Cytokine mRNA gene expression nonactive pulmonary sarcoidosis

European Respiratory Journal

Volumn 10, Issue 9, 1997, Pages 2034-2039

  Minshall, E M ^a   Tsicopoulos, A ^b   Yasruel, Z ^a   Wallaert, B ^b   Akoum, H ^b   Vorng, H ^b   Tonnel, A B ^b   Hamid, Q ^a  

^a MCGILL UNIVERSITY   (Canada)

^b INSTITUT PASTEUR DE LILLE   (France)

Author keywords

Cytokines; Macrophages; Pulmonary sarcoidosis; T lymphocytes

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2; MESSENGER RNA;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ACTIVITY; FEMALE; GENE EXPRESSION; HUMAN; MACROPHAGE; MACROPHAGE ACTIVATION; MALE; PRIORITY JOURNAL; SARCOIDOSIS; T LYMPHOCYTE;

ADULT; CD4-POSITIVE T-LYMPHOCYTES; FEMALE; GENE EXPRESSION; HUMANS; IN SITU HYBRIDIZATION; INTERFERON TYPE II; INTERLEUKINS; MALE; MIDDLE AGED; RNA, MESSENGER; SARCOIDOSIS, PULMONARY;

EID: 0030883148     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.97.10092034     Document Type: Article

References (27)

1. Thomas PD, Hunninghake GW. Current concepts of the pathogenesis of sarcoidosis. Am Rev Respir Dis 1987; 135: 747-760.
2. Tsutsumi T, Mikuniya T, Satake N, Izumi T. TNF-α mRNA but not IL-1β is differentially expressed in lung macrophages of patients with active pulmonary sarcoidosis. Sarcoidosis 1994; 11(1): 19-25.
3. Swider C, Laba A, Moniewska A, Gerdes J, Flad HD, Lange A. Presence of mRNA for interferon-γ (IFN-γ) in blood mononuclear cells is associated with an active stage I sarcoidosis. Clin Exp Immunol 1995; 100(3): 401-405.
4. Zheng L, Teschler H, Guzman J, Hubner K, Striz I, Costabel U. Alveolar macrophage TFN-α release and BAL cell phenotypes in sarcoidosis. Am J Respir Crit Care Med 1995; 152: 1061-1066.
5. Robinson BWS, McLemore TL, Crystal RG. Gamma-interferon is spontaneously released by alveolar macrophages and lung T-lymphocytes in patients with pulmonary sarcoidosis. J Clin Invest 1985; 75: 1488-1495.
6. Hunninghake GW. Release of interleukin-1 by alveolar macrophages of patients with active pulmonary sarcoidosis. Am Rev Respir Dis 1984; 129: 569-572.
7. Moller DR, Forman JD, Liu MC, et al. Enhanced expression of IL-12 associated with Th1 cytokine profiles in active pulmonary sarcoidosis. J Immunology 1996; 156: 4952-4960.
8. Zissel G, Homolka J, Schlaak J, Schlaak M, Muller-Quernheim J. Anti-inflammatory cytokine release by alveolar macrophages in pulmonary sarcoidosis. Am J Respir Crit Care Med 1996; 154: 713-719.
9. Itoh A, Yamaguchi E, Furuya K, et al. Correlation of GM-CSF mRNA in bronchoalveolar lavage with indices of clinical activity in sarcoidosis. Thorax 1993; 48: 1230-1234.
10. Baughman RP, Strohofer SA, Buchsbaum J, Lower EE. Release of tumor necrosis factor by alveolar macrophages of patients with sarcoidosis. J Lab Clin Med 1990: 115 (1): 36-42.
11. Crystal, RG, Roberts WC, Hunninghake GW, Gadek JE, Fulmer JD, Line BR. Pulmonary sarcoidosis: a disease characterised and perpetuated by activated lung T-lymphocytes. Ann Intern Med 1981; 94: 73-94.
12. Hunninghake GW, Crystal RG. Pulmonary sarcoidosis: a disorder mediated by excess helper T-lymphocyte activity at sites of disease activity. N Engl J Med 1981; 305: 429-434.
13. Pinkston P, Bitterman PB, Crystal RG. Spontaneous release of interleukin-2 by lung T-lymphocytes in active pulmonary sarcoidosis. N Engl J Med 1983; 308: 793-800.
14. Sahashi K, Ina Y, Takada K, Sato T, Yamamoto M, Morishita M. Significance of interleukin-6 in patients with sarcoidosis. Chest 1994; 106: 156-160.
15. Baudouin SV, du Bois RM. Disease Activity. In: Geraint-James D, ed. Sarcoidosis and Other Granulomatous Diseases. New York, Marcel Dekker Inc., 1994; pp. 573-595.
16. Hamid Q, Wharton J, Terenghi G, et al. Localization of atrial natriuretic peptide mRNA and immunoreactivity in the rat heart and human atrial appendage. Proc Natl Acad Sci USA 1987; 84: 6760-6764.
17. Hunninghake GW, Kawanami O, Ferrans VJ, Young RC, Roberts WC, Crystal RG. Characterization of the inflammatory and immune effector cells in the lung parenchyma of patients with interstitial lung disease. Am Rev Respir Dis 1981; 123: 407-412.
18. Hunninghake GW, Gadek JE, Young RC, Kawanami O, Fermas VJ, Crystal RG. Maintenance of granuloma formation in pulmonary sarcoidosis by T-lymphocytes within the lung. N Engl J Med 1981; 302: 594-598.
19. Ceuppens JL, Lacquet LM, Marien G, Demedts M, Van den Eeckhout A, Stevens E. Alveolar T-cell subsets in pulmonary sarcoidosis: correlation with disease activity and effect of steroid treatment. Am Rev Respir Dis 1984; 129: 563-568.
20. Semenzato G, Agostini C, Trentin L, et al. Evidence of cells bearing interleukin-2 receptor at sites of disease activity in sarcoid patients. Clin Exp Immunol 1984; 57: 331-337.
21. Hudspith BN, Flint KC, Geraint-James D, Brostoff J, Johnson NM. Lack of immune deficiency in sarcoidosis: compartmentalisation of the immune response. Thorax 1987; 42: 250-255.
22. Prior C, Knight RA, Herold M, Ott G, Spiteri MA. Pulmonary sarcoidosis: patterns of cytokine release in vitro. Eur Respir J 1996; 9: 47-53.
23. Robinson DS, Ying S, Taylor IK, et al. Evidence for a Th1-like bronchoalveolar T-cell subset and predominance of interferon-γ gene activation in pulmonary tuberculosis. Am J Respir Crit Care Med 1994; 149: 989-993.
24. Nathan CF, Prendergast TJ, Wiebe ME, et al. Activation of human macrophages. Comparison of other cytokines with interferon-γ. J Exp Med 1984; 160(2): 600-605.
25. Nagasawa H, Miyaura C, Abe E, Suda T, Horiguchi M, Suda T. Fusion and activation of human alveolar macrophages induced by recombinent interferon-γ and their suppression by dexamethasone. Am Rev Respir Dis 1987; 136: 916-921.
26. Bost TW, Riches DWH, Schumacher B, et al. Alveolar macrophages from patients with beryllium disease and sarcoidosis express increased levels of mRNA for tumor necrosis factor-α and interleukin-6 but not interleukin-1α. Am J Respir Cell Mol Biol 1994; 10: 506-513.
27. Moore KW, O'Garra A, de Waal Malefyt R, Viera P, Mosmann TR. Interleukin-10. Annu Rev Immunol 1993; 11: 165-190.