Influence of phenyl ring disubstitution on bisbenzimidazole and terbenzimidazole cytotoxicity: Synthesis and biological evaluation as radioprotectors

Journal of Medicinal Chemistry

Volumn 46, Issue 18, 2003, Pages 3785-3792

  Tawar, Urmila ^a   Jain, Akash K ^a   Dwarakanath, B S ^b   Chandra, Ramesh ^a   Singh, Yogendra ^a,c   Chaudhury, N K ^b   Khaitan, Divya ^b   Tandon, Vibha ^a  

^a UNIVERSITY OF DELHI   (India)

^b INSTITUTE OF NUCLEAR MEDICINE AND ALLIED SCIENCES   (India)

^c CSIR INSTITUTE OF GENOMICS AND INTEGRATIVE BIOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; 5 (4 METHYLPIPERAZIN 1 YL) 2 [2' (3,4 DIMETHOXYPHENYL) 5' BENZIMIDAZOLYL]BENZIMIDAZOLE; 5 (4 METHYLPIPERAZIN 1 YL) 2 [2' [2'' (4 HYDROXY 3 METHOXYPHENYL) 5'' BENZIMIDAZOLYL] 5' BENZIMIDAZOLYL]BENZIMIDAZOLE; BENZIMIDAZOLE DERIVATIVE; HOE 33342; IMIDAZOLE DERIVATIVE; PHENYL GROUP; PIBENZIMOL; TERBENZIMIDAZOLE; UNCLASSIFIED DRUG;

ARTICLE; CELL PROLIFERATION; CLONOGENESIS; CRYSTAL STRUCTURE; DNA DAMAGE; DNA STRAND BREAKAGE; DRUG CYTOTOXICITY; DRUG SCREENING; FLOW CYTOMETRY; GLIOMA CELL; HYDROGEN BOND; LINEAR ENERGY TRANSFER; PROTEIN DNA INTERACTION; RADIATION EXPOSURE; RADIATION INJURY; RADIATION PROTECTION; SYNTHESIS;

ANIMALS; BENZIMIDAZOLES; CELL DIVISION; CELL SURVIVAL; DNA; FLUORESCENCE; GAMMA RAYS; HUMANS; LYMPHOCYTES; PIPERAZINES; RADIATION-PROTECTIVE AGENTS; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0042929700     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030114w     Document Type: Article

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