Acute experimental pancreatitis and NF-κB/Rel activation

Pancreatology

Volumn 2, Issue 6, 2002, Pages 503-509

  Algül, Hana ^a   Tando, Yusuke ^a   Schneider, Günter ^a   Weidenbach, Hans ^a   Adler, Guido ^a   Schmid, Roland M ^a  

^a UNIVERSITY OF ULM   (Germany)

Author keywords

Acute pancreatitis; Cerulein; Cytokines; IKK; Inflammation; Inhibitor protein I B; NF B Rel

Indexed keywords

ACID; BASE; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 6; PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR REL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

DISEASE MODEL; DISEASE SEVERITY; GENE CONTROL; HUMAN; HYPOXIA; INFLAMMATION; KIDNEY FAILURE; LIVER FAILURE; MORBIDITY; MORTALITY; MULTIPLE ORGAN FAILURE; NONHUMAN; PANCREAS NECROSIS; PANCREATITIS; PATHOGENICITY; PRIORITY JOURNAL; RESPIRATORY FAILURE; REVIEW; TISSUE INJURY; WATER RETENTION; ACUTE DISEASE; ANIMAL; METABOLISM; PATHOPHYSIOLOGY;

ACUTE DISEASE; ANIMALS; CYTOKINES; NF-KAPPA B; PANCREATITIS; PROTO-ONCOGENE PROTEINS C-REL;

EID: 0036436837     PISSN: 14243903     EISSN: 14243911     Source Type: Journal    
DOI: 10.1159/000066090     Document Type: Article

References (45)

1. Sen R, Baltimore D: Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism. Cell 1986;47:921-928.
2. Grilli M, Chiu JJ, Lenardo MJ: NF-kappa B and Rel: Participants in a multiform transcriptional regulatory system. Int Rev Cytol 1993;143:1-62.
3. Siebenlist U, Franzoso G, Brown K: Structure, regulation and function of NF-kappa B. Annu Rev Cell Biol 1994;10:405-455.
4. Ghosh S, May MJ, Kopp EB: NF-kappa B and Rel proteins: Evolutionarily conserved mediators of immune responses. Annu Rev Immunol 1998;16:225-260.
5. Beg AA, Baldwin AS Jr: The I kappa B proteins: Multifunctional regulators of Rel/NF-kappa B transcription factors. Genes Dev 1993;7:2064-2070.
6. Schmid RM, Adler G: NF-κB/Rel/IκB: Implications in gastrointestinal diseases. Gastroenterology 2000;118:1208-1228.
7. Finco TS, Baldwin AS: Mechanistic aspects of NF-kappa B regulation: The emerging role of phosphorylation and proteolysis. Immunity 1995;3:263-272.
8. Karin M, Ben-Neriah Y: Phosphorylation meets ubiquitination: The control of NF-κB activity. Annu Rev Immunol 2000;18:621-663.
9. Imbert V, Rupec RA, Livolsi A, Pahl HL, Traenckner EB, Mueller-Dieckmann C, Farahifar D, Rossi B, Auberger P, Bäuerle PA, Peyron JF: Tyrosine phosphorylation of IκB-α activates NF-κB without proteolytic degradation of IκB-α. Cell 1996;86:787-798.
10. Beraud C, Henzel WJ, Bäuerle PA: Involvement of regulatory and catalytic subunits of phosphoinositide 3-kinase in NF-kappaB activation. Proc Natl Acad Sci USA 1999;96:429-434.
11. Gerondakis S, Grossmann M, Nakamura Y, Pohl T, Grumont R: Genetic approaches in mice to understand Rel/NF-κB and IκB function: Transgenics and knockouts. Oncogene 1999;18:6888-6895.
12. Grady T, Liang P, Ernst SA, Logsdon CD: Chemokine gene expression in rat pancreas acinar cells is an early event associated with acute pancreatitis. Gastroenterology 1997;113:1966-1975.
13. Gukovsky I, Gukovskaya AS, Blinman TA, Zaninovic V, Pandol SJ: Early NF-kappaB activation is associated with hormone-induced pancreatitis. Am J Physiol 1998;275:G1402-G1414.
14. Steinle AU, Weidenbach H, Wagner M, Adler G, Schmid RM: NF-kappaB/Rel activation in cerulein pancreatitis. Gastroenterology 1999;116:420-430.
15. 2+ and protein kinase C as messengers. Am J Physiol 1999;277:G678-G686.
16. Han B, Logsdon C: CCK independently activates intracellular trypsinogen and NF-κB in rat pancreatic acinar cells. Am J Physiol 2001;49:C465-C472.
17. Zaninovic V, Gukovskaya AS, Gukovsky I, Mouria M, Pandol SJ: Cerulein upregulates ICAM-1 in pancreatic acinar cells, which mediates neutrophil adhesion to these cells. Am J Physiol 2000;279:G666-G676.
18. Gukovskaya AS, Gukovsky I, Zaninovic V, Song M, Sandoval D, Gukovsky S, Pandol SJ: Pancreatic acinar cells produce, release and respond to tumor necrosis factor-alpha: Role in regulating cell death and pancreatitis. J Clin Invest 1997;100:1853-1862.
19. Schmid RM, Adler G: Cytokines in acute pancreatitis - New pathophysiological concepts evolve. Eur J Gastroenterol Hepatol 1999;11:125-127.
20. Andoh A, Takaya H, Saotome T, Shimada M, Hata K, Araki Y, Nakamura F, Shintani Y, Fujiyama Y, Bamba T: Cytokine regulation of chemokine (Il-8, MCP-1, and RANTES) gene expression in human pancreatic periacinar myofibroblasts. Gastroenterology 2000;119:211-219.
21. Bachem MG, Schneider E, Gros H, Weidenbach H, Schmid RM, Menke A, Siech M, Beger H, Grunert A, Adler G: Identification, culture, and characterization of pancreatic stellate cells in rats and humans. Gastroenterology 1998;115:421-432.
22. Halangk W, Lerch MM, Brandt-Nedelev B, Roth W, Ruthenbürger M, Reinhickel T, Domschke W, Lippert H, Peters C, Deussing J: Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis. J Clin Invest 2000;106:773-781.
23. Grady T, Mah'Moud M, Otani T, Rhee S, Lerch MM, Gorelick FS: Zymogen proteolysis within the pancreatic acinar cell is associated with cell injury. Am J Physiol 1998;275:G1010-G1017.
24. Saluja AK, Donovan EA, Yamanaka K, Yamaguchi Y, Hofbauer B, Steer ML: Cerulein-induced in vitro activation of trypsinogen in rat pancreatic acini is mediated by cathepsin B. Gastroenterology 1997;113:304-310.
25. Saluja AK, Bhagat L, Lee HS, Bhatia M, Frossard JL, Steer ML: Secretagogue-induced digestive enzyme activation and cell injury in rat pancreatic acini. Am J Physiol 1999;276:G835-G842.
26. Hietaranta AJ, Saluja AK, Bhagat L, Singh VP, Song AM, Steer ML: Relationship between NF-kappaB and trypsinogen activation in rat pancreas after supramaximal caerulein stimulation. Biochem Biophys Res Commun 2001;280:388-395.
27. Wada M, Doi R, Hosotani R, Lee JUK, Imamura M: Apoptosis of acinar cells in rat pancreatic duct ligation. J Gastroenterol 1995;30:813-814.
28. Doi R, Wada M, Hosotani R, Lee JU, Koshiba T, Fujimoto K, Mori C, Nakamura N, Shiota K, Imamura M: Role of apoptosis in duct obstruction-induced pancreatic involution in rats. Pancreas 1997;14:39-46.
29. Walker NI, Winterford CM, Williamson RM, Kerr JFR: Ethionine-induced atrophy of rat pancreas involves apoptosis of acinar cells. Pancreas 1993;8:443-449.
30. Kaiser AM, Saluja AK, Sengupta A, Saluja M, Steer ML: Relationship between severity, necrosis and apoptosis in five models of experimental acute pancreatitis. Am J Physiol 1995;269:C1295-C1304.
31. Fujimoto K, Hosotani R, Doi R, Wada M, Lee JU, Koshiba T, Miyamato Y, Imamura M: Role of neutrophils in cerulein-induced pancreatitis in rats: Possible involvement of apoptosis. Digestion 1997;58:421-430.
32. Barkett M, Gilmore TD: Control of apoptosis by Rel/NF-κB transcription factors. Oncogene 1999;18:6910-6924.
33. Satoh A, Shimosegawa T, Fujita M, Kimura K, Masamune A, Koizumi M, Toyota T: Inhibition of nuclear-factor-kappaB activation improves the survival of rats with taurocholate pancreatitis. Gut 1999;44:253-258.
34. Jobin C, Sartor RB: The IκB/NF-κB system: A key determinant of mucosal inflammation and protection. Am J Physiol 2000;278:C451-C462.
35. Norman JG: New approaches to acute pancreatitis: Role of inflammatory mediators. Digestion 1999;60:57-60.
36. Norman JG: The role of cytokines in the pathogenesis of acute pancreatitis. Am J Surg 1998;175:76-83.
37. Norman JG, Fink GW, Denham W, Yang J, Carter G, Sexton C, Falkner J, Gower WR, Franz MG: Tissue-specific cytokine production during experimental acute pancreatitis: A probable mechanism for distant organ dysfunction. Dig Dis Sci 1997;42:1783-1788.
38. Norman JG, Franz M, Messina J, Riker A, Fabri PJ, Rosemurgy AS, Gower WR Jr: Interleukin-1 receptor antagonist decreases severity of experimental acute pancreatitis. Surgery 1995;117:648-655.
39. Kaufmann P, Tilz GP, Smolle KH, Demel U, Krejs GJ: Increased plasma concentrations of circulating intercellular adhesion molecule-1 (cICAM-1) in patients with necrotizing pancreatitis. Immunobiology 1996;195:209-219.
40. Frossard JL, Saluja A, Hofbauer B, Lee HS, Bhatia M, Bhagat L, Steer ML: Deletion of ICAM-1 gene reduces the severity of caerulein-induced pancreatitis and lung injury by interfering with neutrophil sequestration in the pancreas and lung (abstract). Gastroenterology 1998;114(suppl):459.
41. Jaffray C, Yang J, Carter G, Mendez C, Norman J: Pancreatic elastase activates pulmonary nuclear factor kappa B and inhibitory kappa B, mimicking pancreatitis-associated adult respiratory distress syndrome. Surgery 2000;128:225-231.
42. Gao Y, Lecker S, Post MJ, Hietaranta AJ, Li J, Volk R, Li M, Sato K, Saluja AK, Steer ML, Goldberg AL, Simons M: Inhibition of ubiquitin-proteasome pathway-mediated I kappa B alpha degradation by a naturally occurring antibacterial peptide. J Clin Invest 2000;106:439-448.
43. May MJ, D'Acquisto F, Madge LA, Glockner J, Pober JS, Ghosh S: Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex. Science 2000;289:1550-1554.
44. Wahl C, Liptay S, Adler G, Schmid RM: Sulfasalazine: A potent and specific inhibitor of nuclear factor kappa B. J Clin Invest 1998;101:1163-1174.
45. Weber CK, Liptay S, Wirth T, Adler G, Schmid RM: Suppression of NF-κB activity by sulfasalzine is mediated by direct inhibition of IκB kinases α and β. Gastroenterology 2000;119:1209-1218.