Cytochrome P450 bio-affinity detection coupled to gradient HPLC: On-line screening of affinities to cytochrome P4501A2 and 2D6

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 858, Issue 1-2, 2007, Pages 49-58

  Kool, Jeroen ^a   van Liempd, Sebastiaan M ^a   Harmsen, Stefan ^a   Beckman, Joran ^a   van Elswijk, Danny ^b   Commandeur, Jan N M ^a   Irth, Hubertus ^b   Vermeulen, Nico P E ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

^b Kiadis BV   (Netherlands)

Author keywords

Bio affinity detection; Cytochrome P450; HPLC; On line

Indexed keywords

BIO AFFINITY DETECTION; ENZYME AFFINITY DETECTION (EAD); FLOW INJECTION ANALYSIS; INHIBITORY ACTIVITIES;

BINARY MIXTURES; CHIRALITY; DRUG PRODUCTS; ENZYME ACTIVITY; ISOMERS; LIGANDS; ONLINE SYSTEMS; PROTEINS;

AFFINITY CHROMATOGRAPHY;

CODEINE; CYTOCHROME P450 1A2; CYTOCHROME P450 2D6; CYTOCHROME P450 INHIBITOR; DEXTROMETHORPHAN; QUINIDINE; QUININE; SPARTEINE; TRIPROLIDINE;

ARTICLE; CHIRALITY; CONTROLLED STUDY; ENZYME INHIBITION; FLOW INJECTION ANALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; PRIORITY JOURNAL; SCREENING; STEREOISOMERISM;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 CYP2D6; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; STEREOISOMERISM;

EID: 34848921470     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2007.08.005     Document Type: Article

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