Locomotor activity is regulated by D2-like receptors in Drosophila: An anatomic and functional analysis

Developmental Neurobiology

Volumn 67, Issue 3, 2007, Pages 378-393

  Draper, Isabelle ^a   Kurshan, Peri T ^a   McBride, Edward ^a   Jackson, F Rob ^b   Kopin, Alan S ^a  

^a TUFTS MEDICAL CENTER   (United States)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

D2 like receptor; Dopamine; Drosophila; Locomotor activity

Indexed keywords

BROMOCRIPTINE; DOPAMINE; DOPAMINE 2 RECEPTOR;

ARTICLE; BEHAVIORAL SCIENCE; CONTROLLED STUDY; DOPAMINERGIC ACTIVITY; DROSOPHILA MELANOGASTER; IN VIVO STUDY; INSECT GENETICS; LOCOMOTION; NEUROTRANSMISSION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR DOWN REGULATION; REGULATORY MECHANISM; RNA INTERFERENCE;

ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; BEHAVIOR, ANIMAL; BROMOCRIPTINE; DOPAMINE AGONISTS; DROSOPHILA; DROSOPHILA PROTEINS; GENE EXPRESSION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; LARVA; MOTOR ACTIVITY; NERVOUS SYSTEM; RECEPTORS, DOPAMINE D2; RNA INTERFERENCE;

EID: 34548621406     PISSN: 19328451     EISSN: 1932846X     Source Type: Journal    
DOI: 10.1002/dneu.20355     Document Type: Article

References (64)

1. Aizman O, Brismar H, Uhlen P, Zettergren E, Levey AI, Forssberg H, Greengard P, et al. 2000. Anatomical and physiological evidence for D1 and D2 dopamine receptor colocalization in neostriatal neurons. Nat Neurosci 3:226-230.
2. Andretic R, van Swinderen B, Greenspan RJ. 2005. Dopaminergic modulation of arousal in Drosophila. Curr Biol 15:1165-1175.
3. Asico LD, Ladines C, Fuchs S, Accili D, Carey RM, Semeraro C, Pocchiari F, et al. 1998. Disruption of the dopamine D3 receptor gene produces renin-dependent hypertension. J Clin Invest 102:493-498.
4. Baik JH, Picetti R, Saiardi A, Thiriet G, Dierich A, Depaulis A, Le Meur M, et al. 1995. Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors. Nature 377:424-428.
5. Bainton RJ, Tsai LT, Singh CM, Moore MS, Neckameyer WS, Heberlein U. 2000. Dopamine modulates acute responses to cocaine, nicotine and ethanol in Drosophila. Curr Biol 10:187-194.
6. Barone JA. 1999. Domperidone: A peripherally acting dopamine2-receptor antagonist. Ann Pharmacother 33:429-440.
7. Beggs KT, Hamilton IS, Kurshan PT, Mustard JA, Mercer AR. 2005. Characterization of a D2-like dopamine receptor (AmDOP3) in honey bee, Apis mellifera. Insect Biochem Mol Biol 35:873-882.
8. Benveniste RJ, Thor S, Thomas JB, Taghert PH. 1998. Cell type-specific regulation of the Drosophila FMRF-NH2 neuropeptide gene by Apterous, a LIM homeodomain transcription factor. Development 125:4757-4765.
9. Bergson C, Levenson R, Goldman-Rakic PS, Lidow MS. 2003. Dopamine receptor-interacting proteins: The Ca(2+) connection in dopamine signaling. Trends Pharmacol Sci 24:486-492.
10. Birman S. 2005. Arousal mechanisms: Speedy flies don't sleep at night. Curr Biol 15:R511-R513.
11. Blumenthal EM. 2003. Regulation of chloride permeability by endogenously produced tyramine in the Drosophila Malpighian tubule. Am J Physiol Cell Physiol 284: C718-C728.
12. Budnik V, White K. 1988. Catecholamine-containing neurons in Drosophila melanogaster: Distribution and development. J Comp Neurol 268:400-413.
13. Chang HY, Grygoruk A, Brooks ES, Ackerson LC, Maidment NT, Bainton RJ, Krantz DE. 2006. Overexpression of the Drosophila vesicular monoamine transporter increases motor activity and courtship but decreases the behavioral response to cocaine. Mol Psychiatry 11:99-113.
14. Chase DL, Pepper JS, Koelle MR. 2004. Mechanism of extrasynaptic dopamine signaling in Caenorhabditis elegans. Nat Neurosci 7:1096-1103.
15. Davis RL. 2005. Olfactory memory formation in Drosophila: From molecular to systems neuroscience. Annu Rev Neurosci 28:275-302.
16. Emilien G, Maloteaux JM, Geurts M, Hoogenberg K, Cragg S. 1999. Dopamine receptors-physiological understanding to therapeutic intervention potential. Pharmacol Ther 84:133-156.
17. Eveleth DD, Gietz RD, Spencer CA, Nargang FE, Hodgetts RB, Marsh JL. 1986. Sequence and structure of the dopa decarboxylase gene of Drosophila: Evidence for novel RNA splicing variants. EMBO J 5:2663-2672.
18. Feany MB, Bender WW. 2000. A Drosophila model of Parkinson's disease. Nature 404:394-398.
19. Feng G, Hannan F, Reale V, Hon YY, Kousky CT, Evans PD, Hall LM. 1996. Cloning and functional characterization of a novel dopamine receptor from Drosophila melanogaster. J Neurosci 16:3925-3933.
20. Fetsko LA, Xu R, Wang Y. 2005. Effects of age and dopamine D2L receptor-deficiency on motor and learning functions. Neurobiol Aging 26:521-530.
21. Fortier E, Belote JM. 2000. Temperature-dependent gene silencing by an expressed inverted repeat in Drosophila. Genesis 26:240-244.
22. Fowler SC, Zarcone TJ, Vorontsova E, Chen R. 2002. Motor and associative deficits in D2 dopamine receptor knockout mice. Int J Dev Neurosci 20:309-321.
23. Friggi-Grelin F, Coulom H, Meller M, Gomez D, Hirsh J, Birman S. 2003. Targeted gene expression in Drosophila dopaminergic cells using regulatory sequences from tyrosine hydroxylase. J Neurobiol 54:618-627.
24. Gotzes F, Balfanz S, Baumann A. 1994. Primary structure and functional characterization of a Drosophila dopamine receptor with high homology to human D1/5 receptors. Receptors Channels 2:131-141.
25. Greer CL, Grygoruk A, Patton DE, Ley B, Romero-Calderon R, Chang HY, Houshyar R, et al. 2005. A splice variant of the Drosophila vesicular monoamine transporter contains a conserved trafficking domain and functions in the storage of dopamine, serotonin, and octopamine. J Neurobiol 64:239-258.
26. Han KA, Millar NS, Grotewiel MS, Davis RL. 1996. DAMB, a novel dopamine receptor expressed specifically in Drosophila mushroom bodies. Neuron 16:1127-1135.
27. Haywood AF, Staveley BE. 2004. Parkin counteracts symptoms in a Drosophila model of Parkinson's disease. BMC Neurosci 5:14.
28. Hearn MG, Ren Y, McBride EW, Reveillaud I, Beinborn M, Kopin AS. 2002. A Drosophila dopamine 2-like receptor: Molecular characterization and identification of multiple alternatively spliced variants. Proc Natl Acad Sci USA 99:14554-14559.
29. Helfrich-Forster C. 2005. Techniques that revealed the network of the circadian clock of Drosophila. Methods Enzymol 393:439-451.
30. Hemby SE, Trojanowski JQ, Ginsberg SD. 2003. Neuronspecific age-related decreases in dopamine receptor subtype mRNAs. J Comp Neurol 456:176-183.
31. Hendricks JC, Lu S, Kume K, Yin JC, Yang Z, Sehgal A. 2003. Gender dimorphism in the role of cycle (BMAL1) in rest, rest regulation, and longevity in Drosophila melanogaster. J Biol Rhythms 18:12-25.
32. Hussain T, Abdul-Wahab R, Lokhandwala MF. 1997. Bromocriptine stimulates Na+, K(+)-ATPase in renal proximal tubules via the cAMP pathway. Eur J Pharmacol 321:259-263.
33. Ichise M, Ballinger JR, Tanaka F, Moscovitch M, St George-Hyslop PH, Raphael D, Freedman M. 1998. Age-related changes in D2 receptor binding with iodine-123-iodobenzofuran SPECT. J Nucl Med 39:1511-1518.
34. Kim YC, Lee HG, Seong CS, Han KA. 2003. Expression of a D1 dopamine receptor dDA1/DmDOP1 in the central nervous system of Drosophila melanogaster. Gene Expr Patterns 3:237-245.
35. Kume K, Kume S, Park SK, Hirsh J, Jackson FR. 2005. Dopamine is a regulator of arousal in the fruit fly. J Neurosci 25:7377-7384.
36. H, Chaney S, Roberts IJ, Forte M, Hirsh J. 2000. Ectopic G-protein expression in dopamine and serotonin neurons blocks cocaine sensitization in Drosophila melanogaster. Curr Biol 10:211-214.
37. ZS, Schmauss C, Cuenca A, Ratcliffe E, Gershon MD. 2006. Physiological modulation of intestinal motility by enteric dopaminergic neurons and the D2 receptor: Analysis of dopamine receptor expression, location, development, and function in wild-type and knock-out mice. J Neurosci 26:2798-2807.
38. Lima SQ, Miesenbock G. 2005. Remote control of behavior through genetically targeted photostimulation of neurons. Cell 121:141-152.
39. McClung C, Hirsh J. 1998. Stereotypic behavioral responses to free-base cocaine and the development of behavioral sensitization in Drosophila. Curr Biol 8:109-112.
40. Miczek KA, Fish EW, De Bold JF, De Almeida RM. 2002. Social and neural determinants of aggressive behavior: Pharmacotherapeutic targets at serotonin, dopamine and γ-aminobutyric acid systems. Psychopharmacology (Berl) 163:434-458.
41. Min KT, Benzer S. 1999. Preventing neurodegeneration in the Drosophila mutant bubblegum. Science 284:1985-1988. Missale C, Nash SR, Robinson SW, Jaber M, Caron MG. 1998. Dopamine receptors: From structure to function. Physiol Rev 78:189-225.
42. Miyazawa T, Matsumoto M, Kato S, Takeuchi K. 2003. Dopamine-induced protection against indomethacinevoked intestinal lesions in rats-role of anti-intestinal motility mediated by D2 receptors. Med Sci Monit 9:BR71-BR77.
43. Neckameyer WS. 1998. Dopamine modulates female sexual receptivity in Drosophila melanogaster. J Neurogenet 12:101-114.
44. Neckameyer WS, Quinn WG. 1989. Isolation and characterization of the gene for Drosophila tyrosine hydroxylase. Neuron 2:1167-1175.
45. Neckameyer WS, Woodrome S, Holt B, Mayer A. 2000. Dopamine and senescence in Drosophila melanogaster. Neurobiol Aging 21:145-152.
46. Nurnberger A, Rabiger M, Mack A, Diaz J, Sokoloff P, Muhlbauer B, Luippold G. 2004. Subapical localization of the dopamine D3 receptor in proximal tubules of the rat kidney. J Histochem Cytochem 52:1647-1655.
47. Ozono R, Ueda A, Oishi Y, Yano A, Kambe M, Katsuki M, Oshima T. 2003. Dopamine D2 receptor modulates sodium handling via local production of dopamine in the kidney. J Cardiovasc Pharmacol 42 (Suppl 1):S75-S79.
48. Park D, Han M, Kim YC, Han KA, Taghert PH. 2004. Ap-let neurons-a peptidergic circuit potentially controlling ecdysial behavior in Drosophila. Dev Biol 269:95-108.
49. Pollack A. 2004. Coactivation of D1 and D2 dopamine receptors: In marriage, a case of his, hers, and theirs. Sci STKE 2004:pe50.
50. Porzgen P, Park SK, Hirsh J, Sonders MS, Amara SG. 2001. The antidepressant-sensitive dopamine transporter in Drosophila melanogaster: A primordial carrier for catecholamines. Mol Pharmacol 59:83-95.
51. Ricci A, Marchal-Victorion S, Bronzetti E, Parini A, Amenta F, Tayebati SK. 2002. Dopamine D4 receptor expression in rat kidney. Evidence for pre- and postjunctional localization. J Histochem Cytochem 50:1091-1096.
52. Rival T, Soustelle L, Strambi C, Besson MT, Iche M, Birman S. 2004. Decreasing glutamate buffering capacity triggers oxidative stress and neuropil degeneration in the Drosophila brain. Curr Biol 14:599-605.
53. Rothenfluh A, Heberlein U. 2002. Drugs, flies, and video-tape: The effects of ethanol and cocaine on Drosophila locomotion. Curr Opin Neurobiol 12:639-645.
54. Sibley DR. 1999. New insights into dopaminergic receptor function using antisense and genetically altered animals. Annu Rev Pharmacol Toxicol 39:313-341.
55. Spradling AC, Rubin GM. 1982. Transposition of cloned P elements into Drosophila germ line chromosomes. Science 218:341-347.
56. Steffan JS, Bodai L, Pallos J, Poelman M, McCampbell A, Apostol BL, Kazantsev A, et al. 2001. Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila. Nature 413:739-743.
57. Sugamori KS, Demchyshyn LL, McConkey F, Forte MA, Niznik HB. 1995. A primordial dopamine D1-like adenylyl cyclase-linked receptor from Drosophila melanogaster displaying poor affinity for benzazepines. FEBS Lett 362:131-138.
58. Sugiura M, Fuke S, Suo S, Sasagawa N, Van Tol HH, Ishiura S. 2005. Characterization of a novel D2-like dopamine receptor with a truncated splice variant and a D1-like dopamine receptor unique to invertebrates from Caenorhabditis elegans. J Neurochem 94:1146-1157.
59. Suo S, Sasagawa N, Ishiura S. 2003. Cloning and characterization of a Caenorhabditis elegans D2-like dopamine receptor. J Neurochem 86:869-878.
60. Ueda A, Ozono R, Oshima T, Yano A, Kambe M, Teranishi Y, Katsuki M, et al. 2003. Disruption of the type 2 dopamine receptor gene causes a sodium-dependent increase in blood pressure in mice. Am J Hypertens 16:853-858.
61. Vallone D, Picetti R, Borrelli E. 2000. Structure and function of dopamine receptors. Neurosci Biobehav Rev 24:125-132.
62. Volkow ND, Wang GJ, Fowler JS, Logan J, Gatley SJ, MacGregor RR, Schlyer DJ, et al. 1996. Measuring age-related changes in dopamine D2 receptors with 11C-raclopride and 18F-N-methylspiroperidol. Psychiatry Res 67:11-16.
63. Wong DF, Young D, Wilson PD, Meltzer CC, Gjedde A. 1997. Quantification of neuroreceptors in the living human brain. III. D2-like dopamine receptors: Theory, validation, and changes during normal aging. J Cereb Blood Flow Metab 17:316-330.
64. Yellman C, Tao H, He B, Hirsh J. 1997. Conserved and sexually dimorphic behavioral responses to biogenic amines in decapitated Drosophila. Proc Natl Acad Sci USA 94:4131-4136.