Synthesis and biological evaluation of 1-(2,4,5-trisubstituted phenyl)-3-(5-cyanopyrazin-2-yl)ureas as potent Chk1 kinase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 8, 2006, Pages 2293-2298

  Li, Gaoquan ^a   Hasvold, Lisa A ^a   Tao, Zhi Fu ^a   Wang, Gary T ^a   Gwaltney II, Stephen L ^a   Patel, Jyoti ^a   Kovar, Peter ^a   Credo, Robert B ^a   Chen, Zehan ^a   Zhang, Haiying ^a   Park, Chang ^a   Sham, Hing L ^a   Sowin, Thomas ^a   Rosenberg, Saul H ^a   Lin, Nan Horng ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Chk1 inhibitor; Urea

Indexed keywords

1 (5 CHLORO 2,4 DIMETHOXYPHENYL) 3 (5 CYANOPYRAZIN 2 YL)UREA DERIVATIVE; CHECKPOINT KINASE 1; DOXORUBICIN; ENZYME INHIBITOR; N ARYL N' PYRAZINYLUREA CHECKPOINT KINASE 1 INHIBITOR; PHENYL GROUP; UNCLASSIFIED DRUG;

ARTICLE; CELL ASSAY; CELL CYCLE ARREST; CYTOTOXICITY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME MODIFICATION; HUMAN; HUMAN CELL; IC 50; X RAY CRYSTALLOGRAPHY;

ANTIBIOTICS, ANTINEOPLASTIC; CELL CYCLE; CRYSTALLOGRAPHY, X-RAY; DOXORUBICIN; HUMANS; INHIBITORY CONCENTRATION 50; NITRILES; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PYRAZINES; TUMOR CELLS, CULTURED; UREA;

EID: 33644790240     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.01.028     Document Type: Article

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