Increased circulating interleukin-12 (IL-12) p40 in pulmonary sarcoidosis

Clinical and Experimental Immunology

Volumn 132, Issue 1, 2003, Pages 152-157

  Shigehara, Katsunori ^a,b   Shijubo, N ^a,b   Ohmichi, M ^b   Kamiguchi, K ^a   Takahashi, R ^a,b   Morita Ichimura, S ^a,b   Ohchi, T ^a   Tatsuno, T ^b   Hiraga, Y ^b   Abe, S ^a   Sato, N ^a  

^a SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b Sapporo General Hospital of Hokkaido Railway Company   (Japan)

Author keywords

IL 12 p40; Pulmonary sarcoidosis; Th1 predominance

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE; GAMMA INTERFERON; INTERLEUKIN 12; LYSOZYME; PROTEIN P40; PROTEIN P70;

ADULT; ARTICLE; BLOOD LEVEL; CELL LINE; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIOID CELL; FEMALE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LUNG; LYMPH NODE; MACROPHAGE; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SARCOIDOSIS; TH1 CELL; THORAX RADIOGRAPHY;

ANALYSIS OF VARIANCE; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CELL LINE; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITHELIOID CELLS; FEMALE; HUMANS; IMMUNOGLOBULIN ISOTYPES; IMMUNOHISTOCHEMISTRY; INTERFERON TYPE II; INTERLEUKIN-12; LUNG; LYMPH NODES; MACROPHAGES; MALE; MIDDLE AGED; MURAMIDASE; PEPTIDYL-DIPEPTIDASE A; SARCOIDOSIS, PULMONARY; TH1 CELLS;

EID: 0347928885     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2003.02105.x     Document Type: Article

References (25)

1. American Thoracic Society. Statement on sarcoidosis. Joint Statement of the American Thoracic Society (ATS), the European Respiratory Society (ERS) and the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG) adopted by the ATS Board of Directors and by the ERS Executive Committee. Am J Respir Crit Care Med 1999; 160:736-55.
2. Müller-Quernheim J. Sarcoidosis: immunopathogenetic concepts and their clinical application. Eur Respir J 1998; 12:716-38.
3. Trinecheri G. Interleukin-12: a cytokine produced by antigen presenting cells with immunoregulatory functions in the generation of T helper cells type 1 and cytotoxic lymphocytes. Blood 1994; 84:4008-27.
4. Moller DR, Forman JD, Liu MC et al. Enhanced expression of IL-12 associated with Th1 cytokine profile in active pulmonary sarcoidosis. J Immunol 1996; 156:4952-61.
5. Shigehara K, Shijubo N, Ohmichi M et al. IL-12 and IL-18 are increased and stimulate IFN-γ production in sarcoid lungs. J Immunol 2001; 166:642-9.
6. Ling P, Gately MK, Gubler U et al. Human IL-12 p40 homodimer binds to the IL-12 receptor but dose not mediate biologic activity. J Immunol 1995; 154:116-27.
7. Heinzel FP, Hujer AM, Ahmed FN et al. In vivo production and function of IL-12 p40 homodimers. J Immunol 1997; 158:4381-8.
8. Oppmann B, Lesley R, Blom B et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 2000; 13:715-25.
9. Kasahara Y, Ashihara Y. Colorimetry of ACE activity in serum. Clin Chem 1981; 27:1922-5.
10. Ensink FTE, Haeringen NJ. Pitfalls in the assay of lysozyme in human tear fluid. Ophthalmic Res 1977; 9:366-73.
11. Hoshino T, Winkler-Pickett RT, Mason AT et al. IL-13 production by NK cells: IL-13-producing NK and T cells are present in vivo in the absence of IFN-γ. J Immunol 1999; 162:51-9.
12. Semenzato G, Agostini C. Immunologic events in the development of interstitial lung disease: the paradigm of sarcoidosis. In: Schwarz MI, King TE, Jr, eds. Interstitial Lung Disease, 3rd edn. Ontario: BC Dekker Publ., 1998:229-50.
13. Cleveland MG, Gorham JD, Murphy TL et al. Lipoteichoic acid preparation of Gram-positive bacteria induce interleukin-12 through a CD14-dependent pathways. Infect Immun 1996; 64:1906-12.
14. Cella M, Sheidegger D. Palmer-Lehmann K et al. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J Exp Med 1996; 184:747-52.
15. Kato T, Hakamada R, Yamane H et al. Induction of IL-12 p40 mRNA expression and IL-12 production of macrophages via CD40-CD40 ligand interaction. J Immunol 1996; 156:3932-8.
16. Yamane H, Kato T, Nariuuchi H. Effective stimulation for IL-12 p35 mRNA accumulation and bioactive IL-12 production of antigen-presenting cells interacted with Th cells. J Immunol 1999; 162:6433-41.
17. Wang X, Wilkinson VL, Podlaski FJ et al. Characterization of mouse interleukin-12 p40 homodimer binding to the interleukin-12 receptor subunits. Eur J Immunol 1999; 29:2007-13.
18. Mattner F, Ozmen L, Podlaski FJ et al. Treatment with homodimeric interleukin-12 (IL-12) p40 protects mice from IL-12-dependent shock but not from tumor necrosis factor alpha-dependent shock. Infect Immun 1997; 65:4734-7.
19. Yoshimoto T, Wang C-R, Yoneto T et al. Reduced T helper 1 responses in IL-12 p40 transgenic mice. J Immunol 1998; 160:588-94.
20. Bucht A, Larsson P, Weisbort L et al. Expression of interferon gamma (IFN-γ), IL-10, IL-12 and transforming growth factor-beta (TGF-β) mRNA in synovial fluid cells from patients in the early and late phases of rheumatoid arthritis (RA). Clin Exp Immunol 1996; 103:357-67.
21. Gattorno M, Picco P, Vinnola S et al. Serum interleukin 12 concentration in juvenile chronic arthritis. Ann Rheum Dis 1998; 57:425-8.
22. Zhang M, Gately MK, Wang E et al. Interleukin 12 at the site of disease in tuberculosis. J Clin Invest 1994; 93:1733-9.
23. D'Andrea A, Regaraju M, Valiante NM et al. Production of natural killer cell stimulatory factor (NKSF/IL-12) by peripheral blood mononuclear cells. J Exp Med 1992; 176:1387-98.
24. Gattorno M, Picco P, Buoncompagni A et al. Serum p55 and p75 tumor necrosis factor receptors as markers of disease activity in juvenile chronic arthritis. Ann Rheum Dis 1996; 55:243-7.
25. Cooper AM, Kipnis A, Turner J et al. Mice lacking bioactive IL-12 can generate protective, antigen-specific cellular responses to mycobacterial infection only if the IL-12 p40 subunit is present. J Immunol 2002; 168:1322-7.