.
24. LEVALLOIS, C., CALVET, M.C., KAMENKA, J.M., PETITE, D., and PRIVAT, A. (1995). Primary dissociated cultures of human brain stem cells: a useful tool for their characterization and neuroprotection study. Cell Biol. Toxicol. 11, 155-160.
25. 2+ influx underlies potent induction of injury. J. Neurosci. 16, 5457-5465.
26. MAIER, C.M., SUN, G.H., KUNIS, D.M., GIFFARD, R.G., and STEINBERG, G.K. (1995). Neuroprotection by N-methyl-D-aspartate receptor antagonist CGP 40116: in vivo and in vitro studies. J. Neurochem. 65, 652-659.
27. MCINTOSH, T.K. (1993). Novel pharmacologic therapies in the treatment of experimental traumatic brain injury: a review. J. Neurotrauma 10, 215-261.
28. MCLENNAN, H. (1983). Receptors for the excitatory amino acid in the mammalian CNS. Prog. Neurobiol. 20, 251-271.
29. MICHAUD, M., WARREN, H., DRIAN, M.J., et al. (1994). Homochiral structures derived from 1-[-(2-thienyl)cyclohexyl]piperudube (TCP) are potent non-competitive antagonist of glutamate at NMDA receptor sites. Eur. J. Med. Chem. 29, 869-876.
30. MOLANDER, C., XU, Q., and GRANT, G. (1984). The cytoarchitectonic organization of the spinal cord in the rat. I. The lower thoracic and lumbosacral cord. J. Comp. Neurol. 230, 133-141.
31. NILSSON, P., HILLERED, L., PONTEN, V., and UNGERSTEDT, V. (1990). Changes in cortical extracellular levels of energy-related metabolites and amino acids following concussive brain injury in rats. J. Cereb. Blood Flow Metab. 10, 631-637.
32. NOBLE, L.J., and WRATHALL, J.R. (1985). Spinal cord contusion in the rat: morphometric analyses of alterations in the spinal cord. Exp. Neurol. 88, 135-149.
33. PALECEK, J., ABDRACHMANOVA, G., VLACHOVA, V., and VYKLICKY, JR., L. (1999). Properties of NMDA receptors in rat spinal cord motoneurons. Eur. J. Neurosci. 11, 827-836.
34. PENCALET, P., OHANNA, F., POULAT, P., KAMENKA, J.M., and PRIVAT, A. (1993). Thienylphencyclidine protection for the spinal cord of adult rats against extension of lesions secondary to a photochemical injury. J. Neurosurg. 78, 603-609.
35. PRADO, R., DIETRICH, W.D., WATSON, B.D., et al. (1987). Photochemically induced graded spinal cord infarction. Behavioral, electrophysiological, and morphological correlates. J. Neurosurg. 67, 745-753.
36. PRIVAT, A., DRIAN, M.J., PIRAT, J.L., et al. (1990). Protection neurale par les phencyclidines: étude sur des modèles in vitro. Actual. Chim. Ther. 17, 187-200.
37. RAINES, A., DRETCHEN, K.L., MARX, K., et al. (1988). Spinal cord contusion in the rat: somatosensory evoked potentials as function of graded injury. J. Neurotrauma 5, 151-160.
38. RIVLIN, A.S., and TATOR, C.S. (1977). Objective clinical assessment of motor function after experimental spinal cord injury in the rat. J. Neurosurg. 47, 577-581.
39. RONDOUIN, G., DRIAN, M.J., CHICHEPORTICHE, R., KAMENKA, J.M., and PRIVAT, A. (1988). Non-competitive antagonists of N-methyl-D-aspartate receptors protect cortical and hippocampal cell cultures against glutamate neurotoxicity. Neurosci. Lett. 91, 199-203.
40. SANDLER, A.N., and TATOR, C.H. (1976). Review of the effect of spinal cord trauma on the vessels and blood flow in the spinal cord. J. Neurosurg. 45, 638-646.
41. SCATTON, B., BENAVIDES, J., SCHOEMAKER, H., and CARTER, C. (1992). The pharmacology of polyamine site-directed noncompetitive NMDA receptor antagonists, in: Excitatory Amino Acids. R.P. Simon (ed), Theme Medical: New York, pps. 95-101.
42. SIESJO, B. (1978). Brain Energy metabolism. John Wiley & Sons: New York.
43. TARLOV, I. (1954). Spinal cord compression studies. III. Time limits for recovery after gradual compression in dogs. Arch. Neurol. 71, 588-597.
44. TATOR, C.H., and FEHLINGS, M.G. (1991). Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms. J. Neurosurg. 75, 15-26.
45. TATOR, C.H., and ROWED, D.W. (1979). Current concepts in the immediate management of acute spinal cord injuries. Can. Med. Assoc. J. 121, 1453-1464.
46. TOLLE, T.R., BERTHELE, A., ZIEGLGANSBERGER, W., SEEBURG, P.H., and WISDEN, W. (1993). The differential expression of 16 NMDA and non-NMDA receptor subunits in the rat spinal cord and in periaqueductal gray. J. Neurosci. 13, 5009-5028.
47. TOULMOND, S., SERRANO, A., BENAVIDES, J., and SCATTON, B. (1991). Neuroprotective effects of SL82.01715 in an experimental model of brain trauma. J. Cereb. Blood Flow Metab. 11, s313.
48. 3H]TCP) binds to two different sites in rat brain. Localization by autoradiographic and biochemical techniques. Brain Res. 378, 133-141.
49. WALLACE, M.C., TATOR, C.H., and LEWIS, A.J. (1987). Chronic regenerative changes in the spinal cord after cord compression injury in rats. Surg. Neurol. 27, 209-219.
50. WATSON, B.D., DIETRICH, W.D., BUSTO, R., et al. (1985). Introduction of reproducible brain infarction by photochemically initiated thrombosis. Ann. Neurol. 17, 497-504.
51. WATSON, B.D., PRADO, R., DIETRICH, W.D., et al. (1986). Photochemically induced spinal cord injury in the rat. Brain Res. 367, 296-300.
52. WRATHALL, J.R., CHOINIERE, D., and DONG TENG, Y. (1994). Dose-dependent reduction of tissue loss and functional impairment after spinal cord trauma with the AMPA/kainate antagonist NBQX. J. Neurosci. 14, 6598-6607.
53. ZAMANILLO, D., SPRENGEL, R. HVALBY, Ø., et al. (1999). Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learning. Science 284, 1805-1811.