Selective upregulation of the A3 adenosine receptor in eyes with pseudoexfoliation syndrome and glaucoma

Investigative Ophthalmology and Visual Science

Volumn 46, Issue 6, 2005, Pages 2023-2034

  Schlötzer Schrebardt, Ursula ^a   Zenkel, Matthias ^a   Decking, Ulrich ^b   Haubs, Daniela ^b   Kruse, Friedrich E ^a   Jünemann, Anselm ^a   Coca Prados, Miguel ^c   Naumann, Gottfried O H ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE A2A RECEPTOR; ADENOSINE A2B RECEPTOR; ADENOSINE A3 RECEPTOR; HYPOXANTHINE; INOSINE; MESSENGER RNA; RECEPTOR SUBTYPE; XANTHINE;

AGED; ANTERIOR EYE CHAMBER; AQUEOUS HUMOR FORMATION; ARTICLE; BASOLATERAL MEMBRANE; CILIARY BODY EPITHELIUM; CLOSED ANGLE GLAUCOMA; CONTROLLED STUDY; GENE EXPRESSION; GENE LOCATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN TISSUE; HYBRIDIZATION; HYPOXIA; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; IN VITRO STUDY; INTRAOCULAR PRESSURE; INTRAOCULAR PRESSURE ABNORMALITY; ISCHEMIA; NORTHERN HYBRIDIZATION; NUCLEOTIDE SEQUENCE; OPEN ANGLE GLAUCOMA; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSEUDOEXFOLIATION; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR UPREGULATION; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUPERNATANT; ANTERIOR EYE SEGMENT; AQUEOUS HUMOR; CULTURE TECHNIQUE; EXFOLIATION SYNDROME; GENETICS; METABOLISM; NORTHERN BLOTTING; UPREGULATION;

ADENOSINE; AGED; AGED, 80 AND OVER; ANTERIOR EYE SEGMENT; AQUEOUS HUMOR; BLOTTING, NORTHERN; CELL CULTURE TECHNIQUES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EXFOLIATION SYNDROME; GLAUCOMA, ANGLE-CLOSURE; GLAUCOMA, OPEN-ANGLE; HUMANS; HYPOXANTHINE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INOSINE; RECEPTOR, ADENOSINE A3; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; UP-REGULATION; XANTHINE;

EID: 22144475862     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.04-0915     Document Type: Article

References (49)

1. Bruns RF. Adenosine receptors: roles and pharmacology. Ann NY Acad Sci. 1990;603:211-225.
2. Roth S, Rosenbaum PS, Osinski J, et al. Ischemia induces significant changes in purine nucleoside concentration in the retina-choroid in rats. Exp Eye Res. 1997;65:771-779.
3. Von Arnim CAF, Timmler M, Ludolph AC, Riepe MW. Adenosine receptor up-regulation: initiated upon preconditioning but not upheld. Neuroreport. 2000;11:1223-1226.
4. Ramkumar V, Hallam DM, Nie Z. Adenosine, oxidative stress and cytoprotection. Jpn J Pharmacol. 2001;86:265-274.
5. Mubagwa K, Flameng W. Adenosine, adenosine receptors and myocardial protection: an updated overview. Cardiovasc Res. 2001;52:25-39.
6. Safran N, Shneyvays V, Balas N, Jacobson KA, Nawrath H, Shainberg A. Cardioprotective effects of adenosine A1 and A3 receptor activation during hypoxia in isolated rat cardiac myocytes. Mol Cell Biochem. 2001;217:143-152.
7. Fredholm BB, Ijzerman AP, Jacobson KA, Klotz K-N, Linden J. Nomenclature and classification of adenosine receptors. Pharm Rev. 2001;53:527-552.
8. Blazynski C, Woods C, Mathews GC. Evidence for the action of endogenous adenosine in the rabbit retina: modulation of the light-evoked release of acetylcholine. J Neurochem. 1992;58:761-767.
9. Wax M, Sanghavi DM, Lee CH, Kapadia M. Purinergic receptors in ocular ciliary epithelial cells. Exp Eye Res. 1993;57:89-95.
10. Wax MB, Patil RV. Immunoprecipitation of A1 adenosine receptor-GTP-binding protein complexes in ciliary epithelial cells. Invest Ophthalmol Vis Sci. 1994;35:3057-3063.
11. Kvanta A, Seregard S, Sejersen S, Kull B, Fredholm BB. Localization of adenosine receptor messenger RNAs in the rat eye. Exp Eye Res. 1997;65:595-602.
12. Fleischhauer JC, Mitchell CH, Stamer WD, et al. Common actions of adenosine receptor agonists in modulating human trabecular meshwork cell transport. J Membr Biol. 2003;193:121-136.
13. Macaluso C, Frishman LJ, Frueh B, Kaelin-Lang A, Onoe S, Niemeyer G. Multiple effects of adenosine in the arterially perfused mammalian eye: possible mechanisms for the neuroprotective function of adenosine in the retina. Doc Ophthalmol. 2003;106:51-59.
14. Braunagel SC, Xiao JG, Chiou GCY. The potential role of adenosine in regulating blood flow in the eye. J Ocul Pharmacol. 1988;4:61-73.
15. Campochiaro PA, Sen HA. Adenosine and its agonists cause retinal vasodilation and hemorrhages: implications for ischemic retinopathies. Arch Ophthalmol. 1989;107:412-416.
16. Gidday JM, Park TS. Microcirculatory responses to adenosine in the newborn pig retina. Pediatr Res. 1993;33:620-627.
17. Portellos M, Riva CE, Cranstoun SD, Petrig BL, Brucker AJ. Effects of adenosine on ocular blood flow. Invest Ophthalmol Vis Sci. 1995;36:1904-1909.
18. Lutty GA, McLeod DS. Retinal vascular development and oxygen-induced retinopathy. a role for adenosine. Prog Retin Eye Res. 2003;22:95-111.
19. Polska E, Ehrlich P, Luksch AQ, Fuchsjäger-Mayrl G, Schmetterer L. Effects of adenosine on intraocular pressure, optic nerve head blood flow, and choroidal blood flow in healthy humans. Invest Ophthalmol Vis Sci. 2003;44:3110-3114.
20. Gregory CY, Abrams TA, Hall MO. Stimulation of A2 adenosine receptors inhibits the ingestion of photoreceptor outer segments by retinal pigment epithelium. Invest Ophthalmol Vis Sci. 1994;35:819-825.
21. Sen HA, Campochiaro PA. Intravitreous injection of adenosine or its agonists causes breakdown of the blood-retinal barrier. Arch Ophthalmol. 1989;107:1364-1367.
22. Riley MV, Winkler BS, Starnes CA, Peters MI. Adenosine promotes regulation of corneal hydration through cyclic adenosine monophosphate. Invest Ophthalmol Vis Sci. 1996;37:1-10.
23. - channels of nonpigmented ciliary epithelial cells. Am J Physiol. 1997;273:C1354-C1361.
24. - channels of nonpigmented ciliary epithelial cells. Am J Physiol. 1999;276:C659-C666.
25. Crosson CE. Adenosine receptor activation modulates intraocular pressure in rabbits. J Pharmacol Exp Tber. 1995;273:320-326.
26. Crosson CE, Gray T. Characterization of ocular hypertension induced by adenosine agonists. Invest Ophthalmol Vis Sci. 1996;37:1833-1839.
27. Tian B, Gabelt BT, Crosson CE, Kaufman PL. Effects of adenosine agonists on intraocular pressure and aqueous humor dynamics in cynomolgus monkeys. Exp Eye Res. 1997;64:979-989.
28. 3-subtype adenosine receptors modulate intraocular pressure in the mouse. Br J Pharmacol. 2001;134:241-245.
29. 3 adenosine receptors reduces mouse intraocular pressure. Invest Ophthalmol Vis Sci. 2002;43:3021-3026.
30. Okamura T, Kurogi Y, Hashimoto K, et al. Structure-activity relationships of adenosine A3 receptor ligands: new potential therapy for the treatment of glaucoma. Bioorg Med Chem Lett. 2004;14:3775-3779.
31. Daines BS, Kent AR, McAleer MS, Crosson CE. Intraocular adenosine levels in normal and ocular hypertensive patients. J Ocul Pharmacol Tber. 2003;19:113-119.
32. Larsen AK, Osbourne NN. Involvement of adenosine in retinal ischemia: studies on rat. Invest Ophthalmol Vis Sci. 1996;37:2603-2611.
33. Ritch R, Schlötzer-Schrehardt U. Exfoliation syndrome. Surv Ophthalmol. 2001;45:265-315.
34. Helbig H, Schlötzer-Schrehardt U, Noske W, Kellner U, Foerster MH, Naumann GOH. Anterior-chamber hypoxia and iris vasculopathy in pseudoexfoliation syndrome. German J Ophthalmol. 1994;3:148-153.
35. 2A and ascorbic acid concentration in the aqueous humour of patients with exfoliation syndrome. Br J Ophthalmol. 2003;87:353-356.
36. Rozen S, Skaletzky HJ. Primer 3 Code, 1998. Available at http://www-genome.wi.mit.edu/genome_software/other/primer3.html. Accessed October 15, 2003.
37. Schlötzer-Schrehardt U, Zenkel M, Nüsing RM. Expression and localization of FP and EP prostanoid receptor subtypes in human ocular tissues. Invest Ophthalmol Vis Sci. 2002;43:1475-1487.
38. Martin-Vasallo P, Ghosh S, Coca-Prados M. Expression of Na,K-ATPase alpha subunit isoforms in the human ciliary body and cultured ciliary epithelial cells. J Cell Physiol. 1989;141:243-252.
39. Kroll K, Decking UKM, Dreikorn K, Schrader J. Rapid turnover of the AMP-adenosine metabolic cycle in the guinea pig heart. Circ Res. 1993;73:846-856.
40. Civan MM. The fall and rise of active chloride transport: implications for regulation of intraocular pressure. J Exp Zool. 2003;300:5-13.
41. Baraldi PG, Tabrizi MA, Bovero A, et al. Recent developments in the field of A2A and A3 adenosine receptor antagonists. Eur J Med Chem. 2003;38:367-382.
42. Reshkin SJ, Guerra L, Bagorda A, et al. Activation of A(3) adenosine receptor induces calcium entry and chloride secretion in A(6) cells. J Membr Biol. 2000;178:103-113.
43. Liang BT, Jacobson KA. A physiological role of the adenosine A3 receptor: sustained cardioprotection. Proc Natl Acad Sci USA. 1998;95:6995-6999.
44. Maggirwar SB, Dhanraj DN, Somani SM, Ramkumar V. Adenosine acts as an endogenous activator of the cellular antioxidant defense system. Biochem Biophys Res Commun. 1994;201:508-512.
45. Howard M, Sen HA, Capoor S, Herfel R, Crooks PA, Jacobson MK. Measurement of adenosine concentration in aqueous and vitreous. Invest Ophthalmol Vis Sci. 1998;39:1942-1946.
46. Mitchell CH, Carré DA, McGlinn AM, Stone RA, Civan MM. A release mechanism for stored ATP in ocular ciliary epithelial cells. Proc Natl Acad Sci USA. 1998;95:7174-7178.
47. Schulte G. Adenosine Receptor Signaling and the Activation of Mitogen-Activated Protein Kinases. Stockholm, Sweden: Repro Print AB; 2002:2.
48. Harkness RA. Hypoxanthine, xanthine, and uric acid in body fluids, indicators of ATP depletion. J Chromatogr. 1988;429:255-278.
49. Johnson DH, Brubaker RF. Dynamics of aqueous humor in the syndrome of exfoliation with glaucoma. Am J Ophthalmol. 1982;93:629-634.