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Volumn 7, Issue 15, 2007, Pages 1425-1432

Peptide ligands for the melanin-concentrating hormone (MCH) receptor 1

Author keywords

Antagonist; Melanin concentrating hormone; Melanin concentrating hormone receptor; Obesity

Indexed keywords

HORMONE RECEPTOR; HORMONE RECEPTOR BLOCKING AGENT; HORMONE RECEPTOR STIMULATING AGENT; LIGAND; MELANIN CONCENTRATING HORMONE; MELANIN CONCENTRATING HORMONE RECEPTOR 1; MELANIN CONCENTRATING HORMONE RECEPTOR 1 AGONIST; MELANIN CONCENTRATING HORMONE RECEPTOR 1 ANTAGONIST; PEPTIDE DERIVATIVE; UNCLASSIFIED DRUG;

EID: 35448965210     PISSN: 15680266     EISSN: None     Source Type: Journal    
DOI: 10.2174/156802607782194734     Document Type: Review
Times cited : (8)

References (48)
  • 1
    • 0026766094 scopus 로고
    • The melanin-concentrating hormone system of the rat brain: An immuno- and hybridization histochemical characterization
    • Bittencourt, J.C.; Presse, F.; Arias, C. The melanin-concentrating hormone system of the rat brain: An immuno- and hybridization histochemical characterization. J. Comp. Neurol., 1992, 319, 218-245.
    • (1992) J. Comp. Neurol , vol.319 , pp. 218-245
    • Bittencourt, J.C.1    Presse, F.2    Arias, C.3
  • 2
    • 0030033544 scopus 로고    scopus 로고
    • Melanin-concentrating hormone is a potent anorectic peptide regulated by food-depravation and glucopenia in the rat
    • Presse, F.; Sorokovsky, I.; Max, J.P.; Nocolaidis, S.; Nahon, J.L. Melanin-concentrating hormone is a potent anorectic peptide regulated by food-depravation and glucopenia in the rat. Neuroscience, 1996, 71, 735-745.
    • (1996) Neuroscience , vol.71 , pp. 735-745
    • Presse, F.1    Sorokovsky, I.2    Max, J.P.3    Nocolaidis, S.4    Nahon, J.L.5
  • 3
    • 13344279395 scopus 로고    scopus 로고
    • Qu, D.; Ludwig, D. S.; Gammeltoft; S.; Piper, M.; Pelleymounter, M. A.; Cullen, M. J.; Mathes, W. F.; Przypek, K; Kanarek, R.; Maratos-Flier, E. A role for melanin- concentrating hormone in the central regulation of feeding behavior. Nature, 1996, 380, 243-247.
    • Qu, D.; Ludwig, D. S.; Gammeltoft; S.; Piper, M.; Pelleymounter, M. A.; Cullen, M. J.; Mathes, W. F.; Przypek, K; Kanarek, R.; Maratos-Flier, E. A role for melanin- concentrating hormone in the central regulation of feeding behavior. Nature, 1996, 380, 243-247.
  • 4
    • 0031023301 scopus 로고    scopus 로고
    • MCH acutely stimulates feeding, but chronic administration has no effect on body weight
    • Rossi, M.; Choi, S. J.; O'Shea, D.; Miyoshi, T.; Ghatei, M. A.; Bloom, S. R. MCH acutely stimulates feeding, but chronic administration has no effect on body weight. Endocrinology, 1997, 138, 351-355.
    • (1997) Endocrinology , vol.138 , pp. 351-355
    • Rossi, M.1    Choi, S.J.2    O'Shea, D.3    Miyoshi, T.4    Ghatei, M.A.5    Bloom, S.R.6
  • 5
    • 0032542294 scopus 로고    scopus 로고
    • Mice lacking melanin-concentrating hormone are hypophalgic and lean
    • Shimada, M.; Tritos, N. A.; Lowell, B. B.; Flier, J. S.; Maratos-Flier, E. Mice lacking melanin-concentrating hormone are hypophalgic and lean. Nature, 1998, 396, 670-674.
    • (1998) Nature , vol.396 , pp. 670-674
    • Shimada, M.1    Tritos, N.A.2    Lowell, B.B.3    Flier, J.S.4    Maratos-Flier, E.5
  • 9
    • 35448943591 scopus 로고    scopus 로고
    • Segal-Lieberman, G.; Tso, A.W.K.; Trombly, D.; Wang, X.; Gee, H.; Maratos-Flier, E. Mice lacking melanin-concentrating hormone have impaired fertility secondary to abnormal mating behaviour. 84th Endocrine Society Meeting, San Francisco, USA 2002, OR170-5.
    • Segal-Lieberman, G.; Tso, A.W.K.; Trombly, D.; Wang, X.; Gee, H.; Maratos-Flier, E. Mice lacking melanin-concentrating hormone have impaired fertility secondary to abnormal mating behaviour. 84th Endocrine Society Meeting, San Francisco, USA 2002, OR170-5.
  • 10
    • 4544302126 scopus 로고    scopus 로고
    • Actions of the selective melanin-concentrating hormone 1 receptor antagonist, SNAP-7941, in models of potential antidepressant and anxiolytic activity in rodents
    • Millan, M.J.; Dekeyne, A.; Gobert, A. Actions of the selective melanin-concentrating hormone 1 receptor antagonist, SNAP-7941, in models of potential antidepressant and anxiolytic activity in rodents. Eur. J. Neuropharmacol., 2003, 13 (Suppl. 4): S268.
    • (2003) Eur. J. Neuropharmacol , vol.13 , Issue.SUPPL. 4
    • Millan, M.J.1    Dekeyne, A.2    Gobert, A.3
  • 12
    • 0036849570 scopus 로고    scopus 로고
    • Melanin-concentrating hormone receptor antagonists as potential; anti-obesity agents
    • Cartpenter, A.J.; Hertzog, D.L. Melanin-concentrating hormone receptor antagonists as potential; anti-obesity agents. Expert Opin. Ther. Patents, 2002, 12, 1639-1646.
    • (2002) Expert Opin. Ther. Patents , vol.12 , pp. 1639-1646
    • Cartpenter, A.J.1    Hertzog, D.L.2
  • 13
    • 0037869116 scopus 로고    scopus 로고
    • Prospects for obesity treatment MCH receptor antagonists
    • Collins, X.A.; Kym, P.R. Prospects for obesity treatment MCH receptor antagonists. Expert Opin. Invest. Drugs, 2003, 4, 386-394.
    • (2003) Expert Opin. Invest. Drugs , vol.4 , pp. 386-394
    • Collins, X.A.1    Kym, P.R.2
  • 14
    • 4544374046 scopus 로고    scopus 로고
    • Therapeutic potential of melanin-concentrating hormone-1 receptor antagonists for the treatment of obesity
    • Kowalski, T.; McBriar, M.D. Therapeutic potential of melanin-concentrating hormone-1 receptor antagonists for the treatment of obesity. Expert Opin. Invest. Drugs, 2004, 13, 1113-1122.
    • (2004) Expert Opin. Invest. Drugs , vol.13 , pp. 1113-1122
    • Kowalski, T.1    McBriar, M.D.2
  • 15
    • 1642335643 scopus 로고    scopus 로고
    • Recent developments in the discovery of melanin-concentrating hormone antagonists: Novel antiobesity agents
    • Browning, A. Recent developments in the discovery of melanin-concentrating hormone antagonists: Novel antiobesity agents. Expert Opin. Ther. Patents, 2004, 14, 313-325.
    • (2004) Expert Opin. Ther. Patents , vol.14 , pp. 313-325
    • Browning, A.1
  • 17
    • 0020643565 scopus 로고
    • Characterization of melanin-concentrating hormone in chum salmon pituitaries
    • Kawauch, H.; Kawazoe, I.; Tsubokawa, M.; Kishida, M.; Baker, B.I. Characterization of melanin-concentrating hormone in chum salmon pituitaries. Nature, 1983, 305, 321-323.
    • (1983) Nature , vol.305 , pp. 321-323
    • Kawauch, H.1    Kawazoe, I.2    Tsubokawa, M.3    Kishida, M.4    Baker, B.I.5
  • 18
    • 0018749420 scopus 로고
    • The teleost melanin-concentrating hormone; a pituitary hormone of hypothalamic origin
    • Rance, T.A.; Baker, B.I. The teleost melanin-concentrating hormone; a pituitary hormone of hypothalamic origin. Gen. Comp. Endocrinol., 1979, 37, 64-73.
    • (1979) Gen. Comp. Endocrinol , vol.37 , pp. 64-73
    • Rance, T.A.1    Baker, B.I.2
  • 19
    • 0023225555 scopus 로고
    • Structure-activity relationships of melanin-concentrating hormone
    • Kawazoe,I.; Kawauch, H.; Hirano, T.; Naito, N. Structure-activity relationships of melanin-concentrating hormone. Int. J. Pept. Protein Res., 1987, 29, 714-721.
    • (1987) Int. J. Pept. Protein Res , vol.29 , pp. 714-721
    • Kawazoe, I.1    Kawauch, H.2    Hirano, T.3    Naito, N.4
  • 20
    • 0023885196 scopus 로고
    • Melanin- concentrating hormone analogues: Contration of the cyclic structure. I. Agonist activity
    • Lehl, M.; Hruby V.J.; Castrucci, A.M.L., Visconti, M.A.; Hadley, M.E. Melanin- concentrating hormone analogues: Contration of the cyclic structure. I. Agonist activity. J. Med. Chem., 1988, 31, 949-954.
    • (1988) J. Med. Chem , vol.31 , pp. 949-954
    • Lehl, M.1    Hruby, V.J.2    Castrucci, A.M.L.3    Visconti, M.A.4    Hadley, M.E.5
  • 23
    • 0024321288 scopus 로고
    • Melanin concentrating hormone (MCH): Synthesis and bioactivity studies of MCH fragment analogs
    • Matsunaga, T.O.; Castrucci, A.M.L.; Hadley, M.E.; Hruby, V.J. Melanin concentrating hormone (MCH): Synthesis and bioactivity studies of MCH fragment analogs, Peptides, 1989, 10, 349-354.
    • (1989) Peptides , vol.10 , pp. 349-354
    • Matsunaga, T.O.1    Castrucci, A.M.L.2    Hadley, M.E.3    Hruby, V.J.4
  • 25
    • 0024447871 scopus 로고
    • Characterization of melanin- concentrating hormone from the rat hypothalamus
    • Vaughan, J.M.; Fisher, W.H.; Hoeger, C.; Rivier, J.; Vale, W. Characterization of melanin- concentrating hormone from the rat hypothalamus. Endocrinology, 1989, 125, 1660-1665
    • (1989) Endocrinology , vol.125 , pp. 1660-1665
    • Vaughan, J.M.1    Fisher, W.H.2    Hoeger, C.3    Rivier, J.4    Vale, W.5
  • 26
    • 0025259499 scopus 로고
    • Structure of the human melanin-concentrating hormone mRNA
    • Presse, F.; Nation, J-L.; Fischer, W. H.; Vale, W. Structure of the human melanin-concentrating hormone mRNA. Mol. Endocrinol., 1990, 4, 632-637.
    • (1990) Mol. Endocrinol , vol.4 , pp. 632-637
    • Presse, F.1    Nation, J.-L.2    Fischer, W.H.3    Vale, W.4
  • 27
    • 0028949670 scopus 로고
    • Binding sites for melanin-cancentrating hormone (MCH) in brain synaptosomes and membranes from peripheral tissues identified with highly tritiated MCH
    • Drozdz, R.; Eberle, A.N. Binding sites for melanin-cancentrating hormone (MCH) in brain synaptosomes and membranes from peripheral tissues identified with highly tritiated MCH. J. Recept. Signal Trans. Res. 1995, 15, 487-502.
    • (1995) J. Recept. Signal Trans. Res , vol.15 , pp. 487-502
    • Drozdz, R.1    Eberle, A.N.2
  • 28
    • 0029171262 scopus 로고
    • Synthesis and iodination of human (phenylalanine13, tyrosine19)melanin-concentrating hormone for radioreceptor assay
    • Drozdz, R.; Eberle, A.N. Synthesis and iodination of human (phenylalanine13, tyrosine19)melanin-concentrating hormone for radioreceptor assay. J. Pept. Sci., 1995, 1, 58-65
    • (1995) J. Pept. Sci , vol.1 , pp. 58-65
    • Drozdz, R.1    Eberle, A.N.2
  • 29
    • 0033024989 scopus 로고    scopus 로고
    • Synthesis and characterization of new radioligands for the melanin-concentrating hormone (MCH) receptor
    • Hinterman, E.; Drozdz, R.; Tanner, H.: Eberle, A.N. Synthesis and characterization of new radioligands for the melanin-concentrating hormone (MCH) receptor. J. Recept. Signal Trans. Res., 1999, 19, 411-422.
    • (1999) J. Recept. Signal Trans. Res , vol.19 , pp. 411-422
    • Hinterman, E.1    Drozdz, R.2    Tanner, H.3    Eberle, A.N.4
  • 31
    • 0033807442 scopus 로고    scopus 로고
    • Melanin-concentrating hormone receptor: An orphan receptor fits the key
    • Saito, Y.; Nothacker, H.P.; Civelli, O. Melanin-concentrating hormone receptor: An orphan receptor fits the key. Trends Endocrinol. Metab., 2000, 11, 299-303.
    • (2000) Trends Endocrinol. Metab , vol.11 , pp. 299-303
    • Saito, Y.1    Nothacker, H.P.2    Civelli, O.3
  • 32
    • 0034525477 scopus 로고    scopus 로고
    • The melanin- concentrating hormone receptor couples to multiple G proteins to activate diverse intracellular signaling pathways
    • Hawes, B. E.; Kil, E.; Green, B.; O'Neill, K.; Fried, S.; Graziano, M.P. The melanin- concentrating hormone receptor couples to multiple G proteins to activate diverse intracellular signaling pathways. Endocrinology, 2000, 141, 4524-4532.
    • (2000) Endocrinology , vol.141 , pp. 4524-4532
    • Hawes, B.E.1    Kil, E.2    Green, B.3    O'Neill, K.4    Fried, S.5    Graziano, M.P.6
  • 33
    • 0035912709 scopus 로고    scopus 로고
    • Sailer, A. W., Sano, H., Zeng, Z., McDonald, T. P., Pan, J., Pong S-S., Feighner, S. D., Tan, C. P., Fukami, T., Iwaasa, H., Hreniuk, D. L., Morin, N. R., Sadowski, D. J., Nossoughi, R., Ito, M., Ito, M., Bansal, A., Ky, B., Figueroa, D. J., Jiang, Q., Austin, C. P., MacNeil, D. J., Ishihara, A., Ihara, M., Kanatani, A., Van der Ploeg, L. H. T., Howard, A. D. and Qingyun Liu, Q. Identification and characterization of a second melanin- concentrating hormone receptor, MCH-2R. Proc. Natl. Aad. Sci. USA, 2001, 98, 7564-7569.
    • Sailer, A. W., Sano, H., Zeng, Z., McDonald, T. P., Pan, J., Pong S-S., Feighner, S. D., Tan, C. P., Fukami, T., Iwaasa, H., Hreniuk, D. L., Morin, N. R., Sadowski, D. J., Nossoughi, R., Ito, M., Ito, M., Bansal, A., Ky, B., Figueroa, D. J., Jiang, Q., Austin, C. P., MacNeil, D. J., Ishihara, A., Ihara, M., Kanatani, A., Van der Ploeg, L. H. T., Howard, A. D. and Qingyun Liu, Q. Identification and characterization of a second melanin- concentrating hormone receptor, MCH-2R. Proc. Natl. Aad. Sci. USA, 2001, 98, 7564-7569.
  • 35
    • 0042816504 scopus 로고    scopus 로고
    • Melanin-concentrating hormone receptor 1 activates extracellular signal-regulated kinase and synergizes with G(s)- coupled pathways
    • Pissios, P.; Trombly, D.J., Tzameli, I.; Maratos-Flier, E. Melanin-concentrating hormone receptor 1 activates extracellular signal-regulated kinase and synergizes with G(s)- coupled pathways. Endocrinology, 2003, 144, 3514-3523.
    • (2003) Endocrinology , vol.144 , pp. 3514-3523
    • Pissios, P.1    Trombly, D.J.2    Tzameli, I.3    Maratos-Flier, E.4
  • 36
    • 0033938778 scopus 로고    scopus 로고
    • Molecular characterization of the melanin-concentrating hormone/receptor complex: Identification of critical residues involved in binding and activation
    • MacDonald, D.; Murgolo, N.; Zhang, R.; Durkin, J.P.; Yao, X.; Strader, C.D.; Graziano, M.P. Molecular characterization of the melanin-concentrating hormone/receptor complex: Identification of critical residues involved in binding and activation. Mol. Pharmacol. 2000, 58, 217-225.
    • (2000) Mol. Pharmacol , vol.58 , pp. 217-225
    • MacDonald, D.1    Murgolo, N.2    Zhang, R.3    Durkin, J.P.4    Yao, X.5    Strader, C.D.6    Graziano, M.P.7
  • 40
    • 0035822669 scopus 로고    scopus 로고
    • Bednarek, M.,A.; Feighner, S.D.; Hreniuk, D.L.; Palyha, O.C.; Morin, N.R.; Sadowski, S.J.; MacNeil, D.J.; Howard, A.D.; Van der Ploeg, L.H.Y. Short segment of human melanin-concentrating hormone that is sufficient for full activation of human melanin- concentrating hormone receptors 1 and 2. Biochemistry, 2001, 40, 9379-9386
    • Bednarek, M.,A.; Feighner, S.D.; Hreniuk, D.L.; Palyha, O.C.; Morin, N.R.; Sadowski, S.J.; MacNeil, D.J.; Howard, A.D.; Van der Ploeg, L.H.Y. Short segment of human melanin-concentrating hormone that is sufficient for full activation of human melanin- concentrating hormone receptors 1 and 2. Biochemistry, 2001, 40, 9379-9386
  • 43
    • 35448983989 scopus 로고    scopus 로고
    • Peptide antagonists, and bioactive conformation of melanin-concentrating hormone (MCH), an important regulatory hormone in feeding behavior
    • Danho, W.; Swistok, J.; Khan, W.; Salari, H.; Greeley, D.; Fry, D.; Sun, H.; Falcioni, F. Peptide antagonists, and bioactive conformation of melanin-concentrating hormone (MCH), an important regulatory hormone in feeding behavior. Peptides, 2002 Proc. Eur. Pept. Symp., 2002 726-727.
    • (2002) Peptides, 2002 Proc. Eur. Pept. Symp , pp. 726-727
    • Danho, W.1    Swistok, J.2    Khan, W.3    Salari, H.4    Greeley, D.5    Fry, D.6    Sun, H.7    Falcioni, F.8
  • 44
    • 0037150078 scopus 로고    scopus 로고
    • Synthesis and biological evaluation in vitro of selective, high affinity peptide antagonists of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1
    • Bednarek, MA.; Hreniuk, D.L.; Tan, C.; Palyha, O.C.; MacNeil, D.J.; Van der Ploeg, L.H.Y.; Howard, A.D.; Feighner, S.D. Synthesis and biological evaluation in vitro of selective, high affinity peptide antagonists of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1. Biochemistry, 2002 41, 6383-6390.
    • (2002) Biochemistry , vol.41 , pp. 6383-6390
    • Bednarek, M.A.1    Hreniuk, D.L.2    Tan, C.3    Palyha, O.C.4    MacNeil, D.J.5    Van der Ploeg, L.H.Y.6    Howard, A.D.7    Feighner, S.D.8
  • 47
    • 0037134451 scopus 로고    scopus 로고
    • Synthesis and biological evaluation in vitro of a selective, high potency peptide agonist of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1
    • Bednarek, M.A.; Tan, C.; Hreniuk, D.L.; Palyha, O.C.; MacNeil, D.J.; Van der Ploeg, L.H.Y.; Howard, A.D.; Feighner, S.D. Synthesis and biological evaluation in vitro of a selective, high potency peptide agonist of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1. J. Biol. Chem., 2002, 277, 13821-13826.
    • (2002) J. Biol. Chem , vol.277 , pp. 13821-13826
    • Bednarek, M.A.1    Tan, C.2    Hreniuk, D.L.3    Palyha, O.C.4    MacNeil, D.J.5    Van der Ploeg, L.H.Y.6    Howard, A.D.7    Feighner, S.D.8
  • 48
    • 33645693576 scopus 로고    scopus 로고
    • Kym, P.R.; Souers, A.J.; Campbell, T.J.; Lynch, J.K.; Judd, A,S.; Iyengar, R.; Vasudevan, A.; Gao, J.; Freeman, J.C.; Wodka, D.; Mulhem, M.; Zhao, G.; Wagaw, S.H.; Napier, J.J.; Brodjiam, S.; Dayton, B.D.; Reilly, R.M.; Segreti, J.A.; Fryer, R.M.; Preusser, L.C.; Reinhart, G.A.; Hernandez, L.; Marsh, K.C.; Sham, H.L.; Collins, C.A.; Polskowski, J.S. Screening for cardiovascular safety: A structure-activity approach for guiding lead selection of melanin concentrating hormone receptor 1 antagonists. J. Med. Chem., 2006, 49, 2339-2352.
    • Kym, P.R.; Souers, A.J.; Campbell, T.J.; Lynch, J.K.; Judd, A,S.; Iyengar, R.; Vasudevan, A.; Gao, J.; Freeman, J.C.; Wodka, D.; Mulhem, M.; Zhao, G.; Wagaw, S.H.; Napier, J.J.; Brodjiam, S.; Dayton, B.D.; Reilly, R.M.; Segreti, J.A.; Fryer, R.M.; Preusser, L.C.; Reinhart, G.A.; Hernandez, L.; Marsh, K.C.; Sham, H.L.; Collins, C.A.; Polskowski, J.S. Screening for cardiovascular safety: A structure-activity approach for guiding lead selection of melanin concentrating hormone receptor 1 antagonists. J. Med. Chem., 2006, 49, 2339-2352.


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