-
1
-
-
0037447489
-
Familial hyperkalemic hypertension: Phenotypic analysis in a large family with the WNK1 deletion mutation
-
Achard JM, Warnock DG, Disse-Nicodeme S, Fiquet-Kempf BB, Corvol P, Fournier A, Jeunemaitre X. Familial hyperkalemic hypertension: phenotypic analysis in a large family with the WNK1 deletion mutation. Am J Med 114: 495-498, 2003.
-
(2003)
Am J Med
, vol.114
, pp. 495-498
-
-
Achard, J.M.1
Warnock, D.G.2
Disse-Nicodeme, S.3
Fiquet-Kempf, B.B.4
Corvol, P.5
Fournier, A.6
Jeunemaitre, X.7
-
2
-
-
33746644724
-
- cotransporter in HeLa cells
-
- cotransporter in HeLa cells. Proc Natl Acad Sci USA 103: 10883-10888, 2006.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 10883-10888
-
-
Anselmo, A.N.1
Earnest, S.2
Chen, W.3
Juang, Y.C.4
Kim, S.C.5
Zhao, Y.6
Cobb, M.H.7
-
3
-
-
33846505390
-
Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene
-
Bianco SD, Peng JB, Takanaga H, Suzuki Y, Crescenzi A, Kos CH, Zhuang L, Freeman MR, Gouveia CH, Wu J, Luo H, Mauro T, Brown EM, Hediger MA. Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene. J Bone Miner Res 22: 274-285, 2007.
-
(2007)
J Bone Miner Res
, vol.22
, pp. 274-285
-
-
Bianco, S.D.1
Peng, J.B.2
Takanaga, H.3
Suzuki, Y.4
Crescenzi, A.5
Kos, C.H.6
Zhuang, L.7
Freeman, M.R.8
Gouveia, C.H.9
Wu, J.10
Luo, H.11
Mauro, T.12
Brown, E.M.13
Hediger, M.A.14
-
4
-
-
0037171857
-
Deafness and renal tubular acidosis in mice lacking the K-Cl co-transporter Kcc4
-
Boettger T, Hubner CA, Maier H, Rust MB, Beck FX, Jentsch TJ. Deafness and renal tubular acidosis in mice lacking the K-Cl co-transporter Kcc4. Nature 416: 874-878, 2002.
-
(2002)
Nature
, vol.416
, pp. 874-878
-
-
Boettger, T.1
Hubner, C.A.2
Maier, H.3
Rust, M.B.4
Beck, F.X.5
Jentsch, T.J.6
-
5
-
-
33745076253
-
WNK4 kinase regulates surface expression of the human sodium chloride cotransporter in mammalian cells
-
Cai H, Cebotaru V, Wang YH, Zhang XM, Cebotaru L, Guggino SE, Guggino WB. WNK4 kinase regulates surface expression of the human sodium chloride cotransporter in mammalian cells. Kidney Int 69: 2162-2170, 2006.
-
(2006)
Kidney Int
, vol.69
, pp. 2162-2170
-
-
Cai, H.1
Cebotaru, V.2
Wang, Y.H.3
Zhang, X.M.4
Cebotaru, L.5
Guggino, S.E.6
Guggino, W.B.7
-
6
-
-
0027958441
-
+ channel is made of three homologous subunits
-
+ channel is made of three homologous subunits. Nature 367: 463-467, 1994.
-
(1994)
Nature
, vol.367
, pp. 463-467
-
-
Canessa, C.M.1
Schild, L.2
Buell, G.3
Thorens, B.4
Gautschi, I.5
Horisberger, J.D.6
Rossier, B.C.7
-
8
-
-
26444509763
-
TRPV4 and the mammalian kidney
-
Cohen DM. TRPV4 and the mammalian kidney. Pflügers Arch 451: 168-175, 2005.
-
(2005)
Pflügers Arch
, vol.451
, pp. 168-175
-
-
Cohen, D.M.1
-
10
-
-
33745811310
-
WNK1 affects surface expression of the ROMK potassium channel independent of WNK4
-
Cope G, Murthy M, Golbang AP, Hamad A, Liu CH, Cuthbert AW, O'shaughnessy KM. WNK1 affects surface expression of the ROMK potassium channel independent of WNK4. J Am Soc Nephrol 17: 1867-1874, 2006.
-
(2006)
J Am Soc Nephrol
, vol.17
, pp. 1867-1874
-
-
Cope, G.1
Murthy, M.2
Golbang, A.P.3
Hamad, A.4
Liu, C.H.5
Cuthbert, A.W.6
O'shaughnessy, K.M.7
-
12
-
-
0025942250
-
Immunocytochemical localization of the cystic fibrosis gene product CFTR
-
Crawford I, Maloney PC, Zeitlin PL, Guggino WB, Hyde SC, Turley H, Gatter KC, Harris A, Higgins CF. Immunocytochemical localization of the cystic fibrosis gene product CFTR. Proc Natl Acad Sci USA 88: 9262-9266, 1991.
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 9262-9266
-
-
Crawford, I.1
Maloney, P.C.2
Zeitlin, P.L.3
Guggino, W.B.4
Hyde, S.C.5
Turley, H.6
Gatter, K.C.7
Harris, A.8
Higgins, C.F.9
-
13
-
-
32444437942
-
WNK3 bypasses the tonicity requirement for K-Cl cotransporter activation via a phosphatase-dependent pathway
-
de los HP, Kahle KT, Rinehart J, Bobadilla NA, Vazquez N, San CP, Mount DB, Lifton RP, Hebert SC, Gamba G. WNK3 bypasses the tonicity requirement for K-Cl cotransporter activation via a phosphatase-dependent pathway. Proc Natl Acad Sci USA 103: 1976-1981, 2006.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 1976-1981
-
-
de los, H.P.1
Kahle, K.T.2
Rinehart, J.3
Bobadilla, N.A.4
Vazquez, N.5
San, C.P.6
Mount, D.B.7
Lifton, R.P.8
Hebert, S.C.9
Gamba, G.10
-
14
-
-
18244392958
-
+ channel cell surface expression
-
+ channel cell surface expression. EMBO J 20: 7052-7059, 2001.
-
(2001)
EMBO J
, vol.20
, pp. 7052-7059
-
-
Debonneville, C.1
Flores, S.Y.2
Kamynina, E.3
Plant, P.J.4
Tauxe, C.5
Thomas, M.A.6
Munster, C.7
Chraibi, A.8
Pratt, J.H.9
Horisberger, J.D.10
Pearce, D.11
Loffing, J.12
Staub, O.13
-
15
-
-
0344197746
-
Multiple promoters in the WNK1 gene: One controls expression of a kidney-specific kinase-defective isoform
-
Delaloy C, Lu J, Houot AM, sse-Nicodeme S, Gasc JM, Corvol P, Jeunemaitre X. Multiple promoters in the WNK1 gene: one controls expression of a kidney-specific kinase-defective isoform. Mol Cell Biol 23: 9208-9221, 2003.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 9208-9221
-
-
Delaloy, C.1
Lu, J.2
Houot, A.M.3
sse-Nicodeme, S.4
Gasc, J.M.5
Corvol, P.6
Jeunemaitre, X.7
-
16
-
-
0348142491
-
Identification and characterization of a novel human vanilloid receptor-like protein, VRL-2
-
Delany NS, Hurle M, Facer P, Alnadaf T, Plumpton C, Kinghorn I, I, See CG, Costigan M, Anand P, Woolf CJ, Crowther D, Sanseau P, Tate SN. Identification and characterization of a novel human vanilloid receptor-like protein, VRL-2. Physiol Genomics 4: 165-174, 2001.
-
(2001)
Physiol Genomics
, vol.4
, pp. 165-174
-
-
Delany, N.S.1
Hurle, M.2
Facer, P.3
Alnadaf, T.4
Plumpton, C.5
Kinghorn, I.I.6
See, C.G.7
Costigan, M.8
Anand, P.9
Woolf, C.J.10
Crowther, D.11
Sanseau, P.12
Tate, S.N.13
-
17
-
-
33744820299
-
SPAK and OSR1, key kinases involved in the regulation of chloride transport
-
Delpire E, Gagnon KB. SPAK and OSR1, key kinases involved in the regulation of chloride transport. Acta Physiol (Oxf) 187: 103-113, 2006.
-
(2006)
Acta Physiol (Oxf)
, vol.187
, pp. 103-113
-
-
Delpire, E.1
Gagnon, K.B.2
-
18
-
-
0029824211
-
Developmental regulation of CFTR expression during human nephrogenesis
-
Devuyst O, Burrow CR, Schwiebert EM, Guggino WB, Wilson PD. Developmental regulation of CFTR expression during human nephrogenesis. Am J Physiol Renal Fluid Electrolyte Physiol 271: F723-F735, 1996.
-
(1996)
Am J Physiol Renal Fluid Electrolyte Physiol
, vol.271
-
-
Devuyst, O.1
Burrow, C.R.2
Schwiebert, E.M.3
Guggino, W.B.4
Wilson, P.D.5
-
19
-
-
0037782086
-
Genetic variants of WNK4 in whites and African Americans with hypertension
-
Erlich PM, Cui J, Chazaro I, Farrer LA, Baldwin CT, Gavras H, DeStefano AL. Genetic variants of WNK4 in whites and African Americans with hypertension. Hypertension 41: 1191-1195, 2003.
-
(2003)
Hypertension
, vol.41
, pp. 1191-1195
-
-
Erlich, P.M.1
Cui, J.2
Chazaro, I.3
Farrer, L.A.4
Baldwin, C.T.5
Gavras, H.6
DeStefano, A.L.7
-
20
-
-
84949312562
-
Familial hyperpotassemia and hypertension accompanied by normal plasma aldosterone levels: Possible hereditary cell membrane defect
-
Farfel Z, Iaina A, Rosenthal T, Waks U, Shibolet S, Gafni J. Familial hyperpotassemia and hypertension accompanied by normal plasma aldosterone levels: possible hereditary cell membrane defect. Arch Intern Med 138: 1828-1832, 1978.
-
(1978)
Arch Intern Med
, vol.138
, pp. 1828-1832
-
-
Farfel, Z.1
Iaina, A.2
Rosenthal, T.3
Waks, U.4
Shibolet, S.5
Gafni, J.6
-
21
-
-
20444431956
-
+ transport: Study of familial hyperkalaemia and hypertension
-
+ transport: study of familial hyperkalaemia and hypertension. Eur J Clin Invest 35: 410-415, 2005.
-
(2005)
Eur J Clin Invest
, vol.35
, pp. 410-415
-
-
Farfel, Z.1
Mayan, H.2
Yaacov, Y.3
Mouallem, M.4
Shaharabany, M.5
Pauzner, R.6
Kerem, E.7
Wilschanski, M.8
-
22
-
-
0344897193
-
WNK kinases, distal tubular ion handling and hypertension
-
Faure S, Delaloy C, Leprivey V, Hadchouel J, Warnock DG, Jeunemaitre X, Achard JM. WNK kinases, distal tubular ion handling and hypertension. Nephrol Dial Transplant 18: 2463-2467, 2003.
-
(2003)
Nephrol Dial Transplant
, vol.18
, pp. 2463-2467
-
-
Faure, S.1
Delaloy, C.2
Leprivey, V.3
Hadchouel, J.4
Warnock, D.G.5
Jeunemaitre, X.6
Achard, J.M.7
-
24
-
-
30644458584
-
- cotransporters is modulated by the interaction of two kinases: Ste20-related proline-alanine-rich kinase and WNK4
-
- cotransporters is modulated by the interaction of two kinases: Ste20-related proline-alanine-rich kinase and WNK4. Am J Physiol Cell Physiol 290: C134-C142, 2006.
-
(2006)
Am J Physiol Cell Physiol
, vol.290
-
-
Gagnon, K.B.1
England, R.2
Delpire, E.3
-
25
-
-
15544384004
-
Molecular physiology and pathophysiology of electroneutral cation-chloride cotransporters
-
Gamba G. Molecular physiology and pathophysiology of electroneutral cation-chloride cotransporters. Physiol Rev 85: 423-493, 2005.
-
(2005)
Physiol Rev
, vol.85
, pp. 423-493
-
-
Gamba, G.1
-
26
-
-
12144272609
-
Role of WNK kinases in regulating tubular salt and potassium transport and in the development of hypertension
-
Gamba G. Role of WNK kinases in regulating tubular salt and potassium transport and in the development of hypertension. Am J Physiol Renal Physiol 288: F245-F252, 2005.
-
(2005)
Am J Physiol Renal Physiol
, vol.288
-
-
Gamba, G.1
-
27
-
-
34147142555
-
- cotransporters
-
- cotransporters. Am J Physiol Renal Physiol 292: F1197-F1207, 2007.
-
(2007)
Am J Physiol Renal Physiol
, vol.292
-
-
Garzán-Muvdi, T.1
Pacheco-Alvarez, D.2
Gagnon, K.B.3
Vázquez, N.4
Ponce-Coria, J.5
Moreno, E.6
Delpire, E.7
Gamba, G.8
-
28
-
-
33845361061
-
Regulation of the expression of the Na/Cl cotransporter by WNK4 and WNK1: Evidence that accelerated dynamin-dependent endocytosis is not involved
-
Golbang AP, Cope G, Hamad A, Murthy M, Liu CH, Cuthbert AW, O'shaughnessy KM. Regulation of the expression of the Na/Cl cotransporter by WNK4 and WNK1: evidence that accelerated dynamin-dependent endocytosis is not involved. Am J Physiol Renal Physiol 291: F1369-F1376, 2006.
-
(2006)
Am J Physiol Renal Physiol
, vol.291
-
-
Golbang, A.P.1
Cope, G.2
Hamad, A.3
Murthy, M.4
Liu, C.H.5
Cuthbert, A.W.6
O'shaughnessy, K.M.7
-
29
-
-
23244460555
-
A new kindred with pseudohypoaldosteronism type II and a novel mutation (564D>H) in the acidic motif of the WNK4 gene
-
Golbang AP, Murthy M, Hamad A, Liu CH, Cope G, Van't HW, Cuthbert A, O'shaughnessy KM. A new kindred with pseudohypoaldosteronism type II and a novel mutation (564D>H) in the acidic motif of the WNK4 gene. Hypertension 46: 295-300, 2005.
-
(2005)
Hypertension
, vol.46
, pp. 295-300
-
-
Golbang, A.P.1
Murthy, M.2
Hamad, A.3
Liu, C.H.4
Cope, G.5
Van't, H.W.6
Cuthbert, A.7
O'shaughnessy, K.M.8
-
30
-
-
33645379951
-
Familial hyperkalemic hypertension
-
Hadchouel J, Delaloy C, Faure S, Achard JM, Jeunemaitre X. Familial hyperkalemic hypertension. J Am Soc Nephrol 17: 208-217, 2006.
-
(2006)
J Am Soc Nephrol
, vol.17
, pp. 208-217
-
-
Hadchouel, J.1
Delaloy, C.2
Faure, S.3
Achard, J.M.4
Jeunemaitre, X.5
-
31
-
-
33750462777
-
Life and death of the distal nephron: WNK4 and NCC as major players
-
Hadchouel J, Jeunemaitre X. Life and death of the distal nephron: WNK4 and NCC as major players. Cell Metab 4: 335-337, 2006.
-
(2006)
Cell Metab
, vol.4
, pp. 335-337
-
-
Hadchouel, J.1
Jeunemaitre, X.2
-
32
-
-
0029092801
-
Hypertension caused by a truncated epithelial sodium channel gamma subunit: Genetic heterogeneity of Liddle syndrome
-
Hansson JH, Nelson-Williams C, Suzuki H, Schild L, Shimkets R, Lu Y, Canessa C, Iwasaki T, Rossier B, Lifton RP. Hypertension caused by a truncated epithelial sodium channel gamma subunit: genetic heterogeneity of Liddle syndrome. Nat Genet 11: 76-82, 1995.
-
(1995)
Nat Genet
, vol.11
, pp. 76-82
-
-
Hansson, J.H.1
Nelson-Williams, C.2
Suzuki, H.3
Schild, L.4
Shimkets, R.5
Lu, Y.6
Canessa, C.7
Iwasaki, T.8
Rossier, B.9
Lifton, R.P.10
-
33
-
-
34147121186
-
Intersectin links WNK kinases to endocytosis of ROMK1
-
He G, Wang HR, Huang SK, Huang CL. Intersectin links WNK kinases to endocytosis of ROMK1. J Clin Invest 117: 1078-1087, 2007.
-
(2007)
J Clin Invest
, vol.117
, pp. 1078-1087
-
-
He, G.1
Wang, H.R.2
Huang, S.K.3
Huang, C.L.4
-
34
-
-
0033605642
-
3-responsive epithelia
-
3-responsive epithelia. J Biol Chem 274: 8375-8378, 1999.
-
(1999)
J Biol Chem
, vol.274
, pp. 8375-8378
-
-
Hoenderop, J.G.1
van der Kemp, A.W.2
Hartog, A.3
van de Graaf, S.F.4
Van Os, C.H.5
Willems, P.H.6
Bindels, R.J.7
-
35
-
-
0347320924
-
2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5
-
2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5. J Clin Invest 112: 1906-1914, 2003.
-
(2003)
J Clin Invest
, vol.112
, pp. 1906-1914
-
-
Hoenderop, J.G.1
van Leeuwen, J.P.2
van der Eerden, B.C.3
Kersten, F.F.4
van der Kemp, A.W.5
Merillat, A.M.6
Waarsing, J.H.7
Rossier, B.C.8
Vallon, V.9
Hummler, E.10
Bindels, R.J.11
-
36
-
-
2942579352
-
Cloning, genomic organization, alternative splicing and expression analysis of the human gene WNK3 (PRKWNK3)
-
Holden S, Cox J, Raymond FL. Cloning, genomic organization, alternative splicing and expression analysis of the human gene WNK3 (PRKWNK3). Gene 335: 109-119, 2004.
-
(2004)
Gene
, vol.335
, pp. 109-119
-
-
Holden, S.1
Cox, J.2
Raymond, F.L.3
-
37
-
-
33845991201
-
Study of claudin function by RNA interference
-
Hou J, Gomes AS, Paul DL, Goodenough DA. Study of claudin function by RNA interference. J Biol Chem 281: 36117-36123, 2006.
-
(2006)
J Biol Chem
, vol.281
, pp. 36117-36123
-
-
Hou, J.1
Gomes, A.S.2
Paul, D.L.3
Goodenough, D.A.4
-
38
-
-
33846884647
-
WNK4 enhances TRPV5-mediated calcium transport: Potential role in hypercalciuria of familial hyperkalemic hypertension caused by gene mutation of WNK4
-
Jiang Y, Ferguson WB, Peng JB. WNK4 enhances TRPV5-mediated calcium transport: potential role in hypercalciuria of familial hyperkalemic hypertension caused by gene mutation of WNK4. Am J Physiol Renal Physiol 292: F545-F554, 2007.
-
(2007)
Am J Physiol Renal Physiol
, vol.292
-
-
Jiang, Y.1
Ferguson, W.B.2
Peng, J.B.3
-
39
-
-
1242319290
-
- flux in extrarenal epithelia
-
- flux in extrarenal epithelia. Proc Natl Acad Sci USA 101: 2064-2069, 2004.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 2064-2069
-
-
Kahle, K.T.1
Gimenez, I.2
Hassan, H.3
Wilson, F.H.4
Wong, R.D.5
Forbush, B.6
Aronson, P.S.7
Lifton, R.P.8
-
40
-
-
6944227814
-
- permeability is regulated by WNK4 kinase: Insight into normal physiology and hypertension
-
- permeability is regulated by WNK4 kinase: insight into normal physiology and hypertension. Proc Natl Acad Sci USA 101: 14877-14882, 2004.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 14877-14882
-
-
Kahle, K.T.1
MacGregor, G.G.2
Wilson, F.H.3
Van Hoek, A.N.4
Brown, D.5
Ardito, T.6
Kashgarian, M.7
Giebisch, G.8
Hebert, S.C.9
Boulpaep, E.L.10
Lifton, R.P.11
-
41
-
-
28044473649
-
- in and out of cells: Implications for control of cell volume and neuronal excitability
-
- in and out of cells: implications for control of cell volume and neuronal excitability. Proc Natl Acad Sci USA 102: 16783-16788, 2005.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 16783-16788
-
-
Kahle, K.T.1
Rinehart, J.2
de los, H.P.3
Louvi, A.4
Meade, P.5
Vazquez, N.6
Hebert, S.C.7
Gamba, G.8
Gimenez, I.9
Lifton, R.P.10
-
42
-
-
33749440293
-
- flux by altering the phosphorylation state of the Na-K-Cl and K-Cl cotransporters
-
- flux by altering the phosphorylation state of the Na-K-Cl and K-Cl cotransporters. Physiology (Bethesda) 21: 326-335, 2006.
-
(2006)
Physiology (Bethesda)
, vol.21
, pp. 326-335
-
-
Kahle, K.T.1
Rinehart, J.2
Ring, A.3
Gimenez, I.4
Gamba, G.5
Hebert, S.C.6
Lifton, R.P.7
-
43
-
-
4344656182
-
WNK kinases: Molecular regulators of integrated epithelial ion transport
-
Kahle KT, Wilson FH, Lalioti M, Toka H, Qin H, Lifton RP. WNK kinases: molecular regulators of integrated epithelial ion transport. Curr Opin Nephrol Hypertens 13: 557-562, 2004.
-
(2004)
Curr Opin Nephrol Hypertens
, vol.13
, pp. 557-562
-
-
Kahle, K.T.1
Wilson, F.H.2
Lalioti, M.3
Toka, H.4
Qin, H.5
Lifton, R.P.6
-
44
-
-
0345659215
-
+ secretion
-
+ secretion. Nat Genet 35: 372-376, 2003.
-
(2003)
Nat Genet
, vol.35
, pp. 372-376
-
-
Kahle, K.T.1
Wilson, F.H.2
Leng, Q.3
Lalioti, M.D.4
O'Connell, A.D.5
Dong, K.6
Rapson, A.K.7
MacGregor, G.G.8
Giebisch, G.9
Hebert, S.C.10
Lifton, R.P.11
-
45
-
-
15944412561
-
Regulation of diverse ion transport pathways by WNK4 kinase: A novel molecular switch
-
Kahle KT, Wilson FH, Lifton RP. Regulation of diverse ion transport pathways by WNK4 kinase: a novel molecular switch. Trends Endocrinol Metab 16: 98-103, 2005.
-
(2005)
Trends Endocrinol Metab
, vol.16
, pp. 98-103
-
-
Kahle, K.T.1
Wilson, F.H.2
Lifton, R.P.3
-
48
-
-
0036208599
-
Differential expression patterns of claudins, tight junction membrane proteins, in mouse nephron segments
-
Kiuchi-Saishin Y, Gotoh S, Furuse M, Takasuga A, Tano Y, Tsukita S. Differential expression patterns of claudins, tight junction membrane proteins, in mouse nephron segments. J Am Soc Nephrol 13: 875-886, 2002.
-
(2002)
J Am Soc Nephrol
, vol.13
, pp. 875-886
-
-
Kiuchi-Saishin, Y.1
Gotoh, S.2
Furuse, M.3
Takasuga, A.4
Tano, Y.5
Tsukita, S.6
-
49
-
-
0035979278
-
Identification of a chloride-formate exchanger expressed on the brush border membrane of renal proximal tubule cells
-
Knauf F, Yang CL, Thomson RB, Mentone SA, Giebisch G, Aronson PS. Identification of a chloride-formate exchanger expressed on the brush border membrane of renal proximal tubule cells. Proc Natl Acad Sci USA 98: 9425-9430, 2001.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 9425-9430
-
-
Knauf, F.1
Yang, C.L.2
Thomson, R.B.3
Mentone, S.A.4
Giebisch, G.5
Aronson, P.S.6
-
50
-
-
4744369165
-
Identification of 108 SNPs in TSC, WNK1, and WNK4 and their association with hypertension in a Japanese general population
-
Kokubo Y, Kamide K, Inamoto N, Tanaka C, Banno M, Takiuchi S, Kawano Y, Tomoike H, Miyata T. Identification of 108 SNPs in TSC, WNK1, and WNK4 and their association with hypertension in a Japanese general population. J Hum Genet 49: 507-515, 2004.
-
(2004)
J Hum Genet
, vol.49
, pp. 507-515
-
-
Kokubo, Y.1
Kamide, K.2
Inamoto, N.3
Tanaka, C.4
Banno, M.5
Takiuchi, S.6
Kawano, Y.7
Tomoike, H.8
Miyata, T.9
-
52
-
-
33749118898
-
Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule
-
Lalioti MD, Zhang J, Volkman HM, Kahle KT, Hoffmann KE, Toka HR, Nelson-Williams C, Ellison DH, Flavell R, Booth CJ, Lu Y, Geller DS, Lifton RP. Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule. Nat Genet 38: 1124-1132, 2006.
-
(2006)
Nat Genet
, vol.38
, pp. 1124-1132
-
-
Lalioti, M.D.1
Zhang, J.2
Volkman, H.M.3
Kahle, K.T.4
Hoffmann, K.E.5
Toka, H.R.6
Nelson-Williams, C.7
Ellison, D.H.8
Flavell, R.9
Booth, C.J.10
Lu, Y.11
Geller, D.S.12
Lifton, R.P.13
-
53
-
-
31944441600
-
Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms
-
Lazrak A, Liu Z, Huang CL. Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms. Proc Natl Acad Sci USA 103: 1615-1620, 2006.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 1615-1620
-
-
Lazrak, A.1
Liu, Z.2
Huang, C.L.3
-
54
-
-
4444327825
-
WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding
-
Lee BH, Min X, Heise CJ, Xu BE, Chen S, Shu H, Luby-Phelps K, Goldsmith EJ, Cobb MH. WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding. Mol Cell 15: 741-751, 2004.
-
(2004)
Mol Cell
, vol.15
, pp. 741-751
-
-
Lee, B.H.1
Min, X.2
Heise, C.J.3
Xu, B.E.4
Chen, S.5
Shu, H.6
Luby-Phelps, K.7
Goldsmith, E.J.8
Cobb, M.H.9
-
55
-
-
22844441657
-
Properties of WNK1 and implications for other family members
-
Lenertz LY, Lee BH, Min X, Xu BE, Wedin K, Earnest S, Goldsmith EJ, Cobb MH. Properties of WNK1 and implications for other family members. J Biol Chem 280: 26653-26658, 2005.
-
(2005)
J Biol Chem
, vol.280
, pp. 26653-26658
-
-
Lenertz, L.Y.1
Lee, B.H.2
Min, X.3
Xu, B.E.4
Wedin, K.5
Earnest, S.6
Goldsmith, E.J.7
Cobb, M.H.8
-
56
-
-
33645901817
-
+ channel ROMK1 (Kir1.1)
-
+ channel ROMK1 (Kir1.1). J Physiol 571: 275-286, 2006.
-
(2006)
J Physiol
, vol.571
, pp. 275-286
-
-
Leng, Q.1
Kahle, K.T.2
Rinehart, J.3
MacGregor, G.G.4
Wilson, F.H.5
Canessa, C.M.6
Lifton, R.P.7
Hebert, S.C.8
-
58
-
-
0034721648
-
Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmo-receptor
-
Liedtke W, Choe Y, Marti-Renom MA, Bell AM, Denis CS, Sali A, Hudspeth AJ, Friedman JM, Heller S. Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmo-receptor. Cell 103: 525-535, 2000.
-
(2000)
Cell
, vol.103
, pp. 525-535
-
-
Liedtke, W.1
Choe, Y.2
Marti-Renom, M.A.3
Bell, A.M.4
Denis, C.S.5
Sali, A.6
Hudspeth, A.J.7
Friedman, J.M.8
Heller, S.9
-
59
-
-
0035936780
-
Molecular mechanisms of human hypertension
-
Lifton RP, Gharavi AG, Geller DS. Molecular mechanisms of human hypertension. Cell 104: 545-556, 2001.
-
(2001)
Cell
, vol.104
, pp. 545-556
-
-
Lifton, R.P.1
Gharavi, A.G.2
Geller, D.S.3
-
60
-
-
0037376254
-
Sodium and calcium transport pathways along the mammalian distal nephron: From rabbit to human
-
Loffing J, Kaissling B. Sodium and calcium transport pathways along the mammalian distal nephron: from rabbit to human. Am J Physiol Renal Physiol 284: F628-F643, 2003.
-
(2003)
Am J Physiol Renal Physiol
, vol.284
-
-
Loffing, J.1
Kaissling, B.2
-
61
-
-
0035662188
-
Distribution of transcellular calcium and sodium transport pathways along mouse distal nephron
-
Loffing J, Loffing-Cueni D, Valderrabano V, Klausli L, Hebert SC, Rossier BC, Hoenderop JG, Bindels RJ, Kaissling B. Distribution of transcellular calcium and sodium transport pathways along mouse distal nephron. Am J Physiol Renal Physiol 281: F1021-F1027, 2001.
-
(2001)
Am J Physiol Renal Physiol
, vol.281
-
-
Loffing, J.1
Loffing-Cueni, D.2
Valderrabano, V.3
Klausli, L.4
Hebert, S.C.5
Rossier, B.C.6
Hoenderop, J.G.7
Bindels, R.J.8
Kaissling, B.9
-
62
-
-
33644659475
-
CFTR is required for PKA-regulated ATP sensitivity of Kir1.1 potassium channels in mouse kidney
-
Lu M, Leng Q, Egan ME, Caplan MJ, Boulpaep EL, Giebisch GH, Hebert SC. CFTR is required for PKA-regulated ATP sensitivity of Kir1.1 potassium channels in mouse kidney. J Clin Invest 116: 797-807, 2006.
-
(2006)
J Clin Invest
, vol.116
, pp. 797-807
-
-
Lu, M.1
Leng, Q.2
Egan, M.E.3
Caplan, M.J.4
Boulpaep, E.L.5
Giebisch, G.H.6
Hebert, S.C.7
-
63
-
-
4043170112
-
Hypercalciuria in familial hyperkalemia and hypertension accompanies hyperkalemia and precedes hypertension: Description of a large family with the Q565E WNK4 mutation
-
Mayan H, Munter G, Shaharabany M, Mouallem M, Pauzner R, Holtzman EJ, Farfel Z. Hypercalciuria in familial hyperkalemia and hypertension accompanies hyperkalemia and precedes hypertension: description of a large family with the Q565E WNK4 mutation. J Clin Endocrinol Metab 89: 4025-4030, 2004.
-
(2004)
J Clin Endocrinol Metab
, vol.89
, pp. 4025-4030
-
-
Mayan, H.1
Munter, G.2
Shaharabany, M.3
Mouallem, M.4
Pauzner, R.5
Holtzman, E.J.6
Farfel, Z.7
-
64
-
-
0036328423
-
Pseudohypoaldosteronism type II: Marked sensitivity to thiazides, hypercalciuria, normomagnesemia, and low bone mineral density
-
Mayan H, Vered I, Mouallem M, Tzadok-Witkon M, Pauzner R, Farfel Z. Pseudohypoaldosteronism type II: marked sensitivity to thiazides, hypercalciuria, normomagnesemia, and low bone mineral density. J Clin Endocrinol Metab 87: 3248-3254, 2002.
-
(2002)
J Clin Endocrinol Metab
, vol.87
, pp. 3248-3254
-
-
Mayan, H.1
Vered, I.2
Mouallem, M.3
Tzadok-Witkon, M.4
Pauzner, R.5
Farfel, Z.6
-
65
-
-
4644308674
-
Sodium and potassium handling by the aldosterone-sensitive distal nephron: The pivotal role of the distal and connecting tubule
-
Meneton P, Loffing J, Warnock DG. Sodium and potassium handling by the aldosterone-sensitive distal nephron: the pivotal role of the distal and connecting tubule. Am J Physiol Renal Physiol 287: F593-F601, 2004.
-
(2004)
Am J Physiol Renal Physiol
, vol.287
-
-
Meneton, P.1
Loffing, J.2
Warnock, D.G.3
-
66
-
-
30044442784
-
WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1
-
Moriguchi T, Urushiyama S, Hisamoto N, Iemura S, Uchida S, Natsume T, Matsumoto K, Shibuya H. WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1. J Biol Chem 280: 42685-42693, 2005.
-
(2005)
J Biol Chem
, vol.280
, pp. 42685-42693
-
-
Moriguchi, T.1
Urushiyama, S.2
Hisamoto, N.3
Iemura, S.4
Uchida, S.5
Natsume, T.6
Matsumoto, K.7
Shibuya, H.8
-
70
-
-
0035473453
-
Mitogenesis and endocytosis: What's at the INTERSECTIoN?
-
O'Bryan JP, Mohney RP, Oldham CE. Mitogenesis and endocytosis: what's at the INTERSECTIoN? Oncogene 20: 6300-6308, 2001.
-
(2001)
Oncogene
, vol.20
, pp. 6300-6308
-
-
O'Bryan, J.P.1
Mohney, R.P.2
Oldham, C.E.3
-
71
-
-
33748043980
-
Dietary electrolyte-driven responses in the renal WNK kinase pathway in vivo
-
O'Reilly M, Marshall E, Macgillivray T, Mittal M, Xue W, Kenyon CJ, Brown RW. Dietary electrolyte-driven responses in the renal WNK kinase pathway in vivo. J Am Soc Nephrol 17: 2402-2413, 2006.
-
(2006)
J Am Soc Nephrol
, vol.17
, pp. 2402-2413
-
-
O'Reilly, M.1
Marshall, E.2
Macgillivray, T.3
Mittal, M.4
Xue, W.5
Kenyon, C.J.6
Brown, R.W.7
-
72
-
-
0141455346
-
WNK1, a gene within a novel blood pressure control pathway, tissue-specifically generates radically different isoforms with and without a kinase domain
-
O'Reilly M, Marshall E, Speirs HJ, Brown RW. WNK1, a gene within a novel blood pressure control pathway, tissue-specifically generates radically different isoforms with and without a kinase domain. J Am Soc Nephrol 14: 2447-2456, 2003.
-
(2003)
J Am Soc Nephrol
, vol.14
, pp. 2447-2456
-
-
O'Reilly, M.1
Marshall, E.2
Speirs, H.J.3
Brown, R.W.4
-
73
-
-
33748430618
-
Overexpression of human WNK1 increases paracellular chloride permeability and phosphorylation of claudin-4 in MDCKII cells
-
Ohta A, Yang SS, Rai T, Chiga M, Sasaki S, Uchida S. Overexpression of human WNK1 increases paracellular chloride permeability and phosphorylation of claudin-4 in MDCKII cells. Biochem Biophys Res Commun 349: 804-808, 2006.
-
(2006)
Biochem Biophys Res Commun
, vol.349
, pp. 804-808
-
-
Ohta, A.1
Yang, S.S.2
Rai, T.3
Chiga, M.4
Sasaki, S.5
Uchida, S.6
-
74
-
-
33749386424
-
- cotransporter is activated and phosphorylated at the amino-terminal domain upon intracellular chloride depletion
-
- cotransporter is activated and phosphorylated at the amino-terminal domain upon intracellular chloride depletion. J Biol Chem 281: 28755-28763, 2006.
-
(2006)
J Biol Chem
, vol.281
, pp. 28755-28763
-
-
Pacheco-Alvarez, D.1
Cristobal, P.S.2
Meade, P.3
Moreno, E.4
Vazquez, N.5
Munoz, E.6
Diaz, A.7
Juarez, M.E.8
Gimenez, I.9
Gamba, G.10
-
75
-
-
0035878469
-
Structural conservation of the genes encoding CaT1, CaT2, and related cation channels
-
Peng JB, Brown EM, Hediger MA. Structural conservation of the genes encoding CaT1, CaT2, and related cation channels. Genomics 76: 99-109, 2001.
-
(2001)
Genomics
, vol.76
, pp. 99-109
-
-
Peng, J.B.1
Brown, E.M.2
Hediger, M.A.3
-
76
-
-
0034623088
-
A rat kidney-specific calcium transporter in the distal nephron
-
Peng JB, Chen XZ, Berger UV, Vassilev PM, Brown EM, Hediger MA. A rat kidney-specific calcium transporter in the distal nephron. J Biol Chem 275: 28186-28194, 2000.
-
(2000)
J Biol Chem
, vol.275
, pp. 28186-28194
-
-
Peng, J.B.1
Chen, X.Z.2
Berger, U.V.3
Vassilev, P.M.4
Brown, E.M.5
Hediger, M.A.6
-
77
-
-
0033529713
-
Molecular cloning and characterization of a channel-like transporter mediating intestinal calcium absorption
-
Peng JB, Chen XZ, Berger UV, Vassilev PM, Tsukaguchi H, Brown EM, Hediger MA. Molecular cloning and characterization of a channel-like transporter mediating intestinal calcium absorption. J Biol Chem 274: 22739-22746, 1999.
-
(1999)
J Biol Chem
, vol.274
, pp. 22739-22746
-
-
Peng, J.B.1
Chen, X.Z.2
Berger, U.V.3
Vassilev, P.M.4
Tsukaguchi, H.5
Brown, E.M.6
Hediger, M.A.7
-
78
-
-
0037184942
-
Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1)
-
Piechotta K, Lu J, Delpire E. Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1). J Biol Chem 277: 50812-50819, 2002.
-
(2002)
J Biol Chem
, vol.277
, pp. 50812-50819
-
-
Piechotta, K.1
Lu, J.2
Delpire, E.3
-
79
-
-
33748755186
-
Type 2 pseudohypoaldosteronism: New insights into renal potassium, sodium, and chloride handling
-
Proctor G, Linas S. Type 2 pseudohypoaldosteronism: new insights into renal potassium, sodium, and chloride handling. Am J Kidney Dis 48: 674-693, 2006.
-
(2006)
Am J Kidney Dis
, vol.48
, pp. 674-693
-
-
Proctor, G.1
Linas, S.2
-
80
-
-
0033963206
-
Mammalian distal tubule: Physiology, pathophysiology, and molecular anatomy
-
Reilly RF, Ellison DH. Mammalian distal tubule: physiology, pathophysiology, and molecular anatomy. Physiol Rev 80: 277-313, 2000.
-
(2000)
Physiol Rev
, vol.80
, pp. 277-313
-
-
Reilly, R.F.1
Ellison, D.H.2
-
81
-
-
28044458544
-
- cotransporters required for normal blood pressure homeostasis
-
- cotransporters required for normal blood pressure homeostasis. Proc Natl Acad Sci USA 102: 16777-16782, 2005.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 16777-16782
-
-
Rinehart, J.1
Kahle, K.T.2
de los, H.P.3
Vazquez, N.4
Meade, P.5
Wilson, F.H.6
Hebert, S.C.7
Gimenez, I.8
Gamba, G.9
Lifton, R.P.10
-
82
-
-
34247205230
-
+ channel in vitro and in vivo
-
+ channel in vitro and in vivo. Proc Natl Acad Sci USA 104: 4020-4024, 2007.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 4020-4024
-
-
Ring, A.M.1
Cheng, S.X.2
Leng, Q.3
Kahle, K.T.4
Rinehart, J.5
Lalioti, M.D.6
Volkman, H.M.7
Wilson, F.H.8
Hebert, S.C.9
Lifton, R.P.10
-
83
-
-
34247236088
-
+ homeostasis
-
+ homeostasis. Proc Natl Acad Sci USA 104: 4025-4029, 2007.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 4025-4029
-
-
Ring, A.M.1
Leng, Q.2
Rinehart, J.3
Wilson, F.H.4
Kahle, K.T.5
Hebert, S.C.6
Lifton, R.P.7
-
84
-
-
0024597863
-
Chloride- shunt syndrome: An overlooked cause of renal hypercalciuria
-
Rodriguez-Soriano J, Vallo A, Dominguez MJ. "Chloride- shunt" syndrome: an overlooked cause of renal hypercalciuria. Pediatr Nephrol 3: 113-121, 1989.
-
(1989)
Pediatr Nephrol
, vol.3
, pp. 113-121
-
-
Rodriguez-Soriano, J.1
Vallo, A.2
Dominguez, M.J.3
-
85
-
-
0032486393
-
Novel subunit composition of a renal epithelial KATP channel
-
Ruknudin A, Schulze DH, Sullivan SK, Lederer WJ, Welling PA. Novel subunit composition of a renal epithelial KATP channel. J Biol Chem 273: 14165-14171, 1998.
-
(1998)
J Biol Chem
, vol.273
, pp. 14165-14171
-
-
Ruknudin, A.1
Schulze, D.H.2
Sullivan, S.K.3
Lederer, W.J.4
Welling, P.A.5
-
86
-
-
0019480065
-
Mineralocorticoid- resistant renal hyperkalemia without salt wasting (type II pseudohypoaldosteronism): Role of increased renal chloride reabsorption
-
Schambelan M, Sebastian A, Rector FC Jr. Mineralocorticoid- resistant renal hyperkalemia without salt wasting (type II pseudohypoaldosteronism): role of increased renal chloride reabsorption. Kidney Int 19: 716-727, 1981.
-
(1981)
Kidney Int
, vol.19
, pp. 716-727
-
-
Schambelan, M.1
Sebastian, A.2
Rector Jr., F.C.3
-
87
-
-
15444355650
-
- cotransporter of the distal convoluted tubule
-
- cotransporter of the distal convoluted tubule. J Biol Chem 273: 29150-29155, 1998.
-
(1998)
J Biol Chem
, vol.273
, pp. 29150-29155
-
-
Schultheis, P.J.1
Lorenz, J.N.2
Meneton, P.3
Nieman, M.L.4
Riddle, T.M.5
Flagella, M.6
Duffy, J.J.7
Doetschman, T.8
Miller, M.L.9
Shull, G.E.10
-
88
-
-
0032956071
-
CFTR is a conductance regulator as well as a chloride channel
-
Schwiebert EM, Benos DJ, Egan ME, Stutts MJ, Guggino WB. CFTR is a conductance regulator as well as a chloride channel. Physiol Rev 79: S145-S166, 1999.
-
(1999)
Physiol Rev
, vol.79
-
-
Schwiebert, E.M.1
Benos, D.J.2
Egan, M.E.3
Stutts, M.J.4
Guggino, W.B.5
-
89
-
-
0023580221
-
The syndrome of hypertension and hyperkalaemia with normal glomerular function (Gordon's syndrome). A pathophysiological study
-
Semmekrot B, Monnens L, Theelen BG, Rascher W, Gabreels F, Willems J. The syndrome of hypertension and hyperkalaemia with normal glomerular function (Gordon's syndrome). A pathophysiological study. Pediatr Nephrol 1: 473-478, 1987.
-
(1987)
Pediatr Nephrol
, vol.1
, pp. 473-478
-
-
Semmekrot, B.1
Monnens, L.2
Theelen, B.G.3
Rascher, W.4
Gabreels, F.5
Willems, J.6
-
90
-
-
0027946089
-
Liddle's syndrome: Heritable human hypertension caused by mutations in the beta subunit of the epithelial sodium channel
-
Shimkets RA, Warnock DG, Bositis CM, Nelson-Williams C, Hansson JH, Schambelan M, Gill JR Jr, Ulick S, Milora RV, Findling JW. Liddle's syndrome: heritable human hypertension caused by mutations in the beta subunit of the epithelial sodium channel. Cell 79: 407-414, 1994.
-
(1994)
Cell
, vol.79
, pp. 407-414
-
-
Shimkets, R.A.1
Warnock, D.G.2
Bositis, C.M.3
Nelson-Williams, C.4
Hansson, J.H.5
Schambelan, M.6
Gill Jr, J.R.7
Ulick, S.8
Milora, R.V.9
Findling, J.W.10
-
91
-
-
9044235777
-
Gitelman's variant of Bartter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter
-
Simon DB, Nelson-Williams C, Bia MJ, Ellison D, Karet FE, Molina AM, Vaara I, Iwata F, Cushner HM, Koolen M, Gainza FJ, Gitleman HJ, Lifton RP. Gitelman's variant of Bartter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter. Nat Genet 12: 24-30, 1996.
-
(1996)
Nat Genet
, vol.12
, pp. 24-30
-
-
Simon, D.B.1
Nelson-Williams, C.2
Bia, M.J.3
Ellison, D.4
Karet, F.E.5
Molina, A.M.6
Vaara, I.7
Iwata, F.8
Cushner, H.M.9
Koolen, M.10
Gainza, F.J.11
Gitleman, H.J.12
Lifton, R.P.13
-
93
-
-
0034306198
-
OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity
-
Strotmann R, Harteneck C, Nunnenmacher K, Schultz G, Plant TD. OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity. Nat Cell Biol 2: 695-702, 2000.
-
(2000)
Nat Cell Biol
, vol.2
, pp. 695-702
-
-
Strotmann, R.1
Harteneck, C.2
Nunnenmacher, K.3
Schultz, G.4
Plant, T.D.5
-
94
-
-
0028982894
-
CFTR as a cAMP-dependent regulator of sodium channels
-
Stutts MJ, Canessa CM, Olsen JC, Hamrick M, Cohn JA, Rossier BC, Boucher RC. CFTR as a cAMP-dependent regulator of sodium channels. Science 269: 847-850, 1995.
-
(1995)
Science
, vol.269
, pp. 847-850
-
-
Stutts, M.J.1
Canessa, C.M.2
Olsen, J.C.3
Hamrick, M.4
Cohn, J.A.5
Rossier, B.C.6
Boucher, R.C.7
-
95
-
-
33747053620
-
WNK kinases regulate sodium chloride and potassium transport by the aldosterone-sensitive distal nephron
-
Subramanya AR, Yang CL, McCormick JA, Ellison DH. WNK kinases regulate sodium chloride and potassium transport by the aldosterone-sensitive distal nephron. Kidney Int 70: 630-634, 2006.
-
(2006)
Kidney Int
, vol.70
, pp. 630-634
-
-
Subramanya, A.R.1
Yang, C.L.2
McCormick, J.A.3
Ellison, D.H.4
-
97
-
-
2942677310
-
Renal expression of osmotically responsive cation channel TRPV4 is restricted to water-impermeant nephron segments
-
Tian W, Salanova M, Xu H, Lindsley JN, Oyama TT, Anderson S, Bachmann S, Cohen DM. Renal expression of osmotically responsive cation channel TRPV4 is restricted to water-impermeant nephron segments. Am J Physiol Renal Physiol 287: F17-F24, 2004.
-
(2004)
Am J Physiol Renal Physiol
, vol.287
-
-
Tian, W.1
Salanova, M.2
Xu, H.3
Lindsley, J.N.4
Oyama, T.T.5
Anderson, S.6
Bachmann, S.7
Cohen, D.M.8
-
99
-
-
0035817725
-
-
Verissimo F, Jordan P. WNK kinases, a novel protein kinase subfamily in multi-cellular organisms. Oncogene 20: 5562-5569, 2001.
-
Verissimo F, Jordan P. WNK kinases, a novel protein kinase subfamily in multi-cellular organisms. Oncogene 20: 5562-5569, 2001.
-
-
-
-
100
-
-
26844532768
-
The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases
-
Vitari AC, Deak M, Morrice NA, Alessi DR. The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases. Biochem J 391: 17-24, 2005.
-
(2005)
Biochem J
, vol.391
, pp. 17-24
-
-
Vitari, A.C.1
Deak, M.2
Morrice, N.A.3
Alessi, D.R.4
-
101
-
-
33745530924
-
Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1
-
Vitari AC, Thastrup J, Rafiqi FH, Deak M, Morrice NA, Karlsson HK, Alessi DR. Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1. Biochem J 397: 223-231, 2006.
-
(2006)
Biochem J
, vol.397
, pp. 223-231
-
-
Vitari, A.C.1
Thastrup, J.2
Rafiqi, F.H.3
Deak, M.4
Morrice, N.A.5
Karlsson, H.K.6
Alessi, D.R.7
-
102
-
-
33744811449
-
WNK1 kinase isoform switch regulates renal potassium excretion
-
Wade JB, Fang L, Liu J, Li D, Yang CL, Subramanya AR, Maouyo D, Mason A, Ellison DH, Welling PA. WNK1 kinase isoform switch regulates renal potassium excretion. Proc Natl Acad Sci USA 103: 8558-8563, 2006.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 8558-8563
-
-
Wade, J.B.1
Fang, L.2
Liu, J.3
Li, D.4
Yang, C.L.5
Subramanya, A.R.6
Maouyo, D.7
Mason, A.8
Ellison, D.H.9
Welling, P.A.10
-
103
-
-
0034922717
-
Genetic forms of human hypertension
-
Warnock DG. Genetic forms of human hypertension. Curr Opin Nephrol Hypertens 10: 493-499, 2001.
-
(2001)
Curr Opin Nephrol Hypertens
, vol.10
, pp. 493-499
-
-
Warnock, D.G.1
-
104
-
-
17944373014
-
Human hypertension caused by mutations in WNK kinases
-
Wilson FH, Disse-Nicodeme S, Choate KA, Ishikawa K, Nelson-Williams C, Desitter I, Gunel M, Milford DV, Lipkin GW, Achard JM, Feely MP, Dussol B, Berland Y, Unwin RJ, Mayan H, Simon DB, Farfel Z, Jeunemaitre X, Lifton RP. Human hypertension caused by mutations in WNK kinases. Science 293: 1107-1112, 2001.
-
(2001)
Science
, vol.293
, pp. 1107-1112
-
-
Wilson, F.H.1
Disse-Nicodeme, S.2
Choate, K.A.3
Ishikawa, K.4
Nelson-Williams, C.5
Desitter, I.6
Gunel, M.7
Milford, D.V.8
Lipkin, G.W.9
Achard, J.M.10
Feely, M.P.11
Dussol, B.12
Berland, Y.13
Unwin, R.J.14
Mayan, H.15
Simon, D.B.16
Farfel, Z.17
Jeunemaitre, X.18
Lifton, R.P.19
-
105
-
-
0037457965
-
Molecular pathogenesis of inherited hypertension with hyperkalemia: The Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4
-
Wilson FH, Kahle KT, Sabath E, Lalioti MD, Rapson AK, Hoover RS, Hebert SC, Gamba G, Lifton RP. Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4. Proc Natl Acad Sci USA 100: 680-684, 2003.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 680-684
-
-
Wilson, F.H.1
Kahle, K.T.2
Sabath, E.3
Lalioti, M.D.4
Rapson, A.K.5
Hoover, R.S.6
Hebert, S.C.7
Gamba, G.8
Lifton, R.P.9
-
106
-
-
0032773153
-
Cystic fibrosis transmembrane conductance regulator in the kidney: Clues to its role?
-
Wilson PD. Cystic fibrosis transmembrane conductance regulator in the kidney: clues to its role? Exp Nephrol 7: 284-289, 1999.
-
(1999)
Exp Nephrol
, vol.7
, pp. 284-289
-
-
Wilson, P.D.1
-
107
-
-
0034711336
-
Trp12, a novel Trp related protein from kidney
-
Wissenbach U, Bodding M, Freichel M, Flockerzi V. Trp12, a novel Trp related protein from kidney. FEBS Lett 485: 127-134, 2000.
-
(2000)
FEBS Lett
, vol.485
, pp. 127-134
-
-
Wissenbach, U.1
Bodding, M.2
Freichel, M.3
Flockerzi, V.4
-
108
-
-
33746977635
-
Role of with-no-lysine [K] kinases in the pathogenesis of Gordon's syndrome
-
Xie J, Craig L, Cobb MH, Huang CL. Role of with-no-lysine [K] kinases in the pathogenesis of Gordon's syndrome. Pediatr Nephrol 21: 1231-1236, 2006.
-
(2006)
Pediatr Nephrol
, vol.21
, pp. 1231-1236
-
-
Xie, J.1
Craig, L.2
Cobb, M.H.3
Huang, C.L.4
-
109
-
-
0034595634
-
WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II
-
Xu B, English JM, Wilsbacher JL, Stippec S, Goldsmith EJ, Cobb MH. WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II. J Biol Chem 275: 16795-16801, 2000.
-
(2000)
J Biol Chem
, vol.275
, pp. 16795-16801
-
-
Xu, B.1
English, J.M.2
Wilsbacher, J.L.3
Stippec, S.4
Goldsmith, E.J.5
Cobb, M.H.6
-
110
-
-
15944370197
-
WNK1: Analysis of protein kinase structure, downstream targets, and potential roles in hypertension
-
Xu BE, Lee BH, Min X, Lenertz L, Heise CJ, Stippec S, Goldsmith EJ, Cobb MH. WNK1: analysis of protein kinase structure, downstream targets, and potential roles in hypertension. Cell Res 15: 6-10, 2005.
-
(2005)
Cell Res
, vol.15
, pp. 6-10
-
-
Xu, B.E.1
Lee, B.H.2
Min, X.3
Lenertz, L.4
Heise, C.J.5
Stippec, S.6
Goldsmith, E.J.7
Cobb, M.H.8
-
111
-
-
22544472397
-
WNK1 activates SGK1 to regulate the epithelial sodium channel
-
Xu BE, Stippec S, Chu PY, Lazrak A, Li XJ, Lee BH, English JM, Ortega B, Huang CL, Cobb MH. WNK1 activates SGK1 to regulate the epithelial sodium channel. Proc Natl Acad Sci USA 102: 10315-10320, 2005.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 10315-10320
-
-
Xu, B.E.1
Stippec, S.2
Chu, P.Y.3
Lazrak, A.4
Li, X.J.5
Lee, B.H.6
English, J.M.7
Ortega, B.8
Huang, C.L.9
Cobb, M.H.10
-
112
-
-
26644449443
-
WNK1 activates SGK1 by a phosphatidylinositol 3-kinase-dependent and non-catalytic mechanism
-
Xu BE, Stippec S, Lazrak A, Huang CL, Cobb MH. WNK1 activates SGK1 by a phosphatidylinositol 3-kinase-dependent and non-catalytic mechanism. J Biol Chem 280: 34218-34223, 2005.
-
(2005)
J Biol Chem
, vol.280
, pp. 34218-34223
-
-
Xu, B.E.1
Stippec, S.2
Lazrak, A.3
Huang, C.L.4
Cobb, M.H.5
-
113
-
-
0036712421
-
Genome-wide detection of tissue-specific alternative splicing in the human transcriptome
-
Xu Q, Modrek B, Lee C. Genome-wide detection of tissue-specific alternative splicing in the human transcriptome. Nucleic Acids Res 30: 3754-3766, 2002.
-
(2002)
Nucleic Acids Res
, vol.30
, pp. 3754-3766
-
-
Xu, Q.1
Modrek, B.2
Lee, C.3
-
114
-
-
11144354175
-
Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins
-
Yamauchi K, Rai T, Kobayashi K, Sohara E, Suzuki T, Itoh T, Suda S, Hayama A, Sasaki S, Uchida S. Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins. Proc Natl Acad Sci USA 101: 4690-4694, 2004.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 4690-4694
-
-
Yamauchi, K.1
Rai, T.2
Kobayashi, K.3
Sohara, E.4
Suzuki, T.5
Itoh, T.6
Suda, S.7
Hayama, A.8
Sasaki, S.9
Uchida, S.10
-
115
-
-
19744374203
-
Apical localization of renal K channel was not altered in mutant WNK4 transgenic mice
-
Yamauchi K, Yang SS, Ohta A, Sohara E, Rai T, Sasaki S, Uchida S. Apical localization of renal K channel was not altered in mutant WNK4 transgenic mice. Biochem Biophys Res Commun 332: 750-755, 2005.
-
(2005)
Biochem Biophys Res Commun
, vol.332
, pp. 750-755
-
-
Yamauchi, K.1
Yang, S.S.2
Ohta, A.3
Sohara, E.4
Rai, T.5
Sasaki, S.6
Uchida, S.7
-
116
-
-
0037382807
-
WNK kinases regulate thiazide-sensitive Na-Cl cotransport
-
Yang CL, Angell J, Mitchell R, Ellison DH. WNK kinases regulate thiazide-sensitive Na-Cl cotransport. J Clin Invest 111: 1039-1045, 2003.
-
(2003)
J Clin Invest
, vol.111
, pp. 1039-1045
-
-
Yang, C.L.1
Angell, J.2
Mitchell, R.3
Ellison, D.H.4
-
117
-
-
33845969138
-
WNK1 and WNK4 modulate CFTR activity
-
Yang CL, Liu X, Paliege A, Zhu X, Bachmann S, Dawson DC, Ellison DH. WNK1 and WNK4 modulate CFTR activity. Biochem Biophys Res Commun 353: 535-540, 2007.
-
(2007)
Biochem Biophys Res Commun
, vol.353
, pp. 535-540
-
-
Yang, C.L.1
Liu, X.2
Paliege, A.3
Zhu, X.4
Bachmann, S.5
Dawson, D.C.6
Ellison, D.H.7
-
118
-
-
18244373189
-
Mechanisms of WNK1 and WNK4 interaction in the regulation of thiazide-sensitive NaCl cotransport
-
Yang CL, Zhu X, Wang Z, Subramanya AR, Ellison DH. Mechanisms of WNK1 and WNK4 interaction in the regulation of thiazide-sensitive NaCl cotransport. J Clin Invest 115: 1379-1387, 2005.
-
(2005)
J Clin Invest
, vol.115
, pp. 1379-1387
-
-
Yang, C.L.1
Zhu, X.2
Wang, Z.3
Subramanya, A.R.4
Ellison, D.H.5
-
119
-
-
34247617951
-
D561A/+ knockin mouse model
-
D561A/+ knockin mouse model. Cell Metab 5: 331-344, 2007.
-
(2007)
Cell Metab
, vol.5
, pp. 331-344
-
-
Yang, S.S.1
Morimoto, T.2
Rai, T.3
Chiga, M.4
Sohara, E.5
Ohno, M.6
Uchida, K.7
Lin, S.H.8
Moriguchi, T.9
Shibuya, H.10
Kondo, Y.11
Sasaki, S.12
Uchida, S.13
-
120
-
-
20144381210
-
Regulation of apical localization of the thiazide-sensitive NaCl cotransporter by WNK4 in polarized epithelial cells
-
Yang SS, Yamauchi K, Rai T, Hiyama A, Sohara E, Suzuki T, Itoh T, Suda S, Sasaki S, Uchida S. Regulation of apical localization of the thiazide-sensitive NaCl cotransporter by WNK4 in polarized epithelial cells. Biochem Biophys Res Commun 330: 410-414, 2005.
-
(2005)
Biochem Biophys Res Commun
, vol.330
, pp. 410-414
-
-
Yang, S.S.1
Yamauchi, K.2
Rai, T.3
Hiyama, A.4
Sohara, E.5
Suzuki, T.6
Itoh, T.7
Suda, S.8
Sasaki, S.9
Uchida, S.10
-
121
-
-
0038786618
-
Cell surface expression of the ROMK (Kir 1.1) channel is regulated by the aldosterone-induced kinase, SGK-1, and protein kinase A
-
Yoo D, Kim BY, Campo C, Nance L, King A, Maouyo D, Welling PA. Cell surface expression of the ROMK (Kir 1.1) channel is regulated by the aldosterone-induced kinase, SGK-1, and protein kinase A. J Biol Chem 278: 23066-23075, 2003.
-
(2003)
J Biol Chem
, vol.278
, pp. 23066-23075
-
-
Yoo, D.1
Kim, B.Y.2
Campo, C.3
Nance, L.4
King, A.5
Maouyo, D.6
Welling, P.A.7
-
122
-
-
18744369879
-
+ channel ROMK1
-
+ channel ROMK1. J Am Soc Nephrol 13: 2823-2830, 2002.
-
(2002)
J Am Soc Nephrol
, vol.13
, pp. 2823-2830
-
-
Yun, C.C.1
Palmada, M.2
Embark, H.M.3
Fedorenko, O.4
Feng, Y.5
Henke, G.6
Setiawan, I.7
Boehmer, C.8
Weinman, E.J.9
Sandrasagra, S.10
Korbmacher, C.11
Cohen, P.12
Pearce, D.13
Lang, F.14
-
123
-
-
10744226663
-
-
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW Jr, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van S, I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci USA 100: 14109-14114, 2003.
-
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW Jr, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van S, I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci USA 100: 14109-14114, 2003.
-
-
-
-
124
-
-
0036783531
-
Evidence for endocytosis of ROMK potassium channel via clathrin-coated vesicles
-
Zeng WZ, Babich V, Ortega B, Quigley R, White SJ, Welling PA, Huang CL. Evidence for endocytosis of ROMK potassium channel via clathrin-coated vesicles. Am J Physiol Renal Physiol 283: F630-F639, 2002.
-
(2002)
Am J Physiol Renal Physiol
, vol.283
-
-
Zeng, W.Z.1
Babich, V.2
Ortega, B.3
Quigley, R.4
White, S.J.5
Welling, P.A.6
Huang, C.L.7
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