메뉴 건너뛰기




Volumn 8, Issue 3, 2006, Pages 224-230

New developments in clinically relevant mechanisms and treatment of hyperuricemia

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ALLOPURINOL; ATORVASTATIN; BENZBROMARONE; COLCHICINE; EMD 336340; FEBUXOSTAT; FENOFIBRATE; LACTIC ACID; LOSARTAN; NAPROXEN; OXIPURINOL; PEG URICASE; PROBENECID; PROTEIN; PYRAZINAMIDE; RASBURICASE; SALICYLIC ACID; SULFINPYRAZONE; UNCLASSIFIED DRUG; URATE OXIDASE; URATE TRANSPORTER 1; URIC ACID; URICOSURIC AGENT; XANTHINE OXIDASE INHIBITOR; THIAZOLE DERIVATIVE; XANTHINE OXIDASE;

EID: 33747626684     PISSN: 15233774     EISSN: 15346307     Source Type: Journal    
DOI: 10.1007/s11926-996-0029-z     Document Type: Review
Times cited : (21)

References (51)
  • 1
    • 0142123411 scopus 로고    scopus 로고
    • Gout
    • Terkeltaub RA: Gout. N Engl J Med 2003, 349:1647-1655. This comprehensive review provides evidence and clinical recommendations for the treatment of acute and chronic gout. This paper focuses on therapeutic agents that are currently approved and available for the treatment of gout.
    • (2003) N Engl J Med , vol.349 , pp. 1647-1655
    • Terkeltaub, R.A.1
  • 2
    • 0038391240 scopus 로고    scopus 로고
    • A literature review of the epidemiology and treatment of acute gout
    • Kim KY, Schumacher R, Hunsche E, et al.: A literature review of the epidemiology and treatment of acute gout. Clin Ther 2003, 25:1593-1617.
    • (2003) Clin Ther , vol.25 , pp. 1593-1617
    • Kim, K.Y.1    Schumacher, R.2    Hunsche, E.3
  • 3
    • 4043075471 scopus 로고    scopus 로고
    • Gout: On the brink of novel therapeutic options for an ancient disease
    • Bieber JD, Terkeltaub RA: Gout: on the brink of novel therapeutic options for an ancient disease. Arthritis Rheum 2004, 50:2400-2414. This is an excellent review of risk factors associated with gout and comments on potential etiologies for the rising prevalence of gout. This paper further discusses recent advances in translational research and their implications for the management options for gout.
    • (2004) Arthritis Rheum , vol.50 , pp. 2400-2414
    • Bieber, J.D.1    Terkeltaub, R.A.2
  • 4
    • 3442899325 scopus 로고    scopus 로고
    • Increasing prevalence of gout and hyperuricemia over 10 years among older adults in a managed care population
    • Wallace KL, Riedel AA, Joseph-Ridge N, Wortmann R: Increasing prevalence of gout and hyperuricemia over 10 years among older adults in a managed care population. J Rheumatol 2004, 31:1582-1587.
    • (2004) J Rheumatol , vol.31 , pp. 1582-1587
    • Wallace, K.L.1    Riedel, A.A.2    Joseph-Ridge, N.3    Wortmann, R.4
  • 5
    • 0028057410 scopus 로고
    • Hyperuricemia and urate nephropathy in urate oxidae-deficient mice
    • Wu X, Wakamiya M, Vaishnav S, et al.: Hyperuricemia and urate nephropathy in urate oxidae-deficient mice. Proc Natl Acad Sci U S A 1994, 91:742-746.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 742-746
    • Wu, X.1    Wakamiya, M.2    Vaishnav, S.3
  • 6
    • 0031863414 scopus 로고    scopus 로고
    • Optimal range of serum urate concentrations to minimize risk of gouty attacks during anti-hyperuricemic treatment
    • Yamanaka H, Togashi R, Hokoda M, et al.: Optimal range of serum urate concentrations to minimize risk of gouty attacks during anti-hyperuricemic treatment. Adv Exp Med Biol 1998, 431:13-18.
    • (1998) Adv Exp Med Biol , vol.431 , pp. 13-18
    • Yamanaka, H.1    Togashi, R.2    Hokoda, M.3
  • 7
    • 29144531158 scopus 로고    scopus 로고
    • New-onset gout after kidney transplantation: Incidence, risk factors and implications
    • Abbott KC, Kimmel PL, Dharnidharka V, et al.: New-onset gout after kidney transplantation: incidence, risk factors and implications. Transplantation 2005, 80:1383-1391.
    • (2005) Transplantation , vol.80 , pp. 1383-1391
    • Abbott, K.C.1    Kimmel, P.L.2    Dharnidharka, V.3
  • 8
    • 23844514428 scopus 로고    scopus 로고
    • Renal urate handling: Clinical relevance of recent advances
    • Anzai N, Enomoto A, Endou H: Renal urate handling: clinical relevance of recent advances. Curr Rheum Rep 2005, 7:227-234. This review summarizes recent molecular findings of urate transport and provides insights on how these new discoveries may contribute to the development of new uricosuric drugs.
    • (2005) Curr Rheum Rep , vol.7 , pp. 227-234
    • Anzai, N.1    Enomoto, A.2    Endou, H.3
  • 10
    • 0037161834 scopus 로고    scopus 로고
    • Molecular identification of a renal urate anion exchanger that regulates blood urate levels
    • Enomoto A, Kimura H, Chairoungdua A, et al.: Molecular identification of a renal urate anion exchanger that regulates blood urate levels. Nature 2002, 417:447-452.
    • (2002) Nature , vol.417 , pp. 447-452
    • Enomoto, A.1    Kimura, H.2    Chairoungdua, A.3
  • 12
    • 0346734163 scopus 로고    scopus 로고
    • Clinical and molecular analysis of patients with renal hypouricemia in Japan-influence of URAT1 gene on urinary urate excretion
    • Ichida K, Hosoyamada M, Hisatome I, et al.: Clinical and molecular analysis of patients with renal hypouricemia in Japan-influence of URAT1 gene on urinary urate excretion. J Am Soc Nephrol 2004, 15:164-173.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 164-173
    • Ichida, K.1    Hosoyamada, M.2    Hisatome, I.3
  • 13
    • 31144433386 scopus 로고    scopus 로고
    • Association of the human urate transporter 1 with reduced renal uric acid excretion and hyperuricemia in a German Caucasian population
    • Graessler J, Graessler A, Unger S, et al.: Association of the human urate transporter 1 with reduced renal uric acid excretion and hyperuricemia in a German Caucasian population. Arthritis Rheum 2006, 54:292-300.
    • (2006) Arthritis Rheum , vol.54 , pp. 292-300
    • Graessler, J.1    Graessler, A.2    Unger, S.3
  • 14
    • 23644434855 scopus 로고    scopus 로고
    • A common mutation in an organic anion transporter gene, SLC22A12, is a suppressing factor for the development of gout
    • Taniguchi A, Urano W, Yamanaka M, et al.: A common mutation in an organic anion transporter gene, SLC22A12, is a suppressing factor for the development of gout. Arthritis Rheum 2005, 52:2576-2577.
    • (2005) Arthritis Rheum , vol.52 , pp. 2576-2577
    • Taniguchi, A.1    Urano, W.2    Yamanaka, M.3
  • 15
    • 12344327218 scopus 로고    scopus 로고
    • Intake of purine-rich foods, protein, and dairy products and relationship to serum levels of uric acid. The Third National Health and Nutrition Examination Survey
    • Choi HK, Liu S, Curhan G: Intake of purine-rich foods, protein, and dairy products and relationship to serum levels of uric acid. The Third National Health and Nutrition Examination Survey. Arthritis Rheum 2005, 52:283-239.
    • (2005) Arthritis Rheum , vol.52 , pp. 283-1239
    • Choi, H.K.1    Liu, S.2    Curhan, G.3
  • 16
    • 0033936010 scopus 로고    scopus 로고
    • Beneficial effects of weight loss associated with moderate calorie/carbohydrate restriction, and increased proportional intake of protein and unsaturated fat on serum urate and lipoprotein levels in gout: A pilot study
    • Dessein PH, Shipton EA, Stanwix AE, et al.: Beneficial effects of weight loss associated with moderate calorie/carbohydrate restriction, and increased proportional intake of protein and unsaturated fat on serum urate and lipoprotein levels in gout: a pilot study. Ann Rheum Dis 2000, 59:539-543. This is the first paper assessing the impact of dietary modification on serum uric acid level and the frequency of gout flares. Unlike traditional dietary recommendations of low purine and protein intake, this study utilizes a low carbohydrate/high protein diet aimed at lowering insulin resistance to decrease the risk of gout.
    • (2000) Ann Rheum Dis , vol.59 , pp. 539-543
    • Dessein, P.H.1    Shipton, E.A.2    Stanwix, A.E.3
  • 17
    • 10344228746 scopus 로고    scopus 로고
    • Current management of gout in patients unresponsive or allergic to allopurinol
    • Bardin T: Current management of gout in patients unresponsive or allergic to allopurinol. Joint Bone Spine 2004, 71:481-485.
    • (2004) Joint Bone Spine , vol.71 , pp. 481-485
    • Bardin, T.1
  • 18
    • 27544474476 scopus 로고    scopus 로고
    • Effect on serum uric acid levels of drugs prescribed for indications other than treating hyperuricaemia
    • Daskalopoulou SS, Tzovaras V, Mikhailidis DP, Elisaf M: Effect on serum uric acid levels of drugs prescribed for indications other than treating hyperuricaemia. Curr Pharm Des 2005, 11:4161-4175.
    • (2005) Curr Pharm des , vol.11 , pp. 4161-4175
    • Daskalopoulou, S.S.1    Tzovaras, V.2    Mikhailidis, D.P.3    Elisaf, M.4
  • 20
    • 0035959369 scopus 로고    scopus 로고
    • Uricosuric effect of losartan in patients with renal transplants
    • Kamper AI, Nielsen AH: Uricosuric effect of losartan in patients with renal transplants. Transplantation 2001, 72:671-674.
    • (2001) Transplantation , vol.72 , pp. 671-674
    • Kamper, A.I.1    Nielsen, A.H.2
  • 21
    • 0344406269 scopus 로고    scopus 로고
    • Fenofibrate enhances urate reduction in men treated with allopurinol for hyperuricaemia and gout
    • Feher MD, Hepburn AL, Hogarth MB, et al.: Fenofibrate enhances urate reduction in men treated with allopurinol for hyperuricaemia and gout. Rheumatology 2003, 42:321-325.
    • (2003) Rheumatology , vol.42 , pp. 321-325
    • Feher, M.D.1    Hepburn, A.L.2    Hogarth, M.B.3
  • 22
    • 0038543274 scopus 로고    scopus 로고
    • Long term remission from gout associated with fenofibrate therapy
    • Hepburn AL, Kaye SA, Feher MD: Long term remission from gout associated with fenofibrate therapy. Clin Rheumatol 2003, 22:73-76.
    • (2003) Clin Rheumatol , vol.22 , pp. 73-76
    • Hepburn, A.L.1    Kaye, S.A.2    Feher, M.D.3
  • 23
    • 33750416367 scopus 로고    scopus 로고
    • Effect of fenofibrate in combination with urate lowering agents in patients with gout
    • Lee Y, Lee J: Effect of fenofibrate in combination with urate lowering agents in patients with gout. Arthritis Rheum 2005, 52(Suppl 9):S104.
    • (2005) Arthritis Rheum , vol.52 , Issue.SUPPL. 9
    • Lee, Y.1    Lee, J.2
  • 24
    • 33644815752 scopus 로고    scopus 로고
    • Effect of losartan versus candesartan on uric acid, renal function, and fibrinogen in patients with hypertension and hyperuricemia associated with diuretics
    • Rayner BL, Trinder YA, Baines D, et al.: Effect of losartan versus candesartan on uric acid, renal function, and fibrinogen in patients with hypertension and hyperuricemia associated with diuretics. Am J Hypertens 2006, 19:208-213. This paper highlights the uricosuric effect of losartan, independent of its angiotensin II receptor blockade.
    • (2006) Am J Hypertens , vol.19 , pp. 208-213
    • Rayner, B.L.1    Trinder, Y.A.2    Baines, D.3
  • 25
    • 0035126731 scopus 로고    scopus 로고
    • Homocysteine and lipid lowering agents. A comparison between atorvastatin and fenofibrate in patients with mixed hyperlipidemia
    • Giral P, Bruckert E, Jacob N, et al.: Homocysteine and lipid lowering agents. A comparison between atorvastatin and fenofibrate in patients with mixed hyperlipidemia. Atherosclerosis 2001, 154:421-447.
    • (2001) Atherosclerosis , vol.154 , pp. 421-447
    • Giral, P.1    Bruckert, E.2    Jacob, N.3
  • 26
    • 5344244028 scopus 로고    scopus 로고
    • Effects of statin treatment on uric acid homeostasis in patients with primary hyperlipidemia
    • Milionis HJ, Kakafika AI, Tsouli SG, et al.: Effects of statin treatment on uric acid homeostasis in patients with primary hyperlipidemia. Am Heart J 2004, 148:635-640. This is a randomized study designed to evaluate the effects of atorvastatin and simvastatin on uric acid homeostasis. In this trial, only atorvastatin was shown to significantly lower serum uric acid levels.
    • (2004) Am Heart J , vol.148 , pp. 635-640
    • Milionis, H.J.1    Kakafika, A.I.2    Tsouli, S.G.3
  • 28
    • 1542268611 scopus 로고    scopus 로고
    • Effect of statins versus untreated dyslipidemia on serum uric acid levels in patients with coronary heart disease: A subgroup analysis of CREek Atorvastain and Coronary-heart-disease Evaluation (GREACE) study
    • Athyros BG, Elisaf M, Papageorgious AA, et al.: Effect of statins versus untreated dyslipidemia on serum uric acid levels in patients with coronary heart disease: a subgroup analysis of CREek Atorvastain and Coronary-heart-disease Evaluation (GREACE) study. Am J Kidney Dis 2004, 43:589-599.
    • (2004) Am J Kidney Dis , vol.43 , pp. 589-599
    • Athyros, B.G.1    Elisaf, M.2    Papageorgious, A.A.3
  • 29
    • 33748490579 scopus 로고    scopus 로고
    • Potent and rapid uricosuric effect of single and repeated doses of EMD 336340 in healthy volunteers
    • Fouqueray P, Zeiller J: Potent and rapid uricosuric effect of single and repeated doses of EMD 336340 in healthy volunteers. Arthritis Rheum 2005, 52(Suppl 9):S101.
    • (2005) Arthritis Rheum , vol.52 , Issue.SUPPL. 9
    • Fouqueray, P.1    Zeiller, J.2
  • 31
    • 10044275104 scopus 로고    scopus 로고
    • Colchicine for prophylaxis of acute flares when initiating allopurinol for chronic gouty arthritis
    • Borstad GC, Bryant LR, Abel MP, et al.: Colchicine for prophylaxis of acute flares when initiating allopurinol for chronic gouty arthritis. J Rheumatol 2004, 31:2429-2432.
    • (2004) J Rheumatol , vol.31 , pp. 2429-2432
    • Borstad, G.C.1    Bryant, L.R.2    Abel, M.P.3
  • 32
    • 15244349566 scopus 로고    scopus 로고
    • HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol
    • Hung SI, Chung WH, Liou LB, et al.: HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol. Proc Natl Acad Sci U S A 2005, 102:4134-4139.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 4134-4139
    • Hung, S.I.1    Chung, W.H.2    Liou, L.B.3
  • 33
    • 33750395033 scopus 로고    scopus 로고
    • Efficacy and safety of desensitization to allopurinol following cutaneous reactions
    • Fam AG, Dunne SM, Iazzetta J, Paton TW: Efficacy and safety of desensitization to allopurinol following cutaneous reactions. Arthritis Rheum 2001, 60:981-983.
    • (2001) Arthritis Rheum , vol.60 , pp. 981-983
    • Fam, A.G.1    Dunne, S.M.2    Iazzetta, J.3    Paton, T.W.4
  • 34
    • 27944487908 scopus 로고    scopus 로고
    • Rasburicase: A new approach for preventing and/or treating tumor lysis syndrome
    • Bessmertny O, Robitaille LM, Cairo MS: Rasburicase: a new approach for preventing and/or treating tumor lysis syndrome. Curr Pharm Des 2005, 11:4177-4185.
    • (2005) Curr Pharm des , vol.11 , pp. 4177-4185
    • Bessmertny, O.1    Robitaille, L.M.2    Cairo, M.S.3
  • 35
    • 0038102704 scopus 로고    scopus 로고
    • Rasburicase for the treatment and prevention of hyperuricemia
    • Yim BT, Sims-McCallum RP, Chong PH. Rasburicase for the treatment and prevention of hyperuricemia. Ann Pharmacother 2003, 37:1047-1054.
    • (2003) Ann Pharmacother , vol.37 , pp. 1047-1054
    • Yim, B.T.1    Sims-McCallum, R.P.2    Chong, P.H.3
  • 36
    • 33646555250 scopus 로고    scopus 로고
    • Rasburicase treatment in severe tophaceous gout: A novel therapeutic option
    • In press
    • Moolenburgh JD, Reinder MK, Jansen TL: Rasburicase treatment in severe tophaceous gout: a novel therapeutic option. Clin Rheumatol 2005, In press.
    • (2005) Clin Rheumatol
    • Moolenburgh, J.D.1    Reinder, M.K.2    Jansen, T.L.3
  • 37
    • 14044273556 scopus 로고    scopus 로고
    • Urate oxidase (rasburicase) for treatment of severe tophaceous gout
    • Vogt B: Urate oxidase (rasburicase) for treatment of severe tophaceous gout. Nephrol Dial Transplant 2005, 20:431-433.
    • (2005) Nephrol Dial Transplant , vol.20 , pp. 431-433
    • Vogt, B.1
  • 38
    • 4243527744 scopus 로고    scopus 로고
    • Urate-oxidase in the treatment of severe tophaceous gout with hyperuricemia refractory to high-dose allopurinol: Case report and review
    • Phillips M, Hunt RE, Shergy WJ, Hernandez J: Urate-oxidase in the treatment of severe tophaceous gout with hyperuricemia refractory to high-dose allopurinol: case report and review. Arthritis Rheum 2000, 43:S401.
    • (2000) Arthritis Rheum , vol.43
    • Phillips, M.1    Hunt, R.E.2    Shergy, W.J.3    Hernandez, J.4
  • 39
    • 0031863414 scopus 로고    scopus 로고
    • Optimal range of serum urate concentrations to minimize risk of gouty attacks during anti-hyperuricemic treatment
    • Yamanaka H, Togashi R, Hokoda M, et al.: Optimal range of serum urate concentrations to minimize risk of gouty attacks during anti-hyperuricemic treatment. Adv Exp Med Biol 1998, 431:13-18.
    • (1998) Adv Exp Med Biol , vol.431 , pp. 13-18
    • Yamanaka, H.1    Togashi, R.2    Hokoda, M.3
  • 40
    • 33746995205 scopus 로고    scopus 로고
    • Control of hyperuricemia in subjects with refractory gout, and induction of antibody against poly(ethylene) glycol (PEG), in a phase I trial of subcutaneous PEGylated urate oxidase
    • In press
    • Ganson NJ, Kelly SJ, Scarlett E, et al.: Control of hyperuricemia in subjects with refractory gout, and induction of antibody against poly(ethylene) glycol (PEG), in a phase I trial of subcutaneous PEGylated urate oxidase. Arthritis Res Ther 2006, In press. This article provides the safety and pharmacokinetic results of the initial phase I trial of PEG-uricase for patients with refractory gout.
    • (2006) Arthritis Res Ther
    • Ganson, N.J.1    Kelly, S.J.2    Scarlett, E.3
  • 41
    • 33646553436 scopus 로고    scopus 로고
    • A Phase 2 study of multiple doses of intravenous polyethylene glycol (PEG)-uricase in patients with hyperuricemia and refractory gout
    • Sundy J, Becker M, Baraf H, et al.: A Phase 2 study of multiple doses of intravenous polyethylene glycol (PEG)-uricase in patients with hyperuricemia and refractory gout. Arthritis Rheum 2005, 52(Suppl 9): S679-S680.
    • (2005) Arthritis Rheum , vol.52 , Issue.SUPPL. 9
    • Sundy, J.1    Becker, M.2    Baraf, H.3
  • 42
    • 33646546161 scopus 로고    scopus 로고
    • Resolution of tophi with intravenous Peg-uricase in refractory gout
    • Baraf H, Kim S, Matsumoto A, et al.: Resolution of tophi with intravenous Peg-uricase in refractory gout. Arthritis Rheum 2005, 52(Suppl 9):S105.
    • (2005) Arthritis Rheum , vol.52 , Issue.SUPPL. 9
    • Baraf, H.1    Kim, S.2    Matsumoto, A.3
  • 43
    • 14944345365 scopus 로고    scopus 로고
    • Febuxostat, a novel non-purine selective inhibitor of xanthine oxidase
    • Becker MA, Schumacher Jr HR, Wortmann RL, et al.: Febuxostat, a novel non-purine selective inhibitor of xanthine oxidase. Arthritis Rheum 2005, 52:916-923.
    • (2005) Arthritis Rheum , vol.52 , pp. 916-923
    • Becker, M.A.1    Schumacher Jr., H.R.2    Wortmann, R.L.3
  • 44
    • 33646537617 scopus 로고    scopus 로고
    • Febuxostat vs allopurinol and placebo in subjects with hyperuricemia and gout: The 28-week APEX study
    • Schumacher H, Becker M, Wortmann R, et al.: Febuxostat vs allopurinol and placebo in subjects with hyperuricemia and gout: the 28-week APEX study. Arthritis Rheum 2005, 52(Suppl 9):S680.
    • (2005) Arthritis Rheum , vol.52 , Issue.SUPPL. 9
    • Schumacher, H.1    Becker, M.2    Wortmann, R.3
  • 45
    • 33747117812 scopus 로고    scopus 로고
    • Reduction in gout flares in subjects with chronic gout treated with febuxostat or allopurinol for 52-weeks: FACT trial
    • Becker M, Schumacher H, Wortmann R, et al.: Reduction in gout flares in subjects with chronic gout treated with febuxostat or allopurinol for 52-weeks: FACT trial. Arthritis Rheum 2005, 52(Suppl 9):S108.
    • (2005) Arthritis Rheum , vol.52 , Issue.SUPPL. 9
    • Becker, M.1    Schumacher, H.2    Wortmann, R.3
  • 46
    • 28944437578 scopus 로고    scopus 로고
    • Febuxostat compared with allopurinol in patients with hyperuricemia and gout
    • Becker MA, Schumacher Jr HR, Wortmann RL, et al.: Febuxostat compared with allopurinol in patients with hyperuricemia and gout. N Engl J Med 2005, 353:2450-2461. This article provides the latest and the longest follow-up phase III clinical trial data on the safety and efficacy of febuxostat compared to allopurinol in patients with gout and hyperuricemia.
    • (2005) N Engl J Med , vol.353 , pp. 2450-2461
    • Becker, M.A.1    Schumacher Jr., H.R.2    Wortmann, R.L.3
  • 47
    • 33747117812 scopus 로고    scopus 로고
    • Reduction in tophus size in subjects with chronic gout treated with febuxostat or allopurinol for 52 Weeks-FACT trial
    • Wortmann R, Schumacher H, Becker M, et al.: Reduction in tophus size in subjects with chronic gout treated with febuxostat or allopurinol for 52 Weeks-FACT trial. Arthritis Rheum 2005, 52(Suppl 9):S108.
    • (2005) Arthritis Rheum , vol.52 , Issue.SUPPL. 9
    • Wortmann, R.1    Schumacher, H.2    Becker, M.3
  • 48
    • 33748517510 scopus 로고    scopus 로고
    • Impact of serum uric acid on risk of acute gout attacks
    • Sarawate C, Patel P, Brewer K, et al.: Impact of serum uric acid on risk of acute gout attacks. Arthritis Rheum 2005, 52(Suppl 9):S106.
    • (2005) Arthritis Rheum , vol.52 , Issue.SUPPL. 9
    • Sarawate, C.1    Patel, P.2    Brewer, K.3
  • 49
    • 33750413006 scopus 로고    scopus 로고
    • Patient reported outcomes associated with gout: Baseline results from two clinical trials
    • Osterhaus JT, Patel P, Palo WA, et al.: Patient reported outcomes associated with gout: baseline results from two clinical trials. Arthritis Rheum 2005, 52(Suppl 9): S401-S402.
    • (2005) Arthritis Rheum , vol.52 , Issue.SUPPL. 9
    • Osterhaus, J.T.1    Patel, P.2    Palo, W.A.3
  • 50
    • 23244462442 scopus 로고    scopus 로고
    • Serum uric acid and cardiovascular disease: Recent developments, and where do they leave us?
    • Baker JF, Krishnan E, Chen L, Schumacher HR: Serum uric acid and cardiovascular disease: recent developments, and where do they leave us? Am J Med 2005, 118:816-826. This article provides systemic review of recent studies conducted to evaluate the role of hyperuricemia in the development of cardiovascular disease.
    • (2005) Am J Med , vol.118 , pp. 816-826
    • Baker, J.F.1    Krishnan, E.2    Chen, L.3    Schumacher, H.R.4
  • 51
    • 3242785541 scopus 로고    scopus 로고
    • Uric acid level as a risk factor for cardiovascular and all-cause mortality in middle-aged men: A prospective cohort study
    • Niskanen LK, Laaksonen DE, Nyyssonen K, et al.: Uric acid level as a risk factor for cardiovascular and all-cause mortality in middle-aged men: a prospective cohort study. Arch Intern Med 2004, 164:1546-1551.
    • (2004) Arch Intern Med , vol.164 , pp. 1546-1551
    • Niskanen, L.K.1    Laaksonen, D.E.2    Nyyssonen, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.