Flow cytometric analysis of breast cancer resistance protein expression and function

Cytometry

Volumn 48, Issue 2, 2002, Pages 59-65

  Minderman, Hans ^a   Suvannasankha, Attaya ^a   O'Loughlin, Kieran L ^a   Scheffer, George L ^b   Scheper, Rik J ^b   Robey, Robert W ^c   Baer, Maria R ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Breast cancer resistance protein; Mitoxantrone; Multidrug resistance

Indexed keywords

3,3' DIETHYLOXACARBOCYANINE IODIDE; ABC TRANSPORTER; BREAST CANCER RESISTANCE PROTEIN; DOXORUBICIN; FUMITREMORGIN C; GLYCOPROTEIN P; MITOXANTRONE; MONOCLONAL ANTIBODY; MULTIDRUG RESISTANCE PROTEIN 1; RHODAMINE 123; UNCLASSIFIED DRUG; ABCG2 PROTEIN, HUMAN; ANTINEOPLASTIC AGENT; TUMOR PROTEIN;

ARTICLE; BREAST CANCER; CANCER RESISTANCE; CELL LEVEL; CONTROLLED STUDY; DRUG UPTAKE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; PRIORITY JOURNAL; PROTEIN EXPRESSION; BIOSYNTHESIS; BREAST TUMOR; CELL CULTURE; CHEMISTRY; DRUG RESISTANCE; IMMUNOLOGY; METABOLISM; METHODOLOGY; MULTIDRUG RESISTANCE;

ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; BREAST NEOPLASMS; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; FLOW CYTOMETRY; HUMAN; IMMUNOPHENOTYPING; MITOXANTRONE; NEOPLASM PROTEINS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TUMOR CELLS, CULTURED; HUMANS;

EID: 0036591798     PISSN: 01964763     EISSN: None     Source Type: Journal    
DOI: 10.1002/cyto.10111     Document Type: Article

References (27)

1. A multidrug resistance transporter from human MCF-7 breast cancer cells
2. Novel mechanisms of drug resistance in leukemia
3. Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: Demonstration of homology to ABC transport genes
4. A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance
5. A functional assay for detection of the mitoxantrone resistance protein, MXR (ABCG2)
6. Overexpression of the BCRP/MXR/ABCP gene in a topotecan-selected ovarian tumor cell line
7. Camptothecin resistance: Role of the ATP-binding cassette (ABC), mitoxantrone-resistance half-transporter (MXR), and potential for glucuronidation in MXR-expressing cells
8. Breast cancer resistance protein is localized at the plasma membrane in mitoxantrone and topotecan-resistant cell lines
9. Specific detection of breast cancer resistance protein with a monoclonal antibody
10. Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues
11. Methods to detect P-glycoprotein-associated multidrug resistance in patients' tumors: Consensus recommendations
12. Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells
13. Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein
14. Reversal of a novel multidrug resistance mechanism in human colon carcinoma cells by fumitremorgin C
15. Cellular pharmacology of mitoxantrone in p-glycoprotein-positive and -negative human myeloid leukemic cell lines
16. A unique human ovarian carcinoma cell line expressing CD34 in association with selection for multidrug resistance
17. Isolation and characterization of adriamycin-resistant HL60 cells which are not defective in the initial accumulation of the drug
18. Multiple mechanisms confer drug resistance to mitoxantrone in the human 8226 myeloma cell line
19. Proof without prejudice: Use of the Kolmogorov-Smirnov test for the analysis of histograms from flow systems and other sources
20. Titering antibodies
21. Frequency and clinical significance of the expression of the multidrug resistance proteins MDR1/P-glycoprotein, MRP1, and LRP in acute myeloid leukemia: A Southwest Oncology Group Study
22. Subcellular distribution of the anticancer drug mitoxantrone in human and drug-resistant murine cells analyzed by flow cytometry and confocal microscopy and its relationship to the induction of DNA damage
23. Phase III study of the multidrug resistance modulator PSC-833 in previously untreated patients 60 years of age and older with acute myeloid leukemia: Cancer and Leukemia Group B study 9720
24. A novel 7-modified camptothecin analog overcomes breast cancer resistance protein-associated resistance in a mitoxantrone-selected colon carcinoma cell line
25. Circumvention of breast cancer resistance protein (BCRP)-mediated resistance to camptothecins in vitro using non-substrate drugs or the BCRP inhibitor GF120918
26. Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C