Allopurinol induces renal toxicity by impairing pyrimidine metabolism in mice

Life Sciences

Volumn 66, Issue 21, 2000, Pages 2051-2070

  Horiuchi, Hideki ^a   Ota, Mikio ^a   Nishimura, Shin ichi ^a   Kaneko, Hideshi ^a   Kasahara, Yoshinori ^a   Ohta, Tomohiro ^a   Komoriya, Keiji ^a  

^a TEIJIN LTD   (Japan)

Author keywords

Allopurinol; Pyrimidine metabolism; Renal toxicity; Xanthine dehydrogenase xanthine oxidase

Indexed keywords

1 FLUORO 2,4 DINITROBENZENE; ALLOPURINOL; AMINOTRANSFERASE; CREATININE; FEBUXOSTAT; NITROGEN; OROTIDINE; PYRIMIDINE; UNCLASSIFIED DRUG; UREA; XANTHINE OXIDASE INHIBITOR;

AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DOSE RESPONSE; DRUG EFFECT; DRUG STRUCTURE; HISTOPATHOLOGY; MALE; MOUSE; NEPHROTOXICITY; NONHUMAN; PYRIMIDINE METABOLISM; STONE FORMATION; UREA NITROGEN BLOOD LEVEL; URINARY EXCRETION;

ALLOPURINOL; ANIMALS; ANTIMETABOLITES; DINITROFLUOROBENZENE; DRUG HYPERSENSITIVITY; DRUG INTERACTIONS; KIDNEY; KIDNEY DISEASES; MALE; MICE; MICE, INBRED BALB C; PYRIMIDINES; URIDINE;

ANIMALIA;

EID: 0034646735     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(00)00532-4     Document Type: Article

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