Kinetic analysis of the activation of 4-(methylnitrosamino)-1-(3- pyridyl)-1-butanone by heterologously expressed human P450 enzymes and the effect of P450-specific chemical inhibitors on this activation in human liver microsomes

Archives of Biochemistry and Biophysics

Volumn 333, Issue 1, 1996, Pages 127-138

  Patten, Christopher J ^a,d   Smith, Theresa J ^b   Murphy, Sharon E ^c   Wang, Mong Heng ^b   Lee, Jae ^a   Tynes, Ronald E ^a   Koch, Patrick ^a   Yang, Chung S ^b  

^a Sandoz Pharma Ltd   (Switzerland)

^b RUTGERS UNIVERSITY   (United States)

^c AMERICAN HEALTH FOUNDATION   (United States)

^d UNIVERSITY OF MINNESOTA   (United States)

Author keywords

4 (methylnitrosamino) 1 (3 pyridyl) 1 butanone; cytochrome b5; Human cytochrome P450; keto alcohol; keto aldehyde

Indexed keywords

4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE; CYTOCHROME P450;

ARTICLE; CHEMICAL CARCINOGENESIS; DRUG DNA INTERACTION; DRUG PROTEIN BINDING; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME KINETICS; HUMAN; HUMAN TISSUE; HYDROXYLATION; LIVER MICROSOME; PRIORITY JOURNAL; SMOKING;

EID: 0030248683     PISSN: 00039861     EISSN: None     Source Type: Journal    
DOI: 10.1006/abbi.1996.0373     Document Type: Article

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