Streptomyces serine protease (DHP-A) as a new biocatalyst capable of forming chiral intermediates of 1,4-dihydropyridine calcium antagonists

Applied and Environmental Microbiology

Volumn 68, Issue 6, 2002, Pages 2716-2725

  Arisawa, Akira ^a   Matsufuji, Motoko ^a   Nakashima, Takashi ^a   Dobashi, Kazuyuki ^a   Isshiki, Kunio ^a   Yoshioka, Takeo ^a   Yamada, Shigeru ^a   Momose, Haruo ^a   Taguchi, Seiichi ^a  

^a MERCIAN CORPORATION   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM COMPOUNDS; DRUG PRODUCTS; HYDROLYSIS; ORGANIC COMPOUNDS;

CHIRAL INTERMEDIATES;

ENZYMES;

1,4 DIHYDROPYRIDINE; CALCIUM ANTAGONIST; ESTER; GENE PRODUCT; PROTEIN DHP A; PROTEIN SAM P45; SERINE PROTEINASE; SUBTILISIN; UNCLASSIFIED DRUG;

ENZYME;

ARTICLE; BIOCATALYST; CHIRALITY; CONTROLLED STUDY; DRUG INDUSTRY; ENANTIOSELECTIVITY; GENE EXPRESSION; HYDROLYSIS; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; SEQUENCE ANALYSIS; STRAIN DIFFERENCE; STREPTOMYCES; SUPERNATANT;

AMINO ACID SEQUENCE; CATALYSIS; CLONING, MOLECULAR; DIHYDROPYRIDINES; GENE EXPRESSION; HYDROLYSIS; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; SEQUENCE HOMOLOGY, AMINO ACID; SERINE ENDOPEPTIDASES; STREPTOMYCES; SUBSTRATE SPECIFICITY;

ACTINOBACTERIA (CLASS); STREPTOMYCES; STREPTOMYCES ALBOGRISEOLUS; STREPTOMYCES VIRIDOSPORUS; UNCULTURED ACTINOMYCETE;

EID: 0036268885     PISSN: 00992240     EISSN: None     Source Type: Journal    
DOI: 10.1128/AEM.68.6.2716-2725.2002     Document Type: Article

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