In vitro neuroprotection against glutamate toxicity provided by novel non-competitive N-methyl-D-aspartate antagonists

Journal of Neuroscience Research

Volumn 57, Issue 6, 1999, Pages 927-934

  Drian, M J ^a   Kamenka, J M ^b   Privat, Alain ^a,c  

^a INSERM   (France)

^b Centre National de la Recherche Scientifique   (France)

^c UNIV MONTPELLIER   (France)

Author keywords

Glutamate; Neuron culture; Neuroprotection; NMDA

Indexed keywords

DIZOCILPINE; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID; PHENCYCLIDINE DERIVATIVE;

ANIMAL CELL; ARTICLE; BRAIN CELL; CONTROLLED STUDY; ENANTIOMER; IN VITRO STUDY; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; TOXICITY TESTING;

ANIMALS; BINDING, COMPETITIVE; CELLS, CULTURED; DIZOCILPINE MALEATE; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMIC ACID; NEUROGLIA; NEURONS; NEUROPROTECTIVE AGENTS; RATS; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 0033568511     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19990915)57:6<927::AID-JNR18>3.0.CO;2-C     Document Type: Article

References (17)

1. Ascher P, Nowak L. 1988. The role of divalent cations in the N-methyl-D-aspartate responses of mouse central neurones in cultures. J Physiol 399:247-266.
2. Choi D. 1987. Ionic dependence of glutamate neurotoxicity. J Neurosci 7:369-379.
3. Choi D, Maulucci-Gedde M, Kreigstein A. 1987. Glutamate neurotoxicity in cortical cell culture. J Neurosci 7:357-368.
4. Drian MJ, Kamenka JM, Pirat JL, Privat A. 1991. Non-competitive antagonists of N-methyl-D-aspartate prevent spontaneous neuronal death in primary cultures of embryonic rat cortex. J Neurosci Res 29:133-138.
5. Driscoll BF, Deibleir GE, Law MJ, Crane AM. 1993. Damage to neurons in culture following medium change: role of glutamine and extracellular generation of glutamate. J Neurochem 61:1795-1800.
6. Faden AI, Simon R. 1988. The potential role for excitotoxins in the pathophysiology of spinal cord injury. Ann Neurol 3:623-626.
7. Faden AI, Demediuk P, Panter SS, Vink R. 1989. The role of excitatory amino acids and NMDA receptors in traumatic brain injury. Science 244:798-800.
8. Graham SH, Shiraishi K, Panter SS, Simon RP, Faden AI. 1990. Changes in extracellular amino acid neurotransmitters produced by focal cerebral ischemia. Neurosci Lett 110:124-130.
9. Levallois C, Calvet MC, Kamenka JM, Petite D, Privat A. 1992. TCP enhances the survival of human foetal spinal cord cells in culture. Brain Res 573:327-330.
10. MacDermott AB, Mayer ML, Westbrook GL, Smith SJ, Barker JL. 1986. NMDA receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurons. Nature 321:519-522.
11. McIntosh TK. 1993. Novel pharmacologic therapies in the treatment of experimental traumatic brain injury: a review. J Neurotrauma 10:3.
12. Michaud M, Warren H, Drian MJ, Ranbaud J, Cerruti P, Nicolas JP, Vignon J, Privat A, Kamenka JM. 1994. Homochiral structures derived from 1-[1-(2-thienyl)cyclohexyl]piperudube (TCP) are potent non-competitive antagonists of glutamate at NMDA receptor sites. Eur J Med Chem 29:869-876.
13. Privat A, Marson AM, Drian MJ. 1979. In vitro models of neural growth and differentiation. Prog Brain Res (M. Cuenod Ed.) 51:335-356.
14. Regan RF, Choi DW. 1991. Glutamate neurotoxicity in spinal cord cell culture. Neuroscience 43:585-591.
15. Rondouin G, Drian MJ, Chicheportiche R, et al. 1988. Non-competitive antagonists of N-methyl-D-aspartate receptors protect cortical and hippocampal cell cultures against glutamate neurotoxicity. Neurosci Lett 91:199-203.
16. Rose K, Goldberg MP, Choi DW. 1993. Cytotoxicity in murine cortical cell culture. In: Tyson CA, Frazier JM, editors. In vitro biological methods. San Diego: Academic Press, p 46-60.
17. Schurr A, Payne RS, Rigor BM. 1995. Protection by MK-801 against hypoxia-, excitotoxin-, and depolarization-induced neuronal damage in vitro. Neurochem Int 26:519-525.