Indolent Mantle Cell Lymphoma With Nodal Involvement and Mutated Immunoglobulin Heavy Chain Genes

Human Pathology

Volumn 34, Issue 10, 2003, Pages 1030-1034

  Nodit, Laurentia ^a   Bahler, David W ^b   Jacobs, Samuel A ^a   Locker, Joseph ^c   Swerdlow, Steven H ^a,d  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d PRESBYTERIAN UNIVERSITY HOSPITAL   (United States)

Author keywords

B cell lymphoma; Immunoglobulin gene mutation; Mantle cell lymphoma

Indexed keywords

CYCLIN D1; IMMUNOGLOBULIN HEAVY CHAIN;

ADULT; ARTICLE; B LYMPHOCYTE; CASE REPORT; CELL PROLIFERATION; CHRONIC LYMPHATIC LEUKEMIA; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE MUTATION; GENE REARRANGEMENT; GENOTYPE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOGLOBULIN GENE; KARYOTYPING; LYMPH NODE BIOPSY; LYMPHOCYTE COUNT; MANTLE CELL LYMPHOMA; NUCLEOTIDE SEQUENCE; PHENOTYPE; THROMBOCYTOPENIA;

EID: 0142169921     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1053/S0046-8177(03)00410-6     Document Type: Article

References (37)

1. Banks PM, Chan J, Cleary ML, et al: Mantle cell lymphoma. A proposal for unification of morphologic, immunologic, and molecular data. Am J Surg Pathol 16:637-640, 1992
2. Campo E, Raffeld M, Jaffe ES: Mantle-cell lymphoma. Semin Hematol 36:115-127, 1999
3. Swerdlow SH, Williams ME: From centrocytic to mantle cell lymphoma: A clinicopathologic and molecular review of 3 decades. Hum Pathol 33:7-20, 2002
4. Hummel M, Tamaru J, Kalvelage B, et al: Mantle cell (previously centrocytic) lymphomas express VH genes with no or very little somatic mutations like the physiologic cells of the follicle mantle. Blood 84:403-407, 1994
5. A clinical evaluation of the International Lymphoma Study Group classification of non-Hodgkin's lymphoma. The Non-Hodgkin's Lymphoma Classification Project. Blood 89:3909-3918, 1997
6. Swerdlow SH, Berger F, Issacson PG, et al: Mantle cell lymphoma, in Jaffe ES, Harris NL, Stein H, et al (eds): World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues. Lyon, France, IARC, 2001, pp 168-170
7. Zucca E, Stein H, Coiffier B: European Lymphoma Task Force (ELTF): Report of the workshop on mantle cell lymphoma (MCL). Ann Oncol 5:507-511, 1994
8. Walsh SH, Thorselius M, Johnson A, et al: Mutated VH genes and preferential VH3-21 use define new subsets of mantle cell lymphoma. Blood 101:4047-4054, 2003
9. Thorselius M, Walsh S, Eriksson I, et al: Somatic hypermutation and V(H) gene usage in mantle cell lymphoma. Eur J Haematol 68:217-224, 2002
10. Du MQ, Diss TC, Xu CF, et al: Ongoing immunoglobulin gene mutations in mantle cell lymphomas. Br J Haematol 96:124-131, 1997
11. Laszlo T, Nagy M, Kelenyi G, et al: Immunoglobulin V(H) gene mutational analysis suggests that blastic variant of mantle cell lymphoma derives from different stages of B-cell maturation. Leuk Res 24:27-31, 2000
12. Pittaluga S, Tierens A, Pinyol M, et al: Blastic variant of mantle cell lymphoma shows a heterogenous pattern of somatic mutations of the rearranged immunoglobulin heavy chain variable genes. Br J Haematol 102:1301-1306, 1998
13. Graham Osicer D, Rosenwald A, Orchard JA, et al: DNA microarray analysis distinguishes t(11;14) lymphocytosis from chronic lymphocytic leukemia. Blood 100:140a-141a, 2002
14. King BE, Chen C, Locker J, et al: Immunophenotypic and genotypic markers of follicular center cell neoplasia in diffuse large B-cell lymphomas. Mod Pathol 13:1219-1231, 2000
15. Chen CC, Raikow RB, Sonmez-Alpan E, et al: Classification of small B-cell lymphoid neoplasms using a paraffin section immunohistochemical panel. Appl Immunohistochem Mol Morphol 8:1-11, 2000
16. Bahler DW, Miklos JA, Swerdlow SH: Ongoing Ig gene hypermutation in salivary gland mucosa-associated lymphoid tissue-type lymphomas. Blood 89:3335-3344, 1997
17. Lardelli P, Bookman MA, Sundeen J, et al: Lymphocytic lymphoma of intermediate differentiation. Morphologic and immunophenotypic spectrum and clinical correlations. Am J Surg Pathol 14:752-763, 1990
18. Swerdlow SH, Habeshaw JA, Murray LJ, et al: Centrocytic lymphoma: A distinct clinicopathologic and immunologic entity. A multiparameter study of 18 cases at diagnosis and relapse. Am J Pathol 113:181-197, 1983
19. Tolksdorf G, Stein H, Lennert K: Morphological and immunological definition of a malignant lymphoma derived from germinal-centre cells with cleaved nuclei (centrocytes). Br J Cancer 41:168-182, 1980
20. Hofmann WK, de Vos S, Tsukasaki K, et al: Altered apoptosis pathways in mantle cell lymphoma detected by oligonucleotide microarray. Blood 98:787-794, 2001
21. Zhu Y, Hollmen J, Raty R, et al: Investigatory and analytical approaches to differential gene expression profiling in mantle cell lymphoma. Br J Haematol 119:905-915, 2002
22. Garand R, Orchard JA, Davis Z, et al: A subset of mantle cell lymphoma exhibits stable disease and correlates with mutated VH genes and low CD38 expression. Blood 98:724a, 2001 (abst)
23. Kienle DL, Kroeber A, Leupolt E, et al: VH mutation status and gene usage in mantle cell lymphoma: Correlation with genomic aberrations and survival. Blood 100:90a, 2002
24. Andersen NS, Donovan JW, Borus JS, et al: Failure of immunologic purging in mantle cell lymphoma assessed by polymerase chain reaction detection of minimal residual disease. Blood 90:4212-4221, 1997
25. Rosenwald A, Alizadeh AA, Widhopf G, et al: Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia. J Exp Med 194:1639-1647, 2001
26. Klein U, Tu Y, Stolovitzky GA, et al: Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells. J Exp Med 194:1625-1638, 2001
27. Segal GH, Masih AS, Fox AC, et al: CD5-expressing B-cell non-Hodgkin's lymphomas with bcl-1 gene rearrangement have a relatively homogeneous immunophenotype and are associated with an overall poor prognosis. Blood 85:1570-1579, 1995
28. Gaal K, Chen W, Chen YY, et al: Immunoglobulin heavy chain variable region (VH) mutation in peripheral blood B-cell chronic lymphoproliferative disorders: Variability of somatic mutations between leukemic mantle cell lymphomas and t(11;14) positive cases with prolymphocytic features. Mod Pathol 15:241a, 2002 (abst)
29. Avet-Loiseau H, Garand R, Gaillard F, et al: Detection of t(11;14) using interphase molecular cytogenetics in mantle cell lymphoma and atypical chronic lymphocytic leukemia. Genes Chromosomes Cancer 23:175-182, 1998
30. Ruchlemer R, Wotherspoon AC, Brito-Babapulle V, et al: B-prolymphocytic leukemia (B-PLL) revisited-the significance of t(11; 14). Blood 100:569a, 2002 (abst)
31. Schlette E, Bueso-Ramos C, Giles F, et al: Mature B-cell leukemias with more than 55% prolymphocytes. A heterogeneous group that includes an unusual variant of mantle cell lymphoma. Am J Clin Pathol 115:571-581, 2001
32. Wong KF, So CC, Chan JK: Nucleolated variant of mantle cell lymphoma with leukemic manifestations mimicking prolymphocytic leukemia. Am J Clin Pathol 117:246-251, 2002
33. Bahler DW, Aguilera NS, Chen CC, et al: Histological and immunoglobulin VH gene analysis of interfollicular small lymphocytic lymphoma provides evidence for two types. Am J Pathol 157: 1063-1070, 2000
34. Liu Z, Dong HY, Gorczyca W, et al: CD5-mantle cell lymphoma. Am J Clin Pathol 118:216-224, 2002
35. Kaptain S, Zukerberg LR, Ferry JA, et al: BCL-1 cyclin D1+CD5-mantle cell lymphoma. Mod Pathol 11:133A, 1998 (abst)
36. Cong P, Raffeld M, Teruya-Feldstein J, et al: In situ localization of follicular lymphoma: Description and analysis by laser capture microdissection. Blood 99:3376-3382, 2002
37. Rawstron AC, Green MJ, Kuzmicki A, et al: Monoclonal B lymphocytes with the characteristics of "indolent" chronic lymphocytic leukemia are present in 3.5% of adults with normal blood counts. Blood 100:635-639, 2002