Application of chiral technology in a pharmaceutical company. Enantiomeric separation and spectroscopic studies of key asymmetric intermediates using a combination of techniques. Phenylglycidols

Chirality

Volumn 19, Issue 9, 2007, Pages 716-730

  McConnell, Oliver J ^a   He, Yanan ^a   Nogle, Lisa ^a   Sarkahian, Ani ^a,b  

^a PFIZER INC   (United States)

^b GLAXOSMITHKLINE   (United States)

Author keywords

Chiral separations; Determination of absolute stereochemistry; Electronic circular dichroism; Enantiomeric separations; Optical rotation; Phenylglycidol; Supercritical fluid chromatography; Vibrational circular dichroism

Indexed keywords

CHLORINE; CINNAMIC ACID DERIVATIVE; FLUORINE; GLYCIDOL; PHENYLGLYCIDOL; UNCLASSIFIED DRUG;

AB INITIO CALCULATION; ARTICLE; ASYMMETRIC SYNTHESIS; CHIRALITY; CIRCULAR DICHROISM; DRUG INDUSTRY; ENANTIOMER; OPTICAL ROTATION; PRIORITY JOURNAL; STEREOCHEMISTRY; SUPERCRITICAL FLUID CHROMATOGRAPHY;

ALCOHOLS; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, SUPERCRITICAL FLUID; CINNAMATES; CIRCULAR DICHROISM; CRYSTALLOGRAPHY, X-RAY; ELECTRONICS; EPOXY COMPOUNDS; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; MOLECULAR CONFORMATION; SPECTROPHOTOMETRY; SPECTROPHOTOMETRY, INFRARED; STEREOISOMERISM; TECHNOLOGY, PHARMACEUTICAL;

EID: 34748836631     PISSN: 08990042     EISSN: 1520636X     Source Type: Journal    
DOI: 10.1002/chir.20368     Document Type: Article

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