Therapeutic proteasome inhibition in experimental acute pancreatitis

World Journal of Gastroenterology

Volumn 13, Issue 33, 2007, Pages 4452-4457

  Letoha, Tamás ^a   Fehér, Liliána Z ^b   Pecze, László ^b   Somlai, Csaba ^a   Varga, Ilona ^a   Kaszaki, József ^c   Tóth, Gábor ^a   Vizler, Csaba ^b   Tiszlavicz, László ^a   Takács, Tamás ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

^b INSTITUTE OF BIOCHEMISTRY   (Hungary)

^c UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Acute pancreatitis; Cholecystokinin octapeptide; Heat shock proteins; Nuclear factor B; Proteasome inhibition

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CHOLECYSTOKININ OCTAPEPTIDE; HEAT SHOCK PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEASOME; PROTEASOME INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL DAMAGE; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA BINDING; DOSE RESPONSE; DRUG EFFICACY; EXPERIMENTAL MODEL; HISTOPATHOLOGY; INFLAMMATION; MALE; NONHUMAN; OXIDATIVE STRESS; PANCREATITIS; PROTEIN EXPRESSION; RAT;

EID: 34548665713     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v13.i33.4452     Document Type: Article

References (40)

1. Elliott PJ, Zollner TM, Boehncke WH. Proteasome inhibition: a new anti-inflammatory strategy. J Mol Med 2003; 81: 235-245
2. Lawrence T, Gilroy DW, Colville-Nash PR, Willoughby DA. Possible new role for NF-kappaB in the resolution of inflammation. Nat Med 2001; 7: 1291-1297
3. Weber CK, Adler G. From acinar cell damage to systemic inflammatory response: current concepts in pancreatitis. Pancreatology 2001; 1: 356-362
4. Algul H, Tando Y, Schneider G, Weidenbach H, Adler G, Schmid RM. Acute experimental pancreatitis and NF-kappaB/Rel activation. Pancreatology 2002; 2: 503-509
5. Bhatia M, Wong FL, Cao Y, Lau HY, Huang J, Puneet P, Chevali L. Pathophysiology of acute pancreatitis. Pancreatology 2005; 5: 132-144
6. Weber CK, Adler G. Acute pancreatitis. Curr Opin Gastroenterol 2003; 19: 447-450
7. Adler G. Has the biology and treatment of pancreatic diseases evolved? Best Pract Res Clin Gastroenterol 2004; 18 Suppl: 83-90
8. Bhatia M, Neoptolemos JP, Slavin J. Inflammatory mediators as therapeutic targets in acute pancreatitis. Curr Opin Investig Drugs 2001; 2: 496-501
9. Bhatia M. Inflammatory response on the pancreatic acinar cell injury. Scand J Surg 2005; 94: 97-102
10. Letoha T, Somlai C, Takacs T, Szabolcs A, Rakonczay Z Jr, Jarmay K, Szalontai T, Varga I, Kaszaki J, Boros I, Duda E, Hackler L, Kurucz I, Penke B. The proteasome inhibitor MG132 protects against acute pancreatitis. Free Radic Biol Med 2005; 39: 1142-1151
11. Penke B, Hajnal F, Lonovics J, Holzinger G, Kadar T, Telegdy G, Rivier J. Synthesis of potent heptapeptide analogues of cholecystokinin. J Med Chem 1984; 27: 845-849
12. Rakonczay Z Jr, Duda E, Kaszaki J, Ivanyi B, Boros I, Lonovics J, Takacs T. The anti-inflammatory effect of methylprednisolone occurs down-stream of nuclear factor-kappaB DNA binding in acute pancreatitis. Eur J Pharmacol 2003; 464: 217-227
13. Letoha T, Somlai C, Takacs T, Szabolcs A, Jarmay K, Rakonczay Z Jr, Hegyi P, Varga L Kaszaki J, Krizbai L Boros I, Duda E, Kusz E, Penke B. A nuclear import inhibitory peptide ameliorates the severity of cholecystokinin-induced acute pancreatitis. World J Gastroenterol 2005; 11: 990-999
14. Rakonczay Z Jr, Ivanyi B, Varga I, Boros I, Jednakovits A, Nemeth I, Lonovics J, Takacs T. Nontoxic heat shock protein coinducer BRX-220 protects against acute pancreatitis in rats. Free Radic Biol Med 2002; 32: 1283-1292
15. Kuebler WM, Abels C, Schuerer L, Goetz AE. Measurement of neutrophil content in brain and lung tissue by a modified myeloperoxidase assay. Int J Microcirc Clin Exp 1996; 16: 89-97
16. Nagy ZB, Kelemen JZ, Feher LZ, Zvara A, Juhasz K, Puskas LG. Real-time polymerase chain reaction-based exponential sample amplification for microarray gene expression profiling. Anal Biochem 2005; 337: 76-83
17. Wong SH, Knight JA, Hopfer SM, Zaharia O, Leach CN Jr, Sunderman FW Jr. Lipoperoxides in plasma as measured by liquid-chromatographic separation of malondialdehydethiobarbituric acid adduct. Clin Chem 1987; 33: 214-220
18. Sedlak J, Lindsay RH. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal Biochem 1968; 25: 192-205
19. Misra HP, Fridovich I. The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem 1972; 247: 3170-3175
20. Benzie IF, Strain JJ. The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. Anal Biochem 1996; 239: 70-76
21. Ranson JH. Diagnostic standards for acute pancreatitis. World J Surg 1997; 21: 136-142
22. Yadav D, Agarwal N, Pitchumoni CS. A critical evaluation of laboratory tests in acute pancreatitis. Am J Gastroenterol 2002; 97: 1309-1318
23. Bhatia M, Brady M, Shokuhi S, Christmas S, Neoptolemos JP, Slavin J. Inflammatory mediators in acute pancreatitis. J Pathol 2000; 190: 117-125
24. Makhija R, Kingsnorth AN. Cytokine storm in acute pancreatitis. J Hepatobiliary Pancreat Surg 2002; 9: 401-410
25. Klebanoff SJ. Myeloperoxidase: friend and foe. J Leukoc Biol 2005; 77: 598-625
26. Savkovic V, Gaiser S, Iovanna JL, Bodeker H. The stress response of the exocrine pancreas. Dig Dis 2004; 22: 239-246
27. Rakonczay Z Jr, Takacs T, Boros I, Lonovics J. Heat shock proteins and the pancreas. J Cell Physiol 2003; 195: 383-391
28. Schafer C, Williams JA. Stress kinases and heat shock proteins in the pancreas: possible roles in normal function and disease. J Gastroenterol 2000; 35: 1-9
29. Halangk W, Lerch MM, Brandt-Nedelev B, Roth W, Ruthenbuerger M, Reinheckel T, Domschke W, Lippert H, Peters C, Deussing J. Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis. J Clin Invest 2000; 106: 773-781
30. Van Acker GJ, Saluja AK, Bhagat L, Singh VP, Song AM, Steer ML. Cathepsin B inhibition prevents trypsinogen activation and reduces pancreatitis severity. Am J Physiol Gastrointest Liver Physiol 2002; 283: G794-G800
31. Halangk W, Lerch MM. Early events in acute pancreatitis. Clin Lab Med 2005; 25: 1-15
32. Gao Y, Lecker S, Post MJ, Hietaranta AJ, Li J, Volk R, Li M, Sato K, Saluja AK, Steer ML, Goldberg AL, Simons M. Inhibition of ubiquitin-proteasome pathway-mediated I kappa B alpha degradation by a naturally occurring antibacterial peptide. J Clin Invest 2000; 106: 439-448
33. Zaninovic V, Gukovskaya AS, Gukovsky L Mouria M, Pandol SJ. Cerulein upregulates ICAM-1 in pancreatic acinar cells, which mediates neutrophil adhesion to these cells. Am J Physiol Gastrointest Liver Physiol 2000; 279: G666-G676
34. Weber H, Jonas L, Huhns S, Schuff-Werner P. Dysregulation of the calpain-calpastatin system plays a role in the development of cerulein-induced acute pancreatitis in the rat. Am J Physiol Gastrointest Liver Physiol 2004; 286: G932-G941
35. Virlos I, Mazzon E, Serraino I, Genovese T, Di Paola R, Thiemerman C, Siriwardena A, Cuzzocrea S. Calpain I inhibitor ameliorates the indices of disease severity in a murine model of cerulein-induced acute pancreatitis. Intensive Care Med 2004; 30: 1645-1651
36. Lee DH, Goldberg AL. Proteasome inhibitors: valuable new tools for cell biologists. Trends Cell Biol 1998; 8: 397-403
37. Bush KT, Goldberg AL, Nigam SK. Proteasome inhibition leads to a heat-shock response, induction of endoplasmic reticulum chaperones, and thermotolerance. J Biol Chem 1997; 272: 9086-9092
38. Lee DH, Goldberg AL. Proteasome inhibitors cause induction of heat shock proteins and trehalose, which together confer thermotolerance in Saccharomyces cerevisiae. Mol Cell Biol 1998; 18: 30-38
39. Gukovsky I, Gukovskaya AS, Blinman TA, Zaninovic V, Pandol SJ. Early NF-kappaB activation is associated with hormone-induced pancreatitis. Am J Physiol 1998; 275: G1402-G1414
40. Lerch MM, Adler G. Experimental animal models of acute pancreatitis, Int J Pancreatol 1994; 15: 159-170