Progressive pulmonary sarcoidosis is associated with over-expression of TYK2 and p21Waf1/Cip1

Sarcoidosis Vasculitis and Diffuse Lung Diseases

Volumn 23, Issue 2, 2006, Pages 101-107

  Schischmanoff, Pierre Olivier ^a,b   Naccache, Jean Marc ^b   Carrere, Amélie ^a   Richardson, Sylvia ^c   Kambouchner, Marianne ^b   Raphael, Martine ^a,d   Valeyre, Dominique ^b   Fagard, Remi ^a,b  

^a UNIVERSITÉ PARIS 13   (France)

^b AVICENNE HOSPITAL   (France)

^c IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^d UNIVERSITÉ PARIS SACLAY   (France)

Author keywords

Bronchoalveolar lavage fluid; Cip1 protein; Oligonucleotide array sequence analysis; Pulmonary sarcoidosis; TYK2 protein

Indexed keywords

FOCAL ADHESION KINASE 1; GAMMA INTERFERON RECEPTOR; GAMMA INTERFERON RECEPTOR 2; PROTEIN P21; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL ARTICLE; COMPUTER PROGRAM; CONTROLLED STUDY; DISEASE COURSE; FEMALE; GENE OVEREXPRESSION; GENETIC ASSOCIATION; HUMAN; IMMUNE RESPONSE; LABORATORY DIAGNOSIS; LUNG DISEASE; MALE; MICROARRAY ANALYSIS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SARCOIDOSIS; TH1 CELL; UPREGULATION;

ADULT; BRONCHOALVEOLAR LAVAGE FLUID; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DISEASE PROGRESSION; FEMALE; FLOW CYTOMETRY; FOLLOW-UP STUDIES; GENE EXPRESSION; HUMANS; MALE; MICROARRAY ANALYSIS; MIDDLE AGED; RADIOGRAPHY, THORACIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SARCOIDOSIS, PULMONARY; TOMOGRAPHY, X-RAY COMPUTED; TYK2 KINASE;

EID: 34748882659     PISSN: 11240490     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Conron M, du Bois RM: Immunological mechanisms in sarcoidosis. Clin Exp Allergy 2001; 31: 543-54.
2. Hunninghake GW, Crystal RG: Pulmonary sarcoidosis: a disorder mediated by excess helper T-lymphocyte activity at sites of disease activity. N Engl J Med 1981; 305: 429-34.
3. American Thoracic Society 1999, Statement on sarcoidosis. Joint statement of the American Thoracic Society (ATS), the European Respiratory Society (ERS) and the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG) adopted by the ATS Board of Directors and the ERS Executive Committee: Am J Respir Crit Care Med 1999; 160: 736-55.
4. Baughman RP, Lower EE, du Bois RM: Sarcoidosis. Lancet 2003; 361: 1111-8.
5. Bergeron A, Bonay M, Kambouchner M, et al: Cytokine patterns in tuberculous and sarcoid granulomas. J Immunol 1997; 159: 3034-43.
6. Minshall EM, Tsicopoulos A, Yasruel Z, et al: Cytokine mRNA gene expression in active and nonactive pulmonary sarcoidosis. Eur Respir J 1997; 10: 2034-9.
7. Wahlstrom J, Katchar K, Wigzell H, Olerup O, Eklund A, Grunewald J: Analysis of intracellular cytokines in CD4+ and CD8+ lung and blood T cells in sarcoidosis. Am J Respir Crit Care Med 2001; 163: 115-21.
8. Shigehara K, Shijubo N, Ohmichi M, et al: IL-12 and IL-18 are increased and stimulate IFN-gamma production in sarcoid lungs. J Immunol 2001; 166: 642-9.
9. Moller DR, Forman JD, Liu MC et al: Enhanced expression of IL-12 associated with Th1 cytokine profiles in active pulmonary sarcoidosis. J Immunol 1996; 156: 4952-60.
10. Möllers M, Aries SP, Dromann D, Mascher B, Braun J, Dalhoff K: Intracellular cytokine repertoire in different T cell subsets from patients with sarcoidosis. Thorax 2001; 56: 487-93.
11. Shigehara K, Shijubo N, Ohmichi M, et al: Increased circulating interleukin-12 (IL-12) p40 in pulmonary sarcoidosis. Clin Exp Immunol 2003; 132: 152-7.
12. Fukami T, Miyazaki E, Matsumoto T, Kumamoto T, Tsuda T: Elevated expression of interleukin-18 in the granulomatous lesions of muscular sarcoidosis. Clin Immunol 2001; 101: 12-20.
13. Capelli A, Di Stefano A, Lusuardi M, Gnemmi I, Donner CF: Increased macrophage inflammatory protein-1 alpha and macrophage inflammatory protein-1beta levels in bronchoalveolar lavage fluid of patients affected by different stages of pulmonary sarcoidosis. Am J Respir Crit Care Med 2002; 165: 236-41.
14. Baughman RP, Strohofer SA, Buchsbaum J, Lower EE: Release of tumor necrosis factor by alveolar macrophages of patients with sarcoidosis. J Lab Clin Med 1990; 115: 36-42.
15. Ziegenhagen MW, Benner UK, Zissel G, Zabel P, Schlaak M, Muller-Quernheim J: Sarcoidosis: TNF-alpha release from alveolar macrophages and serum level of sIL-2R are prognostic markers. Am J Respir Crit Care Med 1997; 156: 1586-92.
16. Girgis RE, Basha MA, Maliarik M, Popovich J Jr, Iannuzzi MC: Cytokines in the bronchoalveolar lavage fluid of patients with active pulmonary sarcoidosis. Am J Respir Crit Care Med 1995; 152: 71-5.
17. Gibejova A, Mrazek F, Subrtova D, et al: Expression of macrophage inflammatory protein-3 beta/CCL19 in pulmonary sarcoidosis. Am J Respir Crit Care Med 2003; 167: 1695-703.
18. Petrek M, Kolek V, Szotkowska J, du Bois RM: CC and C chemokine expression in pulmonary sarcoidosis. Eur Respir J 2002; 20: 1206-12.
19. Moller DR: Pulmonary fibrosis of sarcoidosis. New approaches, old ideas. Am J Respir Cell Mol Biol 2003; 29 (Suppl): S37-S41.
20. Heller RA, Schena M, Chai A, et al: Discovery and analysis of inflammatory disease-related genes using cDNA microarrays. Proc Natl Acad Sci USA 1997; 94: 2150-5.
21. Tusher VG, Tibshirani R, Chu G: Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci USA 2001; 98: 5116-21. [Published erratum appears in Proc Natl Acad Sci USA 98: 10515.]
22. Gimino VJ, Lande JD, Berryman TR, King RA, Hertz MI: Gene expression profiling of bronchoalveolar lavage cells in acute lung rejection. Am J Respir Crit Care Med 2003; 168: 1237-42.
23. Gaede KI, Mamat U, Muller-Quernheim J: Differential gene expression pattern in alveolar macrophages of patients with sarcoidosis and tuberculosis. J Mol Med 2004; 82: 206-10.
24. Thonhofer R, Maercker C, Popper H: Expression of sarcoidosis related genes in lung lavage cells. Sarcoidosis Vasc Diffuse Lung Dis 2002; 19: 59-65.
25. Rutherford RM, Kehren J, Staedler F, et al: Functional genomics in sarcoidosis - reduced or increased apoptosis? Swiss Med Wkly 2001; 131: 459-70.
26. Fink L, Kohlhoff S, Stein MM, et al: cDNA array hybridization after laser-assisted microdissection from nonneoplastic tissue. Am J Pathol 2002; 160: 81-90.
27. Endege WO, Steinmann KE, Boardman LA, Thibodeau SN, Schlegel R: Representative cDNA libraries and their utility in gene expression profiling. Biotechniques 1999; 26: 542-48,550.
28. Bacon CM, McVicar DW, Ortaldo JR, Rees RC, O'Shea JJ, Johnston JA: Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12. J Exp Med 1995; 181: 399-404.
29. Shimoda K, Kato K, Aoki K, et al: Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function. Immunity 2000; 13: 561-71.
30. Sugimoto N, Nakahira M, Ahn HJ, et al: Differential requirements for JAK2 and TYK2 in T cell proliferation and IFN-gamma production induced by IL-12 alone or together with IL-18. Eur J Immunol 2003; 33: 243-51.
31. Hobeika AC, Etienne W, Torres BA, Johnson HM, Subramaniam PS: IFN-gamma induction of p21(WAF1) is required for cell cycle inhibition and suppression of apoptosis. J Interferon Cytokine Res 1999; 19: 1351-61.
32. Hiramatsu J, Kataoka M, Nakata Y, et al: Propionibacterium acnes DNA detected in bronchoalveolar lavage cells from patients with sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 2003; 20: 197-203.
33. Ziegenhagen MW, Schrum S, Zissel G, Zipfel PF, Schlaak M, Müller-Quernheim: Increased expression of proinflammatory chemokines in bronchoalveolar lavage cells of patients with progressing idiopathic pulmonary fibrosis and sarcoidosis. J Investig Med 1998; 46: 223-31.
34. Xaus J, Besalduch N, Comalada M, et al: A. High expression of p21 Waf1 in sarcoid granulomas: a putative role for long-lasting inflammation. J Leukoc Biol 2003; 74: 295-301.
35. Kunitake R, Kuwano K, Miyazaki H, et al: Expression of p53,p21 (Waf1/Cip1/Sdi1) and Fas antigen in collagen vascular and granulomatous lung diseases. Eur Respir J 1998; 12: 920-5.