Analysis of intracellular cytokines in CD4+ and CD8+ lung and blood T cells in sarcoidosis

American Journal of Respiratory and Critical Care Medicine

Volumn 163, Issue 1, 2001, Pages 115-121

  Wahlstrom J ^a   Katchar, K ^a   Wigzell, H ^a   Olerup, O ^a   Eklund, A ^a   Grunewald, J ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CD4 ANTIGEN; CD8 ANTIGEN; CELL SURFACE MARKER; CYTOKINE; FLUORESCENT DYE; GAMMA INTERFERON; HLA DR ANTIGEN; HLA DR17 ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; SAPONIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; FLOW CYTOMETRY; HLA SYSTEM; HUMAN; HUMAN CELL; INFLAMMATION; LUNG INFILTRATE; LUNG LAVAGE; MALE; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROGNOSIS; SARCOIDOSIS; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH2 CELL;

EID: 0035138504     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.163.1.9906071     Document Type: Article

References (42)

1. Medical progress: Sarcoidosis
2. T cell receptor variable region gene usage by CD4+ and CD8+ T cells in bronchoalveolar lavage fluid and peripheral blood of sarcoidosis patients
3. HLA-DR predicts the prognosis in Scandinavian sarcoidosis patients
4. Biology of human Th1 and Th2 cells
5. Defining protective responses to pathogen: Cytokine profiles in leprosy lesions
6. Type 1 and type 2: A fundamental dichotomy for all T-cell subsets
7. Spontaneous release of interleukin-2 by lung T lymphocytes in active pulmonary sarcoidosis
8. Gamma interferon is spontaneously released by alveolar macrophages and lung T lymphocytes in patients with pulmonary sarcoidosis
9. Pulmonary sarcoidosis: Patterns of cytokine release in vitro
10. Spontaneous production of various cytokines except IL-4 from CD4+ T cells in the affected organs of sarcoidosis patients
11. Clonal analysts of lung and blood T cells in patients with sarcoidosis
12. Th1/Th2 cell distribution in pulmonary sarcoidosis
13. Activated T cells and cytokines in bronchoalveolar lavages from patients with various lung diseases associated with eosinophilia
14. Enhanced expression of IL-12 associated with Th1 cytokine profiles in active pulmonary sarcoidosis
15. Sarcoidosis: Immunopathogenetic concepts and their clinical application
16. Tumor necrosis factor-α gene polymorphism in chronic bronchitis
17. An allelic polymorphism within the human tumor necrosis factor-α promoter region is strongly associated with HLA A1, B8, and DR3 alleles
18. Single cell analyses of cytokine production
19. Cytokine flow cytometry: Understanding cytokine biology at the single-cell level
20. CD4/CD8 ratios in bronchoalveolar lavage fluid: Of value for diagnosing sarcoidosis?
21. Consensus conference: Activity of sarcoidosis
22. Relationship between changed alveolar-capillary permeability and angiotensin converting enzyme activity in serum in sarcoidosis
23. T-cell cytokine profile evaluated at the single cell level in BAL and blood in allergic asthma
24. Assessment of cytokines by immunofluorescence and the paraformaldehyde-saponin procedure
25. Immunocytochemical and flow cytofluorimetric detection of intracellular IL-4, IL-5 and IFN-γ Applications using blood- and airway-derived cells
26. Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies
27. Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper i and T helper 2 populations
28. Phenotypic analysis of lymphocytes and monocytes/macrophages in peripheral blood and bronchoalveolar lavage fluid from patients with pulmonary sarcoidosis
29. Increased expression of IL-12 receptor mRNA in active pulmonary tuberculosis and sarcoidosis
30. CD8 alveolitis in sarcoidosis: Incidence, phenotypic characteristics, clinical features
31. Cytokine patterns in tuberculous and sarcoid granulomas
32. Production of cytokines in sarcoid lymph nodes: Preferential expression of interleukin-1β and interferon-γ genes
33. Corticosteroids restore the balance between locally produced Th1 and Th2 cytokines and immunoglobulin isotypes to normal in sarcoid lung
34. Decreased frequency of interferon-γ- and interleukin-2-producing cells in patients with atopic diseases measured at the single cell level
35. A donal analysis of lung T cells derived by bronchoalveolar lavage of healthy individuals
36. Fusion and activation of human alveolar macrophages induced by recombinant interferon-γ and their suppression by dexamethasone
37. Sarcoidosis: TNF-α release from alveolar macrophages and serum level of sIL-2R are prognostic markers
38. Tumour necrosis factor alpha promoter gene polymorphism in sarcoidosis
39. CD4+ and CD8+ cell cytokine profiles in neonates, older children and adults: Increasing T helper type 1 and T cytotoxic type 1 cell populations with age
40. Postburn constitutional changes in T-cell reactivity occur in CD8+ rather than in CD4+ cells
41. Analysis of Th1 and Th2 cytokines expressing CD4+ and CD8+ T cells in rheumatoid arthritis by flow cytometry
42. Anti-inflammatory cytokine release by alveolar macrophages in pulmonary sarcoidosis