Synthesis of chiral building blocks for use in drug discovery

Molecules

Volumn 9, Issue 6, 2004, Pages 405-426

  Marino, Sharon T ^a   Stachurska Buczek, Danuta ^a   Huggins, Daniel A ^a   Krywult, Beata M ^a   Sheehan, Craig S ^a   Nguyen, Thao ^a   Choi, Neil ^a   Parsons, Jack G ^a   Griffiths, Peter G ^a   James, Ian W ^a   Bray, Andrew M ^a   White, Jonathan M ^b   Boyce, Rustum S ^c  

^a Mimotopes Pty Ltd   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Asymmetric epoxidation; Asymmetric hydrogenation; Chiral building blocks; Chiral drugs; Chiral metal catalysts; DuPHOS; Jacobsen's catalyst; Noyori catalyst

Indexed keywords

METAL;

CATALYSIS; CATALYST; CHEMICAL REACTION; CHIRALITY; CONFERENCE PAPER; ENANTIOMER; EPOXIDATION; HYDROGENATION; REACTION ANALYSIS; STEREOCHEMISTRY; SYNTHESIS;

EID: 3242878246     PISSN: 14203049     EISSN: None     Source Type: Journal    
DOI: 10.3390/90600405     Document Type: Conference Paper

References (7)

1. Robinson, A. J.; Lim, C.Y.; He, L.; Ma, P.; Li, H-Y. Highly Enantioselective Synthesis of α, β-Diaminopropanoic Acid Derivatives Using a Catalytic Asymmetric Hydrogenation Approach. J. Org. Chem. 2001, 66, 4141-4147.
2. Burk, M.; Feaster, J. E.; Nugent, W. A.; Harlow, R. L. Preparation and use of C2-Symmetric Bis(phospholanes): Production of α-Amino Acid Derivatives via Highly Enantioselective Hydrogenation reactions. J. Am. Chem. Soc. 1993, 115, 10125-10138.
3. 1H NMR Spectroscopy. Tetrahedron Lett., 1986, 27, 4033-4034.
4. Gallou-Dagommer, I.; Gastaud, P.; RajanBabu, T. V. Asymmetric Synthesis of Functionalized 1,2,3,4-Tetrahydroquinolines. Org. Lett. 2001, 3, 2053-2056.
5. Ohkuma, T.; Ooka, H.; Yamakawa, M.; Ikariya, T.; Noyori R. Stereoselective Hydrogenation of Simple Ketones Catalyzed by Ruthenium(II) Complexes. J. Org. Chem. 1996, 61, 4972-4873.
6. Lists of atomic coordinates, displacement parameters, structure factors and complete geometry of 25 and 32 have been deposited with the CCDC (deposition numbers 239229 and 239230, respectively). Copies may be obtained through the Managing Editor, Cambridge Crystallographic Data Centre (CCDC), 12 Union Road, Cambridge, CB2 1EZ, England.
7. Larrow, J. F.; Roberts, E.; Verhoeven, T. R.; Ryan, K. M.; Senanayake, C. H.; Reider, P. J.; Jacobsen E. N. (1S,2R)-1-aminoindan-2-ol. Org. Syn., 1998, 76, 46.