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Volumn 12, Issue 3, 2007, Pages 407-422

Emerging drugs for epilepsy

Author keywords

Antiepileptic drug; Becampanel; Brivaracetam; Carisbamate; DP VPA; Eliscarbazepine; Epilepsy; Fluorofclbamate; Ganaxolone; Lacosamide; NS 1209; Retigabine; Rufinamide; Safinamide; Seizure; Seletracetam; Stiripentol; Talampanel; Valpromide; Valrocemide

Indexed keywords

ANTICONVULSIVE AGENT; BECAMPANEL; BENZODIAZEPINE; BIA 2093; BRIVARACETAM; CARBAMAZEPINE; CARBAMIC ACID 2 (2 CHLOROPHENYL) 2 HYDROXYETHYL ESTER; ETHOSUXIMIDE; ETIRACETAM; FELBAMATE; FLUOROFELBAMATE; GABAPENTIN; GANAXOLONE; HARKOSERIDE; LAMOTRIGINE; LICARBAZEPINE; NS 1209; OXCARBAZEPINE; PHENOBARBITAL; PHENYTOIN; PREGABALIN; PRIMIDONE; RETIGABINE; SELETRACETAM; TALAMPANEL; TIAGABINE; TOPIRAMATE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALPROIC ACID; VIGABATRIN; ZONISAMIDE; NEW DRUG;

EID: 34748887734     PISSN: 14728214     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728214.12.3.407     Document Type: Review
Times cited : (60)

References (98)
  • 2
    • 0030317076 scopus 로고    scopus 로고
    • Descriptive epidemiology of epilepsy: Contributions of population-based studies from Rochester, Minnesota
    • HAUSER WA, ANNEGERS JF, ROCCA WA: Descriptive epidemiology of epilepsy: contributions of population-based studies from Rochester, Minnesota. Mayo Clin. Proc. (1996) 71:576-586.
    • (1996) Mayo Clin. Proc , vol.71 , pp. 576-586
    • HAUSER, W.A.1    ANNEGERS, J.F.2    ROCCA, W.A.3
  • 3
    • 0034598762 scopus 로고    scopus 로고
    • Early identification of refractory epilepsy
    • KWAN P, BRODIE MJ: Early identification of refractory epilepsy. N. Engl. J. Med. (2000) 342:314-319.
    • (2000) N. Engl. J. Med , vol.342 , pp. 314-319
    • KWAN, P.1    BRODIE, M.J.2
  • 4
    • 4644242707 scopus 로고    scopus 로고
    • The natural history of epilepsy: An epidemiological view
    • KWAN P, SANDER JW: The natural history of epilepsy: an epidemiological view. J. Neurol. Neurosurg. Psychiatry (2004) 75:1376-1381.
    • (2004) J. Neurol. Neurosurg. Psychiatry , vol.75 , pp. 1376-1381
    • KWAN, P.1    SANDER, J.W.2
  • 5
    • 16344387731 scopus 로고    scopus 로고
    • Epileptic seizures and epilepsy: Definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE)
    • FISHER RS, VAN EMDE BOAS W, BLUME W et al.: Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia (2005) 46:470-472.
    • (2005) Epilepsia , vol.46 , pp. 470-472
    • FISHER, R.S.1    VAN EMDE, B.W.2    BLUME, W.3
  • 6
    • 0019509687 scopus 로고
    • Proposal for revised clinical and electroencephalographic classification of epileptic seizures
    • COMMISSION ON CLASSIFICATION AND TERMINOLOGY OF THE INTERNATIONAL LEAGUE AGAINST EPILEPSY
    • COMMISSION ON CLASSIFICATION AND TERMINOLOGY OF THE INTERNATIONAL LEAGUE AGAINST EPILEPSY: Proposal for revised clinical and electroencephalographic classification of epileptic seizures. Epilepsia (1981) 22:489-501.
    • (1981) Epilepsia , vol.22 , pp. 489-501
  • 7
    • 0024317220 scopus 로고
    • Proposal for revised clinical classification of epilepsies and epileptic syndromes
    • COMMISSION ON CLASSIFICATION AND TERMINOLOGYOF THE INTERNATIONAL LEAGUE AGAINST EPILEPSY
    • COMMISSION ON CLASSIFICATION AND TERMINOLOGYOF THE INTERNATIONAL LEAGUE AGAINST EPILEPSY: Proposal for revised clinical classification of epilepsies and epileptic syndromes. Epilepsia (1989) 30:389-399.
    • (1989) Epilepsia , vol.30 , pp. 389-399
  • 8
    • 0035044178 scopus 로고    scopus 로고
    • On the cellular and network bases of epileptic seizures
    • MCCORMICK DA, CONTRERAS D: On the cellular and network bases of epileptic seizures. Ann. Rev. Physiol. (2001) 63:815-846.
    • (2001) Ann. Rev. Physiol , vol.63 , pp. 815-846
    • MCCORMICK, D.A.1    CONTRERAS, D.2
  • 9
    • 3042798891 scopus 로고    scopus 로고
    • The neurobiology of antiepileptic drugs
    • ROGAWSKI MA, LÖSCHER W: The neurobiology of antiepileptic drugs. Nat. Rev. (2004) 5:553-564.
    • (2004) Nat. Rev , vol.5 , pp. 553-564
    • ROGAWSKI, M.A.1    LÖSCHER, W.2
  • 11
    • 3242756518 scopus 로고    scopus 로고
    • Medical risks in epilepsy: A review with focus on physical injuries, mortality, traffic accidents and their prevention
    • TOMSON T, BEGHI E, SUNDQVIST A, JOHANNESSEN SI: Medical risks in epilepsy: a review with focus on physical injuries, mortality, traffic accidents and their prevention. Epilepsy Res. (2004) 60:1-16.
    • (2004) Epilepsy Res , vol.60 , pp. 1-16
    • TOMSON, T.1    BEGHI, E.2    SUNDQVIST, A.3    JOHANNESSEN, S.I.4
  • 12
    • 8644226161 scopus 로고    scopus 로고
    • Injuries due to seizures in persons with epilepsy: A population-based study
    • LAWN ND, BAMLET WR, RADHAKRISHNAN K, O'BRIEN PC, SO EL: Injuries due to seizures in persons with epilepsy: a population-based study. Neurology (2004) 63:1565-1570.
    • (2004) Neurology , vol.63 , pp. 1565-1570
    • LAWN, N.D.1    BAMLET, W.R.2    RADHAKRISHNAN, K.3    O'BRIEN, P.C.4    SO, E.L.5
  • 14
    • 33646529431 scopus 로고    scopus 로고
    • Mortality in adults with newly diagnosed and chronic epilepsy: A retrospective comparative study
    • MOHANRAJ R, NORRIE J, STEPHEN LJ et al.: Mortality in adults with newly diagnosed and chronic epilepsy: a retrospective comparative study. Lancet Neurol. (2006) 5:481-487.
    • (2006) Lancet Neurol , vol.5 , pp. 481-487
    • MOHANRAJ, R.1    NORRIE, J.2    STEPHEN, L.J.3
  • 15
    • 5344268114 scopus 로고    scopus 로고
    • Comprehensive care of the epilepsy patient - control, comorbidity, and cost
    • BAZIL CWL: Comprehensive care of the epilepsy patient - control, comorbidity, and cost. Epilepsia (2004) 45(Suppl. 6):3-12.
    • (2004) Epilepsia , vol.45 , Issue.SUPPL. 6 , pp. 3-12
    • BAZIL, C.W.L.1
  • 16
    • 33645885625 scopus 로고    scopus 로고
    • Quality of life for patients with epilepsy is determined by more than seizure control: The role of psychosocial factors
    • SCHACHTER SC: Quality of life for patients with epilepsy is determined by more than seizure control: the role of psychosocial factors. Expert Rev. Neurother. (2006) 6:111-118.
    • (2006) Expert Rev. Neurother , vol.6 , pp. 111-118
    • SCHACHTER, S.C.1
  • 17
    • 0034049224 scopus 로고    scopus 로고
    • The cost of epilepsy in the United States: An estimate from population-based clinical and survey data
    • BEGLEY CE, FAMULARI M, ANNERGERS JF et al.: The cost of epilepsy in the United States: an estimate from population-based clinical and survey data. Epilepsia (2000) 41:342-351.
    • (2000) Epilepsia , vol.41 , pp. 342-351
    • BEGLEY, C.E.1    FAMULARI, M.2    ANNERGERS, J.F.3
  • 18
    • 33750045736 scopus 로고    scopus 로고
    • Combination therapy in epilepsy: When and what to use?
    • KWAN P, BRODIE MJ: Combination therapy in epilepsy: when and what to use? Drugs (2006) 66:1817-1829.
    • (2006) Drugs , vol.66 , pp. 1817-1829
    • KWAN, P.1    BRODIE, M.J.2
  • 19
    • 11144356543 scopus 로고    scopus 로고
    • Efficacy and tolerability of the new antiepileptic drugs I: Treatment of new onset epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society
    • FRENCH JA, KANNER AM, BAUTISTA J et al.: Efficacy and tolerability of the new antiepileptic drugs I: treatment of new onset epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Neurology (2004a) 62:1252-1260.
    • (2004) Neurology , vol.62 , pp. 1252-1260
    • FRENCH, J.A.1    KANNER, A.M.2    BAUTISTA, J.3
  • 21
    • 4544312379 scopus 로고    scopus 로고
    • Phenobarbital for the treatment of epilepsy in the 21st century: A critical review
    • KWAN P, BRODIE MJ: Phenobarbital for the treatment of epilepsy in the 21st century: a critical review. Epilepsia (2004) 45:1141-1149.
    • (2004) Epilepsia , vol.45 , pp. 1141-1149
    • KWAN, P.1    BRODIE, M.J.2
  • 22
    • 0038679502 scopus 로고    scopus 로고
    • Clinical trials of antiepileptic medications in newly diagnosed patients with epilepsy
    • KWAN P, BRODIE MJ: Clinical trials of antiepileptic medications in newly diagnosed patients with epilepsy. Neurology (2003) 60(Suppl. 4):S2-S12.
    • (2003) Neurology , vol.60 , Issue.SUPPL. 4
    • KWAN, P.1    BRODIE, M.J.2
  • 23
    • 33846850154 scopus 로고    scopus 로고
    • GROUP: Comparison of levetiracetam and controlled-release carbamazepine in newly diagnosed epilepsy
    • BRODIE MJ, PERUCCA E, RYVLIN P, BEN-MENACHEM E, MEENCKE H-J; FOR THE LEVETIRACETAM MONOTHERAPY STUDY GROUP: Comparison of levetiracetam and controlled-release carbamazepine in newly diagnosed epilepsy. Neurology (2007) 68:402-408.
    • (2007) Neurology , vol.68 , pp. 402-408
    • BRODIE, M.J.1    PERUCCA, E.2    RYVLIN, P.3    BEN-MENACHEM, E.4    MEENCKE, H.-J.5    FOR, T.L.M.S.6
  • 24
    • 33746124186 scopus 로고    scopus 로고
    • ILAE treatment guidelines: Evidence-based analysis of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes
    • GLAUSER T, BEN-MENACHEM E, BOURGEOIS B et al.: ILAE treatment guidelines: evidence-based analysis of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes. Epilepsia (2006) 47:1094-1120.
    • (2006) Epilepsia , vol.47 , pp. 1094-1120
    • GLAUSER, T.1    BEN-MENACHEM, E.2    BOURGEOIS, B.3
  • 25
    • 33947228816 scopus 로고    scopus 로고
    • The SANAD study of effectiveness of valproate, lamotrigine and topiramate for generalised and unclassified epilepsy: An unblinded randomised controlled trial
    • MARSON AG, AL-KHARUSI A, ALWAIDH M et a.: The SANAD study of effectiveness of valproate, lamotrigine and topiramate for generalised and unclassified epilepsy: an unblinded randomised controlled trial. Lancet (2007) 369:1016-1026.
    • (2007) Lancet , vol.369 , pp. 1016-1026
    • MARSON, A.G.1    AL-KHARUSI, A.2    ALWAIDH, M.3    et a4
  • 26
    • 33947241772 scopus 로고    scopus 로고
    • The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: An unblinded randomised controlled trial
    • MARSON AG, AL-KHARUSI AM, ALWAIDH M et al.: The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: an unblinded randomised controlled trial. Lancet (2007) 369:1000-1015.
    • (2007) Lancet , vol.369 , pp. 1000-1015
    • MARSON, A.G.1    AL-KHARUSI, A.M.2    ALWAIDH, M.3
  • 27
    • 33645305420 scopus 로고    scopus 로고
    • Diagnosing refractory epilepsy: Response to sequential treatment schedules
    • MOHANRAJ R, BRODIE MJ: Diagnosing refractory epilepsy: response to sequential treatment schedules. Eur. J. Neurol. (2006) 13:277-282.
    • (2006) Eur. J. Neurol , vol.13 , pp. 277-282
    • MOHANRAJ, R.1    BRODIE, M.J.2
  • 28
    • 0141717605 scopus 로고    scopus 로고
    • Measuring the efficacy of antiepileptic drugs
    • MOHANRAJ R, BRODIE MJ: Measuring the efficacy of antiepileptic drugs. Seizure (2003) 12:413-443.
    • (2003) Seizure , vol.12 , pp. 413-443
    • MOHANRAJ, R.1    BRODIE, M.J.2
  • 29
    • 11144353969 scopus 로고    scopus 로고
    • Efficacy and tolerability of the new antiepileptic drugs II: Treatment of refractory epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society
    • FRENCH JA, KANNER AM, BAUTISTA J et al.: Efficacy and tolerability of the new antiepileptic drugs II: treatment of refractory epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Neurology (2004b) 62:1261-1273.
    • (2004) Neurology , vol.62 , pp. 1261-1273
    • FRENCH, J.A.1    KANNER, A.M.2    BAUTISTA, J.3
  • 30
    • 0034769256 scopus 로고    scopus 로고
    • Life-threatening adverse events of antiepileptic drugs
    • ARROYO S, DE LA MORENA A: Life-threatening adverse events of antiepileptic drugs. Epilepsy Res. (2001) 47:155-174.
    • (2001) Epilepsy Res , vol.47 , pp. 155-174
    • ARROYO, S.1    DE LA MORENA, A.2
  • 31
    • 15244353807 scopus 로고    scopus 로고
    • REGISTRY: Increased rate of major malformations in offspring exposed to valproate during pregnancy
    • WYSZYNSKI DF, NAMBISAN M, SURVE T, ALSDORF RM, SMITH CR, HOLMES LB; FOR THE ANTIEPILEPTIC DRUG PREGNANCY REGISTRY: increased rate of major malformations in offspring exposed to valproate during pregnancy. Neurology (2005) 64:961-965.
    • (2005) Neurology , vol.64 , pp. 961-965
    • WYSZYNSKI, D.F.1    NAMBISAN, M.2    SURVE, T.3    ALSDORF, R.M.4    SMITH, C.R.5    HOLMES, L.B.6    FOR, T.A.D.P.7
  • 32
    • 20444382337 scopus 로고    scopus 로고
    • Antiepileptic drug use of women with epilepsy and congenital malformations in offspring
    • ARTAMA M, AUVINEN A, RAUDASKOSKI T, ISOJARVI I, ISOJARVI J: Antiepileptic drug use of women with epilepsy and congenital malformations in offspring. Neurology (2005) 64:1874-1878.
    • (2005) Neurology , vol.64 , pp. 1874-1878
    • ARTAMA, M.1    AUVINEN, A.2    RAUDASKOSKI, T.3    ISOJARVI, I.4    ISOJARVI, J.5
  • 33
    • 32344440085 scopus 로고    scopus 로고
    • Malformation risks of antiepileptic drugs in pregnancy: A prospective study from the UK Epilepsy and Pregnancy Register
    • MORROW J, RUSSELL A, GUTHRIE E et al.: Malformation risks of antiepileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register. J. Neurol. Neurosurg. Psychiatry (2006) 77:193-198.
    • (2006) J. Neurol. Neurosurg. Psychiatry , vol.77 , pp. 193-198
    • MORROW, J.1    RUSSELL, A.2    GUTHRIE, E.3
  • 34
    • 33746079194 scopus 로고    scopus 로고
    • In utero antiepileptic drug exposure: Fetal death and malformations
    • MEADOR KJ, BAKER GA, FINNELL RH et al.: In utero antiepileptic drug exposure: fetal death and malformations. Neurology (2006) 67:407-412.
    • (2006) Neurology , vol.67 , pp. 407-412
    • MEADOR, K.J.1    BAKER, G.A.2    FINNELL, R.H.3
  • 35
    • 24744449939 scopus 로고    scopus 로고
    • Astrocytic basis of epilepsy
    • TIAN G-F, AZMI H, TAKANO T et al.: Astrocytic basis of epilepsy. Nat. Med. (2005) 11:973-981.
    • (2005) Nat. Med , vol.11 , pp. 973-981
    • TIAN, G.-F.1    AZMI, H.2    TAKANO, T.3
  • 36
    • 0034935392 scopus 로고    scopus 로고
    • The mechanisms of action of commonly used antiepileptic drugs
    • KWAN P, SILLS GJ, BRODIE MJ: The mechanisms of action of commonly used antiepileptic drugs. Pharmacol. Ther. (2001) 90:21-34.
    • (2001) Pharmacol. Ther , vol.90 , pp. 21-34
    • KWAN, P.1    SILLS, G.J.2    BRODIE, M.J.3
  • 37
    • 3042748137 scopus 로고    scopus 로고
    • The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam
    • LYNCH BA, LAMBENG N, NOCKA K et al.: The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam. Proc. Natl. Acad. Sci. USA (2004) 101:9861-9866.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 9861-9866
    • LYNCH, B.A.1    LAMBENG, N.2    NOCKA, K.3
  • 38
    • 0023897574 scopus 로고
    • Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations
    • LÖSCHER W, SCHMIDT D: Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations. Epilepsy Res. (1988) 2:145-181.
    • (1988) Epilepsy Res , vol.2 , pp. 145-181
    • LÖSCHER, W.1    SCHMIDT, D.2
  • 39
    • 0347364701 scopus 로고    scopus 로고
    • Therapy discovery for pharmacoresistant epilepsy and for disease-modifying therapeutics: Summary of the NIH/NINDS/AES models II workshop
    • STABLES JP, BERTRAM E, DUDEK FE et al.: Therapy discovery for pharmacoresistant epilepsy and for disease-modifying therapeutics: summary of the NIH/NINDS/AES models II workshop. Epilepsia (2003) 44:1472-1478.
    • (2003) Epilepsia , vol.44 , pp. 1472-1478
    • STABLES, J.P.1    BERTRAM, E.2    DUDEK, F.E.3
  • 41
    • 0032848061 scopus 로고    scopus 로고
    • Comparative anticonvulsant and mechanistic profile of established and newer antiepileptic drugs
    • WHITE HS: Comparative anticonvulsant and mechanistic profile of established and newer antiepileptic drugs. Epilepsia (1999) 40(Suppl. 5):S2-S10.
    • (1999) Epilepsia , vol.40 , Issue.SUPPL. 5
    • WHITE, H.S.1
  • 42
    • 0027410987 scopus 로고
    • Profile of ucb L059, a novel anticonvulsant drug, in models of partial and generalized epilepsy in mice and rats
    • LÖSCHER W, HONACK D: Profile of ucb L059, a novel anticonvulsant drug, in models of partial and generalized epilepsy in mice and rats. Eur. J. Pharmacol. (1993) 232:147-158.
    • (1993) Eur. J. Pharmacol , vol.232 , pp. 147-158
    • LÖSCHER, W.1    HONACK, D.2
  • 43
    • 33747049831 scopus 로고    scopus 로고
    • Diverse mechanisms of antiepileptic drugs in the development pipeline
    • ROGAWSKI MA: Diverse mechanisms of antiepileptic drugs in the development pipeline. Epilepsy Res. (2006) 69:273-294.
    • (2006) Epilepsy Res , vol.69 , pp. 273-294
    • ROGAWSKI, M.A.1
  • 44
    • 33750695268 scopus 로고    scopus 로고
    • Antiepileptic drugs in development
    • POLLARD JR, FRENCH J: Antiepileptic drugs in development. Lancet Neurol. (2006) 5:1064-1067.
    • (2006) Lancet Neurol , vol.5 , pp. 1064-1067
    • POLLARD, J.R.1    FRENCH, J.2
  • 45
    • 9144238050 scopus 로고    scopus 로고
    • Discovery of 4-substituted pyrrolidone butanamides as new agents with significant antiepileptic activity
    • KENDA BM, MATAGNE AC, TALAGA PE et al.: Discovery of 4-substituted pyrrolidone butanamides as new agents with significant antiepileptic activity. J. Med. Chem. (2004) 47:530-549.
    • (2004) J. Med. Chem , vol.47 , pp. 530-549
    • KENDA, B.M.1    MATAGNE, A.C.2    TALAGA, P.E.3
  • 46
    • 4644301804 scopus 로고    scopus 로고
    • BIALER M, JOHANNESSEN SI, KUPFERBERG HJ, LEVY RH, PERUCCA E, TOMSON T: Progress report on new antiepileptic drugs: a summary of the Seventh Eilat Conference (EILAT VII). Epilepsy Res. (2004) 61:1-48.
    • BIALER M, JOHANNESSEN SI, KUPFERBERG HJ, LEVY RH, PERUCCA E, TOMSON T: Progress report on new antiepileptic drugs: a summary of the Seventh Eilat Conference (EILAT VII). Epilepsy Res. (2004) 61:1-48.
  • 47
  • 48
    • 33846194013 scopus 로고    scopus 로고
    • BIALER M, JOHANNESSEN SI, KUPFERBERG HJ, LEVY RH, PERUCCA E, TOMSON T: Progress report on new antiepileptic drugs: a summary of the Eighth Eilat Conference (EILAT VIII). Epilepsy Res. (2007) 73:1-52.
    • BIALER M, JOHANNESSEN SI, KUPFERBERG HJ, LEVY RH, PERUCCA E, TOMSON T: Progress report on new antiepileptic drugs: a summary of the Eighth Eilat Conference (EILAT VIII). Epilepsy Res. (2007) 73:1-52.
  • 49
    • 14944357363 scopus 로고    scopus 로고
    • Proof of principle in the new AED ucb 34714; use of the photosensitivity model
    • KASTELEIJN-NOLST TRENITÈDGA, PARAIN D, MASNOU P, GENTON P, STEINHOFF BJ, HIRSCH E: Proof of principle in the new AED ucb 34714; use of the photosensitivity model. Epilepsia (2004) 45(Suppl. 7):309.
    • (2004) Epilepsia , vol.45 , Issue.SUPPL. 7 , pp. 309
    • KASTELEIJN-NOLST, T.1    PARAIN, D.2    MASNOU, P.3    GENTON, P.4    STEINHOFF, B.J.5    HIRSCH, E.6
  • 51
    • 0035013202 scopus 로고    scopus 로고
    • Interaction of the novel anticonvulsant, BIA2-093, with voltage-gated sodium channels: Comparison with carbamazepine
    • BONIFACIO MJ, SHERIDAN RD, PARADA A, CUNHA RA, PATMORE L, SOARES-DA-SILVA P: Interaction of the novel anticonvulsant, BIA2-093, with voltage-gated sodium channels: comparison with carbamazepine. Epilepsia (2001) 42:600-608.
    • (2001) Epilepsia , vol.42 , pp. 600-608
    • BONIFACIO, M.J.1    SHERIDAN, R.D.2    PARADA, A.3    CUNHA, R.A.4    PATMORE, L.5    SOARES-DA-SILVA, P.6
  • 52
    • 33750276090 scopus 로고    scopus 로고
    • Novel anticonvulsant drugs targeting voltage-dependent ion channels
    • WUTTKE TV, LERCHE H: Novel anticonvulsant drugs targeting voltage-dependent ion channels. Expert Opin. Investig. Drugs (2006) 15:1167-1177.
    • (2006) Expert Opin. Investig. Drugs , vol.15 , pp. 1167-1177
    • WUTTKE, T.V.1    LERCHE, H.2
  • 53
    • 33847611166 scopus 로고    scopus 로고
    • Eslicarbazepine acetate: A double-blind, add-on, placebo-controlled exploratory trial in adult patients with partial-onset seizures
    • ELGER C, BIALER M, CRAMER JA, MAIA J, ALMEIDA L, SOARES-DA-SILVA P: Eslicarbazepine acetate: a double-blind, add-on, placebo-controlled exploratory trial in adult patients with partial-onset seizures. Epilepsia (2007) 48:497-504.
    • (2007) Epilepsia , vol.48 , pp. 497-504
    • ELGER, C.1    BIALER, M.2    CRAMER, J.A.3    MAIA, J.4    ALMEIDA, L.5    SOARES-DA-SILVA, P.6
  • 55
    • 10844281990 scopus 로고    scopus 로고
    • Investigating the role of 2-phenylpropenal in felbamate-induced idiosyncratic drug reactions
    • POPOVIC M, NIERKENS S, PIETERS R, UETRECHT J: Investigating the role of 2-phenylpropenal in felbamate-induced idiosyncratic drug reactions. Chem. Res. Toxicol. (2004) 17:1568-1576.
    • (2004) Chem. Res. Toxicol , vol.17 , pp. 1568-1576
    • POPOVIC, M.1    NIERKENS, S.2    PIETERS, R.3    UETRECHT, J.4
  • 57
    • 33846229951 scopus 로고    scopus 로고
    • The novel investigational neuromodulator RWJ 333369 displays a broad-spectrum anticonvulsant profile in rodent seizure and epilepsy models
    • San Diego, CA 1-5 December
    • WHITE HS, SRIVASTAVA A, KLEIN B et al.: The novel investigational neuromodulator RWJ 333369 displays a broad-spectrum anticonvulsant profile in rodent seizure and epilepsy models. Presented in 1st North American Epilepsy Congress, San Diego, CA (1-5 December 2006).
    • (2006) Presented in 1st North American Epilepsy Congress
    • WHITE, H.S.1    SRIVASTAVA, A.2    KLEIN, B.3
  • 58
    • 34247598478 scopus 로고    scopus 로고
    • Evaluation of carisbamate, a novel antiepileptic drug in photosensitive epilepsy: An exploratory, placebo-controlled study
    • In Press
    • TRENITE DG, FRENCH JA, HIRSCH E et al.: Evaluation of carisbamate, a novel antiepileptic drug in photosensitive epilepsy: an exploratory, placebo-controlled study. Epilepsy Res. (In Press).
    • Epilepsy Res
    • TRENITE, D.G.1    FRENCH, J.A.2    HIRSCH, E.3
  • 60
    • 33846228427 scopus 로고    scopus 로고
    • Valproic acid: Second generation
    • BIALER M, YAGEN B: Valproic acid: second generation. Neurotherapeutics (2007) 4:130-137.
    • (2007) Neurotherapeutics , vol.4 , pp. 130-137
    • BIALER, M.1    YAGEN, B.2
  • 62
    • 0034677733 scopus 로고    scopus 로고
    • The novel anticonvulsant retigabine activates M-currents in Chinese hamster ovary-cells tranfected with human KCNQ2/3 subunits
    • RUNDFELDT C, NETZER R: The novel anticonvulsant retigabine activates M-currents in Chinese hamster ovary-cells tranfected with human KCNQ2/3 subunits. Neurosci. Lett. (2000) 282:73-76.
    • (2000) Neurosci. Lett , vol.282 , pp. 73-76
    • RUNDFELDT, C.1    NETZER, R.2
  • 63
    • 0034283908 scopus 로고    scopus 로고
    • + channels and the molecular pathogenesis of epilepsy: Implications for therapy
    • + channels and the molecular pathogenesis of epilepsy: implications for therapy. Trends Neurosci. (2000) 23:393-398.
    • (2000) Trends Neurosci , vol.23 , pp. 393-398
    • ROGAWSKI, M.A.1
  • 64
    • 0032536030 scopus 로고    scopus 로고
    • A potassium channel mutation in neonatal human epilepsy
    • BIEVERT C, SCHROEDER BC, KUBISCH C et al.: A potassium channel mutation in neonatal human epilepsy. Science (1998) 279:403-406.
    • (1998) Science , vol.279 , pp. 403-406
    • BIEVERT, C.1    SCHROEDER, B.C.2    KUBISCH, C.3
  • 65
    • 17344372328 scopus 로고    scopus 로고
    • A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns
    • SINGH NA, CHARLIER C, STAUFFER D et al.: A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns. Nat. Genet. (1998) 18:25-29.
    • (1998) Nat. Genet , vol.18 , pp. 25-29
    • SINGH, N.A.1    CHARLIER, C.2    STAUFFER, D.3
  • 66
    • 0031974209 scopus 로고    scopus 로고
    • A pore mutation in a novel KQT-like potassium channel gene in an idiopachic epilepsy family
    • CHARLIER C, SINGH NA, RYAN SG et al.: A pore mutation in a novel KQT-like potassium channel gene in an idiopachic epilepsy family. Nat. Genet. (1998) 18:53-55.
    • (1998) Nat. Genet , vol.18 , pp. 53-55
    • CHARLIER, C.1    SINGH, N.A.2    RYAN, S.G.3
  • 67
    • 0029969951 scopus 로고    scopus 로고
    • D-23129: A new anticonvulsant with a braod spectrum activity in animal models of epileptic seizures
    • ROSTOCK A, TOBER C, RUNDFELDT C et al.: D-23129: a new anticonvulsant with a braod spectrum activity in animal models of epileptic seizures. Epilepsy Res. (1996) 23:211-223.
    • (1996) Epilepsy Res , vol.23 , pp. 211-223
    • ROSTOCK, A.1    TOBER, C.2    RUNDFELDT, C.3
  • 69
    • 34247252905 scopus 로고    scopus 로고
    • PORTER RJ, PARTIOT A, SACHDEO R, NOHRIA V, ALVES WM; FOR THE 205 STUDY GROUP: Randomized, multicentre, dose-ranging trial of retigabine for partial-onset seizures. Neurology (2007) 68:1197-1204.
    • PORTER RJ, PARTIOT A, SACHDEO R, NOHRIA V, ALVES WM; FOR THE 205 STUDY GROUP: Randomized, multicentre, dose-ranging trial of retigabine for partial-onset seizures. Neurology (2007) 68:1197-1204.
  • 71
    • 0036247871 scopus 로고    scopus 로고
    • Non-competitive AMPA antagonists of 2,3-benzodiazepine type
    • SOLYOM S, TARNAWA I: Non-competitive AMPA antagonists of 2,3-benzodiazepine type. Curr. Pharm. Des. (2002) 8:913-939.
    • (2002) Curr. Pharm. Des , vol.8 , pp. 913-939
    • SOLYOM, S.1    TARNAWA, I.2
  • 72
    • 0037062597 scopus 로고    scopus 로고
    • A crossover, add-on trial of talampanel in patients with refractory partial seizures
    • CHAPPELL AS, SANDER JW, BRODIE MJ et al.: A crossover, add-on trial of talampanel in patients with refractory partial seizures. Neurology (2002) 58:1680-1682.
    • (2002) Neurology , vol.58 , pp. 1680-1682
    • CHAPPELL, A.S.1    SANDER, J.W.2    BRODIE, M.J.3
  • 73
    • 33845360447 scopus 로고    scopus 로고
    • Efficacy of the AMPA antagonist talampanel in refractory partial epilepsy
    • Abstract
    • FETELL MR, RAMSAY RE, BELL C, TANG S: Efficacy of the AMPA antagonist talampanel in refractory partial epilepsy J. Neurol. Sci. (2005) (Suppl. 1):A238 (Abstract).
    • (2005) J. Neurol. Sci , Issue.SUPPL. 1
    • FETELL, M.R.1    RAMSAY, R.E.2    BELL, C.3    TANG, S.4
  • 74
    • 3142777130 scopus 로고    scopus 로고
    • Pharmacology of endogenous neuroactive steroids
    • REDDY DS: Pharmacology of endogenous neuroactive steroids. Crit. Rev. Neurobiol. (2003) 15:197-234.
    • (2003) Crit. Rev. Neurobiol , vol.15 , pp. 197-234
    • REDDY, D.S.1
  • 75
    • 0033714804 scopus 로고    scopus 로고
    • Chronic treatment with neuroactive steroid ganaxolone in the rat induces anticonvulsant tolerance to diazepam but not to itself
    • REDDY DS, ROGAWSKI MA: Chronic treatment with neuroactive steroid ganaxolone in the rat induces anticonvulsant tolerance to diazepam but not to itself. J. Pharmacol. Exp. Ther. (2000) 295:1241-1248.
    • (2000) J. Pharmacol. Exp. Ther , vol.295 , pp. 1241-1248
    • REDDY, D.S.1    ROGAWSKI, M.A.2
  • 77
    • 33646911126 scopus 로고    scopus 로고
    • Seeking a mechanism of action for the novel anticonvulsant lacosamide
    • ERRINGTON AC, COYNE L, STÖHR T et al.: Seeking a mechanism of action for the novel anticonvulsant lacosamide. Neuropharmacology (2006) 50:1016-1029.
    • (2006) Neuropharmacology , vol.50 , pp. 1016-1029
    • ERRINGTON, A.C.1    COYNE, L.2    STÖHR, T.3
  • 78
    • 34948820856 scopus 로고    scopus 로고
    • THOMAS D, SCHARFENECKER U, SCHILTMEYER B, DOTY P, CAWELLO W, R HORSTMANN R: Low potential for drug-drug-interaction of lacosamide. Presented in 1st North American Epilepsy Congress, San Diego, CA (1-5 December 2006).
    • THOMAS D, SCHARFENECKER U, SCHILTMEYER B, DOTY P, CAWELLO W, R HORSTMANN R: Low potential for drug-drug-interaction of lacosamide. Presented in 1st North American Epilepsy Congress, San Diego, CA (1-5 December 2006).
  • 80
    • 34447344551 scopus 로고    scopus 로고
    • Efficacy and safety of oral lacosamide as adjunctive therapy in adults with partial-onset seizures
    • In Press
    • BEN-MENACHEM E, BITON V, JATUZIS D, ABOU-KHALIL B, DOTY P, RUDD GD: Efficacy and safety of oral lacosamide as adjunctive therapy in adults with partial-onset seizures. Epilepsia (In Press).
    • Epilepsia
    • BEN-MENACHEM, E.1    BITON, V.2    JATUZIS, D.3    ABOU-KHALIL, B.4    DOTY, P.5    RUDD, G.D.6
  • 81
    • 40849135214 scopus 로고    scopus 로고
    • Intravenous lacosamide (SPM 927) as replacement for oral lacosamide in subjects with partial seizures: A multicenter, open-label, inpatient safety and tolerability trial
    • San Diego, CA 1, 5 December
    • KRAUSS G, BEN-MENACHEM E, MAMENISKIENE R, VAICIENE N, BROCK M, WHITESIDES J: Intravenous lacosamide (SPM 927) as replacement for oral lacosamide in subjects with partial seizures: a multicenter, open-label, inpatient safety and tolerability trial. Presented in 1st North American Epilepsy Congress, San Diego, CA (1 - 5 December 2006).
    • (2006) Presented in 1st North American Epilepsy Congress
    • KRAUSS, G.1    BEN-MENACHEM, E.2    MAMENISKIENE, R.3    VAICIENE, N.4    BROCK, M.5    WHITESIDES, J.6
  • 84
    • 33746111455 scopus 로고    scopus 로고
    • The effects of the new antiepileptic drug rufinamide on cognitive functions
    • ALDENKAMP AP, ALPHERTS WCJ: The effects of the new antiepileptic drug rufinamide on cognitive functions. Epilepsia (2006) 47:1153-1159.
    • (2006) Epilepsia , vol.47 , pp. 1153-1159
    • ALDENKAMP, A.P.1    ALPHERTS, W.C.J.2
  • 85
    • 22244452355 scopus 로고    scopus 로고
    • Rufinamide. GCP 33101, E 2080, RUF 331, Xilep
    • ANONYMOUS
    • ANONYMOUS: Rufinamide. GCP 33101, E 2080, RUF 331, Xilep. Drugs R. D. (2005) 6:249-252.
    • (2005) Drugs R. D , vol.6 , pp. 249-252
  • 86
    • 33749818806 scopus 로고    scopus 로고
    • Rufinamide: Pharmacology, clinical trials, and role in clinical practice
    • CHENG-HAKIMIAN A, ANDERSON GD, MILLER JW: Rufinamide: pharmacology, clinical trials, and role in clinical practice. Int. J. Clin. Pract. (2006) 60:1497-1501.
    • (2006) Int. J. Clin. Pract , vol.60 , pp. 1497-1501
    • CHENG-HAKIMIAN, A.1    ANDERSON, G.D.2    MILLER, J.W.3
  • 88
    • 10244263432 scopus 로고    scopus 로고
    • Safinamide. FCE 26743, NW 1015, PNU 151774, PNU 151774E
    • ANONYMOUS
    • ANONYMOUS: Safinamide. FCE 26743, NW 1015, PNU 151774, PNU 151774E. Drugs R. D. (2004) 5:355-358.
    • (2004) Drugs R. D , vol.5 , pp. 355-358
  • 89
    • 33645528060 scopus 로고    scopus 로고
    • Stiripentol, a putative antiepileptic drug, enhances the duration of opening of GABA-A-receptor channels
    • QUILICHINI PP, CHIRON C, BEN-ARI Y, GOZLAN H: Stiripentol, a putative antiepileptic drug, enhances the duration of opening of GABA-A-receptor channels. Epilepsia (2006) 47:706-716.
    • (2006) Epilepsia , vol.47 , pp. 706-716
    • QUILICHINI, P.P.1    CHIRON, C.2    BEN-ARI, Y.3    GOZLAN, H.4
  • 90
    • 0034638786 scopus 로고    scopus 로고
    • Stiripentol in severe myoclonic epilepsy in infancy: A randomised placebo-controlled syndromededicated trial. STICLO study group
    • CHIRON C, MARCHAND MC, TRAN A et al.: Stiripentol in severe myoclonic epilepsy in infancy: a randomised placebo-controlled syndromededicated trial. STICLO study group. Lancet (2000) 356:1638-1642.
    • (2000) Lancet , vol.356 , pp. 1638-1642
    • CHIRON, C.1    MARCHAND, M.C.2    TRAN, A.3
  • 92
    • 33645851658 scopus 로고    scopus 로고
    • Refractory epilepsy: Mechanisms and solutions
    • KWAN P, BRODIE MJ: Refractory epilepsy: mechanisms and solutions. Expert Rev. Neurother. (2006) 6:397-406.
    • (2006) Expert Rev. Neurother , vol.6 , pp. 397-406
    • KWAN, P.1    BRODIE, M.J.2
  • 93
    • 33846188141 scopus 로고    scopus 로고
    • Molecular targets for antiepileptic drug development
    • MELDRUM BS, ROGAWSKI MA: Molecular targets for antiepileptic drug development. Neurotherapeutics (2007) 4:18-61.
    • (2007) Neurotherapeutics , vol.4 , pp. 18-61
    • MELDRUM, B.S.1    ROGAWSKI, M.A.2
  • 94
    • 0036351947 scopus 로고    scopus 로고
    • Potential new methods for antiepileptic drug delivery
    • FISHER RS, HO J: Potential new methods for antiepileptic drug delivery. CNS Drugs (2002) 16:579-593.
    • (2002) CNS Drugs , vol.16 , pp. 579-593
    • FISHER, R.S.1    HO, J.2
  • 95
    • 34249058785 scopus 로고    scopus 로고
    • ABCB1 genotype and PGP expression, function and therapeutic drug response: A critical review and recommendations for future research
    • LESCHZINER GD, ANDREW T, PIRMOHAMED M, JOHNSON MR: ABCB1 genotype and PGP expression, function and therapeutic drug response: a critical review and recommendations for future research. Pharmacogenom. J. (2007) 7:154-179.
    • (2007) Pharmacogenom. J , vol.7 , pp. 154-179
    • LESCHZINER, G.D.1    ANDREW, T.2    PIRMOHAMED, M.3    JOHNSON, M.R.4
  • 96
    • 34447619872 scopus 로고    scopus 로고
    • Association between ABCB1 C3435T polymorphism and drug resistant epilepsy in Han Chinese
    • In Press
    • KWAN P, BAUM L, WONG V et al.: Association between ABCB1 C3435T polymorphism and drug resistant epilepsy in Han Chinese. Epilepsy Behav. (In Press).
    • Epilepsy Behav
    • KWAN, P.1    BAUM, L.2    WONG, V.3
  • 97
    • 1842784823 scopus 로고    scopus 로고
    • Medical genetics: A marker for Stevens-Johnson syndrome
    • CHUNG WH, HUNG SI, HONG HS et al.: Medical genetics: a marker for Stevens-Johnson syndrome. Nature (2004) 428:486.
    • (2004) Nature , vol.428 , pp. 486
    • CHUNG, W.H.1    HUNG, S.I.2    HONG, H.S.3
  • 98
    • 34248589506 scopus 로고    scopus 로고
    • Association between HLA-B* 1502 allele and antiepileptic drugs-induced cutaneous reactions in Han Chinese
    • MAN CBL, KWAN P, BAUM L et al.: Association between HLA-B* 1502 allele and antiepileptic drugs-induced cutaneous reactions in Han Chinese. Epilepsia (2007) 48:1015-1018.
    • (2007) Epilepsia , vol.48 , pp. 1015-1018
    • MAN, C.B.L.1    KWAN, P.2    BAUM, L.3


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